Personalized epigenetics:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Acad. Press
2015
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| Schriftenreihe: | Translation epigenetics series
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Academic Press is an imprint of Elsevier |
| Beschreibung: | XVII, 591 S. graph. Darst. |
| ISBN: | 9780124201354 |
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Datensatz im Suchindex
| _version_ | 1804153107401146368 |
|---|---|
| adam_text | Titel: Personalized epigenetics
Autor: Tollefsbol, Trygve O
Jahr: 2015
Contents
Contributors xiii
Preface xvii
_I_
OVERVIEW
1. Epigenetics of Personalized Medicine
TRYGVE O. TOLLEFSBOL
1. Introduction 4
2. Epigenetic Variations among Individuals 4
3. Bioinformatics of Personalized Epigenetics 6
4- Diagnostic and Prognostic Epigenetic Approaches to Personalized Medicine 6
5. Environmental Personalized Epigenetics 8
6. Pharmacology and Drug Development of Personalized Epigenetics 8
7. Personalized Epigenetics of Disorders and Disease Management 9
8. Challenges and Future Directions 11
9. Conclusion 11
References 12
_II_
EPIGENETIC VARIATIONS AMONG INDIVIDUALS
2. Interindividual Variability of DNA Methylation
LOUIS P. WATANABE AND NICOLE C. RIDDLE
1. Introduction 18
2. Biochemical Pathways Regulating DNA Methylation 19
3. Challenges in Studying DNA Methylation 21
4. Classification of Epigenotypes 22
5. Early Evidence of Interindividual Variation in DNA Methylation from DNA
Methylation Mutants 23
6. Studies of Natural Variation in DNA Methylation—Model Systems 25
7. Studies of Natural Variation in DNA Methylation—Humans 30
8. Twin Studies 36
9. Methylation Quantitative Trait Loci and Epigenetic Quantitative Trait
Loci Studies 41
vi CONTENTS
10. Impact of Variation in DNA Methylation on Personalized Medicine 42
11. Conclusion 43
List of Acronyms and Abbreviations 44
Acknowledgments 45
References 45
3. Differences in Histone Modifications Between Individuals
CHRISTOPH A. ZIMMERMANN, ANKE HOFFMANN, ELISABETH B. BINDER
AND DIETMAR SPENGLER
1. Introduction 56
2. Chromatin Structure and Histone Modifications 57
3. An Analytical Toolbox for Chromatin Structure and Histone Modifications 59
4. The Discovery of cis-Regulatory Mutations 61
5. An Abundance of cis-Regulatory Mutations 62
6. Cis-Regulatory Mutations Influence Chromatin Structure, Histone
Modifications, and Transcriptional Output 63
7. Cis-Regulatory Mutations Can Act in a Cell-Type-Dependent Manner 67
8. Expression Quantitative Trait Loci, Chromatin Accessibility, and Disease
Pathways 70
9. Chromatin Translates Genetic Variation into Transcriptional Phenotypes 72
10. Prospects for the Analysis of Histone Modifications in Humans 76
List of Acronyms and Abbreviations 77
References 78
4. Individual Noncoding RNA Variations: Their Role in
Shaping and Maintaining the Epigenetic Landscape
EMILY MACHIELA, ANTHONY POPKIE AND LORENZO F. SEMPERE
1. Introduction 84
2. Regulatory Interactions between MicroRNAs and Epigenetic Machinery 86
3. Epigenetic Alterations and Regulation of Trinucleotide Repeats in
Neurodegenerative Diseases 102
4. Long Noncoding RNAs Guide the Epigenetic Machinery and Interfere with
Other Noncoding RNA Functions to Regulate Gene Expression 106
5. Conclusion 110
Glossary 112
List of Acronyms and Abbreviations 113
References 114
5. Personalized Epigenetics: Analysis and Interpretation of
DNA Methylation Variation
HEHUANG XIE
1. Introduction 124
2. DNA Methylation and Demethylation Mechanisms 126
3. Genetic and Epigenetic Variations 129
4. Allelic-Specific DNA Methylation 131
CONTENTS
5. Blood Cellular Heterogeneity and Methylation Variation
6. Brain Cellular Heterogeneity and Methylation Variation
7. Stem Cellular Heterogeneity and Methylation Variation
8. Quantitative Assessment of DNA Methylation Variation
9. Closing Remarks
List of Acronyms and Abbreviations
References
_III
BIOINFORMATICS OF PERSONALIZED
EPIGENETICS
6. Computational Methods in Epigenetics
VANESSA AGUIAR-PULIDO, VICTORIA SUAREZ-ULLOA, JOSE M. EIRIN-LOPEZ,
JAVIER PEREIRA AND GIRI NARASIMHAN
1. Introduction 154
2. Epigenetic Profiling: Heterogeneous Data and Particular Challenges of
Different Epigenetic Factors 155
3. Epigenetic Data Integration and Analysis 161
4- Conclusions and Future Trends 174
List of Acronyms and Abbreviations 175
References 175
_IV_
DIAGNOSTIC AND PROGNOSTIC EPIGENETIC
APPROACHES TO PERSONALIZED MEDICINE
7. Epigenetic Biomarkers in Personalized Medicine
FABIO COPPEDE, ANGELA LOPOMO AND LUCIA MIGLIORE
1. Introduction
2. Cancer
3. Noncancerous Diseases
4- Concluding Remarks
References
8. Epigenetic Fingerprint
LEDA KOVATSI, ATHINA VIDAKI, DOMNIKI FRAGOU AND D. SYNDERCOMBE COURT
Outline 222
1. Introduction 222
2. Identifying a Stain s Tissue Source 225
3. Estimating Biological Age 228
Vll
134
136
138
141
143
144
145
184
189
204
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210
viii CONTENTS
4. Exposure to the Heavy Metals, Arsenic and Lead 231
5. MZ Twins 234
6. Clinical Profiling 236
7. Conclusions 238
References 239
9. Epigenetics of Personalized Toxicology
ALEXANDRE E AISSA AND LUSANIA M.G. ANTUNES
Outline
1. Introduction
2. Basic Epigenetics
3. Individual Epigenetic Variation in Response to Toxicants
4- Epigenetic Changes that are Induced by Toxic Exposure
5. Epigenetic Evaluation of Toxicity
6. Epigenetic Toxicity of Environmental Chemicals
7. Epigenetic Toxicology of Drug Intoxication
8. Interaction between Genetic and Epigenetic Variation in Toxicology
9. Conclusion
Glossary
List of Acronyms and Abbreviations
References
_V_
ENVIRONMENTAL PERSONALIZED EPIGENETICS
10. Environmental Contaminants and Their Relationship to the
Epigenome
ANDREW E. YOSIM, MONICA D. NYE AND REBECCA C. FRY
1. Introduction 286
2. Overview of Epigenetic Mechanisms and Methods for Assessment 287
3. Air Pollution-Associated Chemicals and the Epigenome 290
4. Alcohol and the Epigenome 292
5. Metals and the Epigenome 294
6. Pharmacological Agents and the Epigenome 300
7. Cigarette Smoke and the Epigenome 302
8. Further Considerations 304
List of Acronyms and Abbreviations 305
References 307
11. Nutriepigenomics: Personalized Nutrition Meets Epigenetics
ANDERS M. LINDROTH, JOO H. PARK, YEONGRAN YOO AND YOON J. PARK
1. Introduction 314
2. Connection between Chromatin Structure and Metabolic Status 316
3. Evidence for Dietary Factors Affecting Epigenetic Patterns 321
246
246
248
253
257
260
264
270
271
272
272
273
275
CONTENTS ix
4. Epigenetic Biomarkers—Novel Tools to Assess Metabolic Disorders and
Diet Response 333
5. Conclusions and Future Prospects 338
Glossary 339
List of Acronyms and Abbreviations 339
References 342
_VI_
PHARMACOLOGY AND DRUG DEVELOPMENT
OF PERSONALIZED EPIGENETICS
12. Personalized Pharmacoepigenomics
JACOB PEEDICAYIL
1. Introduction 352
2. Genome-Wide Epigenetic Studies 352
3. Pharmacoepigenomics in Relation to Pharmacodynamics 355
4- Personalized Pharmacoepigenomics in Relation to Pharmacodynamics 358
5. Personalized Pharmacoepigenomics in Relation to Pharmacokinetics 360
6. Personalized Pharmacoepigenomics in Relation to Adverse Drug Reactions 361
7. Conclusions 362
8. Future Directions 362
Glossary 362
List of Acronyms and Abbreviations 363
References 363
13. Personalized Medicine and Epigenetic Drug Development
KENNETH LUNDSTROM
1. Introduction 369
2. Epigenetics and Drug Discovery 371
3. Personalized Medicines 378
4- Conclusions 381
References 382
_vn_
PERSONALIZED EPIGENETICS OF DISORDERS
AND DISEASE MANAGEMENT
14. Epigenetics and Personalized Pain Management
SEENA K. AJIT
1. Introduction
2. Epigenetic Regulation
390
391
X CONTENTS
3. DNA Methylation
4- DNA Methylation and Pain
5. Methylation Changes in Response to Drugs
6. Histone Modifications
7. Histone Modifications in Pain States and in Response to Drugs
8. Nucleosome Positioning and Chromatin Remodelers
9. Genomic Imprinting
10. Noncoding RNAs
11. MicroRNA and Pain
12. Long Noncoding RNA and Pain
13. Conclusions and Future Perspectives
Acknowledgments
References
15. Understanding Interindividual Epigenetic Variations
in Obesity and Its Management
SONAL PATEL, ARPANKUMAR CHOKSI AND SAMIT CHATTOPADHYAY
1. Introduction
2. Identification of Susceptibility Loci for Obesity
3. How Do Epigenetic Changes Contribute to Obesity?
4. Nutritional Epigenetics
5. When Do Dietary Factors Influence the Epigenome?
6. Genomic Imprinting in Obesity
7. Obesity Management
8. Challenges and Future Perspectives
List of Acronyms and Abbreviations
References
16. Epigenetic Modifications of miRNAs in Cancer
AMMAD A. FAROOQI, MUHAMMAD Z. QURESHI AND MUHAMMAD ISMAIL
1. Introduction
2. DNA Methylation
3. DNA Methyltransferases
4. microRNA: General Overview
5. DNA Methyltransferases 1
6. DNA Methyltransferases 3A
7. DNMT3A Regulation by microRNA
8. DNA Methyltransferases 3B
9. DNMT3B Regulation by microRNA
10. Histone Modifications
11. Histone Deacetylases and microRNA
12. Long Noncoding RNAs
13. DNA Hypomethylation-Dependent Activation of microRNAs
14- miR-370 and miR-373 and miR-375
15. microRNA Regulation of FANCA, KIF14, and KLF6
392
394
399
401
403
407
408
408
409
416
416
419
419
430
431
431
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448
450
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452
453
462
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463
463
463
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466
466
467
467
467
468
468
469
469
CONTENTS
16. Interplay of NF-kB and microRN As
17. Carcinogens
18. In vivo
19. Conclusion
References
17. Managing Autoimmune Disorders through Personalized
Epigenetic Approaches
CHRISTOPHER CHANG
1. Introduction
2. Evolution of the Treatment of Autoimmunity
3. Epigenetic Basis for Autoimmunity
4. Lessons from Oncology
5. Personalized Epigenetic Therapy in Autoimmune Diseases
6. Specific Epigenetic Agents in Autoimmunity
7. Environmental Agents Involved in Autoimmunity that Influence Epigenetics
8. Big data and Epigenetics
9. Discussion
10. Conclusions
References
18. Cardiovascular Diseases and Personalized Epigenetics
ADAM M. ZAWADA AND GUNNAR H. HEINE
1. Introduction—Cardiovascular Disease and Epigenetics
2. DNA Methylation and Cardiovascular Disease
3. CI Metabolism and Cardiovascular Disease
4. Histone Modifications in Cardiovascular Disease
5. MicroRNAs in Cardiovascular Disease
6. Conclusions and Further Perspectives
List of Acronyms and Abbreviations
References
_VIII_
CHALLENGES AND FUTURE DIRECTIONS
19. Future Challenges and Prospects for Personalized Epigenetics
PENG ZHANG, YING LIU, QIANJIN LU AND CHRISTOPHER CHANG
1. Introduction
2. Personalized Epigenetics
3. Future Direction of Personalized Medicine in Epigenetics
4- Epigenetic Data versus Genetic Data in Personalized Medicine
5. Computational Epigenetics
XI
470
470
470
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477
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484
484
491
494
495
499
500
508
512
518
525
528
540
542
543
554
555
556
563
563
xii CONTENTS
6. Challenges of Personalized Epigenetics 567
7. Conclusions 568
List of Acronyms and Abbreviations 569
References 569
Index
573
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| spelling | Personalized epigenetics ed. by Trygve O. Tollefsbol Amsterdam [u.a.] Acad. Press 2015 XVII, 591 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Translation epigenetics series Academic Press is an imprint of Elsevier Epigenetik (DE-588)7566079-9 gnd rswk-swf Epigenetik (DE-588)7566079-9 s DE-604 Tollefsbol, Trygve O. 1952- (DE-588)106064830X edt HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027863227&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Personalized epigenetics |
| title_auth | Personalized epigenetics |
| title_exact_search | Personalized epigenetics |
| title_full | Personalized epigenetics ed. by Trygve O. Tollefsbol |
| title_fullStr | Personalized epigenetics ed. by Trygve O. Tollefsbol |
| title_full_unstemmed | Personalized epigenetics ed. by Trygve O. Tollefsbol |
| title_short | Personalized epigenetics |
| title_sort | personalized epigenetics |
| topic | Epigenetik (DE-588)7566079-9 gnd |
| topic_facet | Epigenetik |
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