Evaluation of enzyme inhibitors in drug discovery: a guide for medicinal chemists and pharmacologists
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Hoboken, N.J.
J. Wiley
©2005
|
| Schriftenreihe: | Methods of biochemical analysis
v. 46 |
| Schlagworte: | |
| Online-Zugang: | FAW01 FAW02 Volltext |
| Beschreibung: | Includes bibliographical references and index Why enzymes as drug targets? -- Enzyme reaction mechanisms. -- Reversible modes of inhibitor interactions with enzymes. -- Assay considerations for compound library screening. -- Lead organization and structure-activity relationships for reversible inhibitors. -- Slow binding inhibitors. -- Tight binding inhibitors. -- Irreversible enzyme inactivators. -- Appendix 1. Kinetics if biochemical reactions. -- Appendix 2. Derivation of the enzyme-ligand binding isotherm equation. -- Appendix 3. Serial dilution schemes Most enzymology textbooks, including his own, address biochemists and other researchers, says Copeland, a researcher in enzymology and mechanistic pharmacology at a large pharmaceutical corporation. Here he provides chemists and pharmacologists with key information to answer such questions as what opportunities for inhibitor interactions with enzym |
| Beschreibung: | 1 Online-Ressource (xvii, 271 pages) |
| ISBN: | 0471723266 9780471723264 |
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| 245 | 1 | 0 | |a Evaluation of enzyme inhibitors in drug discovery |b a guide for medicinal chemists and pharmacologists |c Robert A. Copeland |
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| 490 | 0 | |a Methods of biochemical analysis |v v. 46 | |
| 500 | |a Includes bibliographical references and index | ||
| 500 | |a Why enzymes as drug targets? -- Enzyme reaction mechanisms. -- Reversible modes of inhibitor interactions with enzymes. -- Assay considerations for compound library screening. -- Lead organization and structure-activity relationships for reversible inhibitors. -- Slow binding inhibitors. -- Tight binding inhibitors. -- Irreversible enzyme inactivators. -- Appendix 1. Kinetics if biochemical reactions. -- Appendix 2. Derivation of the enzyme-ligand binding isotherm equation. -- Appendix 3. Serial dilution schemes | ||
| 500 | |a Most enzymology textbooks, including his own, address biochemists and other researchers, says Copeland, a researcher in enzymology and mechanistic pharmacology at a large pharmaceutical corporation. Here he provides chemists and pharmacologists with key information to answer such questions as what opportunities for inhibitor interactions with enzym | ||
| 650 | 7 | |a MEDICAL / Drug Guides |2 bisacsh | |
| 650 | 7 | |a MEDICAL / Pharmacology |2 bisacsh | |
| 650 | 7 | |a MEDICAL / Pharmacy |2 bisacsh | |
| 650 | 7 | |a MEDICAL / Nursing / Pharmacology |2 bisacsh | |
| 650 | 4 | |a Antienzymes / Emploi en thérapeutique / Tests | |
| 650 | 4 | |a Médicaments / Conception | |
| 650 | 4 | |a Antienzymes / Relations structure-activité | |
| 650 | 7 | |a Enzyminhibitoren |2 gtt | |
| 650 | 4 | |a Enzyme Inhibitors / therapeutic use | |
| 650 | 4 | |a Drug Design | |
| 650 | 4 | |a Enzyme Inhibitors / chemistry | |
| 650 | 4 | |a Medizin | |
| 650 | 4 | |a Enzyme inhibitors |x Therapeutic use |x Testing | |
| 650 | 4 | |a Drugs |x Design | |
| 650 | 4 | |a Enzyme inhibitors |x Structure-activity relationships | |
| 650 | 0 | 7 | |a Enzyminhibitor |0 (DE-588)4152479-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Arzneimittelentwicklung |0 (DE-588)4143176-5 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
| _version_ | 1804175472869769216 |
|---|---|
| any_adam_object | |
| author | Copeland, Robert Allen |
| author_facet | Copeland, Robert Allen |
| author_role | aut |
| author_sort | Copeland, Robert Allen |
| author_variant | r a c ra rac |
| building | Verbundindex |
| bvnumber | BV043080814 |
| classification_rvk | VS 5350 |
| collection | ZDB-4-EBA |
| ctrlnum | (OCoLC)58964965 (DE-599)BVBBV043080814 |
| dewey-full | 615/.19 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.19 |
| dewey-search | 615/.19 |
| dewey-sort | 3615 219 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Electronic eBook |
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| id | DE-604.BV043080814 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:16:50Z |
| institution | BVB |
| isbn | 0471723266 9780471723264 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028505006 |
| oclc_num | 58964965 |
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| owner_facet | DE-1046 DE-1047 |
| physical | 1 Online-Ressource (xvii, 271 pages) |
| psigel | ZDB-4-EBA ZDB-4-EBA FAW_PDA_EBA |
| publishDate | 2005 |
| publishDateSearch | 2005 |
| publishDateSort | 2005 |
| publisher | J. Wiley |
| record_format | marc |
| series2 | Methods of biochemical analysis |
| spelling | Copeland, Robert Allen Verfasser aut Evaluation of enzyme inhibitors in drug discovery a guide for medicinal chemists and pharmacologists Robert A. Copeland Hoboken, N.J. J. Wiley ©2005 1 Online-Ressource (xvii, 271 pages) txt rdacontent c rdamedia cr rdacarrier Methods of biochemical analysis v. 46 Includes bibliographical references and index Why enzymes as drug targets? -- Enzyme reaction mechanisms. -- Reversible modes of inhibitor interactions with enzymes. -- Assay considerations for compound library screening. -- Lead organization and structure-activity relationships for reversible inhibitors. -- Slow binding inhibitors. -- Tight binding inhibitors. -- Irreversible enzyme inactivators. -- Appendix 1. Kinetics if biochemical reactions. -- Appendix 2. Derivation of the enzyme-ligand binding isotherm equation. -- Appendix 3. Serial dilution schemes Most enzymology textbooks, including his own, address biochemists and other researchers, says Copeland, a researcher in enzymology and mechanistic pharmacology at a large pharmaceutical corporation. Here he provides chemists and pharmacologists with key information to answer such questions as what opportunities for inhibitor interactions with enzym MEDICAL / Drug Guides bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh MEDICAL / Nursing / Pharmacology bisacsh Antienzymes / Emploi en thérapeutique / Tests Médicaments / Conception Antienzymes / Relations structure-activité Enzyminhibitoren gtt Enzyme Inhibitors / therapeutic use Drug Design Enzyme Inhibitors / chemistry Medizin Enzyme inhibitors Therapeutic use Testing Drugs Design Enzyme inhibitors Structure-activity relationships Enzyminhibitor (DE-588)4152479-2 gnd rswk-swf Arzneimittelentwicklung (DE-588)4143176-5 gnd rswk-swf Enzyminhibitor (DE-588)4152479-2 s Arzneimittelentwicklung (DE-588)4143176-5 s 1\p DE-604 Erscheint auch als Druck-Ausgabe, Hardcover 0-471-68696-4 Erscheint auch als Druck-Ausgabe, Hardcover 978-0-471-68696-5 http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=129367 Aggregator Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Copeland, Robert Allen Evaluation of enzyme inhibitors in drug discovery a guide for medicinal chemists and pharmacologists MEDICAL / Drug Guides bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh MEDICAL / Nursing / Pharmacology bisacsh Antienzymes / Emploi en thérapeutique / Tests Médicaments / Conception Antienzymes / Relations structure-activité Enzyminhibitoren gtt Enzyme Inhibitors / therapeutic use Drug Design Enzyme Inhibitors / chemistry Medizin Enzyme inhibitors Therapeutic use Testing Drugs Design Enzyme inhibitors Structure-activity relationships Enzyminhibitor (DE-588)4152479-2 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| subject_GND | (DE-588)4152479-2 (DE-588)4143176-5 |
| title | Evaluation of enzyme inhibitors in drug discovery a guide for medicinal chemists and pharmacologists |
| title_auth | Evaluation of enzyme inhibitors in drug discovery a guide for medicinal chemists and pharmacologists |
| title_exact_search | Evaluation of enzyme inhibitors in drug discovery a guide for medicinal chemists and pharmacologists |
| title_full | Evaluation of enzyme inhibitors in drug discovery a guide for medicinal chemists and pharmacologists Robert A. Copeland |
| title_fullStr | Evaluation of enzyme inhibitors in drug discovery a guide for medicinal chemists and pharmacologists Robert A. Copeland |
| title_full_unstemmed | Evaluation of enzyme inhibitors in drug discovery a guide for medicinal chemists and pharmacologists Robert A. Copeland |
| title_short | Evaluation of enzyme inhibitors in drug discovery |
| title_sort | evaluation of enzyme inhibitors in drug discovery a guide for medicinal chemists and pharmacologists |
| title_sub | a guide for medicinal chemists and pharmacologists |
| topic | MEDICAL / Drug Guides bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh MEDICAL / Nursing / Pharmacology bisacsh Antienzymes / Emploi en thérapeutique / Tests Médicaments / Conception Antienzymes / Relations structure-activité Enzyminhibitoren gtt Enzyme Inhibitors / therapeutic use Drug Design Enzyme Inhibitors / chemistry Medizin Enzyme inhibitors Therapeutic use Testing Drugs Design Enzyme inhibitors Structure-activity relationships Enzyminhibitor (DE-588)4152479-2 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| topic_facet | MEDICAL / Drug Guides MEDICAL / Pharmacology MEDICAL / Pharmacy MEDICAL / Nursing / Pharmacology Antienzymes / Emploi en thérapeutique / Tests Médicaments / Conception Antienzymes / Relations structure-activité Enzyminhibitoren Enzyme Inhibitors / therapeutic use Drug Design Enzyme Inhibitors / chemistry Medizin Enzyme inhibitors Therapeutic use Testing Drugs Design Enzyme inhibitors Structure-activity relationships Enzyminhibitor Arzneimittelentwicklung |
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