Resistance to Aromatase Inhibitors in Breast Cancer:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cham [u.a.]
Springer International Publishing
2015
|
| Schriftenreihe: | Resistance to Targeted Anti-Cancer Therapeutics
8 |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Abstract |
| Beschreibung: | 1 Online-Ressource (XVI, 288 p. 56 illus., 27 illus. in color) |
| ISBN: | 9783319179728 |
| DOI: | 10.1007/978-3-319-17972-8 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804153310334156800 |
|---|---|
| adam_text | RESISTANCE TO AROMATASE INHIBITORS IN BREAST CANCER
/ LARIONOV, ALEXEY
: 2015
ABSTRACT / INHALTSTEXT
THE BOOK BRINGS TOGETHER CURRENT KNOWLEDGE ABOUT MOLECULAR AND CLINICAL
ASPECTS OF RESISTANCE TO AROMATASE INHIBITORS (AIS). THE TOPICS AND
FEATURES INCLUDE: THE HISTORY OF DEVELOPMENT AND CLINICAL ROLE OF
AROMATASE INHIBITORS IN BREAST CANCER. THE STRUCTURE AND FUNCTION OF
AROMATASE GENE AND PROTEIN, INCLUDING TISSUE-SPECIFIC SPLICING AND
REGULATION OF THE GENE, CRYSTAL STRUCTURE OF THE ENZYME, FUNCTIONING OF
ITS ACTIVE SITE AND STRUCTURAL BASIS FOR DEVELOPMENT OF NEW AROMATASE
INHIBITORS. EXPERIMENTAL AND PRE-CLINICAL MODELS OF RESISTANCE TO
AROMATASE INHIBITORS (INCLUDING CELL LINES AND XENOGRAFTS) AS WELL AS
METHODS AND RESULTS OF MEASURING OESTROGEN CONCENTRATIONS IN BLOOD AND
TUMOUR TISSUE OF BREAST CANCER PATIENTS.DIVERSITY OF MOLECULAR
MECHANISMS OF AI RESISTANCE, INCLUDING (I) LIGAND-INDEPENDENT SIGNALLING
THROUGH OESTROGEN RECEPTOR PATHWAY, (II) HYPERSENSITIVITY TO LOW
CONCENTRATIONS OF OESTROGENS, (III) CROSSTALK WITH NON-ENDOCRINE
SIGNALLING (INCLUDING PI3K/MTOR, IGF, GDNF AND MYC PATHWAYS), (IV)
INVOLVEMENT OF OESTROGEN-INDUCED APOPTOSIS AND TISSUE MICROENVIRONMENT
(INCLUDING INFLAMMATORY IMMUNE CELLS AND ADIPOCYTES) AS WELL AS (V) THE
ROLE OF EPIGENETIC MECHANISMS AND PIONEERING FACTORS IN ER SIGNALLING
AND AI RESISTANCE. MOLECULAR MARKERS AND MULTI-GENE SIGNATURES TO
PREDICT RESPONSE TO AIS, CLINICAL TRIALS AIMED AT PREVENTING OR
OVERCOMING RESISTANCE BY COMBINING AIS WITH NOVEL TARGETED AGENTS
(INCLUDING AI COMBINATIONS WITH HER2, EGFR, MTOR, PI3K, AKT, CDK4/6,
FGFR, HDAC, IGF-1, SRC, PROTEOSOME- AND ANGIOGENIC- TARGETING AGENTS). A
REVIEW OF THE EFFECTS AND CLINICAL INDICATIONS OF AROMATASE INHIBITORS
BEYOND BREAST CANCER.MANY OF THE CHAPTERS PROVIDE EXTENSIVE HISTORICAL
OVERVIEWS TO CONNECT CURRENT KNOWLEDGE WITH THE HISTORY AND INNER LOGIC
OF THE FIELD. THE AUTHORS’ TEAM INCLUDES WORLD-LEADING EXPERTS, MAKING
THE BOOK AN ESSENTIAL RESOURCE FOR SCIENTISTS DEVELOPING NEW TREATMENTS
FOR BREAST CANCER AND FOR MEDICS TREATING BREAST CANCER PATIENTS WITH
AROMATASE INHIBITORS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| id | DE-604.BV042544587 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T01:24:34Z |
| institution | BVB |
| isbn | 9783319179728 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027978593 |
| oclc_num | 909079270 |
| open_access_boolean | |
| owner | DE-91 DE-BY-TUM DE-703 |
| owner_facet | DE-91 DE-BY-TUM DE-703 |
| physical | 1 Online-Ressource (XVI, 288 p. 56 illus., 27 illus. in color) |
| psigel | ZDB-2-SBL ZDB-2-SBL_2015 |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Springer International Publishing |
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| series | Resistance to Targeted Anti-Cancer Therapeutics |
| series2 | Resistance to Targeted Anti-Cancer Therapeutics |
| spelling | Resistance to Aromatase Inhibitors in Breast Cancer Alexey Larionov Cham [u.a.] Springer International Publishing 2015 1 Online-Ressource (XVI, 288 p. 56 illus., 27 illus. in color) txt rdacontent c rdamedia cr rdacarrier Resistance to Targeted Anti-Cancer Therapeutics 8 Medicine Oncology Drug interactions Biomedicine Cancer Research Drug Resistance Molecular Medicine Medizin Larionov, Alexey Sonstige oth Erscheint auch als Druckausgabe 978-3-319-17971-1 Resistance to Targeted Anti-Cancer Therapeutics 8 (DE-604)BV041037744 8 https://doi.org/10.1007/978-3-319-17972-8 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027978593&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Resistance to Aromatase Inhibitors in Breast Cancer Resistance to Targeted Anti-Cancer Therapeutics Medicine Oncology Drug interactions Biomedicine Cancer Research Drug Resistance Molecular Medicine Medizin |
| title | Resistance to Aromatase Inhibitors in Breast Cancer |
| title_auth | Resistance to Aromatase Inhibitors in Breast Cancer |
| title_exact_search | Resistance to Aromatase Inhibitors in Breast Cancer |
| title_full | Resistance to Aromatase Inhibitors in Breast Cancer Alexey Larionov |
| title_fullStr | Resistance to Aromatase Inhibitors in Breast Cancer Alexey Larionov |
| title_full_unstemmed | Resistance to Aromatase Inhibitors in Breast Cancer Alexey Larionov |
| title_short | Resistance to Aromatase Inhibitors in Breast Cancer |
| title_sort | resistance to aromatase inhibitors in breast cancer |
| topic | Medicine Oncology Drug interactions Biomedicine Cancer Research Drug Resistance Molecular Medicine Medizin |
| topic_facet | Medicine Oncology Drug interactions Biomedicine Cancer Research Drug Resistance Molecular Medicine Medizin |
| url | https://doi.org/10.1007/978-3-319-17972-8 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027978593&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV041037744 |
| work_keys_str_mv | AT larionovalexey resistancetoaromataseinhibitorsinbreastcancer |