Antibody-Drug Conjugates: The 21st Century Magic Bullets for Cancer
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cham [u.a.]
Springer
2015
|
| Schriftenreihe: | AAPS Advances in the Pharmaceutical Sciences Series
17 |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource (X, 252 p. 59 illus., 32 illus. in color) |
| ISBN: | 9783319130811 |
| DOI: | 10.1007/978-3-319-13081-1 |
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Datensatz im Suchindex
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|---|---|
| adam_text | ANTIBODY-DRUG CONJUGATES
/ WANG, JEFFREY
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
1 ANTIBODY-DRUG CONJUGATES: A HISTORICAL REVIEW
2 PAYLOADS OF ANTIBODY-DRUG CONJUGATES
3 SELECTING AN OPTIMAL ANTIBODY FOR ANTIBODY-DRUG CONJUGATE THERAPY
4 LINKER DESIGN FOR ANTIBODY-DRUG CONJUGATES
5 FORMULATION DEVELOPMENT FOR ANTIBODY-DRUG CONJUGATES
6 BIOANALYTICAL ASSAY FOR CHARACTERIZATION OF ANTIBODY DRUG CONJUGATES
7 PHARMACOKINETICS/PHARMACODYNAMICS AND DISPOSITION OF ANTIBODY-DRUG
CONJUGATES
8 REGULATORY CONSIDERATIONS
9 MAJOR ADC COMPANIES, CURRENT CLINICAL TRIALS, RECENT PATENTS ISSUED
AND PATENT APPLICATIONS, AND COST ANALYSIS OF DRUG THERAPY
10 MYLOTARG: REVISITING ITS CLINICAL POTENTIAL POST-WITHDRAWAL
11 ADCETRIS: A REGULATORY CASE STUDY OF A NEW GENERATION ANTIBODY DRUG
CONJUGATE
12 ADO-TRASTUZUMAB EMTANSINE
13 THE ANTIBODY-DRUG CONJUGATE GLEMBATUMUMAB VEDOTIN (CDX-011) AND ITS
USE IN TREATMENT OF BREAST CANCER
14 SUMMARY AND FUTURE DIRECTIONS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
ANTIBODY-DRUG CONJUGATES
/ WANG, JEFFREY
: 2015
ABSTRACT / INHALTSTEXT
THIS AUTHORITATIVE VOLUME PROVIDES A HOLISTIC PICTURE OF ANTIBODY-DRUG
CONJUGATES (ADCS). FOURTEEN COMPREHENSIVE CHAPTERS ARE DIVIDED INTO SIX
SECTIONS INCLUDING AN INTRODUCTION TO ADCS, THE ADC CONSTRUCT,
DEVELOPMENT ISSUES, LANDSCAPE, IP AND PHARMACOECONOMICS, CASE STUDIES,
AND THE FUTURE OF THE FIELD. THE BOOK EXAMINES EVERYTHING FROM THE
SELECTION OF THE ANTIBODY, THE DRUG, AND THE LINKER TO A DISCUSSION OF
DEVELOPMENTAL ISSUES SUCH AS FORMULATIONS, BIO-ANALYSIS,
PHARMACOKINETIC-PHARMACODYNAMIC RELATIONSHIPS, AND TOXICOLOGICAL AND
REGULATORY CHALLENGES. IT ALSO EXPLORES PHARMACOECOMONICS AND
INTELLECTUAL PROPERTIES, INCLUDING RECENTLY ISSUED PATENTS AND THE COST
ANALYSIS OF DRUG THERAPY. CASE STUDIES ARE PRESENTED FOR THE THREE ADCS
THAT HAVE RECEIVED FDA APPROVAL: GEMTUZUMAB OZOGAMICIN (MYLOTARG),
BRENTUXIMAB VEDOTIN (ADCETRIS), AND ADO-TRASTUZUMAB EMTANSINE
(KADCYLA), AS WELL AS AN ADC IN LATE-STAGE CLINICAL TRIALS,
GLEMBATUMUMAB VEDOTIN (CDX-011). FINALLY, THE VOLUME PRESENTS A
PERSPECTIVE BY THE EDITORS ON THE FUTURE DIRECTIONS OF ADC DEVELOPMENT
AND CLINICAL APPLICATIONS. ANTIBODY-DRUG CONJUGATES IS A PRACTICAL AND
SYSTEMATIC RESOURCE FOR SCIENTISTS, PROFESSORS, AND STUDENTS INTERESTED
IN EXPANDING THEIR KNOWLEDGE OF CUTTING-EDGE RESEARCH IN THIS EXCITING
FIELD
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| spelling | Antibody-Drug Conjugates The 21st Century Magic Bullets for Cancer Jeffrey Wang, Wei-Chiang Shen, Jennica L. Zaro, ed. Cham [u.a.] Springer 2015 1 Online-Ressource (X, 252 p. 59 illus., 32 illus. in color) txt rdacontent c rdamedia cr rdacarrier AAPS Advances in the Pharmaceutical Sciences Series 17 Medicine Pharmaceutical technology Biomedicine Pharmaceutical Sciences/Technology Medizin Wang, Jeffrey Sonstige oth Shen, Wei-Chiang Sonstige oth Zaro, Jennica L. Sonstige oth Erscheint auch als Druckausgabe 978-3-319-13080-4 AAPS Advances in the Pharmaceutical Sciences Series 17 (DE-604)BV041360401 17 https://doi.org/10.1007/978-3-319-13081-1 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916694&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027916694&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Antibody-Drug Conjugates The 21st Century Magic Bullets for Cancer AAPS Advances in the Pharmaceutical Sciences Series Medicine Pharmaceutical technology Biomedicine Pharmaceutical Sciences/Technology Medizin |
| title | Antibody-Drug Conjugates The 21st Century Magic Bullets for Cancer |
| title_auth | Antibody-Drug Conjugates The 21st Century Magic Bullets for Cancer |
| title_exact_search | Antibody-Drug Conjugates The 21st Century Magic Bullets for Cancer |
| title_full | Antibody-Drug Conjugates The 21st Century Magic Bullets for Cancer Jeffrey Wang, Wei-Chiang Shen, Jennica L. Zaro, ed. |
| title_fullStr | Antibody-Drug Conjugates The 21st Century Magic Bullets for Cancer Jeffrey Wang, Wei-Chiang Shen, Jennica L. Zaro, ed. |
| title_full_unstemmed | Antibody-Drug Conjugates The 21st Century Magic Bullets for Cancer Jeffrey Wang, Wei-Chiang Shen, Jennica L. Zaro, ed. |
| title_short | Antibody-Drug Conjugates |
| title_sort | antibody drug conjugates the 21st century magic bullets for cancer |
| title_sub | The 21st Century Magic Bullets for Cancer |
| topic | Medicine Pharmaceutical technology Biomedicine Pharmaceutical Sciences/Technology Medizin |
| topic_facet | Medicine Pharmaceutical technology Biomedicine Pharmaceutical Sciences/Technology Medizin |
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