Malignancy associated expression of microRNA in canine mammary tumors:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin
Mensch und Buch Verl.
2014 [erschienen] 2015
|
| Schlagworte: | |
| Online-Zugang: | kostenfrei Inhaltsverzeichnis |
| Beschreibung: | Nebentitel: Malignitäts-abhängige Expression von mikroRNA bei Mammatumoren der Hündin |
| Beschreibung: | VII, 79 S. Ill., graph. Darst. |
| ISBN: | 9783863876401 |
Internformat
MARC
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| 246 | 1 | 3 | |a Malignitäts-abhängige Expression von mikroRNA bei Mammatumoren der Hündin |
| 264 | 1 | |a Berlin |b Mensch und Buch Verl. |c 2014 [erschienen] 2015 | |
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| 502 | |a Berlin, Freie Univ., Diss., 2015 | ||
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| 650 | 7 | |a markers |2 cabt | |
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| 650 | 7 | |a metastasis |2 cabt | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-028353517 | ||
Datensatz im Suchindex
| _version_ | 1804175230539661312 |
|---|---|
| adam_text | CONTENTS
CONTENTS V
LIST OF ABBREVIATIONS VII
1 INTRODUCTION 1
1.1 MORPHOLOGY OF THE CANINE MAMMARY GLAND 1
1.2 PREVALENCE AND OCCURRENCE OF CANINE MAMMARY TUMORS 3
1.3 RISK FACTORS 4
1.4 DIAGNOSIS OF CMT 6
1.5 PROGNOSIS OF CMT 7
1.5.1 CLINICAL STAGING 8
1.5.2 TUMORSIZE 8
1.5.3 LYMPH NODE STATUS AND DISTANT METASTASIS 9
1.5.4 HISTOLOGICAL TYPE AND GRADE 10
1.5.5 MICROVESSEL DENSITY 11
1.5.6 LIMITATION OF DIAGNOSIS AND PROGNOSIS 11
1.6 MOLECULAR CARCINOGENESIS 12
1.6.1 MICRORNA 13
1.6.2 SNORNA 16
1.6.3 QUANTIFICATION METHODS OF SMALL RNA SPECIES 17
2 AIMS AND HYPOTHESIS 20
2.1 MAIN HYPOTHESIS 20
2.2 FIRST AIM 20
2.3 SECOND AIM 20
3 RESEARCH PUBLICATIONS IN PEER-REVIEWED JOURNALS 21
3.1 MOLECULAR QUANTIFICATION OF CANINE SPECIFIC MICRORNA SPECIES 21
3.2 MALIGNANCY ASSOCIATED MICRORNA EXPRESSION CHANGES IN CANINE MAMMARY
CANCER
OF DIFFERENT MALIGNANCIES 29
4 CONCLUDING DISCUSSION 35
4.1 FIRST AIM: ESTABLISHMENT OF A CANINE SPECIFIC REAL-TIME PCR ASSAY
WITH SUITABLE
ENDOGENOUS CONTROLS FOR ACCURATE QUANTIFICATION OF MIRNA AND SNORNA 35
V
HTTP://D-NB.INFO/1077267819
4.1.1 REVERSE TRANSCRIPTION 35
4.1.2 QUANTITATIVE REAL-TIME PCR ASSAY 36
4.1.3 STABILITY OF HOUSEKEEPING GENE EXPRESSION 36
4.1.4 SEQUENCE ANALYSIS OF PCR PRODUCTS 37
4.2 SECOND AIM: CORRELATION OF THE EXPRESSION PATTERN OF 16 MIRNAS AND 4
SNORNAS
WITH CANINE MAMMARY GLAND AND CANINE MAMMARY TUMORS AT DIFFERENT STAGES
OF
MALIGNANCY
38
4.2.1 UP-REGULATED EXPRESSION 39
4.2.2 DOWN-REGULATED EXPRESSION 40
4.3 MIRNAS AS BIOMARKERS FOR CANCER DIAGNOSIS 41
4.4 THE STROMA-TUMOR CELL INTERPLAY 42
4.5 THERAPEUTIC APPROACHES BASED ON MIRNA EXPRESSION 43
4.6 CONCLUSION AND OUTLOOK 44
5 SUMMARY 46
6 ZUSAMMENFASSUNG 48
7 REFERENCES 50
8 PUBLICATION LIST 77
9 DANKSAGUNG 78
SELBSTSNDIGKEITSERKIARUNG 79
VI
|
| any_adam_object | 1 |
| author | Deetzen, Marie-Charlotte von |
| author_GND | (DE-588)107747119X |
| author_facet | Deetzen, Marie-Charlotte von |
| author_role | aut |
| author_sort | Deetzen, Marie-Charlotte von |
| author_variant | m c v d mcv mcvd |
| building | Verbundindex |
| bvnumber | BV042926333 |
| collection | ebook |
| ctrlnum | (OCoLC)930056316 (DE-599)BVBBV042926333 |
| dewey-full | 630 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 630 - Agriculture and related technologies |
| dewey-raw | 630 |
| dewey-search | 630 |
| dewey-sort | 3630 |
| dewey-tens | 630 - Agriculture and related technologies |
| discipline | Agrar-/Forst-/Ernährungs-/Haushaltswissenschaft / Gartenbau |
| format | Thesis Book |
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| spelling | Deetzen, Marie-Charlotte von Verfasser (DE-588)107747119X aut Malignancy associated expression of microRNA in canine mammary tumors vorgelegt von Marie-Charlotte von Deetzen, geborene Frielitz Malignitäts-abhängige Expression von mikroRNA bei Mammatumoren der Hündin Berlin Mensch und Buch Verl. 2014 [erschienen] 2015 VII, 79 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Nebentitel: Malignitäts-abhängige Expression von mikroRNA bei Mammatumoren der Hündin Berlin, Freie Univ., Diss., 2015 bitches cabt RNA cabt markers cabt real time PCR cabt mammary gland neoplasms cabt metastasis cabt histopathology cabt Biomarker (DE-588)4425928-1 gnd rswk-swf Brusttumor (DE-588)4284686-9 gnd rswk-swf Carcinogenese (DE-588)4069853-1 gnd rswk-swf Hündin (DE-588)4466335-3 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Hündin (DE-588)4466335-3 s Brusttumor (DE-588)4284686-9 s Carcinogenese (DE-588)4069853-1 s Biomarker (DE-588)4425928-1 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:kobv:188-fudissthesis000000100303-2 http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000100303 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028353517&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Deetzen, Marie-Charlotte von Malignancy associated expression of microRNA in canine mammary tumors bitches cabt RNA cabt markers cabt real time PCR cabt mammary gland neoplasms cabt metastasis cabt histopathology cabt Biomarker (DE-588)4425928-1 gnd Brusttumor (DE-588)4284686-9 gnd Carcinogenese (DE-588)4069853-1 gnd Hündin (DE-588)4466335-3 gnd |
| subject_GND | (DE-588)4425928-1 (DE-588)4284686-9 (DE-588)4069853-1 (DE-588)4466335-3 (DE-588)4113937-9 |
| title | Malignancy associated expression of microRNA in canine mammary tumors |
| title_alt | Malignitäts-abhängige Expression von mikroRNA bei Mammatumoren der Hündin |
| title_auth | Malignancy associated expression of microRNA in canine mammary tumors |
| title_exact_search | Malignancy associated expression of microRNA in canine mammary tumors |
| title_full | Malignancy associated expression of microRNA in canine mammary tumors vorgelegt von Marie-Charlotte von Deetzen, geborene Frielitz |
| title_fullStr | Malignancy associated expression of microRNA in canine mammary tumors vorgelegt von Marie-Charlotte von Deetzen, geborene Frielitz |
| title_full_unstemmed | Malignancy associated expression of microRNA in canine mammary tumors vorgelegt von Marie-Charlotte von Deetzen, geborene Frielitz |
| title_short | Malignancy associated expression of microRNA in canine mammary tumors |
| title_sort | malignancy associated expression of microrna in canine mammary tumors |
| topic | bitches cabt RNA cabt markers cabt real time PCR cabt mammary gland neoplasms cabt metastasis cabt histopathology cabt Biomarker (DE-588)4425928-1 gnd Brusttumor (DE-588)4284686-9 gnd Carcinogenese (DE-588)4069853-1 gnd Hündin (DE-588)4466335-3 gnd |
| topic_facet | bitches RNA markers real time PCR mammary gland neoplasms metastasis histopathology Biomarker Brusttumor Carcinogenese Hündin Hochschulschrift |
| url | http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000100303 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028353517&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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