Ion channels and disease: channelopathies
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
San Diego
Academic Press
©2000
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| Schlagworte: | |
| Online-Zugang: | FAW01 FAW02 Volltext |
| Beschreibung: | Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002 Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype Preface. -- Introduction. -- From Gene to Protein. -- How Channels Work. -- Methods for Studying Ion Channels. -- Voltage-Gated Na<sup>+</sup> Channels. -- Voltage-Gated K<sup>+</sup> Channels. -- Ca-Activated K<sup>+</sup> Channels. -- Inward Rectifier K<sup>+</sup> Channels. -- Voltage-Gated Ca<sup>2+</sup> Channels. -- Voltage-Gated Cl<sup>-</sup> Channels. -- Cyclic Nucleotide-Gated Channels. -- CFTR. -- Epithelia Na<sup>+</sup> Channels. -- Ligand-Gated Ca<sup>2+</sup> Channels. -- ACh Receptor Channels. -- Glutamate Receptor Channels. -- Glycine Receptors. -- GABA Receptors. -- Water Channels. -- Gap Junction Channels. -- Antibodies to Ion Channels. -- Ion Channels in Viruses. -- Ion Channels as Lethal Agents. -- A Miscellany of Ion Channels. -- The Last Word. -- References. -- Subject Index Includes bibliographical references (pages 419-464) and index |
| Beschreibung: | 1 Online-Ressource (xxi, 481 pages) |
| ISBN: | 0080535216 0120653109 1435601122 9780080535210 9780120653102 9781435601123 |
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| 500 | |a Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype | ||
| 500 | |a Preface. -- Introduction. -- From Gene to Protein. -- How Channels Work. -- Methods for Studying Ion Channels. -- Voltage-Gated Na<sup>+</sup> Channels. -- Voltage-Gated K<sup>+</sup> Channels. -- Ca-Activated K<sup>+</sup> Channels. -- Inward Rectifier K<sup>+</sup> Channels. -- Voltage-Gated Ca<sup>2+</sup> Channels. -- Voltage-Gated Cl<sup>-</sup> Channels. -- Cyclic Nucleotide-Gated Channels. -- CFTR. -- Epithelia Na<sup>+</sup> Channels. -- Ligand-Gated Ca<sup>2+</sup> Channels. -- ACh Receptor Channels. -- Glutamate Receptor Channels. -- Glycine Receptors. -- GABA Receptors. -- Water Channels. -- Gap Junction Channels. -- Antibodies to Ion Channels. -- Ion Channels in Viruses. -- Ion Channels as Lethal Agents. -- A Miscellany of Ion Channels. -- The Last Word. -- References. -- Subject Index | ||
| 500 | |a Includes bibliographical references (pages 419-464) and index | ||
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| 650 | 4 | |a Membrane Proteins / physiology | |
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| 650 | 4 | |a Medizin | |
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| 650 | 4 | |a Pathology, Molecular | |
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Datensatz im Suchindex
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| author | Ashcroft, Frances M. |
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| dewey-ones | 616 - Diseases |
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| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
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| publisher | Academic Press |
| record_format | marc |
| spelling | Ashcroft, Frances M. Verfasser aut Ion channels and disease channelopathies Frances M. Ashcroft San Diego Academic Press ©2000 1 Online-Ressource (xxi, 481 pages) txt rdacontent c rdamedia cr rdacarrier Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002 Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype Preface. -- Introduction. -- From Gene to Protein. -- How Channels Work. -- Methods for Studying Ion Channels. -- Voltage-Gated Na<sup>+</sup> Channels. -- Voltage-Gated K<sup>+</sup> Channels. -- Ca-Activated K<sup>+</sup> Channels. -- Inward Rectifier K<sup>+</sup> Channels. -- Voltage-Gated Ca<sup>2+</sup> Channels. -- Voltage-Gated Cl<sup>-</sup> Channels. -- Cyclic Nucleotide-Gated Channels. -- CFTR. -- Epithelia Na<sup>+</sup> Channels. -- Ligand-Gated Ca<sup>2+</sup> Channels. -- ACh Receptor Channels. -- Glutamate Receptor Channels. -- Glycine Receptors. -- GABA Receptors. -- Water Channels. -- Gap Junction Channels. -- Antibodies to Ion Channels. -- Ion Channels in Viruses. -- Ion Channels as Lethal Agents. -- A Miscellany of Ion Channels. -- The Last Word. -- References. -- Subject Index Includes bibliographical references (pages 419-464) and index MEDICAL / Pathology bisacsh MEDICAL / Pathophysiology bisacsh Ion channels fast Pathology, Molecular fast Kanalopathieën gtt Pathologie moléculaire ram Canaux ioniques ram Membrane cellulaire ram Ion Channels / physiology Genetic Diseases, Inborn / physiopathology Membrane Proteins / physiology Metabolism, Inborn Errors / physiopathology Medizin Ion channels Pathology, Molecular Chronische Krankheit (DE-588)4010176-9 gnd rswk-swf Ionenkanal (DE-588)4138699-1 gnd rswk-swf Funktionsstörung (DE-588)4126507-5 gnd rswk-swf Ionenkanal (DE-588)4138699-1 s Chronische Krankheit (DE-588)4010176-9 s 1\p DE-604 Funktionsstörung (DE-588)4126507-5 s 2\p DE-604 http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=141522 Aggregator Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Ashcroft, Frances M. Ion channels and disease channelopathies MEDICAL / Pathology bisacsh MEDICAL / Pathophysiology bisacsh Ion channels fast Pathology, Molecular fast Kanalopathieën gtt Pathologie moléculaire ram Canaux ioniques ram Membrane cellulaire ram Ion Channels / physiology Genetic Diseases, Inborn / physiopathology Membrane Proteins / physiology Metabolism, Inborn Errors / physiopathology Medizin Ion channels Pathology, Molecular Chronische Krankheit (DE-588)4010176-9 gnd Ionenkanal (DE-588)4138699-1 gnd Funktionsstörung (DE-588)4126507-5 gnd |
| subject_GND | (DE-588)4010176-9 (DE-588)4138699-1 (DE-588)4126507-5 |
| title | Ion channels and disease channelopathies |
| title_auth | Ion channels and disease channelopathies |
| title_exact_search | Ion channels and disease channelopathies |
| title_full | Ion channels and disease channelopathies Frances M. Ashcroft |
| title_fullStr | Ion channels and disease channelopathies Frances M. Ashcroft |
| title_full_unstemmed | Ion channels and disease channelopathies Frances M. Ashcroft |
| title_short | Ion channels and disease |
| title_sort | ion channels and disease channelopathies |
| title_sub | channelopathies |
| topic | MEDICAL / Pathology bisacsh MEDICAL / Pathophysiology bisacsh Ion channels fast Pathology, Molecular fast Kanalopathieën gtt Pathologie moléculaire ram Canaux ioniques ram Membrane cellulaire ram Ion Channels / physiology Genetic Diseases, Inborn / physiopathology Membrane Proteins / physiology Metabolism, Inborn Errors / physiopathology Medizin Ion channels Pathology, Molecular Chronische Krankheit (DE-588)4010176-9 gnd Ionenkanal (DE-588)4138699-1 gnd Funktionsstörung (DE-588)4126507-5 gnd |
| topic_facet | MEDICAL / Pathology MEDICAL / Pathophysiology Ion channels Pathology, Molecular Kanalopathieën Pathologie moléculaire Canaux ioniques Membrane cellulaire Ion Channels / physiology Genetic Diseases, Inborn / physiopathology Membrane Proteins / physiology Metabolism, Inborn Errors / physiopathology Medizin Chronische Krankheit Ionenkanal Funktionsstörung |
| url | http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=141522 |
| work_keys_str_mv | AT ashcroftfrancesm ionchannelsanddiseasechannelopathies |