Ubiquitin Chains: Degradation and Beyond
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cham [u.a.]
Springer International Publishing
2015
|
| Schriftenreihe: | Springer Theses
|
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource (XV, 103 p. 45 illus., 33 illus. in color) |
| ISBN: | 9783319149653 |
| ISSN: | 2190-5053 |
| DOI: | 10.1007/978-3-319-14965-3 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804153211426177024 |
|---|---|
| adam_text | UBIQUITIN CHAINS: DEGRADATION AND BEYOND
/ DE, ARNAB
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
1 IMMUNE HOMEOSTASIS: ACTIVATION AND DOWNREGULATION OF NF-ΚB
2 REGULATION OF NF-ΚB SIGNALING BY REGULATORY UBIQUITINATION: SPECIFIC
PATHWAYS AND A20
3 THE DEUBIQUITINASE ACTIVITY OF A20 IS DISPENSABLE FOR ITS ROLE IN
NF-ΚB SIGNALING
4 PERSPECTIVES ON REGULATORY UBIQUITINATION
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
UBIQUITIN CHAINS: DEGRADATION AND BEYOND
/ DE, ARNAB
: 2015
ABSTRACT / INHALTSTEXT
THIS THESIS EXAMINES THE EVIDENCE FOR REGULATORY UBIQUITINATION BY
FOCUSING ON A20. IT PROVIDES AN INSIGHTFUL AND IN-DEPTH EVALUATION OF
THE CURRENT LITERATURE BY CRITICALLY EXAMINING THE EVIDENCE OF
K63-LINKED REGULATORY UBIQUITINATION IN REGULATING CELL-SIGNALLING. IT
IS ALSO THE FIRST THESIS TO DIRECTLY TEST THE ROLE OF REGULATORY
UBIQUITINATION IN NF-KB SIGNALING IN VIVO. THE CASE FOR REGULATORY
UBIQUITINATION HAS BEEN TO A LARGE EXTENT PREDICATED UPON THE PRESUMED
DEUBIQUITINASE ACTIVITY OF A20, LONG CONSIDERED A KEY REGULATOR OF
INFLAMMATORY RESPONSES AS MICE LACKING A20 DIE FROM MULTI-ORGAN
INFLAMMATION AND CACHEXIA. THE THESES REPORTS THE CREATION AND
CHARACTERIZATION OF A KNOCK-IN MOUSE THAT EXPRESSES A MUTATED FORM OF
A20 WHICH SELECTIVELY LACKS THE DEUBIQUITINASE ACTIVITY. THE KNOCK-IN
MICE SURPRISINGLY DISPLAY COMPLETELY NORMAL NF-ΚB ACTIVATION WITH NO
ACCOMPANYING INFLAMMATORY PHENOTYPE.GIVEN THAT THE PRESUMED ROLE OF A20
AS A DEUBIQUITINASE HAS BEEN USED TO SUPPORT THE IMPORTANCE OF
REGULATORY K63-LINKED UBIQUITINATION IN NF-KB SIGNALING, THIS STUDY WILL
HELP FOCUS FUTURE RESEARCH EFFORTS INTO ALTERNATIVE TARGET PATHWAYS THAT
DO NOT DEPEND ON K63 UBIQUITINATION. IN FACT, THE WORK SUGGESTS THAT IT
MIGHT BE IMPORTANT TO REVISIT THE ROLE OF K63-LINKED POLYUBIQUITINATION
IN CELL-SIGNALLING. UBIQUITIN CHAINS: DEGRADATION AND BEYOND IS
ESSENTIAL READING FOR ANYONE CONDUCTING RESEARCH IN CELL-SIGNALLING AND
IMMUNOLOGY. DR. ARNAB DE RECEIVED HIS PHD FROM THE DEPARTMENT OF
MICROBIOLOGY & IMMUNOLOGY AT COLUMBIA UNIVERSITY. DURING HIS PHD, HE
DEVELOPED TRANSGENIC MICE TO STUDY THE MECHANISM OF ACTION OF A CRITICAL
TUMOR-SUPPRESSOR CALLED A20. HE IS ALSO WELL KNOWN FOR HAVING DEVELOPED
PEPTIDE-BASED PRODRUGS AS THERAPEUTICS FOR DIABETES. HIS WORK HAS BEEN
REPORTED BY THE MEDIA, AND HAS RESULTED IN MULTIPLE PATENTSAND
PUBLICATIONS IN PEER REVIEWED JOURNALS.HE PRESENTED HIS FINDINGS AT THE
AMERICAN PEPTIDE SYMPOSIUM AND WAS AWARDED THE YOUNG INVESTIGATOR’S
AWARD. HE IS THE AUTHOR OF THE BOOK ENTITLED APPLICATION OF
PEPTIDE-BASED PRODRUG CHEMISTRY IN DRUG DEVELOPMENT, WITH A FOREWORD
WRITTEN BY PROFESSOR JEAN MARTINEZ (FORMER PRESIDENT, EUROPEAN PEPTIDE
SOCIETY) AND PUBLISHED IN THE SERIES SPRINGERBRIEFS IN PHARMACEUTICAL
SCIENCE & DRUG DEVELOPMENT. HIS RESEARCH INTERESTS LIE AT THE
INTERSECTION OF CHEMISTRY AND MEDICINE. BESIDES BIOMEDICAL RESEARCH,
HE IS ALSO GENERALLY INTERESTED IN PUBLIC HEALTH POLICY AND GENERAL
SCIENTIFIC OUTREACH
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| discipline | Biologie |
| doi_str_mv | 10.1007/978-3-319-14965-3 |
| format | Thesis Electronic eBook |
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| indexdate | 2024-07-10T01:23:00Z |
| institution | BVB |
| isbn | 9783319149653 |
| issn | 2190-5053 |
| language | English |
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| spelling | De, Arnab Verfasser aut Ubiquitin Chains Degradation and Beyond Arnab De Cham [u.a.] Springer International Publishing 2015 1 Online-Ressource (XV, 103 p. 45 illus., 33 illus. in color) txt rdacontent c rdamedia cr rdacarrier Springer Theses 2190-5053 Zugl.: New York, NY, Columbia University, Diss. Life sciences Immunology Biochemistry Cell cycle Life Sciences Protein Science Cell Cycle Analysis Biowissenschaften (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Druckausgabe 978-3-319-14964-6 https://doi.org/10.1007/978-3-319-14965-3 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916773&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916773&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | De, Arnab Ubiquitin Chains Degradation and Beyond Life sciences Immunology Biochemistry Cell cycle Life Sciences Protein Science Cell Cycle Analysis Biowissenschaften |
| subject_GND | (DE-588)4113937-9 |
| title | Ubiquitin Chains Degradation and Beyond |
| title_auth | Ubiquitin Chains Degradation and Beyond |
| title_exact_search | Ubiquitin Chains Degradation and Beyond |
| title_full | Ubiquitin Chains Degradation and Beyond Arnab De |
| title_fullStr | Ubiquitin Chains Degradation and Beyond Arnab De |
| title_full_unstemmed | Ubiquitin Chains Degradation and Beyond Arnab De |
| title_short | Ubiquitin Chains |
| title_sort | ubiquitin chains degradation and beyond |
| title_sub | Degradation and Beyond |
| topic | Life sciences Immunology Biochemistry Cell cycle Life Sciences Protein Science Cell Cycle Analysis Biowissenschaften |
| topic_facet | Life sciences Immunology Biochemistry Cell cycle Life Sciences Protein Science Cell Cycle Analysis Biowissenschaften Hochschulschrift |
| url | https://doi.org/10.1007/978-3-319-14965-3 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916773&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916773&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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