Sample size determination in clinical trials with multiple endpoints:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cham [u.a.]
Springer
2015
|
| Schriftenreihe: | SpringerBriefs in statistics
|
| Schlagworte: | |
| Online-Zugang: | BTU01 FRO01 TUM01 UBM01 UBT01 UBW01 UPA01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource (VI, 95 S.) 17 illus |
| ISBN: | 9783319220055 |
| ISSN: | 2191-544X |
| DOI: | 10.1007/978-3-319-22005-5 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804175020691292160 |
|---|---|
| adam_text | SAMPLE SIZE DETERMINATION IN CLINICAL TRIALS WITH MULTIPLE ENDPOINTS
/ SOZU, TAKASHI
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
1.INTRODUCTION
2.CONTINUOUS CO-PRIMARY ENDPOINTS
3.BINARY CO-PRIMARY ENDPOINTS
4.CONVENIENT SAMPLE SIZE FORMULA
5.CONTINUOUS PRIMARY ENDPOINTS
6. FURTHER DEVELOPMENTS
A.SAMPLE SIZE CALCULATION USING OTHER CONTRASTS FOR BINARY ENDPOINTS
B.EMPIRICAL POWER FOR SAMPLE SIZE CALCULATION FOR BINARY CO-PRIMARY
ENDPOINTS
C.NUMERICAL TABLES FOR CK IN THE CONVENIENT SAMPLE SIZE FORMULA FOR THE
THREE CO-PRIMARY CONTINUOUS ENDPOINTS CACE
D.SOFTWARE PROGRAMS FOR SAMPLE SIZE CALCULATION FOR CONTINUOUS
CO-PRIMARY ENDPOINTS
REFERENCES
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
SAMPLE SIZE DETERMINATION IN CLINICAL TRIALS WITH MULTIPLE ENDPOINTS
/ SOZU, TAKASHI
: 2015
ABSTRACT / INHALTSTEXT
THIS BOOK INTEGRATES RECENT METHODOLOGICAL DEVELOPMENTS FOR CALCULATING
THE SAMPLE SIZE AND POWER IN TRIALS WITH MORE THAN ONE ENDPOINT
CONSIDERED AS MULTIPLE PRIMARY OR CO-PRIMARY, OFFERING AN IMPORTANT
REFERENCE WORK FOR STATISTICIANS WORKING IN THIS AREA. THE DETERMINATION
OF SAMPLE SIZE AND THE EVALUATION OF POWER ARE FUNDAMENTAL AND CRITICAL
ELEMENTS IN THE DESIGN OF CLINICAL TRIALS. IF THE SAMPLE SIZE IS TOO
SMALL, IMPORTANT EFFECTS MAY GO UNNOTICED; IF THE SAMPLE SIZE IS TOO
LARGE, IT REPRESENTS A WASTE OF RESOURCES AND UNETHICALLY PUTS MORE
PARTICIPANTS AT RISK THAN NECESSARY. RECENTLY MANY CLINICAL TRIALS HAVE
BEEN DESIGNED WITH MORE THAN ONE ENDPOINT CONSIDERED AS MULTIPLE PRIMARY
OR CO-PRIMARY, CREATING A NEED FOR NEW APPROACHES TO THE DESIGN AND
ANALYSIS OF THESE CLINICAL TRIALS. THE BOOK FOCUSES ON THE EVALUATION OF
POWER AND SAMPLE SIZE DETERMINATION WHEN COMPARING THE EFFECTS OF TWO
INTERVENTIONS IN SUPERIORITY CLINICAL TRIALS WITH MULTIPLE ENDPOINTS.
METHODS FOR SAMPLE SIZE CALCULATION IN CLINICAL TRIALS WHERE THE
ALTERNATIVE HYPOTHESIS IS THAT THERE ARE EFFECTS ON ALL ENDPOINTS ARE
DISCUSSED IN DETAIL. THE BOOK ALSO BRIEflY EXAMINES TRIALS DESIGNED
WITH AN ALTERNATIVE HYPOTHESIS OF AN EFFECT ON AT LEAST ONE ENDPOINT
WITH A PRESPECIfiED NON-ORDERING OF ENDPOINTS.
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| discipline | Mathematik |
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| isbn | 9783319220055 |
| issn | 2191-544X |
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| spelling | Sample size determination in clinical trials with multiple endpoints Takashi Sozu ... Cham [u.a.] Springer 2015 1 Online-Ressource (VI, 95 S.) 17 illus txt rdacontent c rdamedia cr rdacarrier SpringerBriefs in statistics 2191-544X Statistics Statistical methods Mathematical statistics Statistical Theory and Methods Statistics for Life Sciences, Medicine, Health Sciences Biostatistics Statistik Sozu, Takashi Sonstige (DE-588)1076628060 oth Erscheint auch als Druckausgabe 978-3-319-22004-8 https://doi.org/10.1007/978-3-319-22005-5 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218092&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218092&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Sample size determination in clinical trials with multiple endpoints Statistics Statistical methods Mathematical statistics Statistical Theory and Methods Statistics for Life Sciences, Medicine, Health Sciences Biostatistics Statistik |
| title | Sample size determination in clinical trials with multiple endpoints |
| title_auth | Sample size determination in clinical trials with multiple endpoints |
| title_exact_search | Sample size determination in clinical trials with multiple endpoints |
| title_full | Sample size determination in clinical trials with multiple endpoints Takashi Sozu ... |
| title_fullStr | Sample size determination in clinical trials with multiple endpoints Takashi Sozu ... |
| title_full_unstemmed | Sample size determination in clinical trials with multiple endpoints Takashi Sozu ... |
| title_short | Sample size determination in clinical trials with multiple endpoints |
| title_sort | sample size determination in clinical trials with multiple endpoints |
| topic | Statistics Statistical methods Mathematical statistics Statistical Theory and Methods Statistics for Life Sciences, Medicine, Health Sciences Biostatistics Statistik |
| topic_facet | Statistics Statistical methods Mathematical statistics Statistical Theory and Methods Statistics for Life Sciences, Medicine, Health Sciences Biostatistics Statistik |
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