Nonviral vectors for gene therapy:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego, CA
Academic Press
c1999
|
| Schlagworte: | |
| Online-Zugang: | FAW01 FAW02 Volltext |
| Beschreibung: | Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways. Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians. Key Features * Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine * Covers all types of nonviral vectors, from molecular structure to therapeutic application Provides a comprehensive review of synthetic vectors * Includes contributions from major investigators and leading experts in the field Introduction, L. Huang and E. Viroonhatapan. -- Cationic Liposomes: -- Progress in Gene Delivery Research and Development, P. Felgner. -- Cationic Lipid-Mediated Gene Delivery to the Airways, J. Marshall, N. Yew, S. Eastman, C. Jiang, R. Scheule, S. Cheng. -- Structure and Structure-Activity Relationship of Lipid-Based Gene Delivery Systems, D. Lasic. -- Self-Assembled Structures of Lipid/DNA Nonviral Gene Delivery Systems from Synchorotron X-Ray Diffraction, C. Safinya, I. Koltover. -- Sites of Uptake and Expression of Cationic Liposome/DNA Complexes Injected Intravenously, J. McLean, G. Thurston, D. McDonald. -- Other Vectors: -- Nuclear Transport of Exogenous DNA, M. Sebestyén and J. Wolff. -- Particle-Mediated Gene Delivery: Applications to Canine and Other Larger Animal Systems, N.-S. Yang, G. Hogge, E.G. MacEwen. -- Polyethylenimines: A Family of Potent Polymers for Nucleic Acid Delivery, A. Kichler, J.-P. Behr, P. Erbacher. -- Ligand-Polycation Conjugates for Receptor-Targeted Gene Transfer, E. Wagner. -- The Perplexing Delivery Mechanism of Lipoplexes, L. Barron and F. Szoka, Jr. -- Biopolymer-DNA Nanospheres, K. Leong. -- Novel Lipidic Vectors for Gene Transfer, S. Li, L. Huang. -- Animal Models and Clinical Trials: -- Mechanisms of Cationic Liposome-Mediated Transfection of the Lung Endothelium, D. Liu, J. Knapp, Y. Song. -- Cystic Fibrosis Gene Therapy, U. Griesenbach, D. Geddes, E. Alton. -- Targeting HER-2/neu-Overexpressing Cancer Cells with Transcriptional Repressor Genes Delivered by Cationic Liposome, M.-C. Hung, S.-C. Wang, G. Hortobagyi. -- Immune Pathways Used in Nucleic Acid Vaccination, G. Rhodes. -- A Novel Gene Regulatory System, S. Chua, M. Burcin, Y. Wang, S. Tsai. -- Index Includes bibliographical references and index |
| Beschreibung: | 1 Online-Ressource (xxv, 442 p.) |
| ISBN: | 0080479774 0123584655 9780080479774 9780123584656 |
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| 500 | |a Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways. Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians. Key Features * Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine * Covers all types of nonviral vectors, from molecular structure to therapeutic application Provides a comprehensive review of synthetic vectors * Includes contributions from major investigators and leading experts in the field | ||
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| spelling | Nonviral vectors for gene therapy edited by Leaf Huang, Mien-chie Hung, Ernst Wagner San Diego, CA Academic Press c1999 1 Online-Ressource (xxv, 442 p.) txt rdacontent c rdamedia cr rdacarrier Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways. Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians. Key Features * Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine * Covers all types of nonviral vectors, from molecular structure to therapeutic application Provides a comprehensive review of synthetic vectors * Includes contributions from major investigators and leading experts in the field Introduction, L. Huang and E. Viroonhatapan. -- Cationic Liposomes: -- Progress in Gene Delivery Research and Development, P. Felgner. -- Cationic Lipid-Mediated Gene Delivery to the Airways, J. Marshall, N. Yew, S. Eastman, C. Jiang, R. Scheule, S. Cheng. -- Structure and Structure-Activity Relationship of Lipid-Based Gene Delivery Systems, D. Lasic. -- Self-Assembled Structures of Lipid/DNA Nonviral Gene Delivery Systems from Synchorotron X-Ray Diffraction, C. Safinya, I. Koltover. -- Sites of Uptake and Expression of Cationic Liposome/DNA Complexes Injected Intravenously, J. McLean, G. Thurston, D. McDonald. -- Other Vectors: -- Nuclear Transport of Exogenous DNA, M. Sebestyén and J. Wolff. -- Particle-Mediated Gene Delivery: Applications to Canine and Other Larger Animal Systems, N.-S. Yang, G. Hogge, E.G. MacEwen. -- Polyethylenimines: A Family of Potent Polymers for Nucleic Acid Delivery, A. Kichler, J.-P. Behr, P. Erbacher. -- Ligand-Polycation Conjugates for Receptor-Targeted Gene Transfer, E. Wagner. -- The Perplexing Delivery Mechanism of Lipoplexes, L. Barron and F. Szoka, Jr. -- Biopolymer-DNA Nanospheres, K. Leong. -- Novel Lipidic Vectors for Gene Transfer, S. Li, L. Huang. -- Animal Models and Clinical Trials: -- Mechanisms of Cationic Liposome-Mediated Transfection of the Lung Endothelium, D. Liu, J. Knapp, Y. Song. -- Cystic Fibrosis Gene Therapy, U. Griesenbach, D. Geddes, E. Alton. -- Targeting HER-2/neu-Overexpressing Cancer Cells with Transcriptional Repressor Genes Delivered by Cationic Liposome, M.-C. Hung, S.-C. Wang, G. Hortobagyi. -- Immune Pathways Used in Nucleic Acid Vaccination, G. Rhodes. -- A Novel Gene Regulatory System, S. Chua, M. Burcin, Y. Wang, S. Tsai. -- Index Includes bibliographical references and index Genetic transformation HEALTH & FITNESS / Diseases / Genetic bisacsh MEDICAL / Genetics bisacsh DNA-ligand interactions fast Drug targeting fast Gene therapy fast Genetic vectors fast Liposomes fast Genetic Vectors / therapeutic use Medizin Gene therapy Genetic vectors DNA-ligand interactions Liposomes Drug targeting Gentherapie (DE-588)4296957-8 gnd rswk-swf Gentherapie (DE-588)4296957-8 s 1\p DE-604 Huang, Leaf Sonstige oth Hung, Mien-chie Sonstige oth Wagner, Ernst Sonstige oth http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=196127 Aggregator Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Nonviral vectors for gene therapy Genetic transformation HEALTH & FITNESS / Diseases / Genetic bisacsh MEDICAL / Genetics bisacsh DNA-ligand interactions fast Drug targeting fast Gene therapy fast Genetic vectors fast Liposomes fast Genetic Vectors / therapeutic use Medizin Gene therapy Genetic vectors DNA-ligand interactions Liposomes Drug targeting Gentherapie (DE-588)4296957-8 gnd |
| subject_GND | (DE-588)4296957-8 |
| title | Nonviral vectors for gene therapy |
| title_auth | Nonviral vectors for gene therapy |
| title_exact_search | Nonviral vectors for gene therapy |
| title_full | Nonviral vectors for gene therapy edited by Leaf Huang, Mien-chie Hung, Ernst Wagner |
| title_fullStr | Nonviral vectors for gene therapy edited by Leaf Huang, Mien-chie Hung, Ernst Wagner |
| title_full_unstemmed | Nonviral vectors for gene therapy edited by Leaf Huang, Mien-chie Hung, Ernst Wagner |
| title_short | Nonviral vectors for gene therapy |
| title_sort | nonviral vectors for gene therapy |
| topic | Genetic transformation HEALTH & FITNESS / Diseases / Genetic bisacsh MEDICAL / Genetics bisacsh DNA-ligand interactions fast Drug targeting fast Gene therapy fast Genetic vectors fast Liposomes fast Genetic Vectors / therapeutic use Medizin Gene therapy Genetic vectors DNA-ligand interactions Liposomes Drug targeting Gentherapie (DE-588)4296957-8 gnd |
| topic_facet | Genetic transformation HEALTH & FITNESS / Diseases / Genetic MEDICAL / Genetics DNA-ligand interactions Drug targeting Gene therapy Genetic vectors Liposomes Genetic Vectors / therapeutic use Medizin Gentherapie |
| url | http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=196127 |
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