Neural surface antigens: from basic biology towards biomedical applications
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| Format: | Buch |
| Sprache: | English |
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Amsterdam [u.a.]
Elsevier Acad. Press
2015
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| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 235 S. Ill., graph. Darst. |
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Datensatz im Suchindex
| _version_ | 1804153158938656768 |
|---|---|
| adam_text | Titel: Neural surface antigens
Autor: Pruszak, Jan Friedrich
Jahr: 2015
Contents
Contributors
Foreword
Preface
1. Fundamentals of Neurogenesis and
Neural Stem Cell Development
1.1 Neurulation: Formation of the Central
Nervous System Anlage
1.2 Neurulation and Neural Tube Formation
1.3 Regionalization of the Mammalian Neural
Tube
1.3.1 Molecular Basis of Regionalization
1.3.2 Structural Organization of Cellular
Compartments and Boundaries in the
Developing Neural Tube
1.4 Onset of Neurogenesis in the
Telencephalon
1.5 The Transition of the Neurepithelium to
Neural Stem Cells
1.5.1 Asymmetric versus Symmetric Cell
Divisions
1.6 Progenitor Fate Commitment and
Restriction
1.6.1 The Common Progenitor Model
1.6.2 Multiple Progenitor Model
1.7 Molecular Mechanisms of Neural Stem Cell
Maintenance
1.7.1 Notch Signaling as a Key Regulator in
Maintenance of NSCs
1.8 Interneuron Generation from the Ventral
Telencephalon
1.9 Formation of the Cerebral Isocortex and
Cortical Layering
1.10 Oligodendrogenesis and Astrogenesis
1.10.1 Fluman Neocorticogenesis
References
2. A Brief Introduction to Neural Flow
Cytometry from a Practical Perspective
Geoffrey W. Osborne
xi 2.3 Challenges and Opportunities of Neural
xiii Flow Cytometry 17
XV 2.4 Cell Sorting of Neural Cells—Step by Step 18
2.5 Flow Cytometric Analysis of NSCs 20
2.6 Flow Cytometry of Neurons 20
2.7 Flow Cytometric Analysis of Glial Cell
Types 22
r 2.8 Conclusion 24
References 24
1
1
2
2
3. CD36, CD44, and CD83 Expression and
Putative Functions in Neural Tissues
Isaias Glezer, Serge Rivest and
Andre Machado Xavier
27
2.1 Introduction
2.2 What ls . Flow Cytometry?
3.1 Introduction
4 3.2 The Putative CD36 Functions in the CNS:
A Multifunctional Scavenger Receptor
4 and Lipid Sensor 27
3.2.1 CD36 Structure and General
4 Functions 27
3.2.2 Cd36 Gene Expression Maps to
6 Olfactory Relays and Reproductive
Behavior-Associated Brain Regions 29
6 3.2.3 CD36 Functions in the Nervous
6 System 29
6 3.3 The Expression of CD44 Adhesion Molecule
in Neural Cells 30
7 3.3.1 CD44 Structure and General
Functions 30
7 3.3.2 Constitutive Murine Cd44 Gene
Expression Maps to Intralaminar
8 Nuclei of the Thalamus and Few
Other Limited Nuclei of the CNS 31
9 3.3.3 CD44 Glycoprotein Expression and
9 Functions in the Nervous System 32
10 3.4 The Glycoprotein CD83 33
11 3.4.1 CD83 Structure and General Functions 33
3.4.2 Neuronal Cd83 Gene Expression is
Widespread in Murine Brain, albeit
Not Ubiquitous 34
3.4.3 Possible CD83 Functions in the
Nervous System 34
15 3.5 Concluding Remarks 36
15 References 36
vi Contents
4. Life and Death in the CNS: The Role
of CD95
Si Chen, Robert Hermann, Enric Llorens-Bobadilla
and Ana Martin-Villalba
4.1 Introduction
4.2 CD95 Expression in the Healthy and
Diseased Brain
4.2.1 CD95 Expression in the Developing
and Healthy Adult Brain
4.2.2 CD95 Expression after Brain Injury
4.2.3 CD95 Expression in Brain Tumors
4.2.4 Controversies Regarding CD95
Detection
4.3 Functions and Signaling of CD95 in the CNS
4.3.1 CD95-Mediated Neurite Growth in
Neurons
4.3.2 Functional Relevance of CD95 in the
Injured CNS
4.3.3 RoleofCD95 in Neural Progenitors
4.3.4 Multifaceted Functions of CD95 in
Brain Tumors
4.4 Conclusions
References
5. Role of Fundamental Pathways of
Innate and Adaptive Immunity in Neural
Differentiation: Focus on Toll-like
Receptors, Complement System, and
T-Cell-Related Signaling
Helene Boudin and Antoine Louveau
41 6.7
42
6.8
42
43 6.9
43
6.10
43 6.11
43 6.12
43
6.13
44
45 6.14
46 6.15
51
51 6.16
6.17
5.1
5.2
5.3
Molecules from Innate Immunity 55
5.1.1 Toll-Like Receptors 55
5.1.2 Complement System 58
Molecules from Adaptive Immunity 59
5.2.1 Major Histocompatibility Complex
Molecules 59
5.2.2 Costimulatory Molecules 60
5.2.3 CD3£ 60
Conclusion 62
References 62
6. Neuropilins in Development and
Disease of the Nervous System
Mathew Tata, Miguel Tillo and Christiana Ruhrberg
6.1
6.2
6.3
6.4
65
65
Introduction
Neuropilins Associate with Plexins to
Mediate Semaphorin Signaling
Neuropilins and Plexins Cooperate to
Confer Specificity to Semaphorin Signaling 66
Neuropilin-Mediated Repulsion in Axon
Guidance 66
6.5 Neuropilins Can Mediate Attractive
Responses by Axons to Semaphorins 67
6.6 Neuropilins Organize Axon Projections
to Provide a Substrate for Migrating
Neurons 67
Semaphorin Signaling through
Neuropilins in Neurons Promotes
Neuronal Migration 67
VEGF-A as an Alternative Neuropilin
Ligand in the Nervous System 68
Differential VEGF-A Isoform Affinity
for the Two Neuropilins 68
VEGF-A Signaling through Neuropilin 1 68
NRP1 in CNS Angiogenesis 70
VEGF-A/NRP1 Signaling Promotes
Contralateral Axon Projection across
the Optic Chiasm 70
VEGF-A Signals through NRP1 to Promote
Neuronal Migration 70
Semaphorin Signaling through NRP1
Impairs CNS, but not PNS Regeneration 71
VEGF Signaling through NRP1 Promotes
Survival of Developing Neurons 71
Neuropilin in Synaptogenesis and
Plasticity 71
Outlook 72
References 72
Growth and Neurotrophic Factor
Receptors in Neural Differentiation
and Phenotype Specification
Talita Glaser, Agatha Oliveira, Laura Sarda-Arroyo
and Henning Ulrich
7.1 Introduction 77
7.2 Neurotrophins 77
7.3 Nerve Growth Factor 79
7.4 Brain-Derived Neurotrophic Factor 82
7.5 Neurotrophin-3 82
7.6 Epidermal Growth Factor 83
7.7 Fibroblast Growth Factor 83
7.8 Glial Cell Line-Derived Neurotrophic
Factor 84
7.9 Insulin-like Growth Factor 85
7.10 Conclusion 86
References 86
8. Glycolipid Antigens in Neural Stem
Cells
Yutaka Itokazu and Robert K. Yu
8.1 Introduction
8.1.1 Glycosphingolipids and
Development
8.1.2 Gangliosides
91
91
91
91
Contents vii
8.2 Stage-Specific Embryonic Antigen-1
(CD15) 93
8.2.1 SSEA-1 in Early Embryogenesis 93
8.2.2 SSEA-1 in Neural Stem Cells 94
8.2.3 SSEA-1 and Integrin 94
8.2.4 SSEA-1 and Notch Signaling 95
SSEA-4 95
GD3 Ganglioside 95
8.4.1 GD3 as a Specific Marker for NSCs 95
8.4.2 GD3-Synthase-KO NSCs 95
8.4.3 GD3 and Endocytosis 96
9-O-acetyl GD3 96
GM1 Ganglioside 96
8.6.1 GM1 and Its Epigenetic
Regulation 96
8.6.2 Integrin-Focal Adhesion Kinase
Signaling 97
8.7 The C-series Gangliosides 97
8.8 GalCer and Sulfatide 97
8.9 Sialosyl Galactosylceramide 97
8.10 Phosphatidylglucoside 98
8.11 Conclusions and Prospective Studies 98
Acknowledgments 99
References 99
8.3
8.4
8.5
8.6
10. Comprehensive Overview of
CD133 Biology in Neural Tissues
across Species
Jozsef Jaszai, Denis Corbeil and
Christine A. Fargeas
10.1 Introduction
10.1.1 CD133
10.1.2 Detecting Mammalian (Mouse and
Human) CD133
10.1.3 CD133: A Unique Cell Surface
Antigen for Cell-Based Therapy
and Tissue Engineering
10.2 Cell Biology of CD133 Protein in the
Nervous System
10.2.1 CD133+ Membrane Particles
10.2.2 Symmetric versus Asymmetric
Distribution of CD133
10.3 Compartmentalization of CD133 in
Mammalian Neural Tissues
10.3.1 Developing Mammalian Brain
10.3.2 Adult Mammalian Brain
10.4 CD133+ Neural Stem and Progenitor
Cells across Species
113
113
115
117
117
117
118
118
119
119
120
NG2 (Cspg4): Cell Surface Proteoglycan 10.5 CD133+ Cells and Regeneration 122
on Oligodendrocyte Progenitor Cells 10.6 CD133 and Neural Diseases 122
in the Developing and Mature Nervous 10.7 CD133 and Photoreceptor Neuron
System Morphogenesis 123
Acknowledgments 124
Akiko Nishiyama, Aaron Lee and References 124
Christopher B. Brunquell
9.1 Introduction 103 11. Fundamentals of NCAM Expression,
9.2 The Structure of NG2 103 Function, and Regulation of
9.2.1 NG2 in Different Species 104 Alternative Splicing in Neuronal
9.3 Expression of NG2 in the Nervous Differentiation
System 105 Ana Fiszbein, Ignacio E. Schor and Alberto R. Kornblihtt
9.3.1 NG2 in the Central Nervous System 105
9.3.2 NG2 in the Peripheral Nervous
System 106 11.1 Introduction 131
9.4 The Role of NG2 in Cell Attachment and 11.2 NCAM Gene and Alternative Splicing
Migration 106 Isoforms 131
9.5 The Role of NG2 in Axon-NG2 Cell 11.3 Molecular Structure and Function
Interactions 107 of NCAM 133
9.5.1 NG2 and Developing Axons 107 11.4 Alternative Splicing Regulation 134
9.5.2 NG2 and Axons in the Injured CNS 107 11.5 Chromatin Structure Regulates
9.6 The Role of NG2 in Cell Proliferation 108 Alternative Splicing 135
9.7 The Role of NG2 in Intracellular 11.6 Background in NCAM Alternative
Signaling 109 Splicing Regulation 136
9.7.1 Activation of Rho Family GTPases 109 11.7 Regulation of NCAM Alternative
9.7.2 Extracellular Signal-Regulated Kinase Splicing by Chromatin Changes in
Signaling 109 Neuronal Differentiation 136
9.7.3 Akt Signaling 110 11.8 Conclusions 137
9.8 Concluding Remarks 110 Acknowledgments 138
References 110 References 138
viii Contents
12. Role of the Clustered Protocadherins
in Promoting Neuronal Diversity and
Function
Takeshi Yagi
12.1 Introduction 141
12.2 The Cadherin Superfamily and the
Clustered Pcdhs 141
12.3 Genomic Structures of the Clustered
Pcdh Genes 142
12.4 Gene Expression of the Clustered Pcdhs 143
12.5 Gene Regulation of the Clustered Pcdhs 144
12.6 Cell Adhesion Activity of the
Clustered Pcdhs
12.7 Cell Signaling Mediated by the
Clustered Pcdhs
12.8 Roles of Clustered Pcdhs in the
Nervous System
12.9 Conclusions
References
13. pi -Integrin Function and Interplay
during Enteric Nervous System
Development
Sylvie Dufour, Florence Broders-Bondon and
Nadege Bondurand
13.1 Introduction 153
13.2 Functions of the ECM and Integrins
during ENS Development 154
13.2.1 ECM and Integrin Expression
during ENS Development 154
13.2.2 Integrin Function during ENCC
Migration and ENS Development 155
13.3 Effectors of the Integrin Signaling
Pathway during ENS Development 156
13.3.1 Phactr-4 and Integrin Signaling 156
13.3.2 Role of Phosphatase and Tensin
Homolog 157
13.3.3 Roles of Integrin-Linked Kinase
and Pinch 157
13.3.4 Role of FAK 158
13.4 p1-Integrin Crosstalk with ENS
Genes and N-Cadherin during ENS
Development 158
13.4.1 Interplay between pi -Integrins
and SOX 10 158
13.4.2 pi-Integrins and GDNF/RET
Crosstalk 158
13.4.3 pi-Integrins and N-Cadherin
Crosstalk 159
13.5 Control of Integrin Gene Expression 161
13.5.1 Organization of 5 Regions/
Promoters 161
13.5.2 Control of Integrin Gene Expression
by SP1 and Interacting TFs 161
13.5.3 Control of Integrin Gene Expression
by other TFs 161
13.5.4 Posttranscriptional Control of
Integrin Expression by MicroRNAs 162
13.6 Conclusion 162
References 162
14. Neural Flow Cytometry - A Historical
Account from a Personal Perspective
Henry J. Klassen
147 14.1 Surface Markers on Neural
Progenitor Cells 168
147 14.2 CD15 169
14.3 CD133 169
148 14.4 GD2 Ganglioside 169
148 14.5 Tetraspanins: CD9 and CD81 169
149 14.6 MHC 170
14.7 Fas/CD95 171
14.8 Retinal Progenitor Cells 171
14.9 Further Studies of Surface Markers 171
14.10 Conclusions 171
References 172
15. Multimarker Flow Cytometric
Characterization, Isolation and
Differentiation of Neural Stem Cells
and Progenitors of the Normal and
Injured Mouse Subventricular Zone
Krista D. Buono, Matthew T. Goodus, Lisamarie
Moore Amber N. Ziegler and Steven W. Levison
Introduction
Neural Stem Cells and Progenitors
Flow Cytometric Studies on Neural
Precursors - Technical Considerations
Flow Cytometry Studies of the Fetal
Mouse Forebrain
Studies Using Flow Cytometry on the
Neonatal SVZ
Studies Using Flow Cytometry on the
Adult SVZ
Using Flow Cytometry to Evaluate
Effects of Cytokines and Growth
Factors on Neural Precursors
Using Flow Cytometry to Evaluate
Effects of Neurological Injuries and
Diseases on Neural Precursors
Using Flow Cytometry to Better
Understand Glioblastoma 18^
15.10 Conclusion 18/
References 182
15.1
15.2
15.3
15.4
15.5
15.6
15.7
15.8
15.9
175
175
176
178
178
181
182
182
Contents ix
16. Multiparameter Flow Cytometry
Applications for Analyzing and
Isolating Neural Cell Populations
Derived from Human Pluripotent
Stem Cells
Nil Emre, Jason G. Vidal, Christopher Boyce,
Lissette Wilensky, Mirko Corselli and
Christian T. Carson
16.1 Introduction 187
16.2 Methods for Neural Differentiation of
Human Pluripotent Stem Cells 187
16.3 Cell Surface Signatures for Neural Cell
Isolation from Pluripotent Stem Cells 188
16.4 Neural Applications for Multiparameter
Flow Cytometry 190
16.4.1 Neural Fate Determination 190
16.4.2 In vitro Disease Modeling 190
16.5 Cell Transplantation 192
16.6 The Detection of Intracellular Antigens
by Flow Cytometry 192
16.7 The Utility of Flow Cytometry for
Analyzing Human PSC-Derived
Neural Cells 193
16.8 Cell Surface Marker Screening
Applications for Nonneural Stem Cell
Populations 193
16.9 Pluripotent Stem Cells and Their
Derivatives 194
16.10 Adult Stem Cells 195
16.11 Cancer Stem Cells 195
16.12 Conclusions and Future
Considerations 196
References 196
17. Flow-Cytometric Identification
and Characterization of Neural
Brain Tumor-Initiating Cells for
Pathophysiological Study and
Biomedical Applications
Sujeivan Mahendram, Minomi K. Subapanditha,
Nicole McFarlane, Chitra Venugopal and
Sheila K. Singh
17.5.4 High Aldehyde Dehydrogenase
Activity 203
17.6 Flow-Cytometric Identification and
Characterization 203
17.7 Limitations of Current CSC Markers 204
17.7.1 Hypoxia 204
17.7.2 Cell Dissociation Methods 205
17.7.3 Dynamic Growth 206
17.8 Applications of Functional BTIC Assays 206
17.8.1 Neurosphere Formation 206
17.8.2 In vivo Serial Transplantation 207
17.9 Conclusion 208
References 208
18. Using Cell Surface Signatures to Dissect
Neoplastic Neural Cell Heterogeneity
in Pediatric Brain Tumors
Tamra Werbowetski-Ogilvie
18.1
18.2
18.3
18.4
18.5
18.6
18.7
Cell Surface Markers to Distinguish
Heterogeneity in the Neural Lineage
Hierarchy
Medulloblastoma: An Example of
Genomic, Molecular, and Cellular
Heterogeneity
The CSC Hypothesis and Brain Tumors
In Search of New Markers: The Case
for CD271/p75NTR
CD271: Its Role in Neurodevelopment
and Progenitor/Stem Cell Function
Extending beyond CD133: Using
High-Throughput Flow Cytometry to
Identify Novel Markers of Neural Tumor
Cell Phenotypes
Clinical Implications of Cell Surface
Signatures in MB and Other Brain
Tumor Pathologies
References
213
214
214
215
216
218
218
219
19. Synopsis and Epilogue: Neural Surface
Antigen Studies in Biology and
Biomedicine—What We Have Learned
and What the Future May Hold
Introduction to Neural Stem Cells 199 Jan Pruszak
Tumors of the Central Nervous System 199 19.1 Introduction
17.2.1 Glioblastoma Multiforme 200 19.2 Progress in Neural Stem Cell and
17.2.2 Medulloblastoma 200 Cancer Biology Hinges Upon
Cancer Stem-Cell Hypothesis 201 Understanding Cell-Cell Interactions
Brain Tumor Initiating Cells 201 19.3 Neural Flow Cytometry and Cell
Identification of Neural Surface Antigens 201 Isolation Are Tricky, but Feasible
17.5.1 CD133 201 19.4 Neural Surface Antigens Are Critical
17.5.2 CD15 202 Mediators of Cellular Crosstalk in
17.5.3 CD271 202 Neurobiology
223
223
224
224
x Contents
19.5 Expression of Even Some of the
Better-Characterized Neural Surface
Antigens Is Exceedingly Complex 225
19.6 Toward an Integrated View of Neural
Surface Antigen Signaling 226
19.7 Neural Surface Antigens Serve as
Valuable Markers for Cell Analysis
and Cell Selection 226
19.8 What s Around the Corner? 226
19.9 Conclusion 227
Acknowledgments 227
References 227
Index 229
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV042453751 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T01:22:10Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027888991 |
| oclc_num | 910585262 |
| open_access_boolean | |
| owner | DE-188 DE-20 |
| owner_facet | DE-188 DE-20 |
| physical | XVI, 235 S. Ill., graph. Darst. |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Elsevier Acad. Press |
| record_format | marc |
| spelling | Neural surface antigens from basic biology towards biomedical applications [ed. by] Jan Pruszak Amsterdam [u.a.] Elsevier Acad. Press 2015 XVI, 235 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Neural stem cells Biochemical markers Biomarker (DE-588)4425928-1 gnd rswk-swf Oberflächenantigen (DE-588)4413248-7 gnd rswk-swf Antigen (DE-588)4002272-9 gnd rswk-swf Nervenstammzelle (DE-588)4714646-1 gnd rswk-swf Nervenzelle (DE-588)4041649-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Nervenstammzelle (DE-588)4714646-1 s Biomarker (DE-588)4425928-1 s Oberflächenantigen (DE-588)4413248-7 s Nervenzelle (DE-588)4041649-5 s Antigen (DE-588)4002272-9 s DE-604 Pruszak, Jan 1975- (DE-588)14195065X edt HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027888991&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Neural surface antigens from basic biology towards biomedical applications Neural stem cells Biochemical markers Biomarker (DE-588)4425928-1 gnd Oberflächenantigen (DE-588)4413248-7 gnd Antigen (DE-588)4002272-9 gnd Nervenstammzelle (DE-588)4714646-1 gnd Nervenzelle (DE-588)4041649-5 gnd |
| subject_GND | (DE-588)4425928-1 (DE-588)4413248-7 (DE-588)4002272-9 (DE-588)4714646-1 (DE-588)4041649-5 (DE-588)4143413-4 |
| title | Neural surface antigens from basic biology towards biomedical applications |
| title_auth | Neural surface antigens from basic biology towards biomedical applications |
| title_exact_search | Neural surface antigens from basic biology towards biomedical applications |
| title_full | Neural surface antigens from basic biology towards biomedical applications [ed. by] Jan Pruszak |
| title_fullStr | Neural surface antigens from basic biology towards biomedical applications [ed. by] Jan Pruszak |
| title_full_unstemmed | Neural surface antigens from basic biology towards biomedical applications [ed. by] Jan Pruszak |
| title_short | Neural surface antigens |
| title_sort | neural surface antigens from basic biology towards biomedical applications |
| title_sub | from basic biology towards biomedical applications |
| topic | Neural stem cells Biochemical markers Biomarker (DE-588)4425928-1 gnd Oberflächenantigen (DE-588)4413248-7 gnd Antigen (DE-588)4002272-9 gnd Nervenstammzelle (DE-588)4714646-1 gnd Nervenzelle (DE-588)4041649-5 gnd |
| topic_facet | Neural stem cells Biochemical markers Biomarker Oberflächenantigen Antigen Nervenstammzelle Nervenzelle Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027888991&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT pruszakjan neuralsurfaceantigensfrombasicbiologytowardsbiomedicalapplications |