Autophagic events during Plasmodium infection of hepatocytes:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2014
|
| Ausgabe: | 1. Aufl. |
| Schriftenreihe: | Biology
|
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | 126 S. Ill., graph. Darst. |
| ISBN: | 9783863875534 |
Internformat
MARC
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| 100 | 1 | |a Prado Porras, Mónica |e Verfasser |0 (DE-588)1069357448 |4 aut | |
| 245 | 1 | 0 | |a Autophagic events during Plasmodium infection of hepatocytes |c submitted by Mónica Prado Porras |
| 250 | |a 1. Aufl. | ||
| 264 | 1 | |c 2014 | |
| 300 | |a 126 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Biology | |
| 502 | |a Hamburg, Univ., Diss., 2014 | ||
| 650 | 0 | 7 | |a Plasmodium |0 (DE-588)4248576-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Infektion |0 (DE-588)4161650-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Leberepithelzelle |0 (DE-588)4120659-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Malaria |0 (DE-588)4037197-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Autophagie |g Physiologie |0 (DE-588)4441664-7 |2 gnd |9 rswk-swf |
| 653 | |a Plasmodium | ||
| 653 | |a infection | ||
| 653 | |a hepatocytes | ||
| 653 | |a Malaria | ||
| 653 | |a Autophagy | ||
| 653 | |a Malaria prevalence | ||
| 653 | |a microorganisms | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Malaria |0 (DE-588)4037197-9 |D s |
| 689 | 0 | 1 | |a Leberepithelzelle |0 (DE-588)4120659-9 |D s |
| 689 | 0 | 2 | |a Plasmodium |0 (DE-588)4248576-9 |D s |
| 689 | 0 | 3 | |a Infektion |0 (DE-588)4161650-9 |D s |
| 689 | 0 | 4 | |a Autophagie |g Physiologie |0 (DE-588)4441664-7 |D s |
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Datensatz im Suchindex
| _version_ | 1806330979450617856 |
|---|---|
| adam_text |
TABLE OF CONTENTS
SUMMARY.
8
I LIST OF
FIGURES.
10
II LIST OF
TABLES.
12
III LIST OF
VIDEOS.
13
IV
ABBREVIATIONS.
16
CHAPTER 1:
INTRODUCTION.20
1.1
MALARIA.
20
1.1.1
BACKGROUND.
20
1.1.2 MALARIA
PREVALENCE.21
1.1.3
PATHOPHYSIOLOGY.21
1.1.4 CURRENT
PROBLEMS.22
1.1.4.1 VECTOR
FACTORS.22
1.1.4.2 DRUG
RESISTANCE.23
1.1.4.3
DIAGNOSIS.
23
1.1.5 MALARIA
VACCINE.24
1.1.6 THE
PLASMODIUM SP. LIFE
CYCLE.
25
1.1.6.1 MOSQUITO STAGE IN
DETAIL.
26
1.1.6.2 HEPATIC STAGE IN
DETAIL.
27
1.1.6.3 BLOOD STAGE IN
DETAIL.
29
1.1.7 RODENT MALARIA
MODEL.
30
1.2
AUTOPHAGY.
31
1.2.1 TYPES OF
AUTOPHAGY.33
1.2.1.1 CANONICAL
AUTOPHAGY.
34
1.2.1.2 NON-CANONICAL
AUTOPHAGY.38
1.2.1.3 SELECTIVE
AUTOPHAGY.
38
1.2.2 AUTOPHAGY AND
INFECTION.
39
1.2.2.1 HOST CELL AUTOPHAGY DURING PROTOZOAN
INFECTIONS.
41
1.3 PROJECT
OBJECTIVE.
42
CHAPTER 2: MATERIALS AND METHODS
.
43
2.1
MATERIALS.
43
2.1.1 TECHNICAL AND MECHANICAL
DEVICES.43
2.1.2 LABWARE AND
DISPOSABLES.
44
2.1.3 CHEMICALS AND
REAGENTS.
45
2.1.4 STOCK SOLUTIONS, BUFFERS AND
MEDIA.48
2.1.5 SOFTWARE PROGRAMS AND
DATABASES.49
2.2
METHODS.
50
2.2.1 CULTURE OF PLASMODIUM BERGHEI
PARASITES.
50
2.2.1.1 BLOOD
STAGE.51
2.2.1.1.1 INFECTION OF MICE FROM BLOOD STABILATES FOR MOSQUITOES
INFECTION.51
2.2.1.1.2 DETERMINATION OF PARASITEMIA VIA BLOOD SMEARS
.
51
2.2.1.1.3 BLOOD
STABILATES.
51
2.2.1.2 MOSQUITO
STAGE.
51
2.2.1.2.1 BREEDING OF
MOSQUITOES.51
2.2.1.2.2 INFECTION OF
MOSQUITOES.52
2.2.2 IN VITRO INFECTION MODEL FOR THE LIVER
STAGE.
52
2.2.2.1 CULTURE AND SEEDING OF HEPG2
CELLS.
52
2.2.2.2 SEEDING AND CULTURE OF MOUSE EMBRYONIC FIBROBLAST
(MEF).53
2.2.2.3 PREPARATION OF
SPOROZOITES.
53
2.2.2.4 INFECTION OF
CELLS.53
2.2.3 TRANSFECTION AND CHEMICAL TREATMENTS OF
CELLS.
54
2.2.3.1 TRANSFECTION
METHOD.54
2.2.3.2 CHEMICAL TREATMENTS OF HEPG2
CELLS.
55
2.2.3.2.1 CHLOROQUINE
TREATMENT.
55
2.2.3.2.2 SPAUTIN-1
TREATMENT.
56
2.2.3.2.3 RAPAMYCIN
TREATMENT.
56
2.2.3.2.4 STARVATION
TREATMENT.
56
2.2.4 INDIRECT IMMUNOFLUORESCENCE ANALYSIS OF ADHERENT
CELL.
56
2.2.4.1 PROTOCOL FOR REGULAR IMMUNOFLUORESCENCE STAINING
.
57
2.2.4.2 PROTOCOL FOR FIXATION AND STAINING WITH THE ANTI-LC3
ANTIBODY.57
2.2.4.3 PROTOCOL FOR FIXATION AND STAINING WITH THE ANTI-UBIQUITIN AND
P62 ANTIBODY
.
58
2.2.4A STAINING OF DETACHED
CELLS.
58
2.2.5 ANTIBODIES AND FIXED CELL
STAINS.
58
2.2.6 STAINING OF CELL COMPONENTS FOR LIVE CELL MICROSCOPIC ANALYSES
.
60
2.2.7 LIVE IMAGING PREPARATION AND
SETUP.60
2.2.7.1 TIME POINT
IMAGING.60
2.2.7.2 TIME LAPSE
IMAGING.60
2.2.7.3 IMAGE PROCESSING AND
ANALYSIS.61
2.2.7.3.1 GENERAL PROCESSING (SCALING, TIME
STAMPS).61
2.2.7.3.2 EXPORTED FILE
FORMATS.
61
2.2.7.3.3 TONE CORRECTION AND
FALSE-COLORING.
61
2.2.8 DETERMINATION OF PARASITE SIZE-DENSITY
SLICING.
61
2.2.9 DETERMINATION OF THE NUMBER OF PARASITES DURING LIVE CYCLE
.
61
2.2.10 QUANTIFICATION OF AUTOPHAGY AND DEGRADATION
MARKERS.62
2.2.11 ANIMAL
STUDIES.
62
2.2.11.1 PARASITEMIA IN LAMP-1 KNOCKOUT
MICE.
62
2.2.11.2 P. BERGHEI RNA QUANTIFICATION BY
QRT-PCR.62
2.2.11.2.1 ANIMAL
INFECTION.
63
2.2.11.2.2
IN VIVO
TREATMENTS.
63
2.2.11.2.2.1
CHLOROQUINE.
63
2.2.11.2.2.2
RAPAMYCIN.
63
2.2.11.2.2.3
STARVATION.
63
2.2.11.2.3 RNA
QUANTIFICATION.
63
2.2.11.2.4 CDNA
SYNTHESIS.64
2.2.11.2.5 CONDITIONS FOR CDNA
SYNTHESIS.
64
2.2.11.2.5.1 QRT-PCR
CONDITIONS.64
2.2.12 MEASURING RNA AND DNA CONCENTRATION BY
PHOTOMETER.
64
CHAPTER 3:
RESULTS.65
3.1 HOST CELL RECOGNIZES AND LABELS INVADING PLASMODIUM SPOROZOITES
.
65
LYSOSOMES ARE ATTRACTED AND FUSE WITH THE PVM OF EARLY-STAGE
PARASITES.70
3.2 RECRUITMENT OF LC3 TO LIVER STAGE PLASMODIUM PARASITES: A NOVEL
AUTOPHAGY PATHWAY
.
74
UBIQUITIN LABELING OF THE
PVM.
74
3.3 AUTOPHAGIC ELIMINATION OF
PARASITES.
77
AUTOPHAGY IS INVOLVED IN ELIMINATION OF GROWTH-IMPAIRED PARASITES
.
77
3.4 INDUCED-AUTOPHAGY PATHWAY MEDIATORS ARE NOT INVOLVED DURING
INFECTION
.
81
3.5 MANIPULATION OF HOST CELL AUTOPHAGY AND ITS IMPLICATION IN
PLASMODIUM DEVELOPMENT.86
LYSOSOMES ARE RECRUITED INDEPENDENTLY OF LC3 AND ATG5
.
86
3.6
IN VITRO MANIPULATION OF AUTOPHAGY AFFECTS OPPOSITELY INVASION AND
DEVELOPMENT OF PARASITES. 87
3.7 IN VIVO EFFECTS OF AUTOPHAGY MANIPULATION FOR PLASMODIUM LIVER STAGE
DEVELOPMENT
.
92
3.8 IMMUNE RESPONSES AND AUTOPHAGY DURING PLASMODIUM LIVER STAGE
INFECTION
.
95
GENETICALLY ATTENUATED PARASITES INDUCED A STRONGER HOST AUTOPHAGY
RESPONSE UPON INFECTION
.
96
INFECTION WITH GENETICALLY ATTENUATED PARASITES INDUCE POTENT IMMUNE
RESPONSES
.
99
CHAPTER 4:
DISCUSSION.
101
CHAPTER 5:
REFERENCES.
114
ACKNOLEGMENTS 123
PUBLICATIONS.
124
LANGUAGE
CERTIFICATE.125 |
| any_adam_object | 1 |
| author | Prado Porras, Mónica |
| author_GND | (DE-588)1069357448 |
| author_facet | Prado Porras, Mónica |
| author_role | aut |
| author_sort | Prado Porras, Mónica |
| author_variant | p m p pm pmp |
| building | Verbundindex |
| bvnumber | BV042487942 |
| ctrlnum | (OCoLC)915640690 (DE-599)DNB1066214271 |
| discipline | Biologie |
| edition | 1. Aufl. |
| format | Thesis Book |
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| id | DE-604.BV042487942 |
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| indexdate | 2024-08-03T02:17:41Z |
| institution | BVB |
| isbn | 9783863875534 |
| language | English |
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| owner_facet | DE-188 |
| physical | 126 S. Ill., graph. Darst. |
| publishDate | 2014 |
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| spelling | Prado Porras, Mónica Verfasser (DE-588)1069357448 aut Autophagic events during Plasmodium infection of hepatocytes submitted by Mónica Prado Porras 1. Aufl. 2014 126 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biology Hamburg, Univ., Diss., 2014 Plasmodium (DE-588)4248576-9 gnd rswk-swf Infektion (DE-588)4161650-9 gnd rswk-swf Leberepithelzelle (DE-588)4120659-9 gnd rswk-swf Malaria (DE-588)4037197-9 gnd rswk-swf Autophagie Physiologie (DE-588)4441664-7 gnd rswk-swf Plasmodium infection hepatocytes Malaria Autophagy Malaria prevalence microorganisms (DE-588)4113937-9 Hochschulschrift gnd-content Malaria (DE-588)4037197-9 s Leberepithelzelle (DE-588)4120659-9 s Plasmodium (DE-588)4248576-9 s Infektion (DE-588)4161650-9 s Autophagie Physiologie (DE-588)4441664-7 s DE-188 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=5142786&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027922785&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Prado Porras, Mónica Autophagic events during Plasmodium infection of hepatocytes Plasmodium (DE-588)4248576-9 gnd Infektion (DE-588)4161650-9 gnd Leberepithelzelle (DE-588)4120659-9 gnd Malaria (DE-588)4037197-9 gnd Autophagie Physiologie (DE-588)4441664-7 gnd |
| subject_GND | (DE-588)4248576-9 (DE-588)4161650-9 (DE-588)4120659-9 (DE-588)4037197-9 (DE-588)4441664-7 (DE-588)4113937-9 |
| title | Autophagic events during Plasmodium infection of hepatocytes |
| title_auth | Autophagic events during Plasmodium infection of hepatocytes |
| title_exact_search | Autophagic events during Plasmodium infection of hepatocytes |
| title_full | Autophagic events during Plasmodium infection of hepatocytes submitted by Mónica Prado Porras |
| title_fullStr | Autophagic events during Plasmodium infection of hepatocytes submitted by Mónica Prado Porras |
| title_full_unstemmed | Autophagic events during Plasmodium infection of hepatocytes submitted by Mónica Prado Porras |
| title_short | Autophagic events during Plasmodium infection of hepatocytes |
| title_sort | autophagic events during plasmodium infection of hepatocytes |
| topic | Plasmodium (DE-588)4248576-9 gnd Infektion (DE-588)4161650-9 gnd Leberepithelzelle (DE-588)4120659-9 gnd Malaria (DE-588)4037197-9 gnd Autophagie Physiologie (DE-588)4441664-7 gnd |
| topic_facet | Plasmodium Infektion Leberepithelzelle Malaria Autophagie Physiologie Hochschulschrift |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=5142786&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027922785&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT pradoporrasmonica autophagiceventsduringplasmodiuminfectionofhepatocytes |