Toxicity-pathway-based risk assessment: preparing for paradigm change : a symposium summary
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Washington, D.C.
National Academies Press
c2010
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| Schlagworte: | |
| Online-Zugang: | FAW01 FAW02 Volltext |
| Beschreibung: | Title from PDF title page Includes bibliographical references In 2007, the National Research Council envisioned a new paradigm in which biologically important perturbations in key toxicity pathways would be evaluated with new methods in molecular biology, bioinformatics, computational toxicology, and a comprehensive array of in vitro tests based primarily on human biology. Although some considered the vision too optimistic with respect to the promise of the new science, no one can deny that a revolution in toxicity testing is under way. New approaches are being developed, and data are being generated. As a result, the U.S. Environmental Protection Agency (EPA) expects a large influx of data that will need to be evaluated. EPA also is faced with tens of thousands of chemicals on which toxicity information is incomplete and emerging chemicals and substances that will need risk assessment and possible regulation. Therefore, the agency asked the National Research Council to convene a symposium to stimulate discussion on the application of the new approaches and data in risk assessment. The symposium was held on May 11-13, 2009, in Washington, DC, and included presentations and discussion sessions on pathway-based approaches for hazard identification, applications of new approaches to mode-of-action analyses, the challenges to and opportunities for risk assessment in the changing paradigm, and future directions |
| Beschreibung: | 1 Online-Ressource (1 PDF file (xiv, 119 p.)) |
| ISBN: | 0309154227 0309154235 1282660446 9780309154222 9780309154239 9781282660441 |
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| 245 | 1 | 0 | |a Toxicity-pathway-based risk assessment |b preparing for paradigm change : a symposium summary |c Ellen Mantus, rapporteur ; Standing Committee on Risk Analysis Issues and Reviews, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies |
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| 500 | |a Title from PDF title page | ||
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| 500 | |a In 2007, the National Research Council envisioned a new paradigm in which biologically important perturbations in key toxicity pathways would be evaluated with new methods in molecular biology, bioinformatics, computational toxicology, and a comprehensive array of in vitro tests based primarily on human biology. Although some considered the vision too optimistic with respect to the promise of the new science, no one can deny that a revolution in toxicity testing is under way. New approaches are being developed, and data are being generated. As a result, the U.S. Environmental Protection Agency (EPA) expects a large influx of data that will need to be evaluated. EPA also is faced with tens of thousands of chemicals on which toxicity information is incomplete and emerging chemicals and substances that will need risk assessment and possible regulation. Therefore, the agency asked the National Research Council to convene a symposium to stimulate discussion on the application of the new approaches and data in risk assessment. The symposium was held on May 11-13, 2009, in Washington, DC, and included presentations and discussion sessions on pathway-based approaches for hazard identification, applications of new approaches to mode-of-action analyses, the challenges to and opportunities for risk assessment in the changing paradigm, and future directions | ||
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| 650 | 4 | |a Toxicity testing | |
| 650 | 4 | |a Health risk assessment | |
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Datensatz im Suchindex
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| author | Mantus, Ellen K. |
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| dewey-ones | 615 - Pharmacology and therapeutics |
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| spelling | Mantus, Ellen K. Verfasser aut Toxicity-pathway-based risk assessment preparing for paradigm change : a symposium summary Ellen Mantus, rapporteur ; Standing Committee on Risk Analysis Issues and Reviews, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies Washington, D.C. National Academies Press c2010 1 Online-Ressource (1 PDF file (xiv, 119 p.)) txt rdacontent c rdamedia cr rdacarrier Title from PDF title page Includes bibliographical references In 2007, the National Research Council envisioned a new paradigm in which biologically important perturbations in key toxicity pathways would be evaluated with new methods in molecular biology, bioinformatics, computational toxicology, and a comprehensive array of in vitro tests based primarily on human biology. Although some considered the vision too optimistic with respect to the promise of the new science, no one can deny that a revolution in toxicity testing is under way. New approaches are being developed, and data are being generated. As a result, the U.S. Environmental Protection Agency (EPA) expects a large influx of data that will need to be evaluated. EPA also is faced with tens of thousands of chemicals on which toxicity information is incomplete and emerging chemicals and substances that will need risk assessment and possible regulation. Therefore, the agency asked the National Research Council to convene a symposium to stimulate discussion on the application of the new approaches and data in risk assessment. The symposium was held on May 11-13, 2009, in Washington, DC, and included presentations and discussion sessions on pathway-based approaches for hazard identification, applications of new approaches to mode-of-action analyses, the challenges to and opportunities for risk assessment in the changing paradigm, and future directions Toxicity Tests / Congresses Risk Assessment / Congresses MEDICAL / Toxicology bisacsh Health risk assessment fast Risk management fast Toxicity testing fast Toxicology fast Toxins / Analysis fast Medizin Toxicology Toxins Analysis Toxicity testing Health risk assessment Risk management (DE-588)1071861417 Konferenzschrift gnd-content National Research Council (U.S.) Standing Committee on Risk Analysis Issues and Reviews Sonstige oth http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=326078 Aggregator Volltext |
| spellingShingle | Mantus, Ellen K. Toxicity-pathway-based risk assessment preparing for paradigm change : a symposium summary Toxicity Tests / Congresses Risk Assessment / Congresses MEDICAL / Toxicology bisacsh Health risk assessment fast Risk management fast Toxicity testing fast Toxicology fast Toxins / Analysis fast Medizin Toxicology Toxins Analysis Toxicity testing Health risk assessment Risk management |
| subject_GND | (DE-588)1071861417 |
| title | Toxicity-pathway-based risk assessment preparing for paradigm change : a symposium summary |
| title_auth | Toxicity-pathway-based risk assessment preparing for paradigm change : a symposium summary |
| title_exact_search | Toxicity-pathway-based risk assessment preparing for paradigm change : a symposium summary |
| title_full | Toxicity-pathway-based risk assessment preparing for paradigm change : a symposium summary Ellen Mantus, rapporteur ; Standing Committee on Risk Analysis Issues and Reviews, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies |
| title_fullStr | Toxicity-pathway-based risk assessment preparing for paradigm change : a symposium summary Ellen Mantus, rapporteur ; Standing Committee on Risk Analysis Issues and Reviews, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies |
| title_full_unstemmed | Toxicity-pathway-based risk assessment preparing for paradigm change : a symposium summary Ellen Mantus, rapporteur ; Standing Committee on Risk Analysis Issues and Reviews, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies |
| title_short | Toxicity-pathway-based risk assessment |
| title_sort | toxicity pathway based risk assessment preparing for paradigm change a symposium summary |
| title_sub | preparing for paradigm change : a symposium summary |
| topic | Toxicity Tests / Congresses Risk Assessment / Congresses MEDICAL / Toxicology bisacsh Health risk assessment fast Risk management fast Toxicity testing fast Toxicology fast Toxins / Analysis fast Medizin Toxicology Toxins Analysis Toxicity testing Health risk assessment Risk management |
| topic_facet | Toxicity Tests / Congresses Risk Assessment / Congresses MEDICAL / Toxicology Health risk assessment Risk management Toxicity testing Toxicology Toxins / Analysis Medizin Toxins Analysis Konferenzschrift |
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