Epithelial injury and plasticity of bronchial epithelial cells:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Enthält mehrere Aufsätze aus verschiedenen Zeitschriften |
| Beschreibung: | XII, 114 Seiten Illustrationen, Diagramme |
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Datensatz im Suchindex
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| adam_text | AUS DEM
COMPREHENSIVE PNEUMOLOGY CENTER
(CPQ
INSTITUT FIIR EXPERIMENTELLE PNEUMOLOGIE
DER LUDWIG-MAXIMILIANS-UNIVERSITAT MIINCHEN
DIREKTOR: PROF. DR. MED. OLIVER EICKELBERG
EPITHELIAL INJURY AND PLASTICITY
OF BRONCHIAL EPITHELIAL CELLS
DISSERTATION
ZUM ERWERB DES DOKTORGRADES DER NATURWISSENSCHAFTEN
AN DER MEDIZINISCHEN FAKULTAT
DER LUDWIG-MAXIMILIANS-UNIVERSITAT MIINCHEN
VORGELEGT VON
ANDREA CLAUDIA SCHAMBERGER
AUS MIINCHEN
MIINCHEN
2015
HTTP://D-NB.INFO/1078511942
TABLE OF CONTENTS
EIDESSTATTLICHE VERSLCHERUNG I
TABLE OT CONTENTS III
LIST OF ABBREVIATIONS V
PUBLICATIONS AND MANUSCRIPTS ORIGINATING FROM THIS THESIS VIF
SUMMARY IX
ZUSAMMENFASSUNG XL
1 INTRODUCTION 1
1.1 CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) 1
1.1.1 THE BURDEN OF COPD 1
1.1.2 DIAGNOSIS AND CLASSIFICATION OF COPD 3
1.1.3 THERAPY OF COPD 4
1.1.4 PATHOGENESIS OF COPD 5
1.2 HUMAN AIRWAY EPITHELIUM 6
1.2.1 COMPOSITION OF THE AIRWAY EPITHELIUM 7
1.2.2 EPITHELIAL BARRIER FUNCTION 9
1.2.3 TRANSFORMING GROWTH FACTOR (TGF)-JJ SIGNALLING 10
1.2.4 COPD-RELATED CHANGES OF THE EPITHELIUM 11
1.3 EXPERIMENTAL MODELS 13
1.4 OBJECTIVES OF THIS THESIS 14
1.5 REFERENCES 16
2 CIGARETTE SMOKE-INDUCED DISRUPTION OF BRONCHIAL EPITHELIAL TIGHT
JUNCTIONS IS PREVENTED BY TRANSFORMING GROWTH FACTOR-P 25
2.1 AUTHOR CONTRIBUTIONS 26
2.2 MAIN MANUSCRIPT 27
2.3 SUPPLEMENTAL INFORMATION 41
III
TABLE OF CONTENTS
3 CIGARETTE SMOKE ALTERS PRIMARY HUMAN BRONCHIAL EPITHELIAL CELL
DIFFERENTIATION AT THE AIR-LIQUID INTERFACE 55
3.1 AUTHOR CONTRIBUTIONS 56
3.2 MAIN MANUSCRIPT 57
3.3 SUPPLEMENTAL INFORMATION 67
4 DISCUSSION 79
4.1 ALTERED AIRWAY EPITHELIUM IN COPD 80
4.1.1 MODELS TO STUDY AIRWAY EPITHELIAL DYSFUNCTION 80
4.1.2 CIGARETTE
SMOKE DISRUPTS THE AIRWAY EPITHELIAL BARRIER FUNCTION 83
4.1.3 CIGARETTE
SMOKE ALTERS THE COMPOSITION OF THE AIRWAYS 86
4.2 THE ROLE OF TGF-PI
IN COPD 89
4.3 POTENTIAL NEW
THERAPEUTIC TARGETS FOR COPD 92
4.4 MAIN FINDINGS
AND CONCLUSIONS 94
4.5 FUTURE
STUDIES 95
4.6 REFERENCES 96
DANKSAGUNG 113
IV
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| spelling | Schamberger, Andrea Verfasser (DE-588)1078321612 aut Epithelial injury and plasticity of bronchial epithelial cells vorgelegt von Andrea Claudia Schamberger 2015 XII, 114 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Enthält mehrere Aufsätze aus verschiedenen Zeitschriften Dissertation Ludwigs-Maximilians-Universität München 2015 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028403870&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schamberger, Andrea Epithelial injury and plasticity of bronchial epithelial cells |
| subject_GND | (DE-588)4113937-9 |
| title | Epithelial injury and plasticity of bronchial epithelial cells |
| title_auth | Epithelial injury and plasticity of bronchial epithelial cells |
| title_exact_search | Epithelial injury and plasticity of bronchial epithelial cells |
| title_full | Epithelial injury and plasticity of bronchial epithelial cells vorgelegt von Andrea Claudia Schamberger |
| title_fullStr | Epithelial injury and plasticity of bronchial epithelial cells vorgelegt von Andrea Claudia Schamberger |
| title_full_unstemmed | Epithelial injury and plasticity of bronchial epithelial cells vorgelegt von Andrea Claudia Schamberger |
| title_short | Epithelial injury and plasticity of bronchial epithelial cells |
| title_sort | epithelial injury and plasticity of bronchial epithelial cells |
| topic_facet | Hochschulschrift |
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