Peptide and protein vaccines:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier/AP, Acad. Press
2015
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Advances in protein chemistry and structural biology
99 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 177 S. Ill., graph. Darst. |
| ISBN: | 9780128028278 |
Internformat
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| 245 | 1 | 0 | |a Peptide and protein vaccines |c ed. by Rossen Donev |
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| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier/AP, Acad. Press |c 2015 | |
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Datensatz im Suchindex
| _version_ | 1804174800236576768 |
|---|---|
| adam_text | Titel: Peptide and protein vaccines
Autor: Donev, Rossen
Jahr: 2015
CONTENTS
Contributors ix
Preface xi
1. Peptide Immunotherapy in Vaccine Development:
From Epitope to Adjuvant 1
Hyun Yang and Dong Seok Kim
1. Introduction 1
2. Cancer Vaccine 2
3. Allergy Vaccine 5
4. Alzheimer s Disease Vaccine 6
5. Adjuvant and Delivery 8
6. Perspectives and Conclusions 10
References 10
2. The Use of Liposomes to Shape Epitope Structure
and Modulate Immunogenic Responses of Peptide
Vaccines Against HIV MPER 15
Beatriz Apellaniz and José L. Nieva
1. Introduction 16
2. MPER: A Site of Vulnerability on HIV-1 Env and a Linear Epitope 18
3. Structural Organization of MPER 23
4. Lipid Vesicles: Adjuvants and Devices to Shape MPER Structure 33
5. Immunogenicity Studies of MPER-Derived Peptides in Liposomes 38
References 46
3. Recombinant Lipoproteins as Novel Vaccines with
Intrinsic Adjuvant 55
Pele Chong, Jui-Hsin Huang, Chih-Hsiang Leng, Shih-Jen Liu,
and Hsin-Wei Chen
1. Introduction 56
2. Establishment of High Expression Recombinant Lipoprotein System 58
3. The Lipid Structure of Lipoprotein 59
4. Recombinant Lipoprotein with Intrinsic Adjuvant Properties 62
5. To Engineer Chimeric Lipoproteins with Intrinsic Adjuvant for
Novel Vaccine Development 64
v
vi
Contents
6. Recombinant Chimeric Lipoproteins Can Activate BMDCs 65
7. A Robustness Up- and Downstream Processes for Lipoprotein
Production 67
8. Recombinant Lipoprotein-Based Subunit Vaccine Induces High
Titers of Neutralizing Antibody and Longer Memory Immune Responses 68
9. Recombinant Lipidated Human Papillomavirus E7 Induces Cellular
Immune Responses and Protective Immunity Against Cervical
Cancer in the TC-1 Mouse Model 70
10. Conclusion 70
Acknowledgment 71
References 72
4. Perspective of Peptide Vaccine Composed of Epitope Peptide,
CpG-DNA, and Liposome Complex Without Carriers 75
Younghee Lee, Young Seek Lee, Soo Young Cho, and Hyung-Joo Kwon
1. Introduction 76
2. Licensed Adjuvants 78
3. CpG-DNA: Adjuvant 79
4. Phosphodiester Bond CpG-DNA 81
5. Liposomes: Adjuvants 82
6. Adjuvants for Peptide Vaccine 83
7. Peptide Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome
Complex Without Carriers 84
8. Perspectives 89
Acknowledgments 90
References 91
5. Chemical Platforms for Peptide Vaccine Constructs 99
Suhas Ramesh, Prabhakar Cherkupally, Thavendran Govender,
Hendrik G. Kruger, Fernando Albericio, and Beatriz G. de la Torre
1. Introduction 100
2. Multiple Antigenic Peptide System Using a PolyLys Core: A Boon
to Synthetic Peptide Vaccines 102
3. Synthetic Antigen Carrier Bearing W-(S-acetylmercaptoacetyl)-Glutamyl
Residues 104
4. Thioester as a Replacement for Natural Peptide Bond
(Chemical Ligation): Construction of Proteins 105
5. Synthetic Peptide Dendrimer with Thiazolidinyl Pendant 107
6. Oxime Chemistry for Synthetic Peptide-Based Vaccines 108
Contents vii
7. Polyoxyethylene-Based Heterobifunctional Cross-Linking Reagents 109
8. Double Orthogonal Chemoselective Ligation via a Hydrazone Linkage 110
9. Multiple Antigenic Peptides with Synthetic Chimeric Epitopes 111
10. Gold Nanoparticles as Antigen Carriers 112
11. Branched Lipopeptide Candidate Vaccine 114
12. Antigenic Mimicking with Cys-Based Cyclizod Peptides 115
13. Reverse Thioether Ligation as an Alternative Route for MAPs
Construction 116
14. Self-Adjuvanting Polymer-Peptide Conjugates as Therapeutic
Vaccine Candidates 117
15. Maleimide as a Tool to Increase Peptide Immunogenicity 119
16. Tetra-Branched Maleimido Derivatives as Platforms for Vaccine
Preparation 120
17. Bromomaleimide-Hexanoic Acid as a Linker for Multibranched
Peptides 121
18. Comparative Account of Different Presentation Systems for
HIV Peptide Immunogen 124
19. Merits and Demerits of Chemoselective and SPPS Reactions:
M2e Epitope of Influenza Virus as a Case Study 125
20. Summary and Outlook 126
Acknowledgment 127
References 127
6. Understanding Amino Acid Mutations in Hepatitis B
Virus Proteins for Rational Design of Vaccines and Drugs 131
Ke Shen, Li Shen, Jing Wang, Zhi Jiang, and Bairong Shen
1. Introduction 132
2. Mutation Data and Distribution Analysis 135
3. Bioinformatics Analysis of the Mutations 143
4. Discussion and Conclusion 150
Acknowledgments 151
References 151
Author Index
Subject Index
155
173
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| id | DE-604.BV042623721 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:06:09Z |
| institution | BVB |
| isbn | 9780128028278 |
| language | English |
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| physical | XIII, 177 S. Ill., graph. Darst. |
| publishDate | 2015 |
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| series | Advances in protein chemistry and structural biology |
| series2 | Advances in protein chemistry and structural biology |
| spelling | Peptide and protein vaccines ed. by Rossen Donev 1. ed. Amsterdam [u.a.] Elsevier/AP, Acad. Press 2015 XIII, 177 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in protein chemistry and structural biology 99 Donev, Rossen Sonstige (DE-588)14373945X oth Advances in protein chemistry and structural biology 99 (DE-604)BV035242330 99 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028056397&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Peptide and protein vaccines Advances in protein chemistry and structural biology |
| title | Peptide and protein vaccines |
| title_auth | Peptide and protein vaccines |
| title_exact_search | Peptide and protein vaccines |
| title_full | Peptide and protein vaccines ed. by Rossen Donev |
| title_fullStr | Peptide and protein vaccines ed. by Rossen Donev |
| title_full_unstemmed | Peptide and protein vaccines ed. by Rossen Donev |
| title_short | Peptide and protein vaccines |
| title_sort | peptide and protein vaccines |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028056397&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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