Verfügbarkeit: Nuclear Receptors: From Structure to the Clinic

Nuclear Receptors: From Structure to the Clinic:

Gespeichert in:

Bibliographische Detailangaben
Format:	Elektronisch E-Book
Sprache:	English
Veröffentlicht:	Cham Springer International Publishing 2015
Schlagworte:	Medicine Human genetics Human physiology Endocrinology Biomedicine Human Genetics Human Physiology Medizin
Online-Zugang:	TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract
Beschreibung:	1 Online-Ressource (XI, 236 p. 43 illus., 33 illus. in color)
ISBN:	9783319187297
DOI:	10.1007/978-3-319-18729-7

Internformat

MARC


LEADER	00000nmm a2200000zc 4500
001	BV042788152
003	DE-604
005	20150903
007	cr\|uuu---uuuuu
008	150901s2015 \|\|\|\| o\|\|u\| \|\|\|\|\|\|eng d
020			\|a 9783319187297 \|c Online \|9 978-3-319-18729-7
024	7		\|a 10.1007/978-3-319-18729-7 \|2 doi
035			\|a (OCoLC)920935083
035			\|a (DE-599)BVBBV042788152
040			\|a DE-604 \|b ger \|e aacr
041	0		\|a eng
049			\|a DE-91 \|a DE-703
082	0		\|a 611.01816 \|2 23
082	0		\|a 599.935 \|2 23
084			\|a BIO 000 \|2 stub
245	1	0	\|a Nuclear Receptors: From Structure to the Clinic \|c Iain J. McEwan, Raj Kumar, ed.
264		1	\|a Cham \|b Springer International Publishing \|c 2015
300			\|a 1 Online-Ressource (XI, 236 p. 43 illus., 33 illus. in color)
336			\|b txt \|2 rdacontent
337			\|b c \|2 rdamedia
338			\|b cr \|2 rdacarrier
650		4	\|a Medicine
650		4	\|a Human genetics
650		4	\|a Human physiology
650		4	\|a Endocrinology
650		4	\|a Biomedicine
650		4	\|a Human Genetics
650		4	\|a Human Physiology
650		4	\|a Medizin
700	1		\|a Mcewan, Iain J. \|e Sonstige \|4 oth
700	1		\|a Kumar, Raj \|e Sonstige \|4 oth
776	0	8	\|i Erscheint auch als \|n Druckausgabe \|z 978-3-319-18728-0
856	4	0	\|u https://doi.org/10.1007/978-3-319-18729-7 \|x Verlag \|3 Volltext
856	4	2	\|m Springer Fremddatenuebernahme \|q application/pdf \|u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218030&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA \|3 Inhaltsverzeichnis
856	4	2	\|m Springer Fremddatenuebernahme \|q application/pdf \|u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218030&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA \|3 Abstract
912			\|a ZDB-2-SBL
940	1		\|q ZDB-2-SBL_2015
999			\|a oai:aleph.bib-bvb.de:BVB01-028218030
966	e		\|u https://doi.org/10.1007/978-3-319-18729-7 \|l TUM01 \|p ZDB-2-SBL \|x Verlag \|3 Volltext
966	e		\|u https://doi.org/10.1007/978-3-319-18729-7 \|l UBT01 \|p ZDB-2-SBL \|x Verlag \|3 Volltext

Datensatz im Suchindex

_version_	1804175020563365888
adam_text	NUCLEAR RECEPTORS: FROM STRUCTURE TO THE CLINIC / : 2015 TABLE OF CONTENTS / INHALTSVERZEICHNIS 1. TWENTY-FIVE YEARS OF NUCLEAR RECEPTOR STRUCTURE ANALYSIS: FROM THE LABORATORY TO THE CLINIC PART A. ALLOSTERIC REGULATION AND NUCLEAR RECEPTOR COMPLEX DYNAMICS. -2. CORTICOSTEROID RECEPTORS 3. GLUCOCORTICOID RECEPTOR STRUCTURE AND FUNCTION 4. WHAT DETERMINES THE DIFFERENCE IN DNA BINDING BETWEEN THE ANDROGEN AND THE GLUCOCORTICOID RECEPTORS? 5. ALLOSTERIC REGULATION AND INTRINSIC DISORDER IN NUCLEAR HORMONE RECEPTORS 6. STRUCTURAL ANALYSES OF ORDERED AND DISORDERED REGIONS IN ECDYSTEROID RECEPTOR 7. STRUCTURAL ANALYSIS OF HETERODIMERIC NUCLEAR RECEPTORS PART B. NUCLEAR RECEPTOR CO-REGULATORY PROTEIN INTERACTIONS 8. PRIMATE-SPECIFIC MULTI-FUNCTIONAL ANDROGEN RECEPTOR COREGULATOR AND PROTO-ONCOGENE MELANOMA ANTIGEN-A11 (MAGE-A11) 9. ASSEMBLY AND REGULATION OF NUCLEAR RECEPTOR COREPRESSOR COMPLEXES PART C. TAKING NUCLEAR RECEPTOR STRUCTURE INTO THE CLINIC 10. THINKING OUTSIDE THE BOX: ALTERNATIVE BINDING SITES IN THE LIGAND BINDING DOMAIN OF NUCLEAR RECEPTORS 11. SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERMS) AND SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. NUCLEAR RECEPTORS: FROM STRUCTURE TO THE CLINIC / : 2015 ABSTRACT / INHALTSTEXT NUCLEAR RECEPTORS FOCUSES ON THE STRUCTURAL ANALYSIS OF NUCLEAR RECEPTORS FROM THE INITIAL WORK USING ISOLATED PROTEIN DOMAINS TO THE MORE RECENT EXCITING DEVELOPMENTS INVESTIGATING THE CONFORMATIONAL SHAPE OF FULL-LENGTH RECEPTOR COMPLEXES. THE BOOK ALSO REVIEWS THE STRUCTURE OF KEY NUCLEAR RECEPTOR CO-REGULATORY PROTEINS. THE AIM IS TO BRING TOGETHER, FOR THE FIRST TIME, A COMPREHENSIVE REVIEW OF NUCLEAR RECEPTOR STRUCTURE AND THE IMPORTANCE OF RECEPTOR CONFORMATION UNDERPINNING ALLOSTERIC REGULATION BY DIFFERENT LIGANDS (HORMONE, DRUGS, DNA RESPONSE ELEMENTS, PROTEIN-PROTEIN INTERACTIONS) AND RECEPTOR ACTIVITY. THE NUCLEAR RECEPTOR SUPERFAMILY, INCLUDING RECEPTORS FOR STEROID HORMONES AND NON-STEROID LIGANDS, ARE PIVOTAL TO NORMAL PHYSIOLOGY, REGULATING PROCESSES AS DIVERSE AS REPRODUCTION, METABOLISM, THE IMMUNE SYSTEM AND BRAIN DEVELOPMENT. THE FIRST MEMBERS OF THE FAMILY WERE CLONED OVER 25 YEARS AGO, WHICH HERALDED IN THE IDEA OF A SUPERFAMILY OF INTRACELLULAR RECEPTOR PROTEINS THAT BOUND SMALL MOLECULE LIGANDS: CLASSICAL STEROID HORMONES, VITAMINS, FATTY ACIDS AND OTHER PRODUCTS OF METABOLISM. THESE SIGNALS ARE THEN TRANSMITTED THROUGH MULTIPROTEIN RECEPTOR-DNA COMPLEXES, LEADING TO THE REGULATION OF TARGET GENES, OFTEN IN A CELL-SELECTIVE MANNER. THE CLONING OF THE RECEPTOR CDNAS ALSO USHERED IN AN ERA OF UNPARALLELED ANALYSIS OF THE MECHANISMS OF ACTION OF THESE LIGAND-ACTIVATED TRANSCRIPTION FACTORS DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
any_adam_object	1
building	Verbundindex
bvnumber	BV042788152
classification_tum	BIO 000
collection	ZDB-2-SBL
ctrlnum	(OCoLC)920935083 (DE-599)BVBBV042788152
dewey-full	611.01816 599.935
dewey-hundreds	600 - Technology (Applied sciences) 500 - Natural sciences and mathematics
dewey-ones	611 - Human anatomy, cytology, histology 599 - Mammalia
dewey-raw	611.01816 599.935
dewey-search	611.01816 599.935
dewey-sort	3611.01816
dewey-tens	610 - Medicine and health 590 - Animals
discipline	Biologie Medizin
doi_str_mv	10.1007/978-3-319-18729-7
format	Electronic eBook
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02121nmm a2200505zc 4500</leader><controlfield tag="001">BV042788152</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20150903 </controlfield><controlfield tag="007">cr\|uuu---uuuuu</controlfield><controlfield tag="008">150901s2015 \|\|\|\| o\|\|u\| \|\|\|\|\|\|eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783319187297</subfield><subfield code="c">Online</subfield><subfield code="9">978-3-319-18729-7</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/978-3-319-18729-7</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)920935083</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV042788152</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-91</subfield><subfield code="a">DE-703</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">611.01816</subfield><subfield code="2">23</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">599.935</subfield><subfield code="2">23</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIO 000</subfield><subfield code="2">stub</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Nuclear Receptors: From Structure to the Clinic</subfield><subfield code="c">Iain J. McEwan, Raj Kumar, ed.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Cham</subfield><subfield code="b">Springer International Publishing</subfield><subfield code="c">2015</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (XI, 236 p. 43 illus., 33 illus. in color)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medicine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Human genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Human physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Endocrinology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biomedicine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Human Genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Human Physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medizin</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mcewan, Iain J.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kumar, Raj</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druckausgabe</subfield><subfield code="z">978-3-319-18728-0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1007/978-3-319-18729-7</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Springer Fremddatenuebernahme</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218030&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Springer Fremddatenuebernahme</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218030&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Abstract</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-2-SBL</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">ZDB-2-SBL_2015</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-028218030</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-3-319-18729-7</subfield><subfield code="l">TUM01</subfield><subfield code="p">ZDB-2-SBL</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-3-319-18729-7</subfield><subfield code="l">UBT01</subfield><subfield code="p">ZDB-2-SBL</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection>
id	DE-604.BV042788152
illustrated	Not Illustrated
indexdate	2024-07-10T07:09:39Z
institution	BVB
isbn	9783319187297
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-028218030
oclc_num	920935083
open_access_boolean
owner	DE-91 DE-BY-TUM DE-703
owner_facet	DE-91 DE-BY-TUM DE-703
physical	1 Online-Ressource (XI, 236 p. 43 illus., 33 illus. in color)
psigel	ZDB-2-SBL ZDB-2-SBL_2015
publishDate	2015
publishDateSearch	2015
publishDateSort	2015
publisher	Springer International Publishing
record_format	marc
spelling	Nuclear Receptors: From Structure to the Clinic Iain J. McEwan, Raj Kumar, ed. Cham Springer International Publishing 2015 1 Online-Ressource (XI, 236 p. 43 illus., 33 illus. in color) txt rdacontent c rdamedia cr rdacarrier Medicine Human genetics Human physiology Endocrinology Biomedicine Human Genetics Human Physiology Medizin Mcewan, Iain J. Sonstige oth Kumar, Raj Sonstige oth Erscheint auch als Druckausgabe 978-3-319-18728-0 https://doi.org/10.1007/978-3-319-18729-7 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218030&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218030&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract
spellingShingle	Nuclear Receptors: From Structure to the Clinic Medicine Human genetics Human physiology Endocrinology Biomedicine Human Genetics Human Physiology Medizin
title	Nuclear Receptors: From Structure to the Clinic
title_auth	Nuclear Receptors: From Structure to the Clinic
title_exact_search	Nuclear Receptors: From Structure to the Clinic
title_full	Nuclear Receptors: From Structure to the Clinic Iain J. McEwan, Raj Kumar, ed.
title_fullStr	Nuclear Receptors: From Structure to the Clinic Iain J. McEwan, Raj Kumar, ed.
title_full_unstemmed	Nuclear Receptors: From Structure to the Clinic Iain J. McEwan, Raj Kumar, ed.
title_short	Nuclear Receptors: From Structure to the Clinic
title_sort	nuclear receptors from structure to the clinic
topic	Medicine Human genetics Human physiology Endocrinology Biomedicine Human Genetics Human Physiology Medizin
topic_facet	Medicine Human genetics Human physiology Endocrinology Biomedicine Human Genetics Human Physiology Medizin
url	https://doi.org/10.1007/978-3-319-18729-7 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218030&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028218030&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT mcewaniainj nuclearreceptorsfromstructuretotheclinic AT kumarraj nuclearreceptorsfromstructuretotheclinic

Verfügbarkeit

Es ist kein Print-Exemplar vorhanden.

Fernleihe Bestellen Achtung: Nicht im THWS-Bestand! Volltext öffnen

MARC

Datensatz im Suchindex

Es ist kein Print-Exemplar vorhanden.

Ähnliche Einträge