Assessing Rare Variation in Complex Traits: Design and Analysis of Genetic Studies
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer
2015
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| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource (XI, 261 p. 36 illus., 26 illus. in color) |
| ISBN: | 9781493928248 |
| DOI: | 10.1007/978-1-4939-2824-8 |
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Datensatz im Suchindex
| _version_ | 1804175020553928704 |
|---|---|
| adam_text | ASSESSING RARE VARIATION IN COMPLEX TRAITS
/
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
CALLING RARE VARIANTS FROM GENOTYPE DATA
CALLING VARIANTS FROM SEQUENCE DATA
RARE VARIANT QUALITY CONTROL
RARE STRUCTURAL VARIANTS
FUNCTIONAL ANNOTATION OF RARE GENETIC VARIANTS
THE 1000 GENOMES PROJECT
THE UK10K PROJECT
POPULATION ISOLATES
NATURAL SELECTION AT RARE VARIANTS
COLLAPSING APPROACHES FOR THE ASSOCIATION ANALYSIS OF RARE VARIANTS
RARE VARIANT ASSOCIATION ANALYSIS: BEYOND COLLAPSING APPROACHES
SIGNIFICANCE THRESHOLDS FOR RARE VARIANT SIGNALS
POWER OF RARE VARIANT AGGREGATE TESTS
REPLICATING SEQUENCE-BASED ASSOCIATION STUDIES OF RARE VARIANTS
META-ANALYSIS OF RARE VARIANTS
POPULATION STRATIFICATIONOF RARE VARIANTS
USE OF APPROPRIATE CONTROLS IN RARE VARIANT STUDIES
TRANS-ETHNIC FINE-MAPPING OF RARE CAUSAL VARIANTS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
ASSESSING RARE VARIATION IN COMPLEX TRAITS
/
: 2015
ABSTRACT / INHALTSTEXT
THIS UNIQUE VOLUME IS THE FIRST TO COVER A WIDE RANGE OF DESIGN AND
ANALYSIS ISSUES IN GENETIC STUDIES OF RARE VARIANTS, WITH CONTRIBUTIONS
FROM EXPERTS IN THE FIELD, THROUGH LARGE-SCALE INTERNATIONAL CONSORTIA
INCLUDING THE UK10K PROJECT, GO-T2D AND T2D-GENES. THE BOOK PRESENTS
STATE-OF-THE-ART METHODOLOGY FOR RARE VARIANT DETECTION AND CALLING,
IMPUTATION, AND ANALYSIS IN SAMPLES OF UNRELATED INDIVIDUALS AND
FAMILIES. IT ALSO COVERS ANALYTICAL ISSUES ASSOCIATED WITH THE STUDY OF
RARE VARIANTS, SUCH AS THE IMPACT OF FINE-SCALE POPULATION STRUCTURE,
AND RARE VARIANTS STUDIES IN A META-ANALYSIS FRAMEWORK. THIS BOOK COVERS
MULTIPLE ASPECTS OF STUDY DESIGN, ANALYSIS AND INTERPRETATION FOR
COMPLEX TRAIT STUDIES FOCUSING ON RARE SEQUENCE VARIATION. IN MANY AREAS
OF GENOMIC RESEARCH, INCLUDING COMPLEX TRAIT ASSOCIATION STUDIES,
TECHNOLOGY IS IN DANGER OF OUTSTRIPPING OUR CAPACITY TO ANALYZE AND
INTERPRET THE VAST AMOUNTS OF DATA GENERATED. THE FIELD OF STATISTICAL
GENETICS IN THE WHOLE-GENOME SEQUENCING ERA IS STILL IN ITS INFANCY, BUT
AS THIS BOOK ILLUSTRATES, POWERFUL METHODS TO ANALYZE THE AGGREGATION OF
LOW-FREQUENCY AND RARE VARIANTS ARE NOW STARTING TO EMERGE
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| format | Electronic eBook |
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| indexdate | 2024-07-10T07:09:39Z |
| institution | BVB |
| isbn | 9781493928248 |
| language | English |
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| spelling | Assessing Rare Variation in Complex Traits Design and Analysis of Genetic Studies Eleftheria Zeggini, Andrew Morris, ed. New York, NY Springer 2015 1 Online-Ressource (XI, 261 p. 36 illus., 26 illus. in color) txt rdacontent c rdamedia cr rdacarrier Medicine Human genetics Statistics Biomedicine Human Genetics Molecular Medicine Statistics for Life Sciences, Medicine, Health Sciences Medizin Statistik Zeggini, Eleftheria Sonstige (DE-588)1214403158 oth Morris, Andrew Sonstige oth Erscheint auch als Druckausgabe 978-1-4939-2823-1 https://doi.org/10.1007/978-1-4939-2824-8 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218032&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218032&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Assessing Rare Variation in Complex Traits Design and Analysis of Genetic Studies Medicine Human genetics Statistics Biomedicine Human Genetics Molecular Medicine Statistics for Life Sciences, Medicine, Health Sciences Medizin Statistik |
| title | Assessing Rare Variation in Complex Traits Design and Analysis of Genetic Studies |
| title_auth | Assessing Rare Variation in Complex Traits Design and Analysis of Genetic Studies |
| title_exact_search | Assessing Rare Variation in Complex Traits Design and Analysis of Genetic Studies |
| title_full | Assessing Rare Variation in Complex Traits Design and Analysis of Genetic Studies Eleftheria Zeggini, Andrew Morris, ed. |
| title_fullStr | Assessing Rare Variation in Complex Traits Design and Analysis of Genetic Studies Eleftheria Zeggini, Andrew Morris, ed. |
| title_full_unstemmed | Assessing Rare Variation in Complex Traits Design and Analysis of Genetic Studies Eleftheria Zeggini, Andrew Morris, ed. |
| title_short | Assessing Rare Variation in Complex Traits |
| title_sort | assessing rare variation in complex traits design and analysis of genetic studies |
| title_sub | Design and Analysis of Genetic Studies |
| topic | Medicine Human genetics Statistics Biomedicine Human Genetics Molecular Medicine Statistics for Life Sciences, Medicine, Health Sciences Medizin Statistik |
| topic_facet | Medicine Human genetics Statistics Biomedicine Human Genetics Molecular Medicine Statistics for Life Sciences, Medicine, Health Sciences Medizin Statistik |
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