Biophysical approaches determining ligand binding to biomolecular targets:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cambridge
Royal Society of Chemistry
2010
|
| Schriftenreihe: | RSC biomolecular sciences
|
| Schlagworte: | |
| Online-Zugang: | FAW01 FAW02 Volltext |
| Beschreibung: | The binding of small ligands to biological molecules is central to most aspects of biological function. The past twenty years has seen the development of an increasing armoury of biophysical methods that not only detect such binding, but also provide varying degrees of information about the kinetics, thermodynamics and structural aspects of the process. These methods have received increasing attention with the growth in more rational approaches to drug discovery and design.This book reviews the latest advances in the application of biophysics to the study of ligand binding. It provides a complete overview of current techniques to identify ligands, characterise their binding sites and understand their binding mechanisms. Particular emphasis is given to the combined use of different techniques and their relative strengths and weaknesses. Consistency in the way each technique is described makes it easy for readers to select the most suitable protocol for their research. The introduction explains why some techniques are more suitable than others and emphasizes the possible synergies between them. The following chapters, all written by a specialist in the particular technique, focus on each method individually. The book finishes by describing how several complimentary techniques can be used together for maximum effectiveness.This book is suitable for biomolecular scientists at graduate or post-doctoral level in academia and industry. Biologists and chemists will also find it a useful introduction to the techniques available |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 1849732663 9781849732666 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV043055572 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 151126s2010 |||| o||u| ||||||eng d | ||
| 020 | |a 1849732663 |c electronic bk. |9 1-84973-266-3 | ||
| 020 | |a 9781849732666 |c electronic bk. |9 978-1-84973-266-6 | ||
| 035 | |a (OCoLC)725827817 | ||
| 035 | |a (DE-599)BVBBV043055572 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-1046 |a DE-1047 | ||
| 082 | 0 | |a 572.33 |2 22 | |
| 245 | 1 | 0 | |a Biophysical approaches determining ligand binding to biomolecular targets |c editors, Alberto Podjarny, Annick P. Dejaegere and Bruno Kieffer |
| 264 | 1 | |a Cambridge |b Royal Society of Chemistry |c 2010 | |
| 300 | |a 1 Online-Ressource | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a RSC biomolecular sciences | |
| 500 | |a The binding of small ligands to biological molecules is central to most aspects of biological function. The past twenty years has seen the development of an increasing armoury of biophysical methods that not only detect such binding, but also provide varying degrees of information about the kinetics, thermodynamics and structural aspects of the process. These methods have received increasing attention with the growth in more rational approaches to drug discovery and design.This book reviews the latest advances in the application of biophysics to the study of ligand binding. It provides a complete overview of current techniques to identify ligands, characterise their binding sites and understand their binding mechanisms. Particular emphasis is given to the combined use of different techniques and their relative strengths and weaknesses. Consistency in the way each technique is described makes it easy for readers to select the most suitable protocol for their research. The introduction explains why some techniques are more suitable than others and emphasizes the possible synergies between them. The following chapters, all written by a specialist in the particular technique, focus on each method individually. The book finishes by describing how several complimentary techniques can be used together for maximum effectiveness.This book is suitable for biomolecular scientists at graduate or post-doctoral level in academia and industry. Biologists and chemists will also find it a useful introduction to the techniques available | ||
| 650 | 7 | |a SCIENCE / Life Sciences / Biochemistry |2 bisacsh | |
| 650 | 7 | |a Ligand binding (Biochemistry) |2 fast | |
| 650 | 4 | |a Ligand binding (Biochemistry) | |
| 650 | 0 | 7 | |a Biophysik |0 (DE-588)4006891-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Chemische Bindung |0 (DE-588)4009843-6 |2 gnd |9 rswk-swf |
| 655 | 7 | |8 1\p |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Chemische Bindung |0 (DE-588)4009843-6 |D s |
| 689 | 0 | 1 | |a Biophysik |0 (DE-588)4006891-2 |D s |
| 689 | 0 | |8 2\p |5 DE-604 | |
| 700 | 1 | |a Podjarny, A. D. |e Sonstige |4 oth | |
| 700 | 1 | |a Dejaegere, Annick P. |e Sonstige |4 oth | |
| 700 | 1 | |a Kieffer, Bruno |e Sonstige |4 oth | |
| 856 | 4 | 0 | |u http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519332 |x Aggregator |3 Volltext |
| 912 | |a ZDB-4-EBA | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-028479764 | ||
| 883 | 1 | |8 1\p |a cgwrk |d 20201028 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | |
| 883 | 1 | |8 2\p |a cgwrk |d 20201028 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | |
| 966 | e | |u http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519332 |l FAW01 |p ZDB-4-EBA |q FAW_PDA_EBA |x Aggregator |3 Volltext | |
| 966 | e | |u http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519332 |l FAW02 |p ZDB-4-EBA |q FAW_PDA_EBA |x Aggregator |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804175426965209088 |
|---|---|
| any_adam_object | |
| building | Verbundindex |
| bvnumber | BV043055572 |
| collection | ZDB-4-EBA |
| ctrlnum | (OCoLC)725827817 (DE-599)BVBBV043055572 |
| dewey-full | 572.33 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572.33 |
| dewey-search | 572.33 |
| dewey-sort | 3572.33 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03765nmm a2200505zc 4500</leader><controlfield tag="001">BV043055572</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">151126s2010 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">1849732663</subfield><subfield code="c">electronic bk.</subfield><subfield code="9">1-84973-266-3</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781849732666</subfield><subfield code="c">electronic bk.</subfield><subfield code="9">978-1-84973-266-6</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)725827817</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV043055572</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-1046</subfield><subfield code="a">DE-1047</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">572.33</subfield><subfield code="2">22</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Biophysical approaches determining ligand binding to biomolecular targets</subfield><subfield code="c">editors, Alberto Podjarny, Annick P. Dejaegere and Bruno Kieffer</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Cambridge</subfield><subfield code="b">Royal Society of Chemistry</subfield><subfield code="c">2010</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">RSC biomolecular sciences</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">The binding of small ligands to biological molecules is central to most aspects of biological function. The past twenty years has seen the development of an increasing armoury of biophysical methods that not only detect such binding, but also provide varying degrees of information about the kinetics, thermodynamics and structural aspects of the process. These methods have received increasing attention with the growth in more rational approaches to drug discovery and design.This book reviews the latest advances in the application of biophysics to the study of ligand binding. It provides a complete overview of current techniques to identify ligands, characterise their binding sites and understand their binding mechanisms. Particular emphasis is given to the combined use of different techniques and their relative strengths and weaknesses. Consistency in the way each technique is described makes it easy for readers to select the most suitable protocol for their research. The introduction explains why some techniques are more suitable than others and emphasizes the possible synergies between them. The following chapters, all written by a specialist in the particular technique, focus on each method individually. The book finishes by describing how several complimentary techniques can be used together for maximum effectiveness.This book is suitable for biomolecular scientists at graduate or post-doctoral level in academia and industry. Biologists and chemists will also find it a useful introduction to the techniques available</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">SCIENCE / Life Sciences / Biochemistry</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Ligand binding (Biochemistry)</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ligand binding (Biochemistry)</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Biophysik</subfield><subfield code="0">(DE-588)4006891-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Chemische Bindung</subfield><subfield code="0">(DE-588)4009843-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="8">1\p</subfield><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Chemische Bindung</subfield><subfield code="0">(DE-588)4009843-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Biophysik</subfield><subfield code="0">(DE-588)4006891-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="8">2\p</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Podjarny, A. D.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dejaegere, Annick P.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kieffer, Bruno</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519332</subfield><subfield code="x">Aggregator</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-4-EBA</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-028479764</subfield></datafield><datafield tag="883" ind1="1" ind2=" "><subfield code="8">1\p</subfield><subfield code="a">cgwrk</subfield><subfield code="d">20201028</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#cgwrk</subfield></datafield><datafield tag="883" ind1="1" ind2=" "><subfield code="8">2\p</subfield><subfield code="a">cgwrk</subfield><subfield code="d">20201028</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#cgwrk</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519332</subfield><subfield code="l">FAW01</subfield><subfield code="p">ZDB-4-EBA</subfield><subfield code="q">FAW_PDA_EBA</subfield><subfield code="x">Aggregator</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519332</subfield><subfield code="l">FAW02</subfield><subfield code="p">ZDB-4-EBA</subfield><subfield code="q">FAW_PDA_EBA</subfield><subfield code="x">Aggregator</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| genre | 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV043055572 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:16:06Z |
| institution | BVB |
| isbn | 1849732663 9781849732666 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028479764 |
| oclc_num | 725827817 |
| open_access_boolean | |
| owner | DE-1046 DE-1047 |
| owner_facet | DE-1046 DE-1047 |
| physical | 1 Online-Ressource |
| psigel | ZDB-4-EBA ZDB-4-EBA FAW_PDA_EBA |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| publisher | Royal Society of Chemistry |
| record_format | marc |
| series2 | RSC biomolecular sciences |
| spelling | Biophysical approaches determining ligand binding to biomolecular targets editors, Alberto Podjarny, Annick P. Dejaegere and Bruno Kieffer Cambridge Royal Society of Chemistry 2010 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier RSC biomolecular sciences The binding of small ligands to biological molecules is central to most aspects of biological function. The past twenty years has seen the development of an increasing armoury of biophysical methods that not only detect such binding, but also provide varying degrees of information about the kinetics, thermodynamics and structural aspects of the process. These methods have received increasing attention with the growth in more rational approaches to drug discovery and design.This book reviews the latest advances in the application of biophysics to the study of ligand binding. It provides a complete overview of current techniques to identify ligands, characterise their binding sites and understand their binding mechanisms. Particular emphasis is given to the combined use of different techniques and their relative strengths and weaknesses. Consistency in the way each technique is described makes it easy for readers to select the most suitable protocol for their research. The introduction explains why some techniques are more suitable than others and emphasizes the possible synergies between them. The following chapters, all written by a specialist in the particular technique, focus on each method individually. The book finishes by describing how several complimentary techniques can be used together for maximum effectiveness.This book is suitable for biomolecular scientists at graduate or post-doctoral level in academia and industry. Biologists and chemists will also find it a useful introduction to the techniques available SCIENCE / Life Sciences / Biochemistry bisacsh Ligand binding (Biochemistry) fast Ligand binding (Biochemistry) Biophysik (DE-588)4006891-2 gnd rswk-swf Chemische Bindung (DE-588)4009843-6 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Chemische Bindung (DE-588)4009843-6 s Biophysik (DE-588)4006891-2 s 2\p DE-604 Podjarny, A. D. Sonstige oth Dejaegere, Annick P. Sonstige oth Kieffer, Bruno Sonstige oth http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519332 Aggregator Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Biophysical approaches determining ligand binding to biomolecular targets SCIENCE / Life Sciences / Biochemistry bisacsh Ligand binding (Biochemistry) fast Ligand binding (Biochemistry) Biophysik (DE-588)4006891-2 gnd Chemische Bindung (DE-588)4009843-6 gnd |
| subject_GND | (DE-588)4006891-2 (DE-588)4009843-6 (DE-588)4143413-4 |
| title | Biophysical approaches determining ligand binding to biomolecular targets |
| title_auth | Biophysical approaches determining ligand binding to biomolecular targets |
| title_exact_search | Biophysical approaches determining ligand binding to biomolecular targets |
| title_full | Biophysical approaches determining ligand binding to biomolecular targets editors, Alberto Podjarny, Annick P. Dejaegere and Bruno Kieffer |
| title_fullStr | Biophysical approaches determining ligand binding to biomolecular targets editors, Alberto Podjarny, Annick P. Dejaegere and Bruno Kieffer |
| title_full_unstemmed | Biophysical approaches determining ligand binding to biomolecular targets editors, Alberto Podjarny, Annick P. Dejaegere and Bruno Kieffer |
| title_short | Biophysical approaches determining ligand binding to biomolecular targets |
| title_sort | biophysical approaches determining ligand binding to biomolecular targets |
| topic | SCIENCE / Life Sciences / Biochemistry bisacsh Ligand binding (Biochemistry) fast Ligand binding (Biochemistry) Biophysik (DE-588)4006891-2 gnd Chemische Bindung (DE-588)4009843-6 gnd |
| topic_facet | SCIENCE / Life Sciences / Biochemistry Ligand binding (Biochemistry) Biophysik Chemische Bindung Aufsatzsammlung |
| url | http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519332 |
| work_keys_str_mv | AT podjarnyad biophysicalapproachesdeterminingligandbindingtobiomoleculartargets AT dejaegereannickp biophysicalapproachesdeterminingligandbindingtobiomoleculartargets AT kiefferbruno biophysicalapproachesdeterminingligandbindingtobiomoleculartargets |