Munc 13-3 superprimes synaptic vesicles at granule cell-to-basket cell synapses in the mouse cerebellum:
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| Format: | Abschlussarbeit Elektronisch Software E-Book |
| Sprache: | English |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | IX, 64 Bl. Ill., graph. Darst. 12 cm |
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Datensatz im Suchindex
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| adam_text | TABLE OF CONTENTS
1. INTRODUCTION 1
1.1 SYNAPTIC TRANSMISSION 1
1.2 SHORT-TERM SYNAPTIC PLASTICITY 4
1.3 MUNCL3 6
2. MATERIALS AND METHODS 12
2.1 ANIMALS 12
2.2 ELECTROPHYSIOLOGICAL RECORDINGS 13
2.3 CA
2+
IMAGING 15
2.4 STATISTICAL ANALYSIS 16
3. RESULTS 18
3.1 NORMAL KINETICS AND CHARGE OF UEPSCS IN MUNCH^ SYNAPSES 18
3.2 INCREASE IN SYNAPTIC FAILURE AND FACILITATION IN MUNCL3-3
_/
SYNAPSES 22
3.3 REDUCTION IN RELEASE PROBABILITY IN MUNCL3-3
_/
SYNAPSES 24
3.4 REDUCED RELEASE PROBABILITY IN MUNCHO SYNAPSES IS NOT DUE TO
ALTERED
CA
2+
INFLUX 28
3.5 NORMAL REPLENISHMENT OF VESICLES IN MUNCL3-3
/_
SYNAPSES 29
3.6 ALTERED CA
2+
SENSITIVITY OF RELEASE IN MUNCL3-3
_/
SYNAPSES 31
4. DISCUSSION 33
4.1 EXPERIMENTAL CONFIGURATION 34
4.2 ISOFORM SPECIFIC FUNCTION OF MUNCL3-3 36
4.3 CONTRIBUTION OF MUNCL3-3 TO SHORT-TERM PLASTICITY 38
4.4 SUPERPRIMING: MODULATION OF CA
2+
SENSITIVITY 39
4.5 OUTLOOK 41
ZUSAMMENFASSUNG 43
ABSTRACT 48
4
REFERENCES 52
ACKNOWLEDGEMENT 61
CURRICULUM VITAE 62
V
HTTP://D-NB.INFO/1067298770
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| author | Ishiyama, Shimpei 1984- |
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| bvnumber | BV042681244 |
| ctrlnum | (OCoLC)913601167 (DE-599)DNB1067298770 |
| discipline | Medizin |
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| spelling | Ishiyama, Shimpei 1984- Verfasser (DE-588)1066464936 aut Munc 13-3 superprimes synaptic vesicles at granule cell-to-basket cell synapses in the mouse cerebellum vorgelegt von Shimpei Ishiyama 2014 IX, 64 Bl. Ill., graph. Darst. 12 cm txt rdacontent c rdamedia cd rdacarrier Leipzig, Univ., Diss., 2014 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028113083&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ishiyama, Shimpei 1984- Munc 13-3 superprimes synaptic vesicles at granule cell-to-basket cell synapses in the mouse cerebellum |
| subject_GND | (DE-588)4113937-9 |
| title | Munc 13-3 superprimes synaptic vesicles at granule cell-to-basket cell synapses in the mouse cerebellum |
| title_auth | Munc 13-3 superprimes synaptic vesicles at granule cell-to-basket cell synapses in the mouse cerebellum |
| title_exact_search | Munc 13-3 superprimes synaptic vesicles at granule cell-to-basket cell synapses in the mouse cerebellum |
| title_full | Munc 13-3 superprimes synaptic vesicles at granule cell-to-basket cell synapses in the mouse cerebellum vorgelegt von Shimpei Ishiyama |
| title_fullStr | Munc 13-3 superprimes synaptic vesicles at granule cell-to-basket cell synapses in the mouse cerebellum vorgelegt von Shimpei Ishiyama |
| title_full_unstemmed | Munc 13-3 superprimes synaptic vesicles at granule cell-to-basket cell synapses in the mouse cerebellum vorgelegt von Shimpei Ishiyama |
| title_short | Munc 13-3 superprimes synaptic vesicles at granule cell-to-basket cell synapses in the mouse cerebellum |
| title_sort | munc 13 3 superprimes synaptic vesicles at granule cell to basket cell synapses in the mouse cerebellum |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028113083&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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