Fundamentals of protein structure and function:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cham [u.a.]
Springer
2015
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| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 521 S. zahlr. Ill., graph. Darst. |
| ISBN: | 9783319199191 |
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| 245 | 1 | 0 | |a Fundamentals of protein structure and function |c Engelbert Buxbaum |
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Datensatz im Suchindex
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| adam_text | Titel: Fundamentals of protein structure and function
Autor: Buxbaum, Engelbert
Jahr: 2015
Contents Part I Proteins 1 Amino Acids................................................................. 3 1.1 Basic Structure of Amino Acids..................................... 3 1.2 The Isoelectric Point................................................. 4 1.3 The One-Letter Code................................................. 9 1.4 Biological Function of Amino Acid Variety........................ 10 1.5 Exercises.............................................................. 12 1.5.1 Problems.................................................... 12 1.5.2 Solutions.................................................... 12 Reference..................................................................... 13 2 Protein Structure........................................................... 15 2.1 Primary Structure..................................................... 15 2.1.1 Protein Sequences and Evolution.......................... IS 2.2 Secondary Structure.................................................. 20 2.2.1 Thea-Helix................................................. 22 2.2.2 ß Strand..................................................... 24 2.2.3 The P M (syn.: Poly-Pro or Polypeptide II) Helix.......... 28 2.2.4 Hairpin Turns............................................... 30 2.2.5 Rare Structures.............................................. 31 2.2.6 Coils......................................................... 32 2.3 Tertiary Structure..................................................... 32 2.3.1 Classification of Proteins by Folding Pattern.............. 34 2.4 Quaternary Structure................................................. 37 2.5 Further Aspects of Protein Structure................................ 38 2.5.1 Levinthal s paradox: .................................... 38 2.5.2 Energetics and Kinetics of Protein Folding ............... 40 2.5.3 Morpheeins ................................................. 41 2.5.4
Molecular Chaperones and Chaperonins.................. 42 2.5.5 Protein Denaturation ........................................ 42 2.5.6 Protein Folding ............................................. 43 ix
x Contents 2.6 PosUranslational Modifications of Proteins......................... 47 2.6.1 Glycosylation ............................................... 47 2.6.2 Glucation.................................................... 49 2.6.3 Disulphide Bond Formation................................ 50 2.6.4 Proteolysis .................................................. 51 2.6.5 Hydroxylation ............................................... 52 2.6.6 Phosphorylation/Dephosphorylation ...................... 53 2.6.7 Acetylation/Deacetylation.................................. 53 2.6.8 Methylation/Demethylation................................ 54 2.6.9 Addition/Removal of Hydrophobic Tails.................. 55 2.6.10 S-Nitrosylation.............................................. 55 2.6.11 ADP-Ribosylation.......................................... 55 2.6.12 Deamidation ................................................ 55 2.6.13 AMPylation (Adenylylation)............................... 57 2.6.14 Transfer of Peptides........................................ 57 2.7 The Relationship Between Protein Structure and Function: Green Fluorescent Protein........................... 59 2.8 Exercises.............................................................. 61 2.8.1 Problems.................................................... 61 2.8.2 Solutions.................................................... 62 References.................................................................... 62 3 Proteins in the Lab ......................................................... 65 3.1 Protein Purification................................................... 65 3.1.1 Homogenisation and Fractionisation of Cells and Tissues.................................................. 65 3.1.2 Precipitation Methods...................................... 66 3.1.3 Chromatography............................................ 67 3.1.4 Electrophoresis
............................................. 71 3.1.5 Membrane Proteins......................................... 73 3.2 Determination of Protein Concentration ............................ 76 3.3 Protein Sequencing................................................... 78 3.3.1 Edman Degradation ........................................ 78 3.3.2 Mass Spectrometry......................................... 79 3.3.3 Phylogenetic Trees ......................................... 83 3.4 Synthesis of Peptides................................................. 85 3.5 How Do We Determine Secondary Structure?...................... 85 3.5.1 X-Ray Crystallography..................................... 86 3.5.2 Electron Microscopy ....................................... 87 3.5.3 Nuclear Magnetic Resonance.............................. 87 3.5.4 Computer Predictions ...................................... 88 3.6 Exercises.............................................................. 89 3.6.1 Problems.................................................... 89 3.6.2 Solutions.................................................... 91 References.................................................................... 91
Contents Part II Enzymes 4 Enzymes Are Biocatalysts ........................................ 4.1 The Nature of Catalysis..................................... 4.1.1 A Brief History of Enzymology .................. 4.2 Enzyme Classification and EC Code 4.2.1 Chemical and Biological Direction of a Reaction 4.3 Inherited Diseases of Metabolism.......................... 4.4 Exercises..................................................... 4.4.1 Problems........................................... 4.4.2 Solutions........................................... References........................................................... 5 Enzyme Kinetics and Mechanism ............................... 5.1 The Henri-Michaelis-Menten Equation............. 5.1.1 Efficiency Constant and Catalytic Perfection — 5.1.2 Application: Forensic Determination of Blood Alcohol Concentration ............................ 5.1.3 Linearisation of the HMM-Equation ............. 5.1.4 Experimental Pitfalls.............................. 5.1.5 Environmental Influences on Enzyme Activity .. 5.2 Enzymes with Several Substrates........................... 5.2.1 Nomenclature...................................... 5.2.2 How Do We Determine the Mechanism of Multisubstrate Enzymes?....................... 5.3 Enzyme Precursors and Their Activation .................. 5.4 The Coupled Spectrophotometric Assay of WARBURG ... 5.5 How Do Enzymes Work?................................... 5.5.1 Molecular Mechanism of Serine-Proteases and -Esterases...................................... 5.6 Exercises..................................................... 5.6.1 Problems........................................... 5.6.2 Solutions........................................... References........................................................... 6 Inhibition and Inactivation of Enzymes......................... 6.1 Enzyme Inhibition........................................... 6.2 Competitive
Inhibition...................................... 6.3 Uncompetitive Inhibition ................................... 6.4 Noncompetitive Inhibition.................................. 6.5 Partial Inhibition............................................. 6.6 Inactivation of Enzymes .................................... 6.7 Exercises..................................................... 6.7.1 Problems........................................... 6.7.2 Solutions........................................... References........................................................... XI 97 97 98 101 104 104 109 109 109 110 111 111 117 119 120 123 126 126 127 128 129 130 131 133 135 135 137 139 141 141 142 147 148 151 154 157 157 160 161
Contents xii 7 Hæmoglobin and Myoglobin: Cooperativity............................ 163 7.1 Structure.............................................................. 165 7.2 Oxygen Binding and Cooperativity ................................. 165 7.2.1 Functional Significance of Cooperativity.................. 167 7.2.2 Mechanism of Cooperativity............................... 168 7.2.3 Other Factors Involving Oxygen Affinity of Hæmoglobin ............................................. 173 7.3 Hæmoglobin Related Diseases ...................................... 176 7.3.1 Subunit Composition of Human Hæmoglobin ............ 176 7.3.2 Inherited Diseases Relating to Hæmoglobin .............. 177 7.4 Exercises.............................................................. 183 7.4.1 Problems.................................................... 183 7.4.2 Solutions.................................................... 183 References.................................................................... 183 8 Enzyme Kinetics: Special Cases........................................... 185 8.1 Activation Cascades.................................................. 185 8.2 Feedback-Networks.................................................. 188 8.3 Multiple Phosphorylation............................................ 190 References.................................................................... 191 9 The Flow of Metabolites Through Metabolic Pathways................ 193 9.1 Flux Control Theory ................................................. 194 9.1.1 Supply/Demand Analysis.................................. 197 9.1.2 Mechanism of Flux Control................................ 197 References.................................................................... 199 Part III Special Proteins 10 Protein Folding Diseases................................................... 203 10.1 Intrinsically Disordered
Proteins.................................... 203 10.1.1 Protein-Only Elements of Inheritance..................... 205 10.2 Antyloidoses.......................................................... 206 10.2.1 Prion Proteins and Prion Diseases......................... 207 10.2.2 Neuronal Amyloidoses..................................... 213 10.2.3 Amyloidoses in Other Organs.............................. 218 10.2.4 Amyloidoses Secondary to Other Diseases ............... 220 10.3 Exercises.............................................................. 221 10.3.1 Problems.................................................... 221 10.3.2 Solutions.................................................... 221 References.................................................................... 222 11 Immunoproteins............................................................ 225 11.1 Overview.............................................................. 226 11.1.1 Cells of the Immune System............................... 227 11.2 Humoral Immunity: Immunoglobulins.............................. 231 11.2.1 Structure oflmmunoglobulins............................. 231
Contents xiii 11.2.2 How Is the Large Number of Ig-Molecules Obtained? ... 234 11.2.3 Time Course of Antibody Response....................... 241 11.2.4 Immunisation............................................... 244 11.2.5 Monoclonal Antibodies .................................... 246 11.2.6 Laboratory Uses of Antibodies ............................ 247 11.3 Destroying Invaders: The Complement System .................... 249 11.3.1 How Is Complement Activated?........................... 251 11.3.2 What Does Complement Do?.............................. 253 11.3.3 How Is Complement Inactivated?.......................... 256 11.4 Cellular Immunity.................................................... 258 11.4.1 The Major Histocompatibility Complex................... 258 11.4.2 The T-Cell Receptor........................................ 267 11.5 Proteins Involved in Innate Immunity............................... 270 11.5.1 PAMP-Receptors ........................................... 270 11.5.2 Cytokines ................................................... 275 11.5.3 The Acute-Phase Response ................................ 277 11.5.4 Antibacterial Proteins ...................................... 278 11.6 Exercises.............................................................. 281 11.6.1 Problems.................................................... 281 11.6.2 Solutions.................................................... 282 References.................................................................... 283 12 Cell Skeleton................................................................ 287 12.1 The Microfilament.................................................... 288 12.1.1 Basic Actin Structure....................................... 288 12.1.2 Actin-Binding Proteins..................................... 291 12.1.3 Functions of Actin.......................................... 295 12.1.4
Actin-Networks............................................. 295 12.2 Microtubules.......................................................... 296 12.2.1 Microtubule Structure...................................... 297 12.3 Intermediate Filament................................................ 299 12.3.1 IF-Proteins Are Cell-Type Specific........................ 300 12.3.2 Structure of Intermediate Filaments....................... 302 12.3.3 Intermediate Filaments and Cell Cycle.................... 303 12.3.4 Other Proteins Associated with Intermediate Filaments.................................................... 303 12.4 Exercises.............................................................. 304 12.4.1 Problems.................................................... 304 12.4.2 Solutions.................................................... 304 References.................................................................... 304 13 Motor Proteins and Movement............................................ 305 13.1 Myosin Moves Along Actin Filaments.............................. 305 13.1.1 Myosin Structure ........................................... 305 13.1.2 Myosin-II ................................................... 306
Contents xiv 13.1.3 Myosin-I .................................................... 310 13.1.4 Myosin-V ................................................... 311 13.2 Kinesin and Dynein Move Along Microtubules .................... 311 13.2.1 Kinesin Is Responsible for Anterograde (Minus to Plus) Transport.................................. 311 13.2.2 Dynein Is Responsible for Retrograde (Plus to Minus) Movement.......................................... 313 13.3 Cilia and Flagella..................................................... 313 13.3.1 Generic Structure of Cilia and Flagella.................... 313 13.3.2 Mechanism of Movement.................................. 315 13.3.3 Cilia and Flagella Start Growing at the Basal Body...... 317 13.4 The Mitotic Spindle.................................................. 317 References.................................................................... 322 14 Cell-Cell Interactions...................................................... 323 14.1 Extracellular Matrix.................................................. 323 14.1.1 Collagen..................................................... 324 14.1.2 Elastin....................................................... 331 14.2 Cell Adhesion Molecules............................................ 335 14.3 Junctions.............................................................. 337 14.3.1 Disintegrins................................................. 339 14.4 Exercises.............................................................. 339 14.4.1 Problems.................................................... 339 14.4.2 Solutions.................................................... 340 References.................................................................... 340 15 Aiding in Folding: Molecular Chaperones and Chaperonins.......... 343 15.1 Hsp70 Is an Example for Molecular Chaperones................... 345 15.2 Other Heat Shock Proteins also Have
Chaperone Activity......... 350 15.2.1 Hsp90 ....................................................... 350 15.2.2 Small Heat Shock Proteins................................. 353 15.3 The GroEL/GroES-Foldosomc Is an Example for Molecular Chaperonins .......................................... 354 15.4 Exercises.............................................................. 357 15.4.1 Problems.................................................... 357 15.4.2 Solutions.................................................... 358 References.................................................................... 358 Part IV Membrane Transport 16 Protein Transport Across Membranes................................... 363 16.1 Structure of Membrane Components................................ 363 16.1.1 Membrane Lipid............................................ 363 16.1.2 Membrane Proteins......................................... 364 16.2 Transport of Proteins into Mitochondria............................ 368 16.2.1 The Mitochondrium in the Cell Cycle..................... 368 16.2.2 Mitochondrial Proteins and Lipids......................... 369
Contents xv 16.3 Synthesis and Sorting of Mitochondrial Proteins in the Cytosol ... 371 16.4 Transfer of Protein into the ER Lumen.............................. 375 16.5 Folding and Quality Control of Membrane Proteins ............... 377 16.5.1 Posttranslational Modification in the ER.................. 377 16.5.2 Glycosylation ............................................... 379 16.5.3 Protein Quality Control in the ER......................... 385 16.6 Exercises .............................................................. 387 16.6.1 Problems.................................................... 387 16.6.2 Solutions.................................................... 389 References .................................................................... 389 17 Vesicular Transport in Eukaryotic Cells ................................. 393 17.1 Two Models for Transport Between Compartments................ 393 17.1.1 Maturation .................................................. 393 17.1.2 Vesicular Transport......................................... 395 17.1.3 Experimental Evidence..................................... 395 17.2 Clathrin............................................................... 395 17.2.1 Endocytosis, Membrane Protein Recycling, and Transcytosis............................................ 396 17.3 ß-Coat Protein........................................................ 403 17.3.1 Vesicular Transport Between ER and Golgi Stacks..... 403 17.4 The Specificity of Membrane Fusion................................ 409 17.4.1 v-SNAREs and t-SNAREs................................. 409 17.4.2 Rab Proteins ................................................ 409 17.4.3 How Do Proteins Know Where They Belong?............ 410 17.5 Other Vesicular Transport Pathways ................................ 412 17.5.1 Transport of Newly Synthesised Proteins to Their Destination ........................................ 412 17.5.2
Proteins Taken Up by the Cell ............................. 416 17.6 Exercises.............................................................. 417 17.6.1 Problems.................................................... 417 17.6.2 Solutions.................................................... 418 References.................................................................... 419 18 Transport of Solutes Across Membranes ................................ 421 18.1 Passive Diffusion..................................................... 422 18.2 Transporters .......................................................... 423 18.2.1 Primary Active Transporters (Pumps)..................... 424 18.2.2 Secondary Active Transporter (Cotransporter)............ 454 18.2.3 Facilitated Diffusion........................................ 458 18.3 Exercises.............................................................. 465 18.3.1 Problems.................................................... 465 18.3.2 Solutions.................................................... 466 References.................................................................... 467
xvi Contents Appendix A: Short Biographies of Scientists Mentioned in This Book____ 469 Appendix B: List of Symbols.................................................... 489 Appendix C: Greek Alphabet................................................... 491 Appendix D: The Genetic Code ................................................ 493 Appendix E: Acronyms.......................................................... 495 Index............................................................................... 507
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| indexdate | 2024-07-10T07:12:24Z |
| institution | BVB |
| isbn | 9783319199191 |
| language | English |
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| spelling | Buxbaum, Engelbert Verfasser aut Fundamentals of protein structure and function Engelbert Buxbaum 2. ed. Cham [u.a.] Springer 2015 XVI, 521 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Protéines Protéines - Structure Proteins Proteins Structure Proteinfaltung (DE-588)4324567-5 gnd rswk-swf Enzym (DE-588)4014988-2 gnd rswk-swf Proteine (DE-588)4076388-2 gnd rswk-swf Proteine (DE-588)4076388-2 s Proteinfaltung (DE-588)4324567-5 s Enzym (DE-588)4014988-2 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028328884&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Buxbaum, Engelbert Fundamentals of protein structure and function Protéines Protéines - Structure Proteins Proteins Structure Proteinfaltung (DE-588)4324567-5 gnd Enzym (DE-588)4014988-2 gnd Proteine (DE-588)4076388-2 gnd |
| subject_GND | (DE-588)4324567-5 (DE-588)4014988-2 (DE-588)4076388-2 |
| title | Fundamentals of protein structure and function |
| title_auth | Fundamentals of protein structure and function |
| title_exact_search | Fundamentals of protein structure and function |
| title_full | Fundamentals of protein structure and function Engelbert Buxbaum |
| title_fullStr | Fundamentals of protein structure and function Engelbert Buxbaum |
| title_full_unstemmed | Fundamentals of protein structure and function Engelbert Buxbaum |
| title_short | Fundamentals of protein structure and function |
| title_sort | fundamentals of protein structure and function |
| topic | Protéines Protéines - Structure Proteins Proteins Structure Proteinfaltung (DE-588)4324567-5 gnd Enzym (DE-588)4014988-2 gnd Proteine (DE-588)4076388-2 gnd |
| topic_facet | Protéines Protéines - Structure Proteins Proteins Structure Proteinfaltung Enzym Proteine |
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