A Mathematical Approach to Multilevel, Multiscale Health Interventions: Pharmaceutical Industry Decline and Policy Response
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Singapore
World Scientific Publishing Company
2013
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| Schlagworte: | |
| Online-Zugang: | Volltext |
| Beschreibung: | Description based upon print version of record This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule "magic bullet" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States - from 200 million in 1950 to 1.2 billion in 2010 - has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mu Includes bibliographical references (p. 207-222) and index 1. Beyond magic bullets. 1.1. The pharmaceutical catastrophe. 1.2. A new perspective. 1.3. Cognition as 'language'. 1.4. The human cognome -- 2. Expanding the theory. 2.1. No free lunch. 2.2. Multiple broadcasts, punctuated detection. 2.3. Metabolic constraints. 2.4. Environmental signals -- 3. Dynamic 'regression' models. 3.1. The simplest approach. 3.2. A rate distortion reformulation. 3.3. Multiple time scales. 3.4. Incoming information. 3.5. Pathologies. 3.6. Refining the model -- 4. An evolutionary excursion. 4.1. Introduction. 4.2. Ecosystems as information sources. 4.3. Genetic heritage. 4.4. Gene expression. 4.5. Interacting information sources. 4.6. Conclusions -- 5. Example: mental disorders. 5.1. Introduction. 5.2. Two classes. 5.3. Global broadcast models. 5.4. Gene expression. 5.5. Summary -- - 6. Example: protein folding. 6.1. Introduction. 6.2. Spontaneous symmetry breaking. 6.3. A formal approach. 6.4. The energy picture. 6.5. The developmental picture. 6.6. A comprehensive treatment. 6.7. Aging and protein folding. 6.8. Summary -- 7. Example: glycome determinants. 7.1. Introduction. 7.2. Stochastic topology. 7.3. The glycomic conundrum. 7.4. Another cognitive paradigm. 7.5. Regulating glycan determinants. 7.6. Glycan spectra. 7.7. Summary -- 8. Example: glycan/lectin logic gates. 8.1. Introduction. 8.2. The critical exponent. 8.3. Two examples. 8.4. Information catalysis. 8.5. A tiling symmetry model. 8.6. Summary -- 9. Example: IDP logic gates. 9.1. Introduction. 9.2. Symbolic dynamics of molecular switching. 9.3. Another dual information source. 9.4. Information catalysis. 9.5. Summary -- - 10. Treatment. 10.1. The generalized retina. 10.2. Therapeutic efficacy. 10.3. Psychosocial stress. 10.4. Flight, fight, and helplessness. 10.5. Institutions as niche construction. 10.6. The hall of mirrors. 10.7. Side effects reconsidered -- 11. History and health. 11.1. Malaria and the Fulani. 11.2. The American catastrophe -- 12. Beyond Glasperlenspiel -- 13. Mathematical appendix. 13.1. The tuning theorem. 13.2. The rate distortion theorem. 13.3. Stochastic differential equations. 13.4. Morse theory. 13.5. Groupoids. 13.6. 'Biological' renormalization. 13.7. Large deviations |
| Beschreibung: | 1 Online-Ressource (238 p.) |
| ISBN: | 9781848169975 1848169973 1848169965 9781848169968 9781299462168 1299462162 |
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| 100 | 1 | |a Wallace, Rodrick |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a A Mathematical Approach to Multilevel, Multiscale Health Interventions |b Pharmaceutical Industry Decline and Policy Response |
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| 500 | |a This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule "magic bullet" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States - from 200 million in 1950 to 1.2 billion in 2010 - has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mu | ||
| 500 | |a Includes bibliographical references (p. 207-222) and index | ||
| 500 | |a 1. Beyond magic bullets. 1.1. The pharmaceutical catastrophe. 1.2. A new perspective. 1.3. Cognition as 'language'. 1.4. The human cognome -- 2. Expanding the theory. 2.1. No free lunch. 2.2. Multiple broadcasts, punctuated detection. 2.3. Metabolic constraints. 2.4. Environmental signals -- 3. Dynamic 'regression' models. 3.1. The simplest approach. 3.2. A rate distortion reformulation. 3.3. Multiple time scales. 3.4. Incoming information. 3.5. Pathologies. 3.6. Refining the model -- 4. An evolutionary excursion. 4.1. Introduction. 4.2. Ecosystems as information sources. 4.3. Genetic heritage. 4.4. Gene expression. 4.5. Interacting information sources. 4.6. Conclusions -- 5. Example: mental disorders. 5.1. Introduction. 5.2. Two classes. 5.3. Global broadcast models. 5.4. Gene expression. 5.5. Summary -- | ||
| 500 | |a - 6. Example: protein folding. 6.1. Introduction. 6.2. Spontaneous symmetry breaking. 6.3. A formal approach. 6.4. The energy picture. 6.5. The developmental picture. 6.6. A comprehensive treatment. 6.7. Aging and protein folding. 6.8. Summary -- 7. Example: glycome determinants. 7.1. Introduction. 7.2. Stochastic topology. 7.3. The glycomic conundrum. 7.4. Another cognitive paradigm. 7.5. Regulating glycan determinants. 7.6. Glycan spectra. 7.7. Summary -- 8. Example: glycan/lectin logic gates. 8.1. Introduction. 8.2. The critical exponent. 8.3. Two examples. 8.4. Information catalysis. 8.5. A tiling symmetry model. 8.6. Summary -- 9. Example: IDP logic gates. 9.1. Introduction. 9.2. Symbolic dynamics of molecular switching. 9.3. Another dual information source. 9.4. Information catalysis. 9.5. Summary -- | ||
| 500 | |a - 10. Treatment. 10.1. The generalized retina. 10.2. Therapeutic efficacy. 10.3. Psychosocial stress. 10.4. Flight, fight, and helplessness. 10.5. Institutions as niche construction. 10.6. The hall of mirrors. 10.7. Side effects reconsidered -- 11. History and health. 11.1. Malaria and the Fulani. 11.2. The American catastrophe -- 12. Beyond Glasperlenspiel -- 13. Mathematical appendix. 13.1. The tuning theorem. 13.2. The rate distortion theorem. 13.3. Stochastic differential equations. 13.4. Morse theory. 13.5. Groupoids. 13.6. 'Biological' renormalization. 13.7. Large deviations | ||
| 650 | 4 | |a Drug development | |
| 650 | 4 | |a Drugs / Design / Mathematical models | |
| 650 | 4 | |a Drugs / Research | |
| 650 | 4 | |a Medical geography | |
| 650 | 7 | |a BUSINESS & ECONOMICS / Industries / Pharmaceutical & Biotechnology |2 bisacsh | |
| 650 | 7 | |a Pharmaceutical industry |2 fast | |
| 650 | 7 | |a Pharmaceutical industry / Economic aspects |2 fast | |
| 650 | 7 | |a Pharmaceutical industry / Government policy |2 fast | |
| 650 | 4 | |a Industrie | |
| 650 | 4 | |a Mathematisches Modell | |
| 650 | 4 | |a Politik | |
| 650 | 4 | |a Wirtschaft | |
| 650 | 4 | |a Pharmaceutical industry |z United States | |
| 650 | 4 | |a Pharmaceutical industry |x Economic aspects |z United States | |
| 650 | 4 | |a Pharmaceutical industry |x Government policy |z United States | |
| 651 | 4 | |a USA | |
| 700 | 1 | |a Wallace, Deborah |e Sonstige |4 oth | |
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Datensatz im Suchindex
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| any_adam_object | |
| author | Wallace, Rodrick |
| author_facet | Wallace, Rodrick |
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| author_sort | Wallace, Rodrick |
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| dewey-full | 615.580151 615.5/80151 362.1015118 |
| dewey-hundreds | 600 - Technology (Applied sciences) 300 - Social sciences |
| dewey-ones | 615 - Pharmacology and therapeutics 362 - Social problems and services to groups |
| dewey-raw | 615.580151 615.5/80151 362.1015118 |
| dewey-search | 615.580151 615.5/80151 362.1015118 |
| dewey-sort | 3615.580151 |
| dewey-tens | 610 - Medicine and health 360 - Social problems and services; associations |
| discipline | Soziologie Medizin |
| format | Electronic eBook |
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| isbn | 9781848169975 1848169973 1848169965 9781848169968 9781299462168 1299462162 |
| language | English |
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| spelling | Wallace, Rodrick Verfasser aut A Mathematical Approach to Multilevel, Multiscale Health Interventions Pharmaceutical Industry Decline and Policy Response Singapore World Scientific Publishing Company 2013 1 Online-Ressource (238 p.) txt rdacontent c rdamedia cr rdacarrier Description based upon print version of record This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule "magic bullet" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States - from 200 million in 1950 to 1.2 billion in 2010 - has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mu Includes bibliographical references (p. 207-222) and index 1. Beyond magic bullets. 1.1. The pharmaceutical catastrophe. 1.2. A new perspective. 1.3. Cognition as 'language'. 1.4. The human cognome -- 2. Expanding the theory. 2.1. No free lunch. 2.2. Multiple broadcasts, punctuated detection. 2.3. Metabolic constraints. 2.4. Environmental signals -- 3. Dynamic 'regression' models. 3.1. The simplest approach. 3.2. A rate distortion reformulation. 3.3. Multiple time scales. 3.4. Incoming information. 3.5. Pathologies. 3.6. Refining the model -- 4. An evolutionary excursion. 4.1. Introduction. 4.2. Ecosystems as information sources. 4.3. Genetic heritage. 4.4. Gene expression. 4.5. Interacting information sources. 4.6. Conclusions -- 5. Example: mental disorders. 5.1. Introduction. 5.2. Two classes. 5.3. Global broadcast models. 5.4. Gene expression. 5.5. Summary -- - 6. Example: protein folding. 6.1. Introduction. 6.2. Spontaneous symmetry breaking. 6.3. A formal approach. 6.4. The energy picture. 6.5. The developmental picture. 6.6. A comprehensive treatment. 6.7. Aging and protein folding. 6.8. Summary -- 7. Example: glycome determinants. 7.1. Introduction. 7.2. Stochastic topology. 7.3. The glycomic conundrum. 7.4. Another cognitive paradigm. 7.5. Regulating glycan determinants. 7.6. Glycan spectra. 7.7. Summary -- 8. Example: glycan/lectin logic gates. 8.1. Introduction. 8.2. The critical exponent. 8.3. Two examples. 8.4. Information catalysis. 8.5. A tiling symmetry model. 8.6. Summary -- 9. Example: IDP logic gates. 9.1. Introduction. 9.2. Symbolic dynamics of molecular switching. 9.3. Another dual information source. 9.4. Information catalysis. 9.5. Summary -- - 10. Treatment. 10.1. The generalized retina. 10.2. Therapeutic efficacy. 10.3. Psychosocial stress. 10.4. Flight, fight, and helplessness. 10.5. Institutions as niche construction. 10.6. The hall of mirrors. 10.7. Side effects reconsidered -- 11. History and health. 11.1. Malaria and the Fulani. 11.2. The American catastrophe -- 12. Beyond Glasperlenspiel -- 13. Mathematical appendix. 13.1. The tuning theorem. 13.2. The rate distortion theorem. 13.3. Stochastic differential equations. 13.4. Morse theory. 13.5. Groupoids. 13.6. 'Biological' renormalization. 13.7. Large deviations Drug development Drugs / Design / Mathematical models Drugs / Research Medical geography BUSINESS & ECONOMICS / Industries / Pharmaceutical & Biotechnology bisacsh Pharmaceutical industry fast Pharmaceutical industry / Economic aspects fast Pharmaceutical industry / Government policy fast Industrie Mathematisches Modell Politik Wirtschaft Pharmaceutical industry United States Pharmaceutical industry Economic aspects United States Pharmaceutical industry Government policy United States USA Wallace, Deborah Sonstige oth http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=564487 Aggregator Volltext |
| spellingShingle | Wallace, Rodrick A Mathematical Approach to Multilevel, Multiscale Health Interventions Pharmaceutical Industry Decline and Policy Response Drug development Drugs / Design / Mathematical models Drugs / Research Medical geography BUSINESS & ECONOMICS / Industries / Pharmaceutical & Biotechnology bisacsh Pharmaceutical industry fast Pharmaceutical industry / Economic aspects fast Pharmaceutical industry / Government policy fast Industrie Mathematisches Modell Politik Wirtschaft Pharmaceutical industry United States Pharmaceutical industry Economic aspects United States Pharmaceutical industry Government policy United States |
| title | A Mathematical Approach to Multilevel, Multiscale Health Interventions Pharmaceutical Industry Decline and Policy Response |
| title_auth | A Mathematical Approach to Multilevel, Multiscale Health Interventions Pharmaceutical Industry Decline and Policy Response |
| title_exact_search | A Mathematical Approach to Multilevel, Multiscale Health Interventions Pharmaceutical Industry Decline and Policy Response |
| title_full | A Mathematical Approach to Multilevel, Multiscale Health Interventions Pharmaceutical Industry Decline and Policy Response |
| title_fullStr | A Mathematical Approach to Multilevel, Multiscale Health Interventions Pharmaceutical Industry Decline and Policy Response |
| title_full_unstemmed | A Mathematical Approach to Multilevel, Multiscale Health Interventions Pharmaceutical Industry Decline and Policy Response |
| title_short | A Mathematical Approach to Multilevel, Multiscale Health Interventions |
| title_sort | a mathematical approach to multilevel multiscale health interventions pharmaceutical industry decline and policy response |
| title_sub | Pharmaceutical Industry Decline and Policy Response |
| topic | Drug development Drugs / Design / Mathematical models Drugs / Research Medical geography BUSINESS & ECONOMICS / Industries / Pharmaceutical & Biotechnology bisacsh Pharmaceutical industry fast Pharmaceutical industry / Economic aspects fast Pharmaceutical industry / Government policy fast Industrie Mathematisches Modell Politik Wirtschaft Pharmaceutical industry United States Pharmaceutical industry Economic aspects United States Pharmaceutical industry Government policy United States |
| topic_facet | Drug development Drugs / Design / Mathematical models Drugs / Research Medical geography BUSINESS & ECONOMICS / Industries / Pharmaceutical & Biotechnology Pharmaceutical industry Pharmaceutical industry / Economic aspects Pharmaceutical industry / Government policy Industrie Mathematisches Modell Politik Wirtschaft Pharmaceutical industry United States Pharmaceutical industry Economic aspects United States Pharmaceutical industry Government policy United States USA |
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