Holdings: High-resolution profiling of Protein-RNA interactions

High-resolution profiling of Protein-RNA interactions:

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Bibliographic Details
Main Author:	Munschauer, Mathias 1985- (Author)
Format:	Thesis Electronic eBook
Language:	English
Published:	Cham [u.a.] Springer 2015
Series:	Springer theses : Recognizing outstanding Ph. D. research
Subjects:	Engineering Bioinformatics Biological models Biomedical engineering Biomedical Engineering Systems Biology Computational Biology/Bioinformatics Ingenieurwissenschaften Hochschulschrift
Online Access:	BHS01 BTU01 FAB01 FAW01 FHA01 FHI01 FHN01 FHR01 FKE01 FRO01 FWS01 FWS02 UBY01 Volltext Inhaltsverzeichnis Abstract
Physical Description:	1 Online-Ressource (XXIII, 121 p. 25 illus., 20 illus. in color)
ISBN:	9783319162539
DOI:	10.1007/978-3-319-16253-9

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adam_text	HIGH-RESOLUTION PROFILING OF PROTEIN-RNA INTERACTIONS / MUNSCHAUER, MATHIAS : 2015 TABLE OF CONTENTS / INHALTSVERZEICHNIS INTRODUCTION MAPPING REGULATORY INTERACTIONS OF THE RNA-BINDING PROTEIN LIN28B EXPLORING THE SEQUENCE SPACE CONTACTED BY THE ENSEMBLE OF RNA-BINDING PROTEINS REVEALING CELL-TYPE SPECIFIC DIFFERENCES IN PROTEIN OCCUPANCY ON RNA DISCUSSION DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. HIGH-RESOLUTION PROFILING OF PROTEIN-RNA INTERACTIONS / MUNSCHAUER, MATHIAS : 2015 ABSTRACT / INHALTSTEXT THE WORK REPORTED IN THIS BOOK REPRESENTS AN EXCELLENT EXAMPLE OF HOW CREATIVE EXPERIMENTATION AND TECHNOLOGY DEVELOPMENT, COMPLEMENTED BY COMPUTATIONAL DATA ANALYSIS, CAN YIELD IMPORTANT INSIGHTS THAT FURTHER OUR UNDERSTANDING OF BIOLOGICAL ENTITIES FROM A SYSTEMS PERSPECTIVE. THE BOOK DESCRIBES HOW THE STUDY OF A SINGLE RNA-BINDING PROTEIN AND ITS INTERACTION SITES LED TO THE DEVELOPMENT OF THE NOVEL ‘PROTEIN OCCUPANCY PROFILING’ TECHNOLOGY THAT FOR THE FIRST TIME CAPTURED THE MRNA SEQUENCE SPACE CONTACTED BY THE ENSEMBLE OF EXPRESSED RNA BINDERS. APPLICATION OF PROTEIN OCCUPANCY PROFILING TO EUKARYOTIC CELLS REVEALED THAT EXTENSIVE SEQUENCE STRETCHES IN 3’ UTRS CAN BE CONTACTED BY RBPS AND THAT EVOLUTIONARY CONSERVATION AS WELL AS NEGATIVE SELECTION ACT ON PROTEIN-RNA CONTACT SITES, SUGGESTING FUNCTIONAL IMPORTANCE. COMPARATIVE ANALYSIS OF THE RBP-BOUND SEQUENCE SPACE HAS THE POTENTIAL TO UNRAVEL PUTATIVE CIS-ACTING RNA ELEMENTS WITHOUT A PRIORI KNOWLEDGE OF THE BOUND REGULATORS. HERE, DR. MUNSCHAUER PROVIDES A COMPREHENSIVE INTRODUCTION TO THE FIELD OF POST-TRANSCRIPTIONAL GENE REGULATION, EXAMINES STATE-OF-THE-ART TECHNOLOGIES, AND COMBINES THE CONCLUSIONS FROM SEVERAL JOURNAL ARTICLES INTO A COHERENT AND LOGICAL STORY FROM THE FRONTIERS OF SYSTEMS-BIOLOGY INSPIRED LIFE SCIENCE. THIS THESIS, SUBMITTED TO THE DEPARTMENT OF BIOLOGY, CHEMISTRY AND PHARMACY AT FREIE UNIVERSITAET BERLIN, WAS SELECTED AS OUTSTANDING WORK BY THE BERLIN INSTITUTE FOR MEDICAL SYSTEMS BIOLOGY AT THE MAX-DELBRUECK CENTER FOR MOLECULAR MEDICINE, GERMANY. DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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record_format	marc
series2	Springer theses : Recognizing outstanding Ph. D. research
spellingShingle	Munschauer, Mathias 1985- High-resolution profiling of Protein-RNA interactions Engineering Bioinformatics Biological models Biomedical engineering Biomedical Engineering Systems Biology Computational Biology/Bioinformatics Ingenieurwissenschaften
subject_GND	(DE-588)4113937-9
title	High-resolution profiling of Protein-RNA interactions
title_auth	High-resolution profiling of Protein-RNA interactions
title_exact_search	High-resolution profiling of Protein-RNA interactions
title_full	High-resolution profiling of Protein-RNA interactions Mathias Munschauer
title_fullStr	High-resolution profiling of Protein-RNA interactions Mathias Munschauer
title_full_unstemmed	High-resolution profiling of Protein-RNA interactions Mathias Munschauer
title_short	High-resolution profiling of Protein-RNA interactions
title_sort	high resolution profiling of protein rna interactions
topic	Engineering Bioinformatics Biological models Biomedical engineering Biomedical Engineering Systems Biology Computational Biology/Bioinformatics Ingenieurwissenschaften
topic_facet	Engineering Bioinformatics Biological models Biomedical engineering Biomedical Engineering Systems Biology Computational Biology/Bioinformatics Ingenieurwissenschaften Hochschulschrift
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