Physico-chemical and pharmacokinetic study of whey protein coated liposomes as delivery system for bioactive compounds in food applications:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | German |
| Veröffentlicht: |
Uelvesbüll
Der Andere Verlag
2014
|
| Schriftenreihe: | Schriftenreihe des Instituts für Humanernährung und Lebensmittelkunde der Christian-Albrechts-Univ. zu Kiel
76 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | XXIX, 150 S. Ill., graph. Darst. |
| ISBN: | 9783862474813 |
Internformat
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| 245 | 1 | 0 | |a Physico-chemical and pharmacokinetic study of whey protein coated liposomes as delivery system for bioactive compounds in food applications |c Monika Frenzel |
| 264 | 1 | |a Uelvesbüll |b Der Andere Verlag |c 2014 | |
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| 336 | |b txt |2 rdacontent | ||
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| 490 | 1 | |a Schriftenreihe des Instituts für Humanernährung und Lebensmittelkunde der Christian-Albrechts-Univ. zu Kiel |v 76 | |
| 502 | |a Zugl.: Kiel, Univ., Diss., 2014 | ||
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Datensatz im Suchindex
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| adam_text | TABLE OF CONTENT
ABSTRACT V
KURZDARSTELLUNG .. VII
PRESENTATIONS RELATED TO THIS STUDY IX
LIST OF FIGURES XXI
LIST OF TABLES XXV
LIST OF EQUATIONS XXVII
LIST OF ABBREVIATIONS XXIX
1. MOTIVATION AND OBJECTIVES OF THE STUDY 1
2. THEORETICAL BACKGROUND 5
2.1 FUNCTIONAL FOODS, LIPOPHILIC BIOACTIVE COMPOUNDS AND DELIVERY
SYSTEMS 5
2.2 LIPOSOMES 6
2.2.1 STABILITY OF LIPOSOMES 7
2.2.2 LIPOSOME HYDRATION 7
2.2.3 LIPOSOME PERMEABILITY 8
2.2.4 PHASE TRANSITION OF PHOSPHOLIPIDS 8
2.3 LIPOSOME COATING 9
2.3.1 LAYER-BY-LAYER TECHNIQUE 9
2.3.2 OVERVIEW ON COATING AGENTS 9
2.3.3 FOCUS: WHEY PROTEIN 10
2.3.4 BIOPHYSICAL ASPECTS OF POLYMER BINDING TO LIPOSOMES 11
2.4 ENCAPSULATED COMPOUNDS 12
2.4.1 QUERCETIN 12
2.4.2 FISH OIL 14
2.5 EXPERIMENTAL APPROACH I - PHYSICO-CHEMICAL METHODS.. 15
2.5.1 DYNAMIC LIGHT SCATTERING FOR DETERMINATION OF PARTICLE SIZE
DISTRIBUTION 15
2.5.2 LASER DOPPLER ELECTROPHORESIS MEASUREMENTS FOR DETERMINATION OF
ZETA POTENTIAL 16
2.5.3 ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY 17
2.5.4 PHOSPHOLIPID OXIDATION IN LIPOSOMES 20
2.5.5 QUERCETIN QUANTIFICATION AND ENCAPSULATION EFFICIENCY - HPLC AND
SEC 23
2.6 EXPERIMENTAL APPROACH II - TECHNOLOGY AND PRODUCT DEVELOPMENT 24
2.6.1 LIPOSOME PRODUCTION, COATING AND POWDERIZATION 24
2.6.2 DRINK PRODUCTION 24
XVII
HTTP://D-NB.INFO/1064558097
TABLE OF CONTENT
2.7 EXPERIMENTAL APPROACH III - LN-VITRO DIGESTION AND IN-VIVO
PHARMACOKINETICS 26
2.7.1 LN-VITRO DIGESTION MODELS 26
2.7.2 IN-VIVO BIOAVAILABILITY - CONCEPTS AND STUDY DESIGNS 28
3. MANUSCRIPT 1: ENCAPSULATION OF QUERCETIN AND FISH OIL IN LIPOSOMES 31
3.1 ABSTRACT 33
3.2 INTRODUCTION 33
3.3 MATERIALS AND METHODS 34
3.3.1 MATERIALS 34
3.3.2 LIPOSOME PRODUCTION 35
3.3.3 PARTICLE SIZE AND ZETA POTENTIAL 35
3.3.4 DETERMINATION OF QUERCETIN CONCENTRATION AND ENCAPSULATION
EFFICIENCY 35
3.3.5 LIPID OXIDATION 36
3.3.6 MEMBRANE PROPERTIES ASSESSED BY EPR SPIN PROBING 37
3.4 RESULTS AND DISCUSSION 37
3.4.1 QUERCETIN SOLUBILITY IN DIFFERENT MEDIA 37
3.4.2 PHYSICAL STABILITY OF QUERCETIN LOADED LIPOSOMES AT 4*C 39
3.4.3 CHEMICAL AND PHYSICAL STABILITY OF QUERCETIN LOADED LIPOSOMES AT
ELEVATED TEMPERATURES 40
3.4.4 CHEMICAL AND PHYSICAL STABILITY OF FISH OIL LOADED LIPOSOMES AT
ELEVATED TEMPERATURES 44
3.4.5 INFLUENCE OF QUERCETIN AND FISH OIL ON TB SOLUBILIZATION IN THE
MEMBRANE BILAYER 45
3.5 CONCLUSIONS 49
4. MANUSCRIPT 2: WHEY PROTEIN-COATED LIPOSOMES EXHIBIT INCREASED BILAYER
RIGIDITY AND STABILITY COMPARED TO
UNCOATED LIPOSOMES - A STUDY WITH RESPECT TO FOOD APPLICATIONS 51
4.1 ABSTRACT S3
4.2 INTRODUCTION S3
4.3 MATERIALS AND METHODS 55
4.3.1 LIPOSOME PRODUCTION 55
4.3.2 LIPOSOME COATING 55
4.3.3 PARTICLE SIZE AND ZETA POTENTIAL 56
4.3.4 EPR SPIN PROBING 56
4.3.5 LN-VITRO DIGESTION MODEL 57
4.3.6 FREE FATTY ACIDS 57
4.3.7 STATISTICAL ANALYSIS 57
4.4 RESULTS AND DISCUSSION 57
4.4.1 OPTIMUM WPI CONCENTRATION FOR COATING LIPOSOMES 58
4.4.2 MEMBRANE BEHAVIOR OF LIPOSOMES WITH WPI AND CHITOSAN-COATING 59
4.4.3 PHYSICAL STABILITY OF LIPOSOMES WITH WPI-COATING DURING STORAGE 63
XVIII
TABLE OF CONTENT
4.4.4 PHYSICAL STABILITY TOWARDS FOOD INGREDIENTS 64
4.4.5 PHYSICAL STABILITY DURING IN-VITRO DIGESTION 67
4.5 CONCLUSION 69
5. MANUSCRIPT 3: DEVELOPMENT OF A FUNCTIONAL DAIRY DRINK ENRICHED WITH
QUERCETIN ENCAPSULATED IN WHEY
PROTEIN COATED LIPOSOMES 71
5.1 ABSTRACT 73
5.2 INTRODUCTION 73
5.3 MATERIALS AND METHODS 74
5.3.1 MATERIALS 74
5.3.2 LIPOSOME PRODUCTION AND COATING 75
5.3.3 SPRAY DRYING OF COATED LIPOSOMES 75
5.3.4 PREPARATION OF A QUERCETIN ENRICHED WHEY PERMEATE DRINK 75
5.3.5 PARTICLE SIZE AND ZETA POTENTIAL 76
5.3.6 DETERMINATION OF QUERCETIN CONCENTRATION AND ENCAPSULATION
EFFICIENCY 76
5.3.7 FREE RADICALS (ESR) 77
5.3.8 IN-VITRO DIGESTION MODEL 77
5.3.9 FREE FATTY ACIDS (FFA) 77
5.3.10 CELL CULTURE AND CYTOTOXICITY MEASUREMENT 77
5.3.11 QUANTITATIVE DESCRIPTIVE ANALYSIS (QDA) 78
5.4 RESULTS AND DISCUSSION 78
5.4.1 WHEY DRINK COMPOSITION 78
5.4.2 SENSORY PROPERTIES 81
5.4.3 STORAGE STABILITY 83
5.4.4 IN-VITRO DIGESTION 85
5.5 CONCLUSIONS 87
6. MANUSCRIPT 4: IMPACT OF WPI-COATED LIPOSOMAL DELIVERY SYSTEMS ON
QUERCETIN BIOAVAILABILITY IN HUMAN
SUBJECTS 89
6.1 ABSTRACT 91
6.2 INTRODUCTION 91
6.3 SUBJECTS AND MATERIALS & METHODS 92
6.3.1 SUBJECTS 92
6.3.2 STUDY DESIGN 93
6.3.3 MATERIALS USED FOR STUDY PRODUCTS 94
6.3.4 STUDY PRODUCT PREPARATION 94
6.3.5 BLOOD SAMPLING AND PROCESSING 94
6.3.6 EXTRACTION OF QUERCETIN FROM PLASMA AND HPLC ANALYSIS 95
XIX
TABLE OF CONTENT
6.3.7 BIOKINETIC CALCULATIONS 95
6.3.8 STATISTICAL ANALYSES 95
6.4 RESULTS AND DISCUSSION 95
6.5 CONCLUSIONS 98
7. GENERAL DISCUSSION 99
7.1 MEMBRANE BEHAVIOR DURING ENCAPSULATION AND COATING 100
7.1.1 FISH OIL AND QUERCETIN 100
7.1.2 WPI- AND CHITOSAN-COATING 102
7.2 STABILITY OF LIPOSOMES 103
7.2.1 PHYSICAL STABILITY IN MODEL AND FOOD SYSTEMS 104
7.2.2 CHEMICAL STABILITY IN MODEL AND FOOD SYSTEMS 105
7.2.3 STABILITY DURING IN-VITRO DIGESTION 107
7.3 TECHNOLOGICAL AND SENSORY BENEFITS OF COATED DELIVERY SYSTEMS 109
7.4 INFLUENCE OF COATED LIPOSOMES ON QUERCETIN BIOAVAILABILITY 110
7.5 CONCLUDING REMARKS AND OUTLOOK 110
8. REFERENCES 113
9. SUMMARY........................... ......131
10. ZUSAMMENFASSUNG 133
11. EVALUATION OF FUNDAMENTAL METHODOLOGIES AND TECHNIQUES 135
11.1 COMPARISON OF LIPOSOME PRODUCTION METHODS 135
11.2 CHITOSAN-COATING OF LIPOSOMES 138
11.3 COMPARISON OF DRYING TECHNIQUES AND CRYO PROTECTANTS 139
11.4 COMPARISON OF METHODS FOR SEPARATION OF UNENCAPSULATED MATERIAL
FROM LIPOSOMES 141
11.5 DEVELOPMENT OFEPRSPIN TRAPPING METHOD FOR LIPID OXIDATION
EXPERIMENTS 144
11.6 COMPARISON OF MICROSCOPY TECHNIQUES FOR VISUALIZATION OF LIPOSOMES
AND COATING LAYER 147
XX
|
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| author_facet | Frenzel, Monika |
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| dewey-ones | 500 - Natural sciences and mathematics |
| dewey-raw | 500 |
| dewey-search | 500 |
| dewey-sort | 3500 |
| dewey-tens | 500 - Natural sciences and mathematics |
| discipline | Allgemeine Naturwissenschaft Lebensmitteltechnologie |
| format | Thesis Book |
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| indexdate | 2024-07-10T07:06:24Z |
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| isbn | 9783862474813 |
| language | German |
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| series2 | Schriftenreihe des Instituts für Humanernährung und Lebensmittelkunde der Christian-Albrechts-Univ. zu Kiel |
| spelling | Frenzel, Monika Verfasser aut Physico-chemical and pharmacokinetic study of whey protein coated liposomes as delivery system for bioactive compounds in food applications Monika Frenzel Uelvesbüll Der Andere Verlag 2014 XXIX, 150 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Schriftenreihe des Instituts für Humanernährung und Lebensmittelkunde der Christian-Albrechts-Univ. zu Kiel 76 Zugl.: Kiel, Univ., Diss., 2014 Mikroverkapselung (DE-588)4169865-4 gnd rswk-swf Molkenproteine (DE-588)4273083-1 gnd rswk-swf Liposom (DE-588)4122262-3 gnd rswk-swf Quercetin (DE-588)4176704-4 gnd rswk-swf Fischöl (DE-588)4212434-7 gnd rswk-swf Beschichtung (DE-588)4144863-7 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Mikroverkapselung (DE-588)4169865-4 s Fischöl (DE-588)4212434-7 s Quercetin (DE-588)4176704-4 s Liposom (DE-588)4122262-3 s Beschichtung (DE-588)4144863-7 s Molkenproteine (DE-588)4273083-1 s DE-604 Schriftenreihe des Instituts für Humanernährung und Lebensmittelkunde der Christian-Albrechts-Univ. zu Kiel 76 (DE-604)BV000897218 76 DE-101 pdf/application http://d-nb.info/1064558097/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028067045&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Frenzel, Monika Physico-chemical and pharmacokinetic study of whey protein coated liposomes as delivery system for bioactive compounds in food applications Schriftenreihe des Instituts für Humanernährung und Lebensmittelkunde der Christian-Albrechts-Univ. zu Kiel Mikroverkapselung (DE-588)4169865-4 gnd Molkenproteine (DE-588)4273083-1 gnd Liposom (DE-588)4122262-3 gnd Quercetin (DE-588)4176704-4 gnd Fischöl (DE-588)4212434-7 gnd Beschichtung (DE-588)4144863-7 gnd |
| subject_GND | (DE-588)4169865-4 (DE-588)4273083-1 (DE-588)4122262-3 (DE-588)4176704-4 (DE-588)4212434-7 (DE-588)4144863-7 (DE-588)4113937-9 |
| title | Physico-chemical and pharmacokinetic study of whey protein coated liposomes as delivery system for bioactive compounds in food applications |
| title_auth | Physico-chemical and pharmacokinetic study of whey protein coated liposomes as delivery system for bioactive compounds in food applications |
| title_exact_search | Physico-chemical and pharmacokinetic study of whey protein coated liposomes as delivery system for bioactive compounds in food applications |
| title_full | Physico-chemical and pharmacokinetic study of whey protein coated liposomes as delivery system for bioactive compounds in food applications Monika Frenzel |
| title_fullStr | Physico-chemical and pharmacokinetic study of whey protein coated liposomes as delivery system for bioactive compounds in food applications Monika Frenzel |
| title_full_unstemmed | Physico-chemical and pharmacokinetic study of whey protein coated liposomes as delivery system for bioactive compounds in food applications Monika Frenzel |
| title_short | Physico-chemical and pharmacokinetic study of whey protein coated liposomes as delivery system for bioactive compounds in food applications |
| title_sort | physico chemical and pharmacokinetic study of whey protein coated liposomes as delivery system for bioactive compounds in food applications |
| topic | Mikroverkapselung (DE-588)4169865-4 gnd Molkenproteine (DE-588)4273083-1 gnd Liposom (DE-588)4122262-3 gnd Quercetin (DE-588)4176704-4 gnd Fischöl (DE-588)4212434-7 gnd Beschichtung (DE-588)4144863-7 gnd |
| topic_facet | Mikroverkapselung Molkenproteine Liposom Quercetin Fischöl Beschichtung Hochschulschrift |
| url | http://d-nb.info/1064558097/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028067045&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000897218 |
| work_keys_str_mv | AT frenzelmonika physicochemicalandpharmacokineticstudyofwheyproteincoatedliposomesasdeliverysystemforbioactivecompoundsinfoodapplications |
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