Statistics Applied to Clinical Trials:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Dordrecht
Springer Netherlands
2002
|
| Ausgabe: | Second Edition |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Beschreibung: | In 1948 the first randomized controlled trial was published by the English Medical Research Council in the British Medical Journal. Until then, observations had been uncontrolled. Initially, trials frequently did not confirm hypotheses to be tested. This phenomenon was attributed to low sensitivity due to small samples, as well as inappropriate hypotheses based on biased prior trials. Additional flaws were recognized and subsequently were better accounted for: carryover effects due to insufficient washout from previous treatments, time effects due to external factors and the natural history of the condition under study, bias due to asymmetry between treatment groups, lack of sensitivity due to a negative correlation between treatment responses, etc. Such flaws, mainly of a technical nature, have been largely corrected and led to trials after 1970 being of significantly better quality than before. The past decade has focused, in addition to technical aspects, on the need for circumspection in planning and conducting of clinical trials. As a consequence, prior to approval, clinical trial protocols are now routinely scrutinized by different circumstantial bodies, including ethics committees, institutional and federal review boards, national and international scientific organizations, and monitoring committees charged with conducting interim analyses. This book not only explains classical statistical analyses of clinical trials, but addresses relatively novel issues, including equivalence testing, interim analyses, sequential analyses, and meta-analyses, and provides a framework of the best statistical methods currently available for such purposes. The book is not only useful for investigators involved in the field of clinical trials, but also for all physicians who wish to better understand the data of trials as currently published |
| Beschreibung: | 1 Online-Ressource (XIII, 210 p) |
| ISBN: | 9789401003377 9781402005701 |
| DOI: | 10.1007/978-94-010-0337-7 |
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Datensatz im Suchindex
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| author | Cleophas, Ton J. |
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| ctrlnum | (OCoLC)725133886 (DE-599)BVBBV042423778 |
| dewey-full | 519.5 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 519 - Probabilities and applied mathematics |
| dewey-raw | 519.5 |
| dewey-search | 519.5 |
| dewey-sort | 3519.5 |
| dewey-tens | 510 - Mathematics |
| discipline | Mathematik |
| doi_str_mv | 10.1007/978-94-010-0337-7 |
| edition | Second Edition |
| format | Electronic eBook |
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| id | DE-604.BV042423778 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T01:21:14Z |
| institution | BVB |
| isbn | 9789401003377 9781402005701 |
| language | English |
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| spelling | Cleophas, Ton J. Verfasser aut Statistics Applied to Clinical Trials by Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas Second Edition Dordrecht Springer Netherlands 2002 1 Online-Ressource (XIII, 210 p) txt rdacontent c rdamedia cr rdacarrier In 1948 the first randomized controlled trial was published by the English Medical Research Council in the British Medical Journal. Until then, observations had been uncontrolled. Initially, trials frequently did not confirm hypotheses to be tested. This phenomenon was attributed to low sensitivity due to small samples, as well as inappropriate hypotheses based on biased prior trials. Additional flaws were recognized and subsequently were better accounted for: carryover effects due to insufficient washout from previous treatments, time effects due to external factors and the natural history of the condition under study, bias due to asymmetry between treatment groups, lack of sensitivity due to a negative correlation between treatment responses, etc. Such flaws, mainly of a technical nature, have been largely corrected and led to trials after 1970 being of significantly better quality than before. The past decade has focused, in addition to technical aspects, on the need for circumspection in planning and conducting of clinical trials. As a consequence, prior to approval, clinical trial protocols are now routinely scrutinized by different circumstantial bodies, including ethics committees, institutional and federal review boards, national and international scientific organizations, and monitoring committees charged with conducting interim analyses. This book not only explains classical statistical analyses of clinical trials, but addresses relatively novel issues, including equivalence testing, interim analyses, sequential analyses, and meta-analyses, and provides a framework of the best statistical methods currently available for such purposes. The book is not only useful for investigators involved in the field of clinical trials, but also for all physicians who wish to better understand the data of trials as currently published Statistics Statistics for Life Sciences, Medicine, Health Sciences Statistik Medizinische Statistik (DE-588)4127563-9 gnd rswk-swf Medizinische Statistik (DE-588)4127563-9 s 1\p DE-604 Zwinderman, Aeilko H. Sonstige oth Cleophas, Toine F. Sonstige oth https://doi.org/10.1007/978-94-010-0337-7 Verlag Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Cleophas, Ton J. Statistics Applied to Clinical Trials Statistics Statistics for Life Sciences, Medicine, Health Sciences Statistik Medizinische Statistik (DE-588)4127563-9 gnd |
| subject_GND | (DE-588)4127563-9 |
| title | Statistics Applied to Clinical Trials |
| title_auth | Statistics Applied to Clinical Trials |
| title_exact_search | Statistics Applied to Clinical Trials |
| title_full | Statistics Applied to Clinical Trials by Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas |
| title_fullStr | Statistics Applied to Clinical Trials by Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas |
| title_full_unstemmed | Statistics Applied to Clinical Trials by Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas |
| title_short | Statistics Applied to Clinical Trials |
| title_sort | statistics applied to clinical trials |
| topic | Statistics Statistics for Life Sciences, Medicine, Health Sciences Statistik Medizinische Statistik (DE-588)4127563-9 gnd |
| topic_facet | Statistics Statistics for Life Sciences, Medicine, Health Sciences Statistik Medizinische Statistik |
| url | https://doi.org/10.1007/978-94-010-0337-7 |
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