In vitro and in vivo characterization of pathomechanisms of inherited neurodegenerative disorders in dogs:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Gießen
DVG
2015
|
| Ausgabe: | 1. Aufl. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Nebentitel: In vitro and in vivo characterization of inherited neurodegenerative disorders in dogs |
| Beschreibung: | VII, 156 S. Ill., graph. Darst. |
| ISBN: | 9783863452483 |
Internformat
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| 245 | 1 | 0 | |a In vitro and in vivo characterization of pathomechanisms of inherited neurodegenerative disorders in dogs |c by Kerstin Caroline Hahn |
| 250 | |a 1. Aufl. | ||
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| 300 | |a VII, 156 S. |b Ill., graph. Darst. | ||
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| 500 | |a Nebentitel: In vitro and in vivo characterization of inherited neurodegenerative disorders in dogs | ||
| 502 | |a Zugl.: Hannover, Tierärztl. Hochsch., Ph.D. Diss., 2015 | ||
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| 650 | 7 | |a inheritance |2 cabt | |
| 650 | 7 | |a in vitro |2 cabt | |
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Datensatz im Suchindex
| _version_ | 1804174831266037761 |
|---|---|
| adam_text | CONTENTS
1 GENERAL INTRODUCTION 1
1.1 THE DOG AS A TRANSLATIONAL MODEL FOR HUMAN INHERITED
NEURODEGENERATIVE DISEASES 1
1.2 DORSAL ROOT GANGLIA CULTURES AS AN IN VITRO MODEL IN NEUROSCIENCE 2
1.3 GMJ-GANGLIOSIDE IN AGEING, AGE-ASSOCIATED NEURODEGENERATIVE DISEASES
AND GMR
GANGLIOSIDOSIS 3
1.4 AUTOPHAGY IN MAMMALIAN CELLS 6
1.4.1 OVERVIEW AND SUBTYPES OF AUTOPHAGY 6
1.4.2 THE MOLECULAR MECHANISMS OF MACROAUTOPHAGY 7
1.4.3 AUTOPHAGOSOME FORMATION 9
1.4.4 FUSION OF AUTOPHAGOSOMES WITH TYSOSOMES OR ENDOSOMES 11
1.4.5 REFORMATION OF LYSOSOMES FROM AUTOPHAGOLYSOSOMES 13
1.4.6 TRANSCRIPTIONAL REGULATION OF LYSOSOMAL NETWORK PROTEINS 14
1.4.7 SELECTIVE AUTOPHAGY 15
1.4.8 AUTOPHAGY MODULATING FACTORS AND SIGNALING MECHANISMS 15
1.4.9 AUTOPHAGY, ER STRESS, UNFOLDED PROTEIN RESPONSE AND ER-ASSOCIATED
DEGRADATION 16
1.4.10 AUTOPHAGY AND THE UBIQUITIN PROTEASOME SYSTEM 17
1.4.11 THE LYSOSOMAL NETWORK: COUPLING OF ENDOCYTOSIS AND AUTOPHAGY 18
1.4.12 IMPAIRMENTS OF THE LYSOSOMAL NETWORK IN INHERITED
NEURODEGENERATIVE DISEASES 20
1.5 HUMAN HEREDITARY SPASTIC PARAPARESIS AND NEUROAXONAL DYSTROPHIES IN
HUMANS
AND DOGS 23
2 CANINE DORSAL ROOT
GANGLIA CELL CULTURES AS AN IN VITRO MODEL TO CHARACTERIZE
PATHOMECHANISMS OF INHERITED NEURODEGENERATIVE DISORDERS IN DOGS 27
2.1 CULTURING ADULT CANINE SENSORY NEURONS TO OPTIMISE NEURAL REPAIR 27
2.2 GM! GANGLIOSIDE PROMOTES SYNAPTOPHYSIN ACCUMULATIONS AND
CYTOSKELETAL CHANGES IN
NEURONS AND NON-NEURONAL CELLS FROM ADULT DORSAL ROOT GANGLIA CULTURES
28
3 NEUROAXONAL DYSTROPHY IN SPANISH WATER DOGS AS AN IN VIVO MODEL TO
CHARACTERIZE
PATHOMECHANISMS OF INHERITED NEURODEGENERATIVE DISORDERS IN DOGS 67
3.1 TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 2 (TECPR2)
MISSENSE MUTATION -
DISTURBANCES OF THE AUTOPHAGY PATHWAY ASSOCIATED WITH NEUROAXONAL
DYSTROPHY IN
SPANISH WATER DOGS 67
4 GENERAL DISCUSSION 10S
HTTP://D-NB.INFO/107237966X
4.1 ADULT CANINE DORSAL ROOT GANGLIA NEURONS AS AN IN VITRO MODEL TO
STUDY NEURON-GLIA
INTERACTIONS AND GM
T
AND/OR GROWTH FACTOR-MEDIATED EFFECTS 10S
4.2 SPONTANEOUSLY OCCURRING INHERITED CNS DISEASES IN DOGS AS A
TRANSLATIONAL IN VIVO
MODEL TO STUDY PATHOMECHANISMS OF NEURODEGENERATION 108
4.3 CONCLUDING REMARKS 110
5 SUMMARY 113
6 ZUSAMMENFASSUNG 117
7 REFERENCES 121
8 ACKNOWLEDGEMENTS 1S5
|
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| author | Hahn, Kerstin Caroline |
| author_GND | (DE-588)1074210239 |
| author_facet | Hahn, Kerstin Caroline |
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| discipline | Medizin |
| edition | 1. Aufl. |
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| isbn | 9783863452483 |
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| physical | VII, 156 S. Ill., graph. Darst. |
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| spelling | Hahn, Kerstin Caroline Verfasser (DE-588)1074210239 aut In vitro and in vivo characterization of pathomechanisms of inherited neurodegenerative disorders in dogs by Kerstin Caroline Hahn 1. Aufl. Gießen DVG 2015 VII, 156 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Nebentitel: In vitro and in vivo characterization of inherited neurodegenerative disorders in dogs Zugl.: Hannover, Tierärztl. Hochsch., Ph.D. Diss., 2015 dog cabt inheritance cabt in vitro cabt in vitro selectie cabt nervous system diseases cabt (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028077724&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hahn, Kerstin Caroline In vitro and in vivo characterization of pathomechanisms of inherited neurodegenerative disorders in dogs dog cabt inheritance cabt in vitro cabt in vitro selectie cabt nervous system diseases cabt |
| subject_GND | (DE-588)4113937-9 |
| title | In vitro and in vivo characterization of pathomechanisms of inherited neurodegenerative disorders in dogs |
| title_auth | In vitro and in vivo characterization of pathomechanisms of inherited neurodegenerative disorders in dogs |
| title_exact_search | In vitro and in vivo characterization of pathomechanisms of inherited neurodegenerative disorders in dogs |
| title_full | In vitro and in vivo characterization of pathomechanisms of inherited neurodegenerative disorders in dogs by Kerstin Caroline Hahn |
| title_fullStr | In vitro and in vivo characterization of pathomechanisms of inherited neurodegenerative disorders in dogs by Kerstin Caroline Hahn |
| title_full_unstemmed | In vitro and in vivo characterization of pathomechanisms of inherited neurodegenerative disorders in dogs by Kerstin Caroline Hahn |
| title_short | In vitro and in vivo characterization of pathomechanisms of inherited neurodegenerative disorders in dogs |
| title_sort | in vitro and in vivo characterization of pathomechanisms of inherited neurodegenerative disorders in dogs |
| topic | dog cabt inheritance cabt in vitro cabt in vitro selectie cabt nervous system diseases cabt |
| topic_facet | dog inheritance in vitro in vitro selectie nervous system diseases Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028077724&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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