Kinetics of Enzyme-Modifier Interactions: Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Wien [u.a.]
Springer
2015
|
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource (XVII, 489 p. 221 illus) |
| ISBN: | 9783709114025 |
| DOI: | 10.1007/978-3-7091-1402-5 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804174859828199424 |
|---|---|
| adam_text | KINETICS OF ENZYME-MODIFIER INTERACTIONS
/ BAICI, ANTONIO
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
BASIC KNOWLEDGE
THE GENERAL MODIFIER MECHANISM
TAXONOMY OF ENZYME-MODIFIER INTERACTIONS AND THE SPECIFIC VELOCITY PLOT
COMPLEMENTS TO ENZYME-MODIFIER INTERACTIONS
THE BASIC MECHANISMS OF INHIBITION AND NONESSENTIAL ACTIVATION
MULTIPLE ENZYME-MODIFIER INTERACTIONS
MULTIPLE INTERACTIONS: ESSENTIAL ACTIVATION AND LIBERATION
SLOW-ONSET ENZYME INHIBITION
ENZYME INACTIVATION WITH A NOTE ON THE SIGNIFICANCE OF SLOW MODIFICATION
PROCESSES.-DICHOTOMOUS KEYS TO ENZYME-MODIFICATION MECHANISMS.
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
KINETICS OF ENZYME-MODIFIER INTERACTIONS
/ BAICI, ANTONIO
: 2015
ABSTRACT / INHALTSTEXT
THE KINETIC MECHANISMS BY WHICH ENZYMES INTERACT WITH INHIBITORS AND
ACTIVATORS, COLLECTIVELY CALLED MODIFIERS, ARE SCRUTINIZED AND RANKED
TAXONOMICALLY INTO AUTONOMOUS SPECIES IN A WAY SIMILAR TO THAT USED IN
THE BIOLOGICAL CLASSIFICATION OF PLANTS AND ANIMALS. THE SYSTEMATIZATION
OF THE MECHANISMS IS BASED ON TWO FUNDAMENTAL CHARACTERS: THE ALLOSTERIC
LINKAGE BETWEEN SUBSTRATE AND MODIFIER AND THE FACTOR BY WHICH A
MODIFIER AFFECTS THE CATALYTIC CONSTANT OF THE ENZYME. COMBINATIONS OF
THE PHYSICALLY SIGNIFICANT STATES OF THESE TWO CHARACTERS IN AN
ANCESTOR-DESCENDANT-LIKE FASHION REVEAL THE EXISTENCE OF SEVENTEEN MODES
OF INTERACTION THAT COVER THE NEEDS OF TOTAL, PARTIAL AND FINE-TUNING
MODULATION OF ENZYME ACTIVITY.THESE INTERACTIONS COMPRISE FIVE LINEAR
AND FIVE HYPERBOLIC INHIBITION MECHANISMS, FIVE NONESSENTIAL ACTIVATION
MECHANISMS AND TWO HYBRID SPECIES THAT MANIFEST EITHER HYPERBOLIC
INHIBITION OR NONESSENTIAL ACTIVATION CHARACTERISTICS DEPENDING ON
SUBSTRATE CONCENTRATION. FIVE ESSENTIAL ACTIVATION MECHANISMS, WHICH ARE
TAXONOMICALLY INDEPENDENT OF THE MENTIONED BASIC SPECIES, COMPLETE THE
INVENTORY OF ENZYME MODIFIERS. OFTEN MASKED UNDER CONVENTIONAL UMBRELLA
TERMS OR TREATED AS ANOMALOUS CASES, ALL SEVENTEEN BASIC INHIBITION AND
NONESSENTIAL ACTIVATION MECHANISMS ARE REPRESENTED IN THE BIOCHEMICAL
AND PHARMACOLOGICAL LITERATURE OF THIS AND THE PAST CENTURY, EITHER IN
THE FORM OF RAPID OR SLOW-ONSET REVERSIBLE INTERACTIONS, OR AS
IRREVERSIBLE MODIFICATION PROCESSES.THE FULL POTENTIAL OF ENZYME
INHIBITORS AND ACTIVATORS CAN ONLY BE APPRECIATED AFTER ELUCIDATING THE
DETAILS OF THEIR KINETIC MECHANISMS OF ACTION EXPLORING THE ENTIRE RANGE
OF PHYSIOLOGICALLY SIGNIFICANT REACTANT CONCENTRATIONS. THIS BOOK
HIGHLIGHTS THE WIDE SPECTRUM OF ALLOSTERIC ENZYME MODIFICATION IN
PHYSIOLOGICAL OCCURRENCES AS WELL AS IN PHARMACOLOGICAL AND
BIOTECHNOLOGICAL APPLICATIONS THAT EMBRACE SIMPLE AND MULTIPLE
ENZYME-MODIFIER INTERACTIONS. THE READER IS GUIDED IN THE JOURNEY
THROUGH THIS STILL PARTLY UNCHARTED TERRITORY WITH THE AID OF
MECHANISTICALLY-ORIENTED CRITERIA AIMED AT SHOWING THE LOGICAL WAY
TOWARDS THE IDENTIFICATION OF A PARTICULAR MECHANISM
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
| any_adam_object | 1 |
| author | Baici, Antonio |
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| dewey-ones | 572 - Biochemistry |
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| discipline | Biologie |
| doi_str_mv | 10.1007/978-3-7091-1402-5 |
| format | Electronic eBook |
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| isbn | 9783709114025 |
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| spelling | Baici, Antonio Verfasser aut Kinetics of Enzyme-Modifier Interactions Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms Antonio Baici Wien [u.a.] Springer 2015 1 Online-Ressource (XVII, 489 p. 221 illus) txt rdacontent c rdamedia cr rdacarrier Life sciences RNA-ligand interactions Enzymes Biology / Data processing Life Sciences Enzymology Protein-Ligand Interactions Computer Appl. in Life Sciences Biophysics and Biological Physics Biowissenschaften Datenverarbeitung Erscheint auch als Druckausgabe 978-3-7091-1401-8 https://doi.org/10.1007/978-3-7091-1402-5 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028101911&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028101911&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Baici, Antonio Kinetics of Enzyme-Modifier Interactions Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms Life sciences RNA-ligand interactions Enzymes Biology / Data processing Life Sciences Enzymology Protein-Ligand Interactions Computer Appl. in Life Sciences Biophysics and Biological Physics Biowissenschaften Datenverarbeitung |
| title | Kinetics of Enzyme-Modifier Interactions Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms |
| title_auth | Kinetics of Enzyme-Modifier Interactions Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms |
| title_exact_search | Kinetics of Enzyme-Modifier Interactions Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms |
| title_full | Kinetics of Enzyme-Modifier Interactions Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms Antonio Baici |
| title_fullStr | Kinetics of Enzyme-Modifier Interactions Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms Antonio Baici |
| title_full_unstemmed | Kinetics of Enzyme-Modifier Interactions Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms Antonio Baici |
| title_short | Kinetics of Enzyme-Modifier Interactions |
| title_sort | kinetics of enzyme modifier interactions selected topics in the theory and diagnosis of inhibition and activation mechanisms |
| title_sub | Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms |
| topic | Life sciences RNA-ligand interactions Enzymes Biology / Data processing Life Sciences Enzymology Protein-Ligand Interactions Computer Appl. in Life Sciences Biophysics and Biological Physics Biowissenschaften Datenverarbeitung |
| topic_facet | Life sciences RNA-ligand interactions Enzymes Biology / Data processing Life Sciences Enzymology Protein-Ligand Interactions Computer Appl. in Life Sciences Biophysics and Biological Physics Biowissenschaften Datenverarbeitung |
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