Lysosomes and lysosomal diseases:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier, Academic Press
2015
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Methods in cell biology
126 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 398 S., [17] Bl. Ill., graph. Darst. 24 cm |
| ISBN: | 9780128000793 0128000791 |
Internformat
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| 250 | |a 1. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier, Academic Press |c 2015 | |
| 300 | |a XVIII, 398 S., [17] Bl. |b Ill., graph. Darst. |c 24 cm | ||
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| 490 | 1 | |a Methods in cell biology |v 126 | |
| 650 | 4 | |a Lysosomes | |
| 650 | 4 | |a Lysosomal storage diseases | |
| 650 | 4 | |a Phagocytosis | |
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Datensatz im Suchindex
| _version_ | 1804153108155072512 |
|---|---|
| adam_text | Contents
Contributors
..........................................................................................xiii
Preface
...............................................................................................xvii
CHAPTER
1
Methods for Monitoring Lysosomal Morphology
........
ι
Bethan S. Kilpatrick, Emily R. Eden, Leanne
N.
Hockey,
Clare E.
Futter,
Sandip
Patel
Introduction
.......................................................................2
1.
Lysosomal Form
................................................................2
2.
Lysosomal Function
............................................................3
3.
Lysosomal Failure
..............................................................5
4.
Linking Lysosomal Form and Failure
....................................6
5.
Methods
...........................................................................6
6.
Discussion
......................................................................15
Acknowledgments
............................................................16
References
......................................................................16
CHAPTER
2
A Rapid Method for the Preparation of
Ultrapure,
Functional Lysosomes Using Functional
ized
Superparamagnetîc
Iron Oxide Nanoparticles.
.........21
Mathew W. Walker, Emyr Lloyd-Evans
1.
The Endocytic System
......................................................22
2.
The Discovery of Lysosomes and Lysosomal Storage Diseases
23
3.
Biochemical Features of Lysosomes
....................................24
4.
Overview of Methods for Purifying Lysosomes
.....................24
5.
Method for Magnetic Separation of Lysosomes from
Whole Cells
....................................................................28
6.
Technical Considerations
...................................................31
7.
Techniques for Determining Purity of the Lysosomal Fractions
38
8.
Discussion
......................................................................40
Acknowledgments
............................................................41
References
......................................................................
4ł
CHAPTER
3
TFEB and the CLEAR Network
..................................45
Carmine
Settembre,
Diego L. Medina
Introduction
.....................................................................46
1.
TFEB Nuclear
Translocation
Assay
.....................................47
2.
Cell Culture and Treatment
................................................48
References
......................................................................61
vi
Contents
CHAPTER
4
Biosynthesis, Targeting, and Processing of
Lysosomal Proteins: Pulse-Chase Labeling and
Immune Precipitation
.............................................63
Sandra Pohl, Andrej
Hasilik
Introduction
.....................................................................64
Briefly on Functions and Biogenesis of Lysosomes
................64
On Application of Radioactive Isotopes in Studies of
Molecular Forms of Lysosomal Proteins
...............................67
1.
Materials
........................................................................69
2.
Methods
.........................................................................71
3.
Metabolic Labeling and Immune Precipitation of the
Lysosomal Protease Cathepsin
Z
.........................................77
4.
Discussion
......................................................................80
Acknowledgments
............................................................82
References
......................................................................82
CHAPTER
5
Measuring Lysosomal
pH
by Fluorescence
Microscopy.
...........................................................85
Johnathan Canton, Sergio Grinstein
Introduction
.....................................................................86
Instrumentation
................................................................89
Probe Selection
................................................................90
Calibration
......................................................................92
1.
Materials
........................................................................93
2.
Methods
.........................................................................94
Conclusion
......................................................................95
Notes
.............................................................................96
Acknowledgments
............................................................96
References
......................................................................96
CHAPTER
6
Lysosome Fusion in Cultured Mammalian Cells
.....101
Nicholas A. Bright, Lena Wartosch, J. Paul Luzio
1.
Overview of Methods to Study Lysosome Fusion
.................102
2.
Choosing an Assay System
..............................................106
3.
Methods
.......................................................................109
Acknowledgments
..........................................................116
References
....................................................................116
CHAPTER
7
RNAi Screens of Lysosomal Trafficking
................. 119
Saiil Garg, Michael B. Brenner
1.
Methods of Gene Depletion in Lysosomes
........................., 120
Contents
vii
2.
Selection of
Screening
System
..........................................120
3.
Assay Validation
............................................................126
4.
Validation of Hits
...........................................................133
5.
Discussion
....................................................................135
Acknowledgments
..........................................................136
References
....................................................................136
CHAPTER
8
Approaches for Plasma Membrane Wounding
and Assessment of Lysosome-Mediated Repair
Responses
...........................................................139
M.
Corrotte,
T.
Castro-Gomes,
A.B.
Koushik, N.W. Andrews
1.
Overview of Wounding Methods and Plasma Membrane
Repair Mechanisms
........................................................140
2.
Procedures for Plasma Membrane Wounding
......................142
3.
Procedures for Measuring the Extent of Plasma Membrane
Repair
..........................................................................149
4.
Procedures to Measure Exocytosis of Lysosomes
.................152
Acknowledgments
..........................................................157
References
....................................................................157
CHAPTER
9
Imaging Approaches to Measuring Lysosomal
Calcium
...............................................................159
Anthony J. Morgan,
Liarme
с.
Davis, Antony Galione
1.
Endolysosomal Ca2+
.......................................................160
2.
Assessing
Organelle Ca2+:
General Strategies
.....................161
3.
Assessing Endolysosomal Ca2*: Specific Strategies
.............168
4.
Final Remarks
...............................................................189
References.
...................................................................189
CHAPTER
10
Lysosome Electrophysiology....
.............................197
Xi
Z. Zhong, Xian-Ping
Đong
Introduction
...................................................................198
1.
Lysosome
.....................................................................198
2.
Materials
......................................................................203
3.
Methods
.......................................................................204
4.
Discussion
....................................................................210
5.
Summary
......................................................................211
Acknowledgments
..........................................................211
References
....................................................................211
viii Contents
CHAPTER
11
Reconstitution
of Lysosomal Ion Channels into
Artificial Membranes.....
.......................................217
Elisa Venturi,
Rebecca Sitsapesan
Introduction
.................................................................218
1.
The Bilayer Apparatus
..................................................218
2.
Electrical Equipment Used for Single-Channel Recordings..
220
3.
Painting Bilayers
..........................................................222
4.
Ion Channel Incorporation into a Bilayer
..........................223
5.
Single-Channel Current Amplitude and Conductance
Measurements
..............................................,...............225
6.
Choice of Permeant Ion
.................................................227
7.
Measuring the Relative Permeability of Different Ions
........229
8.
Measurements of Liquid Junction Potentials
.....................230
9.
Single-Channel Gating and Measurements of Open
Probability
..................................................................230
10.
Noise Analysis
.............................................................231
11.
Isolation of Native and
Recombinant
Purified Lysosomal
Ion Channels
...............................................................232
12.
Discussion
...................................................................234
References
..................................................................234
CHAPTER
12
Fluorescence Methods for Analysis of Interactions
between Ca2+ Signaling, Lysosomes, and
Endoplasmic Reticulum
........................................237
David
L
Proie,
Cristina
1.
López-Sanjurjo,
Stephen
С.
Tovey,
Colin W. Taylor
1. ER, Lysosomes, andCa2+
Signaling
..................................238
2.
Pharmacological
Tools....................................................240
3.
Fluorescence Methods
.....................................................241
4.
Fluorescence Tools for Analysis of Lysosomes
....................243
5.
Ca2+ Signaling and Lysosomes: Tools and Practical Problems.
245
6.
Single-cell Analyses of
Cytosołic Ca2 +
Signals
...................247
7.
High-throughput Analyses of Cytosolic Ca2+ Signals
...........250
8.
Tracking Interactions between Lysosomes and
ER
by
Fluorescence Microscopy
................................................251
Conclusions
...................................................................254
Acknowledgments
..........................................................254
References
....................................................................255
Contents ix
CHAPTER
13
Methods for the Quantification of Lysosomal
Membrane Permeabilization: A Hallmark
of Lysosomal Cell Death
.......................................261
Sonja
Aits,
Marja Jäättelä, Jesper Nylandsted
Introduction
...................................................................263
Method
1:
Quantification of Cathepsin and
ß-N-acetyl-
glucosaminidase Release into the Cytosol by Enzymatic
Activity Measurement
.....................................................266
1.
Materials
......................................................................266
2.
Protocol
........................................................................267
Method
2:
LMP Visualized by Release of Fluorescent
Dextran to the Cytosol
....................................................271
3.
Materials
......................................................................273
4.
Protocol
........................................................................273
Method
3:
LMP Visualized by Cathepsin
Immunocytochemistry
.....................................................274
5.
Materials
......................................................................275
6.
Protocol
........................................................................275
Method
4:
Detection of Damaged Lysosomes by Galectin-1
and
-3
Translocation
.......................................................278
7.
Materials
......................................................................278
8.
Protocol
........................................................................279
Discussion
.....................................................................281
Acknowledgments
..........................................................283
References
....................................................................283
CHAPTER
14
Measuring the Phagocytic Activity of Cells..
.........287
Nick
Platt,
Paul Fineran
Introduction
.................................................................288
1.
Reasons to Undertake Studies of Phagocytosis
..................289
2.
Components of a Phagocytosis Assay
..............................289
3.
In vitro or In vivo Study?
...............................................289
4.
Methodologies for Analyses of Phagocytosis
.....................290
5.
Selection of Phagocyte Population
...................................291
6.
Choice of Target Particle
...............................................293
7.
Targeting Particles to Specific Phagocytic Receptors
..........294
8.
Detection of Ingested Particles
........................................294
9.
Protocol
1.
Fey Receptor-Mediated Phagocytosis of IgG
Opsonized Sheep Red Blood Cells by
Murine
Macrophages
295
Contents
10.
Materials and Reagents
.................................................295
11.
Equipment
..................................................................296
12.
Protocol
......................................................................296
13.
Protocol
2.
FACS Analysis of Mycobacterium bovis
Internalization by RAW264.7 Cells
.................................298
14.
Materials
.....................................................................299
15.
Equipment
..................................................................300
16.
Summary
....................................................................302
Acknowledgments
........................................................302
References
..................................................................302
CHAPTER
15
Detection and Quantification of Microbial
Manipulation of Phagosomal Function...
................305
Maria Podinovskaia, David G. Russell
Introduction
...................................................................306
An Overview of the Role of the
Macrophage Phagosome
in
Infection
.......................................................................306
The Role of Lysosomes in Microbial Killing
.......................307
Methods Utilized in the Study of Lysosome Function
...........308
1.
Considerations for Choice of Reagents, Cells, and Readouts..
309
2.
Reagents
.......................................................................312
3.
Methods
.......................................................................316
4.
Analytical Platforms, Data Collection and Analysis
.............320
5.
Discussion
....................................................................326
6.
Summary
......................................................................327
Acknowledgments
..........................................................327
Supplementary Data
........................................................328
References
....................................................................328
CHAPTER
16
Measuring Relative Lysosomal Volume for
Monitoring Lysosoma! Storage Diseases
...............331
Danielle
te
Vruchte, Kerri
L
Waliom,
Frances
M.
Platt
1.
Measuring Relative Lysosomal Volume as an Index of
Lysosomal Storage
.........................................................332
2.
In Which Circulating Cell Type Should Relative Lysosomal
Volume Be Measured?
....................................................333
3.
How to Measure Relative Lysosomal Volume in Blood Cells.
334
4.
Methods
.......................................................................336
5.
Summary
......................................................................346
Acknowledgments
..........................................................346
References
....................................................................347
Contents xi
CHAPTER
17
Quantifying Storage Material Accumulation in
TiSSUe Sections
...................................................349
Jonathan D. Cooper, Helen R.E. Brooks, Hemanth R. Nelvagal
Introduction
...................................................................350
1.
Detection of Storage Material
...........................................350
2.
Quantification of Storage Material
.....................................354
Conclusion
....................................................................355
References
....................................................................355
CHAPTER
18
Laboratory Diagnosis of Niemann-Pick Disease
Type C: The
Filipin
Staining Test
...........................357
Marie T. Vanier, Philippe
Latour
Introduction and Rationale
...............................................358
1.
Materials
......................................................................360
2.
Methods
.......................................................................361
3.
Discussion
....................................................................367
Concluding Remarks
.......................................................373
Acknowledgments
..........................................................373
References
....................................................................373
Volumes in Series
.................................................................................377
Index
..................................................................................................389
|
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| id | DE-604.BV042428313 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T01:21:22Z |
| institution | BVB |
| isbn | 9780128000793 0128000791 |
| language | English |
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| physical | XVIII, 398 S., [17] Bl. Ill., graph. Darst. 24 cm |
| publishDate | 2015 |
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| publisher | Elsevier, Academic Press |
| record_format | marc |
| series | Methods in cell biology |
| series2 | Methods in cell biology |
| spelling | Lysosomes and lysosomal diseases ed. by Frances Platt ... 1. ed. Amsterdam [u.a.] Elsevier, Academic Press 2015 XVIII, 398 S., [17] Bl. Ill., graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Methods in cell biology 126 Lysosomes Lysosomal storage diseases Phagocytosis Phagosomes Labortechnik (DE-588)4123602-6 gnd rswk-swf Lysosom (DE-588)4168403-5 gnd rswk-swf Phagozytose (DE-588)4129146-3 gnd rswk-swf Lysosom (DE-588)4168403-5 s Labortechnik (DE-588)4123602-6 s DE-604 Phagozytose (DE-588)4129146-3 s b DE-604 Platt, Frances M. edt Methods in cell biology 126 (DE-604)BV002534878 126 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027863649&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lysosomes and lysosomal diseases Methods in cell biology Lysosomes Lysosomal storage diseases Phagocytosis Phagosomes Labortechnik (DE-588)4123602-6 gnd Lysosom (DE-588)4168403-5 gnd Phagozytose (DE-588)4129146-3 gnd |
| subject_GND | (DE-588)4123602-6 (DE-588)4168403-5 (DE-588)4129146-3 |
| title | Lysosomes and lysosomal diseases |
| title_auth | Lysosomes and lysosomal diseases |
| title_exact_search | Lysosomes and lysosomal diseases |
| title_full | Lysosomes and lysosomal diseases ed. by Frances Platt ... |
| title_fullStr | Lysosomes and lysosomal diseases ed. by Frances Platt ... |
| title_full_unstemmed | Lysosomes and lysosomal diseases ed. by Frances Platt ... |
| title_short | Lysosomes and lysosomal diseases |
| title_sort | lysosomes and lysosomal diseases |
| topic | Lysosomes Lysosomal storage diseases Phagocytosis Phagosomes Labortechnik (DE-588)4123602-6 gnd Lysosom (DE-588)4168403-5 gnd Phagozytose (DE-588)4129146-3 gnd |
| topic_facet | Lysosomes Lysosomal storage diseases Phagocytosis Phagosomes Labortechnik Lysosom Phagozytose |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027863649&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002534878 |
| work_keys_str_mv | AT plattfrancesm lysosomesandlysosomaldiseases |