High-resolution profiling of Protein-RNA interactions:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cham [u.a.]
Springer
2015
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| Schriftenreihe: | Springer theses : Recognizing outstanding Ph. D. research
|
| Schlagworte: | |
| Online-Zugang: | BHS01 BTU01 FAB01 FAW01 FHA01 FHI01 FHN01 FHR01 FKE01 FRO01 FWS01 FWS02 UBY01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource (XXIII, 121 p. 25 illus., 20 illus. in color) |
| ISBN: | 9783319162539 |
| DOI: | 10.1007/978-3-319-16253-9 |
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| adam_text | HIGH-RESOLUTION PROFILING OF PROTEIN-RNA INTERACTIONS
/ MUNSCHAUER, MATHIAS
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
INTRODUCTION
MAPPING REGULATORY INTERACTIONS OF THE RNA-BINDING PROTEIN LIN28B
EXPLORING THE SEQUENCE SPACE CONTACTED BY THE ENSEMBLE OF RNA-BINDING
PROTEINS
REVEALING CELL-TYPE SPECIFIC DIFFERENCES IN PROTEIN OCCUPANCY ON RNA
DISCUSSION
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
HIGH-RESOLUTION PROFILING OF PROTEIN-RNA INTERACTIONS
/ MUNSCHAUER, MATHIAS
: 2015
ABSTRACT / INHALTSTEXT
THE WORK REPORTED IN THIS BOOK REPRESENTS AN EXCELLENT EXAMPLE OF HOW
CREATIVE EXPERIMENTATION AND TECHNOLOGY DEVELOPMENT, COMPLEMENTED BY
COMPUTATIONAL DATA ANALYSIS, CAN YIELD IMPORTANT INSIGHTS THAT FURTHER
OUR UNDERSTANDING OF BIOLOGICAL ENTITIES FROM A SYSTEMS PERSPECTIVE. THE
BOOK DESCRIBES HOW THE STUDY OF A SINGLE RNA-BINDING PROTEIN AND ITS
INTERACTION SITES LED TO THE DEVELOPMENT OF THE NOVEL ‘PROTEIN
OCCUPANCY PROFILING’ TECHNOLOGY THAT FOR THE FIRST TIME CAPTURED THE
MRNA SEQUENCE SPACE CONTACTED BY THE ENSEMBLE OF EXPRESSED RNA BINDERS.
APPLICATION OF PROTEIN OCCUPANCY PROFILING TO EUKARYOTIC CELLS REVEALED
THAT EXTENSIVE SEQUENCE STRETCHES IN 3’ UTRS CAN BE CONTACTED BY RBPS
AND THAT EVOLUTIONARY CONSERVATION AS WELL AS NEGATIVE SELECTION ACT ON
PROTEIN-RNA CONTACT SITES, SUGGESTING FUNCTIONAL IMPORTANCE. COMPARATIVE
ANALYSIS OF THE RBP-BOUND SEQUENCE SPACE HAS THE POTENTIAL TO UNRAVEL
PUTATIVE CIS-ACTING RNA ELEMENTS WITHOUT A PRIORI KNOWLEDGE OF THE BOUND
REGULATORS. HERE, DR. MUNSCHAUER PROVIDES A COMPREHENSIVE INTRODUCTION
TO THE FIELD OF POST-TRANSCRIPTIONAL GENE REGULATION, EXAMINES
STATE-OF-THE-ART TECHNOLOGIES, AND COMBINES THE CONCLUSIONS FROM SEVERAL
JOURNAL ARTICLES INTO A COHERENT AND LOGICAL STORY FROM THE FRONTIERS OF
SYSTEMS-BIOLOGY INSPIRED LIFE SCIENCE. THIS THESIS, SUBMITTED TO THE
DEPARTMENT OF BIOLOGY, CHEMISTRY AND PHARMACY AT FREIE UNIVERSITAET
BERLIN, WAS SELECTED AS OUTSTANDING WORK BY THE BERLIN INSTITUTE FOR
MEDICAL SYSTEMS BIOLOGY AT THE MAX-DELBRUECK CENTER FOR MOLECULAR
MEDICINE, GERMANY.
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
| any_adam_object | 1 |
| author | Munschauer, Mathias 1985- |
| author_GND | (DE-588)1056973420 |
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| author_role | aut |
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| bvnumber | BV042481913 |
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| dewey-full | 610.28 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610.28 |
| dewey-search | 610.28 |
| dewey-sort | 3610.28 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| doi_str_mv | 10.1007/978-3-319-16253-9 |
| format | Thesis Electronic eBook |
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| spellingShingle | Munschauer, Mathias 1985- High-resolution profiling of Protein-RNA interactions Engineering Bioinformatics Biological models Biomedical engineering Biomedical Engineering Systems Biology Computational Biology/Bioinformatics Ingenieurwissenschaften |
| subject_GND | (DE-588)4113937-9 |
| title | High-resolution profiling of Protein-RNA interactions |
| title_auth | High-resolution profiling of Protein-RNA interactions |
| title_exact_search | High-resolution profiling of Protein-RNA interactions |
| title_full | High-resolution profiling of Protein-RNA interactions Mathias Munschauer |
| title_fullStr | High-resolution profiling of Protein-RNA interactions Mathias Munschauer |
| title_full_unstemmed | High-resolution profiling of Protein-RNA interactions Mathias Munschauer |
| title_short | High-resolution profiling of Protein-RNA interactions |
| title_sort | high resolution profiling of protein rna interactions |
| topic | Engineering Bioinformatics Biological models Biomedical engineering Biomedical Engineering Systems Biology Computational Biology/Bioinformatics Ingenieurwissenschaften |
| topic_facet | Engineering Bioinformatics Biological models Biomedical engineering Biomedical Engineering Systems Biology Computational Biology/Bioinformatics Ingenieurwissenschaften Hochschulschrift |
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