Molecular biology of cancer: mechanisms, targets, and therapeutics
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Oxford [u.a.]
Oxford Univ. Press
2016
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| Edition: | 4. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVIII, 375 S. Ill., graph. Darst. |
| ISBN: | 9780198717348 0198717342 |
Staff View
MARC
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Record in the Search Index
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■ DETAILED CONTENTS
1 Introduction 1
1.1 What is cancer? 2
1.2 Evidence suggests that cancer is a disease of the genome at the cellular level 5
1.3 Influential factors in human carcinogenesis 10
1.4 Principles of conventional cancer therapies 13
1.5 Clinical trials 15
1.6 The role of molecular targets in cancer therapies 16
2 DNA structure and stability: mutations versus repair 22
2.1 Gene structure—two parts of a gene: the regulatory region
and the coding region 23
2.2 Mutations 24
2.3 Carcinogenic agents 27
2.4 DNA repair and predispositions to cancer 39
§ Therapeutic strategies 43
2.5 Conventional therapies: chemotherapy and radiation therapy 43
2.5 Strategies that target DNA repair pathways 48
3 Regulation of gene expression 53
3.1 Transcription factors and transcriptional regulation 54
3.2 Chromatin structure 61
3.3 Epigenetic regulation of transcription 62
3.4 Evidence of a role for epigenetics in carcinogenesis 65
3.5 Long non-coding RNAs 68
3.6 MtcroRNAs (miRNAs) and regulation of mRNA expression 68
3.7 Telomeres and telomerase 70
0 Therapeutic strategies 73
3.8 Epigenomic and histonomic drugs 73
3.9 Non-coding RNAs for diagnosis 75
3.10 Telomerase inhibitors 75
4 Growth factor signaling and oncogenes 79
4.1 Epidermal growth factor signaling: an important paradigm 80
4.2 Oncogenes 89
@ Therapeutic strategies 97
4.3 Kinases as drug targets 97
XVI
DETAILED CONTENTS
5 The cell cycle 109
5.1 Cyclins and cyclin-dependent kinases (cdks) 110
5.2 Mechanisms of cdk regulation 112
5.3 Progression through the G, checkpoint 115
5.4 The G2 checkpoint 117
5.5 The mitotic checkpoint 118
5.6 The cell cycle and cancer 120
© Therapeutic strategies 123
5.7 Cyclin-dependent kinase inhibitors 123
5.8 Other cell cycle kinase targets 124
5.9 Inhibitors of the mitotic spindle 124
6 Growth inhibition and tumor suppressor genes 128
6.1 Definitions of tumor suppressor genes 128
6.2 The retinoblastoma gene 133
6.3 Mutations in the RB pathway and cancer 134
6.4 The p53 pathway 135
6.5 Mutations in the p53 pathway and cancer 143
6.6 Interaction of DNA viral protein products with RB and p53 145
© Therapeutic strategies 147
6.7 Targeting of the p53 pathway 14/
7 Apoptosis 155
7.1 Molecular mechanisms of apoptosis 156
7.2 Apoptosis and cancer 166
7.3 Apoptosis and chemotherapy 169
©Therapeutic strategies 171
7.4 Apoptotic drugs 171
8 Cancer stem cells and the regulation of self-renewal and
differentiation pathways: focus on colon cancer and leukemias 178
8.1 Cancer stem cells 180
8.2 The regulation of differentiation by gene expression 192
© Therapeutic strategies 196
8.3 Inhibitors of the Wnt pathway 197
8.4 Inhibitors of the Hh pathway 198
8.5 Inhibitors of PcG proteins 200
8.6 Leukemia and differentiation therapies 200
9 Metastasis 205
9.1 How do tumors spread7 206
9.2 The process of metastasis 206
9.3 Invasion and the epithelial-mesenchymal transition 208
9.4 Intravasation 212
DETAILED CONTENTS
XVII
9.5 Transport 213
9.6 Extravasation 213
9.7 Metastatic colonization 215
©Therapeutic strategies 219
9.8 Metalloproteinase inhibitors (MPIs) 220
9.9 Strategies for restoring metastasis suppressors 220
9.10 Targeting several steps of metastasis at once 222
10 Angiogenesis 228
10.1 The angiogenic switch 229
10.2 Ceil behavior during angiogenic sprouting 234
10.3 Other means of tumor neovascularization 235
©Therapeutic strategies 236
10.4 Anti-angiogenic therapy 236
10.5 Vascular targeting by vascular disrupting agents 240
11 Nutrient and hormone effects on the genome 245
11.1 Introduction to food and cancer 245
11.2 Causative factors 248
11.3 Preventative factors: microconstituents of fruits and vegetables 253
11.4 Reprogramming energy metabolism in tumor cells—an emerging
hallmark of cancer 258
115 Genetic polymorphisms and diet 262
11.6 Vitamin D: a link between nutrients and hormone action 264
11.7 Hormones and cancer 265
©Therapeutic strategies 369
11.8 "Enhanced" foods and dietary supplements for chemoprevention 269
11.9 Drugs that target energy pathways 270
11.10 Drugs that target estrogen 270
12 Tumor immunology and immunotherapy 277
12.1 Lymphocytes: B cells and T cells 278
12.2 The tumor suppressive roles of the immune system 279
12.3 Immune checkpoints 281
12.4 Cancer immunoediting and tumor promotion 284
12.5 Mechanisms of avoiding immune destruction 285
© Therapeutic strategies 286
12.6 Therapeutic antibodies 286
12.7 Cancer vaccines 287
12.8 Immune checkpoint blockades 293
12.9 Adoptive T-cell transfer, modified [ cell receptors, and chimeric
antigen receptors 296
12.10 Oncolytic viruses and virotherapy 298
XVIII
DETAILED CONTENTS
13 Infectious agents and inflammation 302
13.1 Identifying infectious agents as carcinogens 303
13.2 inflammation and cancer 310
® Therapeutic strategies 317
13.3 A national vaccination program against hepatitis B virus in Taiwan 317
13.4 Eradication of H. pylori and the relationship to prevention of gastric cancer 318
13.5 Cancer vaccines to prevent cervical cancer 318
13.6 Inhibition of inflammation 320
14 Technology and drug and diagnostics development 326
14.1 Microarrays and gene expression profiling 327
14.2 Analysis of biomarkers for diagnostics and prognostics 329
14.3 Studying gene function by CRISPR-Cas9 331
14.4 Imaging 332
14.5 Cancer nanotechnology 333
14.6 Strategies of drug development 33b
14.7 Development of imatinib 339
14.8 Second-and third-generation therapeutics 340
14.9 Improved clinical trial design 342
14.10 Personalized medicine and bioinformatics 34b
14.11 Are we making progress'? 347
APPENDIX 1: CElt CYCLE REGULATION 353
GLOSSARY 3 D4
INDEX 36b |
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| isbn | 9780198717348 0198717342 |
| language | English |
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| spelling | Pecorino, Lauren Verfasser (DE-588)1239836945 aut Molecular biology of cancer mechanisms, targets, and therapeutics Lauren Pecorino 4. ed. Oxford [u.a.] Oxford Univ. Press 2016 XVIII, 375 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Molekularbiologie (DE-588)4039983-7 s DE-604 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028323270&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pecorino, Lauren Molecular biology of cancer mechanisms, targets, and therapeutics Krebs Medizin (DE-588)4073781-0 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4073781-0 (DE-588)4039983-7 |
| title | Molecular biology of cancer mechanisms, targets, and therapeutics |
| title_auth | Molecular biology of cancer mechanisms, targets, and therapeutics |
| title_exact_search | Molecular biology of cancer mechanisms, targets, and therapeutics |
| title_full | Molecular biology of cancer mechanisms, targets, and therapeutics Lauren Pecorino |
| title_fullStr | Molecular biology of cancer mechanisms, targets, and therapeutics Lauren Pecorino |
| title_full_unstemmed | Molecular biology of cancer mechanisms, targets, and therapeutics Lauren Pecorino |
| title_short | Molecular biology of cancer |
| title_sort | molecular biology of cancer mechanisms targets and therapeutics |
| title_sub | mechanisms, targets, and therapeutics |
| topic | Krebs Medizin (DE-588)4073781-0 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Krebs Medizin Molekularbiologie |
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