Clinical Trials: a Practical Approach
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Hoboken
Wiley
2013
|
| Schlagworte: | |
| Online-Zugang: | TUM01 Volltext |
| Beschreibung: | Cover; Title Page; Contents; Preface; 1. Introduction: The Rationale of Clinical Trials; 1.1 Types of clinical trial; 1.2 Controlled clinical trials and the scientific method; 1.3 An example of a clinical trial for primary breast cancer; 2. The Historical Development of Clinical Trials; 2.1 Clinical trials before 1950; 2.2 Clinical trials since 1950; 2.3 Cancer chemotherapy in the United States; 2.4 Treatment of acute myocardial infarction; 2.5 The pharmaceutical industry; 3. Organization and Planning; 3.1 The protocol; 3.2 Administration, staff and finance; 3.3 Selection of patients 3.4 Treatment schedules3.5 Evaluation of patient response; 4. The Justification for Randomized Controlled Trials; 4.1 Problems with uncontrolled trials; 4.2 Problems with historical controls; 4.3 Problems with concurrent non-randomized controls; 4.4 Is randomization feasible?; 5. Methods of Randomization; 5.1 Patient registration; 5.2 Preparing the randomization list; 5.3 Stratified randomization; 5.4 Unequal randomization; 6. Blinding and Placebos; 6.1 The justification for double-blind trials; 6.2 The conduct of double-blind trials; 6.3 When is blinding feasible?; 7. Ethical Issues 7.1 Medical progress and individual patient care7.2 Informed patient consent; 8. Crossover Trials; 8.1 Within-patient comparisons; 8.2 The two-period crossover design; 8.3 The analysis and interpretation of crossover trials; 8.4 Multi-period crossover designs; 9. The Size of a Clinical Trial; 9.1 Statistical methods for determining trial size; 9.2 The realistic assessment of trial size; 9.3 The inadequacy of small trials; 9.4 Multi-centre trials; 9.5 The number of treatments and factorial designs; 10. Monitoring Trial Progress; 10.1 Reasons for monitoring; 10.2 Interim analyses 10.3 Repeated significance testing: group sequential designs10.4 Continuous sequential designs; 11. Forms and Data Management; 11.1 Form design; 11.2 Data management; 11.3 The use of computers; 12. Protocol Deviations; 12.1 Ineligible patients; 12.2 Non-compliance and incomplete evaluation; 12.3 Inclusion of withdrawals in analysis; 13. Basic Principles of Statistical Analysis; 13.1 Describing the data; 13.2 Significance tests; 13.3 Estimation and confidence limits; 14. Further Aspects of Data Analysis; 14.1 Prognostic factors; 14.2 The analysis of survival data; 14.3 Multiplicity of data 15. Publication and Interpretation of Findings15.1 Trial reports and their critical evaluation; 15.2 An excess of false-positives; 15.3 Combining evidence and overall strategy; References; Index This comprehensive, unified text on the principles and practice of clinical trials presents a detailed account of how to conduct the trials. It describes the design, analysis, and interpretation of clinical trials in a non-technical manner and provides a general perspective on their historical development, current status, and future strategy. Features examples derived from the author's personal experience |
| Beschreibung: | 1 Online-Ressource (280 pages) |
| ISBN: | 1118793927 9781118793923 |
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| 500 | |a Cover; Title Page; Contents; Preface; 1. Introduction: The Rationale of Clinical Trials; 1.1 Types of clinical trial; 1.2 Controlled clinical trials and the scientific method; 1.3 An example of a clinical trial for primary breast cancer; 2. The Historical Development of Clinical Trials; 2.1 Clinical trials before 1950; 2.2 Clinical trials since 1950; 2.3 Cancer chemotherapy in the United States; 2.4 Treatment of acute myocardial infarction; 2.5 The pharmaceutical industry; 3. Organization and Planning; 3.1 The protocol; 3.2 Administration, staff and finance; 3.3 Selection of patients | ||
| 500 | |a 3.4 Treatment schedules3.5 Evaluation of patient response; 4. The Justification for Randomized Controlled Trials; 4.1 Problems with uncontrolled trials; 4.2 Problems with historical controls; 4.3 Problems with concurrent non-randomized controls; 4.4 Is randomization feasible?; 5. Methods of Randomization; 5.1 Patient registration; 5.2 Preparing the randomization list; 5.3 Stratified randomization; 5.4 Unequal randomization; 6. Blinding and Placebos; 6.1 The justification for double-blind trials; 6.2 The conduct of double-blind trials; 6.3 When is blinding feasible?; 7. Ethical Issues | ||
| 500 | |a 7.1 Medical progress and individual patient care7.2 Informed patient consent; 8. Crossover Trials; 8.1 Within-patient comparisons; 8.2 The two-period crossover design; 8.3 The analysis and interpretation of crossover trials; 8.4 Multi-period crossover designs; 9. The Size of a Clinical Trial; 9.1 Statistical methods for determining trial size; 9.2 The realistic assessment of trial size; 9.3 The inadequacy of small trials; 9.4 Multi-centre trials; 9.5 The number of treatments and factorial designs; 10. Monitoring Trial Progress; 10.1 Reasons for monitoring; 10.2 Interim analyses | ||
| 500 | |a 10.3 Repeated significance testing: group sequential designs10.4 Continuous sequential designs; 11. Forms and Data Management; 11.1 Form design; 11.2 Data management; 11.3 The use of computers; 12. Protocol Deviations; 12.1 Ineligible patients; 12.2 Non-compliance and incomplete evaluation; 12.3 Inclusion of withdrawals in analysis; 13. Basic Principles of Statistical Analysis; 13.1 Describing the data; 13.2 Significance tests; 13.3 Estimation and confidence limits; 14. Further Aspects of Data Analysis; 14.1 Prognostic factors; 14.2 The analysis of survival data; 14.3 Multiplicity of data | ||
| 500 | |a 15. Publication and Interpretation of Findings15.1 Trial reports and their critical evaluation; 15.2 An excess of false-positives; 15.3 Combining evidence and overall strategy; References; Index | ||
| 500 | |a This comprehensive, unified text on the principles and practice of clinical trials presents a detailed account of how to conduct the trials. It describes the design, analysis, and interpretation of clinical trials in a non-technical manner and provides a general perspective on their historical development, current status, and future strategy. Features examples derived from the author's personal experience | ||
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Datensatz im Suchindex
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| any_adam_object | |
| author | Pocock, Stuart J. |
| author_facet | Pocock, Stuart J. |
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| dewey-ones | 610 - Medicine and health |
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| dewey-search | 610.724 |
| dewey-sort | 3610.724 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| indexdate | 2024-07-10T07:09:45Z |
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| isbn | 1118793927 9781118793923 |
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| publisher | Wiley |
| record_format | marc |
| spelling | Pocock, Stuart J. Verfasser aut Clinical Trials a Practical Approach Hoboken Wiley 2013 1 Online-Ressource (280 pages) txt rdacontent c rdamedia cr rdacarrier Cover; Title Page; Contents; Preface; 1. Introduction: The Rationale of Clinical Trials; 1.1 Types of clinical trial; 1.2 Controlled clinical trials and the scientific method; 1.3 An example of a clinical trial for primary breast cancer; 2. The Historical Development of Clinical Trials; 2.1 Clinical trials before 1950; 2.2 Clinical trials since 1950; 2.3 Cancer chemotherapy in the United States; 2.4 Treatment of acute myocardial infarction; 2.5 The pharmaceutical industry; 3. Organization and Planning; 3.1 The protocol; 3.2 Administration, staff and finance; 3.3 Selection of patients 3.4 Treatment schedules3.5 Evaluation of patient response; 4. The Justification for Randomized Controlled Trials; 4.1 Problems with uncontrolled trials; 4.2 Problems with historical controls; 4.3 Problems with concurrent non-randomized controls; 4.4 Is randomization feasible?; 5. Methods of Randomization; 5.1 Patient registration; 5.2 Preparing the randomization list; 5.3 Stratified randomization; 5.4 Unequal randomization; 6. Blinding and Placebos; 6.1 The justification for double-blind trials; 6.2 The conduct of double-blind trials; 6.3 When is blinding feasible?; 7. Ethical Issues 7.1 Medical progress and individual patient care7.2 Informed patient consent; 8. Crossover Trials; 8.1 Within-patient comparisons; 8.2 The two-period crossover design; 8.3 The analysis and interpretation of crossover trials; 8.4 Multi-period crossover designs; 9. The Size of a Clinical Trial; 9.1 Statistical methods for determining trial size; 9.2 The realistic assessment of trial size; 9.3 The inadequacy of small trials; 9.4 Multi-centre trials; 9.5 The number of treatments and factorial designs; 10. Monitoring Trial Progress; 10.1 Reasons for monitoring; 10.2 Interim analyses 10.3 Repeated significance testing: group sequential designs10.4 Continuous sequential designs; 11. Forms and Data Management; 11.1 Form design; 11.2 Data management; 11.3 The use of computers; 12. Protocol Deviations; 12.1 Ineligible patients; 12.2 Non-compliance and incomplete evaluation; 12.3 Inclusion of withdrawals in analysis; 13. Basic Principles of Statistical Analysis; 13.1 Describing the data; 13.2 Significance tests; 13.3 Estimation and confidence limits; 14. Further Aspects of Data Analysis; 14.1 Prognostic factors; 14.2 The analysis of survival data; 14.3 Multiplicity of data 15. Publication and Interpretation of Findings15.1 Trial reports and their critical evaluation; 15.2 An excess of false-positives; 15.3 Combining evidence and overall strategy; References; Index This comprehensive, unified text on the principles and practice of clinical trials presents a detailed account of how to conduct the trials. It describes the design, analysis, and interpretation of clinical trials in a non-technical manner and provides a general perspective on their historical development, current status, and future strategy. Features examples derived from the author's personal experience Clinical medicine Clinical trials Medicine HEALTH & FITNESS / Holism bisacsh HEALTH & FITNESS / Reference bisacsh MEDICAL / Alternative Medicine bisacsh MEDICAL / Atlases bisacsh MEDICAL / Essays bisacsh MEDICAL / Family & General Practice bisacsh MEDICAL / Holistic Medicine bisacsh MEDICAL / Osteopathy bisacsh Medizin Statistik (DE-588)4056995-0 gnd rswk-swf Therapie (DE-588)4059798-2 gnd rswk-swf Methode (DE-588)4038971-6 gnd rswk-swf Klinische Prüfung (DE-588)4031192-2 gnd rswk-swf Klinisches Experiment (DE-588)4164223-5 gnd rswk-swf Klinisches Experiment (DE-588)4164223-5 s Statistik (DE-588)4056995-0 s 1\p DE-604 Therapie (DE-588)4059798-2 s 2\p DE-604 Klinische Prüfung (DE-588)4031192-2 s Methode (DE-588)4038971-6 s 3\p DE-604 http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=925856 Aggregator Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Pocock, Stuart J. Clinical Trials a Practical Approach Clinical medicine Clinical trials Medicine HEALTH & FITNESS / Holism bisacsh HEALTH & FITNESS / Reference bisacsh MEDICAL / Alternative Medicine bisacsh MEDICAL / Atlases bisacsh MEDICAL / Essays bisacsh MEDICAL / Family & General Practice bisacsh MEDICAL / Holistic Medicine bisacsh MEDICAL / Osteopathy bisacsh Medizin Statistik (DE-588)4056995-0 gnd Therapie (DE-588)4059798-2 gnd Methode (DE-588)4038971-6 gnd Klinische Prüfung (DE-588)4031192-2 gnd Klinisches Experiment (DE-588)4164223-5 gnd |
| subject_GND | (DE-588)4056995-0 (DE-588)4059798-2 (DE-588)4038971-6 (DE-588)4031192-2 (DE-588)4164223-5 |
| title | Clinical Trials a Practical Approach |
| title_auth | Clinical Trials a Practical Approach |
| title_exact_search | Clinical Trials a Practical Approach |
| title_full | Clinical Trials a Practical Approach |
| title_fullStr | Clinical Trials a Practical Approach |
| title_full_unstemmed | Clinical Trials a Practical Approach |
| title_short | Clinical Trials |
| title_sort | clinical trials a practical approach |
| title_sub | a Practical Approach |
| topic | Clinical medicine Clinical trials Medicine HEALTH & FITNESS / Holism bisacsh HEALTH & FITNESS / Reference bisacsh MEDICAL / Alternative Medicine bisacsh MEDICAL / Atlases bisacsh MEDICAL / Essays bisacsh MEDICAL / Family & General Practice bisacsh MEDICAL / Holistic Medicine bisacsh MEDICAL / Osteopathy bisacsh Medizin Statistik (DE-588)4056995-0 gnd Therapie (DE-588)4059798-2 gnd Methode (DE-588)4038971-6 gnd Klinische Prüfung (DE-588)4031192-2 gnd Klinisches Experiment (DE-588)4164223-5 gnd |
| topic_facet | Clinical medicine Clinical trials Medicine HEALTH & FITNESS / Holism HEALTH & FITNESS / Reference MEDICAL / Alternative Medicine MEDICAL / Atlases MEDICAL / Essays MEDICAL / Family & General Practice MEDICAL / Holistic Medicine MEDICAL / Osteopathy Medizin Statistik Therapie Methode Klinische Prüfung Klinisches Experiment |
| url | http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=925856 |
| work_keys_str_mv | AT pocockstuartj clinicaltrialsapracticalapproach |