Holdings: Ubiquitin Chains :: THWS Bibkatalog

Ubiquitin Chains: Degradation and Beyond

Saved in:

Bibliographic Details
Main Author:	De, Arnab (Author)
Format:	Thesis Electronic eBook
Language:	English
Published:	Cham [u.a.] Springer International Publishing 2015
Series:	Springer Theses
Subjects:	Life sciences Immunology Biochemistry Cell cycle Life Sciences Protein Science Cell Cycle Analysis Biowissenschaften Hochschulschrift
Online Access:	TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract
Physical Description:	1 Online-Ressource (XV, 103 p. 45 illus., 33 illus. in color)
ISBN:	9783319149653
ISSN:	2190-5053
DOI:	10.1007/978-3-319-14965-3

Staff View

MARC


LEADER	00000nmm a2200000zc 4500
001	BV042481814
003	DE-604
005	20150410
006	a m\|\|\| 00\|\|\|
007	cr\|uuu---uuuuu
008	150402s2015 \|\|\|\| o\|\|u\| \|\|\|\|\|\|eng d
020			\|a 9783319149653 \|c Online \|9 978-3-319-14965-3
024	7		\|a 10.1007/978-3-319-14965-3 \|2 doi
035			\|a (OCoLC)906188410
035			\|a (DE-599)BVBBV042481814
040			\|a DE-604 \|b ger \|e aacr
041	0		\|a eng
049			\|a DE-91 \|a DE-703
082	0		\|a 572.6 \|2 23
084			\|a BIO 000 \|2 stub
100	1		\|a De, Arnab \|e Verfasser \|4 aut
245	1	0	\|a Ubiquitin Chains \|b Degradation and Beyond \|c Arnab De
264		1	\|a Cham [u.a.] \|b Springer International Publishing \|c 2015
300			\|a 1 Online-Ressource (XV, 103 p. 45 illus., 33 illus. in color)
336			\|b txt \|2 rdacontent
337			\|b c \|2 rdamedia
338			\|b cr \|2 rdacarrier
490	0		\|a Springer Theses \|x 2190-5053
502			\|a Zugl.: New York, NY, Columbia University, Diss.
650		4	\|a Life sciences
650		4	\|a Immunology
650		4	\|a Biochemistry
650		4	\|a Cell cycle
650		4	\|a Life Sciences
650		4	\|a Protein Science
650		4	\|a Cell Cycle Analysis
650		4	\|a Biowissenschaften
655		7	\|0 (DE-588)4113937-9 \|a Hochschulschrift \|2 gnd-content
776	0	8	\|i Erscheint auch als \|n Druckausgabe \|z 978-3-319-14964-6
856	4	0	\|u https://doi.org/10.1007/978-3-319-14965-3 \|x Verlag \|3 Volltext
856	4	2	\|m Springer Fremddatenuebernahme \|q application/pdf \|u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916773&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA \|3 Inhaltsverzeichnis
856	4	2	\|m Springer Fremddatenuebernahme \|q application/pdf \|u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916773&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA \|3 Abstract
912			\|a ZDB-2-SBL
940	1		\|q ZDB-2-SBL_2015
999			\|a oai:aleph.bib-bvb.de:BVB01-027916773
966	e		\|u https://doi.org/10.1007/978-3-319-14965-3 \|l TUM01 \|p ZDB-2-SBL \|x Verlag \|3 Volltext
966	e		\|u https://doi.org/10.1007/978-3-319-14965-3 \|l UBT01 \|p ZDB-2-SBL \|x Verlag \|3 Volltext

Record in the Search Index

_version_	1804153211426177024
adam_text	UBIQUITIN CHAINS: DEGRADATION AND BEYOND / DE, ARNAB : 2015 TABLE OF CONTENTS / INHALTSVERZEICHNIS 1 IMMUNE HOMEOSTASIS: ACTIVATION AND DOWNREGULATION OF NF-ΚB 2 REGULATION OF NF-ΚB SIGNALING BY REGULATORY UBIQUITINATION: SPECIFIC PATHWAYS AND A20 3 THE DEUBIQUITINASE ACTIVITY OF A20 IS DISPENSABLE FOR ITS ROLE IN NF-ΚB SIGNALING 4 PERSPECTIVES ON REGULATORY UBIQUITINATION DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. UBIQUITIN CHAINS: DEGRADATION AND BEYOND / DE, ARNAB : 2015 ABSTRACT / INHALTSTEXT THIS THESIS EXAMINES THE EVIDENCE FOR REGULATORY UBIQUITINATION BY FOCUSING ON A20. IT PROVIDES AN INSIGHTFUL AND IN-DEPTH EVALUATION OF THE CURRENT LITERATURE BY CRITICALLY EXAMINING THE EVIDENCE OF K63-LINKED REGULATORY UBIQUITINATION IN REGULATING CELL-SIGNALLING. IT IS ALSO THE FIRST THESIS TO DIRECTLY TEST THE ROLE OF REGULATORY UBIQUITINATION IN NF-KB SIGNALING IN VIVO. THE CASE FOR REGULATORY UBIQUITINATION HAS BEEN TO A LARGE EXTENT PREDICATED UPON THE PRESUMED DEUBIQUITINASE ACTIVITY OF A20, LONG CONSIDERED A KEY REGULATOR OF INFLAMMATORY RESPONSES AS MICE LACKING A20 DIE FROM MULTI-ORGAN INFLAMMATION AND CACHEXIA. THE THESES REPORTS THE CREATION AND CHARACTERIZATION OF A KNOCK-IN MOUSE THAT EXPRESSES A MUTATED FORM OF A20 WHICH SELECTIVELY LACKS THE DEUBIQUITINASE ACTIVITY. THE KNOCK-IN MICE SURPRISINGLY DISPLAY COMPLETELY NORMAL NF-ΚB ACTIVATION WITH NO ACCOMPANYING INFLAMMATORY PHENOTYPE.GIVEN THAT THE PRESUMED ROLE OF A20 AS A DEUBIQUITINASE HAS BEEN USED TO SUPPORT THE IMPORTANCE OF REGULATORY K63-LINKED UBIQUITINATION IN NF-KB SIGNALING, THIS STUDY WILL HELP FOCUS FUTURE RESEARCH EFFORTS INTO ALTERNATIVE TARGET PATHWAYS THAT DO NOT DEPEND ON K63 UBIQUITINATION. IN FACT, THE WORK SUGGESTS THAT IT MIGHT BE IMPORTANT TO REVISIT THE ROLE OF K63-LINKED POLYUBIQUITINATION IN CELL-SIGNALLING. UBIQUITIN CHAINS: DEGRADATION AND BEYOND IS ESSENTIAL READING FOR ANYONE CONDUCTING RESEARCH IN CELL-SIGNALLING AND IMMUNOLOGY. DR. ARNAB DE RECEIVED HIS PHD FROM THE DEPARTMENT OF MICROBIOLOGY & IMMUNOLOGY AT COLUMBIA UNIVERSITY. DURING HIS PHD, HE DEVELOPED TRANSGENIC MICE TO STUDY THE MECHANISM OF ACTION OF A CRITICAL TUMOR-SUPPRESSOR CALLED A20. HE IS ALSO WELL KNOWN FOR HAVING DEVELOPED PEPTIDE-BASED PRODRUGS AS THERAPEUTICS FOR DIABETES. HIS WORK HAS BEEN REPORTED BY THE MEDIA, AND HAS RESULTED IN MULTIPLE PATENTSAND PUBLICATIONS IN PEER REVIEWED JOURNALS.HE PRESENTED HIS FINDINGS AT THE AMERICAN PEPTIDE SYMPOSIUM AND WAS AWARDED THE YOUNG INVESTIGATOR’S AWARD. HE IS THE AUTHOR OF THE BOOK ENTITLED APPLICATION OF PEPTIDE-BASED PRODRUG CHEMISTRY IN DRUG DEVELOPMENT, WITH A FOREWORD WRITTEN BY PROFESSOR JEAN MARTINEZ (FORMER PRESIDENT, EUROPEAN PEPTIDE SOCIETY) AND PUBLISHED IN THE SERIES SPRINGERBRIEFS IN PHARMACEUTICAL SCIENCE & DRUG DEVELOPMENT. HIS RESEARCH INTERESTS LIE AT THE INTERSECTION OF CHEMISTRY AND MEDICINE. BESIDES BIOMEDICAL RESEARCH, HE IS ALSO GENERALLY INTERESTED IN PUBLIC HEALTH POLICY AND GENERAL SCIENTIFIC OUTREACH DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
any_adam_object	1
author	De, Arnab
author_facet	De, Arnab
author_role	aut
author_sort	De, Arnab
author_variant	a d ad
building	Verbundindex
bvnumber	BV042481814
classification_tum	BIO 000
collection	ZDB-2-SBL
ctrlnum	(OCoLC)906188410 (DE-599)BVBBV042481814
dewey-full	572.6
dewey-hundreds	500 - Natural sciences and mathematics
dewey-ones	572 - Biochemistry
dewey-raw	572.6
dewey-search	572.6
dewey-sort	3572.6
dewey-tens	570 - Biology
discipline	Biologie
doi_str_mv	10.1007/978-3-319-14965-3
format	Thesis Electronic eBook
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02233nmm a2200529zc 4500</leader><controlfield tag="001">BV042481814</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20150410 </controlfield><controlfield tag="006">a m\|\|\| 00\|\|\| </controlfield><controlfield tag="007">cr\|uuu---uuuuu</controlfield><controlfield tag="008">150402s2015 \|\|\|\| o\|\|u\| \|\|\|\|\|\|eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783319149653</subfield><subfield code="c">Online</subfield><subfield code="9">978-3-319-14965-3</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/978-3-319-14965-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)906188410</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV042481814</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-91</subfield><subfield code="a">DE-703</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">572.6</subfield><subfield code="2">23</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIO 000</subfield><subfield code="2">stub</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">De, Arnab</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Ubiquitin Chains</subfield><subfield code="b">Degradation and Beyond</subfield><subfield code="c">Arnab De</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Cham [u.a.]</subfield><subfield code="b">Springer International Publishing</subfield><subfield code="c">2015</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (XV, 103 p. 45 illus., 33 illus. in color)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Springer Theses</subfield><subfield code="x">2190-5053</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="a">Zugl.: New York, NY, Columbia University, Diss.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Life sciences</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biochemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cell cycle</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Life Sciences</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Protein Science</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cell Cycle Analysis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biowissenschaften</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druckausgabe</subfield><subfield code="z">978-3-319-14964-6</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1007/978-3-319-14965-3</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Springer Fremddatenuebernahme</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916773&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Springer Fremddatenuebernahme</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916773&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Abstract</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-2-SBL</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">ZDB-2-SBL_2015</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-027916773</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-3-319-14965-3</subfield><subfield code="l">TUM01</subfield><subfield code="p">ZDB-2-SBL</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-3-319-14965-3</subfield><subfield code="l">UBT01</subfield><subfield code="p">ZDB-2-SBL</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection>
genre	(DE-588)4113937-9 Hochschulschrift gnd-content
genre_facet	Hochschulschrift
id	DE-604.BV042481814
illustrated	Not Illustrated
indexdate	2024-07-10T01:23:00Z
institution	BVB
isbn	9783319149653
issn	2190-5053
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-027916773
oclc_num	906188410
open_access_boolean
owner	DE-91 DE-BY-TUM DE-703
owner_facet	DE-91 DE-BY-TUM DE-703
physical	1 Online-Ressource (XV, 103 p. 45 illus., 33 illus. in color)
psigel	ZDB-2-SBL ZDB-2-SBL_2015
publishDate	2015
publishDateSearch	2015
publishDateSort	2015
publisher	Springer International Publishing
record_format	marc
series2	Springer Theses
spelling	De, Arnab Verfasser aut Ubiquitin Chains Degradation and Beyond Arnab De Cham [u.a.] Springer International Publishing 2015 1 Online-Ressource (XV, 103 p. 45 illus., 33 illus. in color) txt rdacontent c rdamedia cr rdacarrier Springer Theses 2190-5053 Zugl.: New York, NY, Columbia University, Diss. Life sciences Immunology Biochemistry Cell cycle Life Sciences Protein Science Cell Cycle Analysis Biowissenschaften (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Druckausgabe 978-3-319-14964-6 https://doi.org/10.1007/978-3-319-14965-3 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916773&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916773&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract
spellingShingle	De, Arnab Ubiquitin Chains Degradation and Beyond Life sciences Immunology Biochemistry Cell cycle Life Sciences Protein Science Cell Cycle Analysis Biowissenschaften
subject_GND	(DE-588)4113937-9
title	Ubiquitin Chains Degradation and Beyond
title_auth	Ubiquitin Chains Degradation and Beyond
title_exact_search	Ubiquitin Chains Degradation and Beyond
title_full	Ubiquitin Chains Degradation and Beyond Arnab De
title_fullStr	Ubiquitin Chains Degradation and Beyond Arnab De
title_full_unstemmed	Ubiquitin Chains Degradation and Beyond Arnab De
title_short	Ubiquitin Chains
title_sort	ubiquitin chains degradation and beyond
title_sub	Degradation and Beyond
topic	Life sciences Immunology Biochemistry Cell cycle Life Sciences Protein Science Cell Cycle Analysis Biowissenschaften
topic_facet	Life sciences Immunology Biochemistry Cell cycle Life Sciences Protein Science Cell Cycle Analysis Biowissenschaften Hochschulschrift
url	https://doi.org/10.1007/978-3-319-14965-3 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916773&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916773&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT dearnab ubiquitinchainsdegradationandbeyond

Holdings

There is no print copy available.

Interlibrary loan Place Request Caution: Not in THWS collection! Get full text

MARC

Record in the Search Index

There is no print copy available.

Similar Items