Biobetters: Protein Engineering to Approach the Curative
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer
2015
|
| Schriftenreihe: | AAPS Advances in the Pharmaceutical Sciences Series
19 |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource (XV, 378 p. 50 illus., 22 illus. in color) |
| ISBN: | 9781493925438 |
| DOI: | 10.1007/978-1-4939-2543-8 |
Internformat
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| 650 | 4 | |a Biomedicine general | |
| 650 | 4 | |a Medizin | |
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Datensatz im Suchindex
| _version_ | 1804175020688146432 |
|---|---|
| adam_text | BIOBETTERS
/
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
INTRODUCTION
TARGETING GLUCOCEREBROSIDASE TO MACROPHAGES FOR EFFECTIVE TREATMENT OF
PATIENTS WITH GAUCHER DISEASE: SETTING THE PARADIGM OF A FIT FOR
PURPOSE APPROACH TO ENZYME REPLACEMENT THERAPY
CHALLENGES OF ENZYME REPLACEMENT THERAPY: POOR TISSUE DISTRIBUTION IN
LYSOSOMAL DISEASES USING POMPE DISEASE AS A MODEL
MUSCLE TARGETING
BLOOD-BRAIN BARRIER TARGETING OF THERAPEUTIC LYSOSOMAL ENZYMES
NOVEL METHODS FOR ADDRESSING IMMUNOGENICITY IN THERAPEUTIC ENZYMES
STRUCTURE OF MONOCLONAL ANTIBODIES
PREDICTION OF AGGREGATION IN VIVO BY STUDIES OF THERAPEUTIC PROTEINS IN
HUMAN PLASMA
EFFECT OF HYDROLYTIC DEGRADATION ON THE IN VIVO PROPERTIES OF MONOCLONAL
ANTIBODIES
OXIDATION OF PROTEINS IN THE IN-VIVO ENVIRONMENT: WHAT WE KNOW; WHAT WE
NEED TO STUDY AND POTENTIAL MITIGATION STRATEGIES
MOLECULAR ASSESSMENT: BALANCING AFFINITY, PK AND MANUFACTURABILITY
PERSPECTIVES ON ENGINEERING BIOBETTER THERAPEUTIC PROTEINS WITH GREATER
STABILITY IN INFLAMMATORY ENVIRONMENTS
ANTIBODY-LIKE MOLECULES DESIGNED FOR SUPERIOR TARGETING AND
PHARMACOKINETICS
ALTERNATIVE PROTEIN SCAFFOLDS AS NOVEL BIOTHERAPEUTICS
CURRENT STRATEGIES FOR PHARMACOKINETIC OPTIMIZATION
BIOSIMILAR AND BIOBETTER SCENARIOS FOR THE US AND EUROPE: WHAT SHOULD WE
EXPECT?
REGULATORY CONSIDERATIONS FOR APPROVAL OF BIOBETTER PRODUCTS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
BIOBETTERS
/
: 2015
ABSTRACT / INHALTSTEXT
OVER THE LAST FEW DECADES, BIOPHARMACEUTICALS HAVE TRANSFORMED MANY
AREAS OF HEALTHCARE AND HAVE GIVEN HOPE AND EXTENDED THE LIVES OF MANY
PATIENTS. CURATIVE TREATMENTS, HOWEVER, REMAIN ELUSIVE IN MOST CASES.
THIS BOOK DESCRIBES STRATEGIES TO DEVELOP IMPROVED VERSIONS OF
BIOPHARMACEUTICALS (“BIOBETTERS”) TO BRIDGE THE GAP BETWEEN EXISTING
THERAPIES AND CURATIVE THERAPIES. WITH AN AIM TO STIMULATE RESEARCH AND
DEVELOPMENT IN A WIDE ARRAY OF THERAPEUTIC AREAS, DIVERSE TOPICS ARE
COVERED, INCLUDING THE FOLLOWING: TISSUE SPECIFIC TARGETING OF ENZYME
REPLACEMENT THERAPIES; THE DEVELOPMENT OF NOVEL PROTEIN STRUCTURES WITH
THE POTENTIAL TO IMPROVE UPON CRITICAL ATTRIBUTES OF CURRENT MONOCLONAL
ANTIBODIES; THE MODIFICATION OF CURRENT MONOCLONAL ANTIBODY DESIGNS TO
IMPROVE THEIR IN VIVO STABILITY; AND FINALLY, THE ECONOMIC AND
REGULATORY CONSIDERATIONS FOR THE DEVELOPMENT OF BIOBETTERS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
| any_adam_object | 1 |
| building | Verbundindex |
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| dewey-full | 615.19 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.19 |
| dewey-search | 615.19 |
| dewey-sort | 3615.19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| doi_str_mv | 10.1007/978-1-4939-2543-8 |
| format | Electronic eBook |
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:09:39Z |
| institution | BVB |
| isbn | 9781493925438 |
| language | English |
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| series | AAPS Advances in the Pharmaceutical Sciences Series |
| series2 | AAPS Advances in the Pharmaceutical Sciences Series |
| spelling | Biobetters Protein Engineering to Approach the Curative Amy Rosenberg, Barthélemy Demeule, ed. New York, NY Springer 2015 1 Online-Ressource (XV, 378 p. 50 illus., 22 illus. in color) txt rdacontent c rdamedia cr rdacarrier AAPS Advances in the Pharmaceutical Sciences Series 19 Medicine Pharmaceutical technology Biomedicine Pharmaceutical Sciences/Technology Biomedicine general Medizin Rosenberg, Amy Sonstige oth Demeule, Barthélemy Sonstige oth Erscheint auch als Druckausgabe 978-1-4939-2542-1 AAPS Advances in the Pharmaceutical Sciences Series 19 (DE-604)BV041360401 19 https://doi.org/10.1007/978-1-4939-2543-8 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218091&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218091&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Biobetters Protein Engineering to Approach the Curative AAPS Advances in the Pharmaceutical Sciences Series Medicine Pharmaceutical technology Biomedicine Pharmaceutical Sciences/Technology Biomedicine general Medizin |
| title | Biobetters Protein Engineering to Approach the Curative |
| title_auth | Biobetters Protein Engineering to Approach the Curative |
| title_exact_search | Biobetters Protein Engineering to Approach the Curative |
| title_full | Biobetters Protein Engineering to Approach the Curative Amy Rosenberg, Barthélemy Demeule, ed. |
| title_fullStr | Biobetters Protein Engineering to Approach the Curative Amy Rosenberg, Barthélemy Demeule, ed. |
| title_full_unstemmed | Biobetters Protein Engineering to Approach the Curative Amy Rosenberg, Barthélemy Demeule, ed. |
| title_short | Biobetters |
| title_sort | biobetters protein engineering to approach the curative |
| title_sub | Protein Engineering to Approach the Curative |
| topic | Medicine Pharmaceutical technology Biomedicine Pharmaceutical Sciences/Technology Biomedicine general Medizin |
| topic_facet | Medicine Pharmaceutical technology Biomedicine Pharmaceutical Sciences/Technology Biomedicine general Medizin |
| url | https://doi.org/10.1007/978-1-4939-2543-8 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218091&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218091&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV041360401 |
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