The cytokines of the immune system: the role of cytokines in disease related to immune response
Gespeichert in:
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
London
Academic Press is an imprint of Elsevier
[2015]
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| Schlagworte: | |
| Online-Zugang: | TUM01 FAW01 Volltext Inhaltsverzeichnis |
| Beschreibung: | Online resource; title from PDF title page (Ebsco, viewed May 29, 2015) |
| Beschreibung: | 1 online resource color illustrations |
| ISBN: | 9780124199989 9780124200104 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804175327477366784 |
|---|---|
| adam_text | Titel: The cytokines of the immune system
Autor: Dembic, Zlatko
Jahr: 2015
CONTENTS
Foreword ix
Acknowledgments xi
1. Introduction—Common Features About Cytokines 1
Division 3
Structure 3
Receptors 6
Intracellular Signal Transduction 8
Hormones and Cytokines 11
Function 14
2. The Immune System—Definition and Development of Immunity 17
Organization of the Immune System 19
Humoral Innate (Nonspecific) Immunity 25
Cellular Innate (Nonspecific) Immunity 30
Adaptive Humoral (Specific) Immune System 39
Cellular Adaptive (Specific) Immune System 42
3. Activation of Cells of the Immune System 57
Activation of Immune Cells in the Periphery of the Immune System 57
Specific Recognition 58
Coreceptors of T Cells: CD4 and C D8 70
Costimulation during T-Cell Activation 71
Signal Transduction in T Cell 72
Signal Transduction in the B Cell 80
Signal Transduction in Mast Cells 81
Further Development of Immune Cells Upon Activation 83
T lymphocyte Homeostasis 93
Repertoire and Tolerance 94
4. The Role arid Regulation of the Immune Responses 99
The Course of the Immune Response 99
Regulation of Immunocyte Development after Activation 105
Important Control Functions of Cytokines 106
The Role ofThl-Type of Immune Response 114
The Role ofTh2-Type of Immune Response 115
The Role ofTh9 Subset 116
v
vi
Contents
The Role ofThl 7 Subset 116
The Role ofTh22 Subset 118
The Role of Th3, and Tri Cells 119
The Role of Regulatory CD4T Lymphocytes—Tregs 119
The Role of the Tfh Subset 121
5. Cytokines of the Immune System: Interferons 123
lnterferon-a/ß 124
Interferon-y (IFN-y) 129
Interferon-X (IFN-X) 140
References 140
Further Reading 142
6. Cytokines of the Immune System: Interleukins 143
IL-1 143
IL-2 151
IL-3 160
IL-4 162
IL-5 166
IL-6 168
IL-7 175
IL-8 178
IL-9 179
IL-10 181
IL-11 184
IL-12 186
IL-13 190
IL-14 (IL-14 Does Not Exist in Databases) 193
IL-15 193
IL-16 197
IL-17 200
IL-18 202
IL-19 205
IL-20 207
IL-21 209
IL-22 212
IL-23 214
IL-24 216
IL-25 218
IL-26 219
1-27 221
Contents vii
IL-28 and IL-29 (Type III Interferon, X.1-3) 224
IL-30 225
IL-31 225
IL-32 227
IL-33 228
IL-34 229
IL-35 230
IL-36 232
IL-37 233
IL-38 234
References 235
Further Reading 238
7. Cytokines of the Immune System: Chemokines 241
About Chemokines 241
The Role of Chemokines in the Immune System 246
CCL Chemokines (CCL1-CCL28) 248
CXCL Chemokines (1-16) 255
CX3CL Chemokine 259
XCL Chemokines (1-2) 260
Other Featu res of Chemokines 260
8. Cytokines Important for Growth and/or Development of
Cells of the Immune System 263
TNF-a/ß 263
TGF-ß 266
TSLP (Thymic Stromal Lymphopoietin) 269
KG F (Keratinocyte Growth Factor) 271
SCF (Stem Cell Factor) and Growth Factors (CSF, GM-CSF, M-CSF) of
Hematopoietic Lines 271
LIF—Leukemia Inhibitory Factor 272
CNTF—Ciliary Neurotrophic Factor 274
OSM—Oncostatin M 276
A Short Description of Other Cytokines that Regulate Growth and
Development of Various Tissues 277
9. Theories about the Function of the Immune System 283
About Scientific Theories 283
Self-Nonself Discrimination 285
The Pathogen-Associated Molecular Pattern (PAMP) Recognition
Theory (Janeway) 288
viii Contents
Idiotypic Networks and Suppression (Jerne) 289
The Danger Model (Matzinger) 291
The Integrity Model (Dembic) 293
OtherTheories About Immunity 299
References 301
Index
303
|
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| spelling | Dembic, Zlatko (DE-588)1072712482 aut The cytokines of the immune system the role of cytokines in disease related to immune response Zlatko Dembic London Academic Press is an imprint of Elsevier [2015] 1 online resource color illustrations txt rdacontent c rdamedia cr rdacarrier Online resource; title from PDF title page (Ebsco, viewed May 29, 2015) Cytokines Immunology Erscheint auch als Druck-Ausgabe Dembic, Zlatko The Cytokines of the Immune System : The Role of Cytokines in Disease Related to Immune Response http://www.sciencedirect.com/science/book/9780124199989 Verlag Volltext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028417044&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dembic, Zlatko The cytokines of the immune system the role of cytokines in disease related to immune response Cytokines Immunology |
| title | The cytokines of the immune system the role of cytokines in disease related to immune response |
| title_auth | The cytokines of the immune system the role of cytokines in disease related to immune response |
| title_exact_search | The cytokines of the immune system the role of cytokines in disease related to immune response |
| title_full | The cytokines of the immune system the role of cytokines in disease related to immune response Zlatko Dembic |
| title_fullStr | The cytokines of the immune system the role of cytokines in disease related to immune response Zlatko Dembic |
| title_full_unstemmed | The cytokines of the immune system the role of cytokines in disease related to immune response Zlatko Dembic |
| title_short | The cytokines of the immune system |
| title_sort | the cytokines of the immune system the role of cytokines in disease related to immune response |
| title_sub | the role of cytokines in disease related to immune response |
| topic | Cytokines Immunology |
| topic_facet | Cytokines Immunology |
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