Holdings: Immunopharmacogenomics

Immunopharmacogenomics:

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Bibliographic Details
Format:	Electronic eBook
Language:	English
Published:	Tokyo Springer Japan 2015
Subjects:	Medicine Oncology Human genetics Toxicology Biomedicine Human Genetics Cancer Research Pharmacology/Toxicology Molecular Medicine Medizin
Online Access:	TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract
Physical Description:	1 Online-Ressource (IX, 162 p. 30 illus., 29 illus. in color)
ISBN:	9784431557265
DOI:	10.1007/978-4-431-55726-5

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MARC


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adam_text	IMMUNOPHARMACOGENOMICS / : 2015 TABLE OF CONTENTS / INHALTSVERZEICHNIS PART I TECHNOLOGIES 1 DEEP SEQUENCING OF T-CELL AND B-CELL RECEPTORS WITH NEXT-GENERATION DNA SEQUENCERS 2 A TCR SEQUENCE DATA ANALYSIS PIPELINE: TCRIP PART II APPLICATIONS 3 PREDICTION OF DRUG-INDUCED ADVERSE REACTIONS: SKIN HYPERSENSITIVITY AND LIVER TOXICITY 4 SELECTION AND MONITORING OF PATIENTS FOR IMMUNOTHERAPY (PEPTIDE VACCINES) 5 PATIENT SELECTION AND MONITORING FOR IMMUNOTHERAPIES: CHALLENGES FOR IMMUNE CHECKPOINT ANTIBODY AND CELL THERAPIES 6 BETTER UNDERSTANDING OF REJECTION AFTER ORGAN TRANSPLANTATION 7 BETTER UNDERSTANDING OF SEVERE IMMUNOLOGICAL REACTIONS: AUTOIMMUNE DISEASES 8 BETTER UNDERSTANDING OF SEVERE IMMUNOLOGICAL REACTIONS: FOOD ALLERGY 9 IMMUNE MICROENVIRONMENT TO PREDICT RESPONSE OF CANCER CHEMOTHERAPY AND RADIOTHERAPY PART III CHALLENGES AND FUTURE 10 CHALLENGES AND FUTURE DIRECTIONS OF IMMUNOPHARMACOGENOMICS DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. IMMUNOPHARMACOGENOMICS / : 2015 ABSTRACT / INHALTSTEXT THIS BOOK PROPOSES IMMUNOGENOMICS, OR IMMUNOPHARMACOGENOMICS, AS THE NEXT-GENERATION BIG SCIENCE TO UNCOVER THE ROLE THAT THE IMMUNE SYSTEM PLAYS IN THE PATHOGENESIS OF MANY DISEASES, BY SUMMARIZING THE IMPORTANCE OF THE DEEP SEQUENCING OF T-CELL AND B-CELL RECEPTORS. IMMUNOGENOMICS/IMMUNOPHARMACOGENOMICS, A GENETIC CHARACTERIZATION OF THE IMMUNE SYSTEM MADE POSSIBLE BY NEXT-GENERATION SEQUENCING (NGS), WILL BE IMPORTANT FOR THE FURTHER UNDERSTANDING OF THE PATHOGENESIS OF VARIOUS DISEASE CONDITIONS. ABNORMAL IMMUNE RESPONSES IN THE BODY LEAD TO DEVELOPMENT OF AUTOIMMUNE DISEASES AND FOOD ALLERGIES. REJECTION OF RECIPIENT CELLS AND TISSUES, AS WELL AS SEVERE IMMUNE REACTIONS TO DONOR CELLS, IS ALSO THE RESULT OF UNCONTROLLED IMMUNE RESPONSES IN THE RECIPIENT BODY. THERE HAVE BEEN MANY REPORTS INDICATING THAT ACTIVATED IMMUNE RESPONSES CAUSED BY THE INTERACTION OF DRUGS AND HLA ARE PRESENT IN DRUG-INDUCED SKIN HYPERSENSITIVITY AND LIVER TOXICITY. THE IMPORTANCE OF THE HOST IMMUNE RESPONSES HAS BEEN RECOGNIZED IN CANCER TREATMENTS, NOT ONLY FOR IMMUNOTHERAPY BUT ALSO FOR CYTOTOXIC AGENTS AND MOLECULAR TARGETED DRUGS. HENCE, CHARACTERIZATION OF THE T-CELL RECEPTOR AND B-CELL RECEPTOR REPERTOIRE BY MEANS OF NGS DEEP SEQUENCING WILL ULTIMATELY MAKE POSSIBLE THE IDENTIFICATION OF THE MOLECULAR MECHANISMS THAT UNDERLIE VARIOUS DISEASES AND DRUG RESPONSES. IN ADDITION, THIS APPROACH MAY CONTRIBUTE TO THE IDENTIFICATION OF ANTIGENS ASSOCIATED WITH THE ONSET OR PROGRESSION OF AUTOIMMUNE DISEASES AS WELL AS FOOD ALLERGIES. ALTHOUGH THE GERMLINE ALTERATIONS AND SOMATIC MUTATIONS HAVE BEEN EXTENSIVELY ANALYZED, CHANGES OR ALTERATIONS OF THE IMMUNE RESPONSES DURING THE COURSE OF VARIOUS DISEASE CONDITIONS OR DURING VARIOUS TREATMENTS HAVE NOT BEEN ANALYZED. IT IS ALSO CLEAR THAT COMPUTATIONAL ANALYSES TO DRAW MEANINGFUL INFERENCES OF FUNCTIONAL RECOGNITION RECEPTORS ON THE IMMUNE CELLS REMAIN A HUGE CHALLENGE DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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dewey-hundreds	500 - Natural sciences and mathematics 600 - Technology (Applied sciences)
dewey-ones	599 - Mammalia 611 - Human anatomy, cytology, histology
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discipline	Biologie Medizin
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format	Electronic eBook
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id	DE-604.BV042788187
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indexdate	2024-07-10T07:09:39Z
institution	BVB
isbn	9784431557265
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-028218065
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physical	1 Online-Ressource (IX, 162 p. 30 illus., 29 illus. in color)
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publishDate	2015
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publisher	Springer Japan
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spelling	Immunopharmacogenomics Yusuke Nakamura, ed. Tokyo Springer Japan 2015 1 Online-Ressource (IX, 162 p. 30 illus., 29 illus. in color) txt rdacontent c rdamedia cr rdacarrier Medicine Oncology Human genetics Toxicology Biomedicine Human Genetics Cancer Research Pharmacology/Toxicology Molecular Medicine Medizin Nakamura, Yusuke Sonstige oth Erscheint auch als Druckausgabe 978-4-431-55725-8 https://doi.org/10.1007/978-4-431-55726-5 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218065&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218065&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract
spellingShingle	Immunopharmacogenomics Medicine Oncology Human genetics Toxicology Biomedicine Human Genetics Cancer Research Pharmacology/Toxicology Molecular Medicine Medizin
title	Immunopharmacogenomics
title_auth	Immunopharmacogenomics
title_exact_search	Immunopharmacogenomics
title_full	Immunopharmacogenomics Yusuke Nakamura, ed.
title_fullStr	Immunopharmacogenomics Yusuke Nakamura, ed.
title_full_unstemmed	Immunopharmacogenomics Yusuke Nakamura, ed.
title_short	Immunopharmacogenomics
title_sort	immunopharmacogenomics
topic	Medicine Oncology Human genetics Toxicology Biomedicine Human Genetics Cancer Research Pharmacology/Toxicology Molecular Medicine Medizin
topic_facet	Medicine Oncology Human genetics Toxicology Biomedicine Human Genetics Cancer Research Pharmacology/Toxicology Molecular Medicine Medizin
url	https://doi.org/10.1007/978-4-431-55726-5 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218065&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218065&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT nakamurayusuke immunopharmacogenomics

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