Holdings: Nuclear Receptors: From Structure to the Clinic

Nuclear Receptors: From Structure to the Clinic:

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Bibliographic Details
Format:	Electronic eBook
Language:	English
Published:	Cham Springer International Publishing 2015
Subjects:	Medicine Human genetics Human physiology Endocrinology Biomedicine Human Genetics Human Physiology Medizin
Online Access:	TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract
Physical Description:	1 Online-Ressource (XI, 236 p. 43 illus., 33 illus. in color)
ISBN:	9783319187297
DOI:	10.1007/978-3-319-18729-7

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adam_text	NUCLEAR RECEPTORS: FROM STRUCTURE TO THE CLINIC / : 2015 TABLE OF CONTENTS / INHALTSVERZEICHNIS 1. TWENTY-FIVE YEARS OF NUCLEAR RECEPTOR STRUCTURE ANALYSIS: FROM THE LABORATORY TO THE CLINIC PART A. ALLOSTERIC REGULATION AND NUCLEAR RECEPTOR COMPLEX DYNAMICS. -2. CORTICOSTEROID RECEPTORS 3. GLUCOCORTICOID RECEPTOR STRUCTURE AND FUNCTION 4. WHAT DETERMINES THE DIFFERENCE IN DNA BINDING BETWEEN THE ANDROGEN AND THE GLUCOCORTICOID RECEPTORS? 5. ALLOSTERIC REGULATION AND INTRINSIC DISORDER IN NUCLEAR HORMONE RECEPTORS 6. STRUCTURAL ANALYSES OF ORDERED AND DISORDERED REGIONS IN ECDYSTEROID RECEPTOR 7. STRUCTURAL ANALYSIS OF HETERODIMERIC NUCLEAR RECEPTORS PART B. NUCLEAR RECEPTOR CO-REGULATORY PROTEIN INTERACTIONS 8. PRIMATE-SPECIFIC MULTI-FUNCTIONAL ANDROGEN RECEPTOR COREGULATOR AND PROTO-ONCOGENE MELANOMA ANTIGEN-A11 (MAGE-A11) 9. ASSEMBLY AND REGULATION OF NUCLEAR RECEPTOR COREPRESSOR COMPLEXES PART C. TAKING NUCLEAR RECEPTOR STRUCTURE INTO THE CLINIC 10. THINKING OUTSIDE THE BOX: ALTERNATIVE BINDING SITES IN THE LIGAND BINDING DOMAIN OF NUCLEAR RECEPTORS 11. SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERMS) AND SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. NUCLEAR RECEPTORS: FROM STRUCTURE TO THE CLINIC / : 2015 ABSTRACT / INHALTSTEXT NUCLEAR RECEPTORS FOCUSES ON THE STRUCTURAL ANALYSIS OF NUCLEAR RECEPTORS FROM THE INITIAL WORK USING ISOLATED PROTEIN DOMAINS TO THE MORE RECENT EXCITING DEVELOPMENTS INVESTIGATING THE CONFORMATIONAL SHAPE OF FULL-LENGTH RECEPTOR COMPLEXES. THE BOOK ALSO REVIEWS THE STRUCTURE OF KEY NUCLEAR RECEPTOR CO-REGULATORY PROTEINS. THE AIM IS TO BRING TOGETHER, FOR THE FIRST TIME, A COMPREHENSIVE REVIEW OF NUCLEAR RECEPTOR STRUCTURE AND THE IMPORTANCE OF RECEPTOR CONFORMATION UNDERPINNING ALLOSTERIC REGULATION BY DIFFERENT LIGANDS (HORMONE, DRUGS, DNA RESPONSE ELEMENTS, PROTEIN-PROTEIN INTERACTIONS) AND RECEPTOR ACTIVITY. THE NUCLEAR RECEPTOR SUPERFAMILY, INCLUDING RECEPTORS FOR STEROID HORMONES AND NON-STEROID LIGANDS, ARE PIVOTAL TO NORMAL PHYSIOLOGY, REGULATING PROCESSES AS DIVERSE AS REPRODUCTION, METABOLISM, THE IMMUNE SYSTEM AND BRAIN DEVELOPMENT. THE FIRST MEMBERS OF THE FAMILY WERE CLONED OVER 25 YEARS AGO, WHICH HERALDED IN THE IDEA OF A SUPERFAMILY OF INTRACELLULAR RECEPTOR PROTEINS THAT BOUND SMALL MOLECULE LIGANDS: CLASSICAL STEROID HORMONES, VITAMINS, FATTY ACIDS AND OTHER PRODUCTS OF METABOLISM. THESE SIGNALS ARE THEN TRANSMITTED THROUGH MULTIPROTEIN RECEPTOR-DNA COMPLEXES, LEADING TO THE REGULATION OF TARGET GENES, OFTEN IN A CELL-SELECTIVE MANNER. THE CLONING OF THE RECEPTOR CDNAS ALSO USHERED IN AN ERA OF UNPARALLELED ANALYSIS OF THE MECHANISMS OF ACTION OF THESE LIGAND-ACTIVATED TRANSCRIPTION FACTORS DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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spelling	Nuclear Receptors: From Structure to the Clinic Iain J. McEwan, Raj Kumar, ed. Cham Springer International Publishing 2015 1 Online-Ressource (XI, 236 p. 43 illus., 33 illus. in color) txt rdacontent c rdamedia cr rdacarrier Medicine Human genetics Human physiology Endocrinology Biomedicine Human Genetics Human Physiology Medizin Mcewan, Iain J. Sonstige oth Kumar, Raj Sonstige oth Erscheint auch als Druckausgabe 978-3-319-18728-0 https://doi.org/10.1007/978-3-319-18729-7 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218030&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218030&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract
spellingShingle	Nuclear Receptors: From Structure to the Clinic Medicine Human genetics Human physiology Endocrinology Biomedicine Human Genetics Human Physiology Medizin
title	Nuclear Receptors: From Structure to the Clinic
title_auth	Nuclear Receptors: From Structure to the Clinic
title_exact_search	Nuclear Receptors: From Structure to the Clinic
title_full	Nuclear Receptors: From Structure to the Clinic Iain J. McEwan, Raj Kumar, ed.
title_fullStr	Nuclear Receptors: From Structure to the Clinic Iain J. McEwan, Raj Kumar, ed.
title_full_unstemmed	Nuclear Receptors: From Structure to the Clinic Iain J. McEwan, Raj Kumar, ed.
title_short	Nuclear Receptors: From Structure to the Clinic
title_sort	nuclear receptors from structure to the clinic
topic	Medicine Human genetics Human physiology Endocrinology Biomedicine Human Genetics Human Physiology Medizin
topic_facet	Medicine Human genetics Human physiology Endocrinology Biomedicine Human Genetics Human Physiology Medizin
url	https://doi.org/10.1007/978-3-319-18729-7 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218030&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218030&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
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