Stem Cell Proliferation and Differentiation: A Multitype Branching Process Model
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1988
|
| Schriftenreihe: | Lecture Notes in Biomathematics
76 |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Beschreibung: | The body contains many cellular systems that require the continuous production of new, fully functional, differentiated cells to replace cells lacking or having limited self-renewal capabilities that die or are damaged during the lifetime of an individual. Such systems include the epidermis, the epithelial lining of the gut, and the blood. For example, erythrocytes (red blood cells) lack nuclei and thus are incapable of self-replication. They have a life span in the circulation of about 120 days. Mature granulocytes, which also lack proliferative capacity, have a much shorter life span - typically 12 hours, though this may be reduced to only two or three hours in times of serious tissue infection. Perhaps a more familiar example is the outermost layer of the skin. This layer is composed of fully mature, dead epidermal cells that must be replaced by the descendants of stem cells lodged in lower layers of the epidermis (cf. Alberts et al. , 1983). In total, to supply the normal steady-state demands of cells, an average human must produce approximately 3. 7 x 1011 cells a day throughout life (Dexter and Spooncer, 1987). Common to each of these cellular systems is a primitive (undifferentiated) stem cell which replenishes cells through the production of offspring, some of which proliferate and gradually differentiate until mature, fully functional cells are produced |
| Beschreibung: | 1 Online-Ressource (VIII, 113p) |
| ISBN: | 9783642933967 9783540501831 |
| ISSN: | 0341-633X |
| DOI: | 10.1007/978-3-642-93396-7 |
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| 245 | 1 | 0 | |a Stem Cell Proliferation and Differentiation |b A Multitype Branching Process Model |c by Catherine A. Macken, Alan S. Perelson |
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| 500 | |a The body contains many cellular systems that require the continuous production of new, fully functional, differentiated cells to replace cells lacking or having limited self-renewal capabilities that die or are damaged during the lifetime of an individual. Such systems include the epidermis, the epithelial lining of the gut, and the blood. For example, erythrocytes (red blood cells) lack nuclei and thus are incapable of self-replication. They have a life span in the circulation of about 120 days. Mature granulocytes, which also lack proliferative capacity, have a much shorter life span - typically 12 hours, though this may be reduced to only two or three hours in times of serious tissue infection. Perhaps a more familiar example is the outermost layer of the skin. This layer is composed of fully mature, dead epidermal cells that must be replaced by the descendants of stem cells lodged in lower layers of the epidermis (cf. Alberts et al. , 1983). In total, to supply the normal steady-state demands of cells, an average human must produce approximately 3. 7 x 1011 cells a day throughout life (Dexter and Spooncer, 1987). Common to each of these cellular systems is a primitive (undifferentiated) stem cell which replenishes cells through the production of offspring, some of which proliferate and gradually differentiate until mature, fully functional cells are produced | ||
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Datensatz im Suchindex
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|---|---|
| any_adam_object | |
| author | Macken, Catherine A. |
| author_facet | Macken, Catherine A. |
| author_role | aut |
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| author_variant | c a m ca cam |
| building | Verbundindex |
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| dewey-tens | 570 - Biology |
| discipline | Biologie Mathematik |
| doi_str_mv | 10.1007/978-3-642-93396-7 |
| format | Electronic eBook |
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| id | DE-604.BV042423130 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T01:21:12Z |
| institution | BVB |
| isbn | 9783642933967 9783540501831 |
| issn | 0341-633X |
| language | English |
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| series2 | Lecture Notes in Biomathematics |
| spelling | Macken, Catherine A. Verfasser aut Stem Cell Proliferation and Differentiation A Multitype Branching Process Model by Catherine A. Macken, Alan S. Perelson Berlin, Heidelberg Springer Berlin Heidelberg 1988 1 Online-Ressource (VIII, 113p) txt rdacontent c rdamedia cr rdacarrier Lecture Notes in Biomathematics 76 0341-633X The body contains many cellular systems that require the continuous production of new, fully functional, differentiated cells to replace cells lacking or having limited self-renewal capabilities that die or are damaged during the lifetime of an individual. Such systems include the epidermis, the epithelial lining of the gut, and the blood. For example, erythrocytes (red blood cells) lack nuclei and thus are incapable of self-replication. They have a life span in the circulation of about 120 days. Mature granulocytes, which also lack proliferative capacity, have a much shorter life span - typically 12 hours, though this may be reduced to only two or three hours in times of serious tissue infection. Perhaps a more familiar example is the outermost layer of the skin. This layer is composed of fully mature, dead epidermal cells that must be replaced by the descendants of stem cells lodged in lower layers of the epidermis (cf. Alberts et al. , 1983). In total, to supply the normal steady-state demands of cells, an average human must produce approximately 3. 7 x 1011 cells a day throughout life (Dexter and Spooncer, 1987). Common to each of these cellular systems is a primitive (undifferentiated) stem cell which replenishes cells through the production of offspring, some of which proliferate and gradually differentiate until mature, fully functional cells are produced Mathematics Immunology Zoology Statistics Mathematical and Computational Biology Statistics for Life Sciences, Medicine, Health Sciences Mathematik Statistik Blutstammzelle (DE-588)4146093-5 gnd rswk-swf Zelldifferenzierung (DE-588)4067536-1 gnd rswk-swf Mathematisches Modell (DE-588)4114528-8 gnd rswk-swf Proliferation (DE-588)4047461-6 gnd rswk-swf Blutstammzelle (DE-588)4146093-5 s Proliferation (DE-588)4047461-6 s Mathematisches Modell (DE-588)4114528-8 s 1\p DE-604 Zelldifferenzierung (DE-588)4067536-1 s 2\p DE-604 Perelson, Alan S. Sonstige oth https://doi.org/10.1007/978-3-642-93396-7 Verlag Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Macken, Catherine A. Stem Cell Proliferation and Differentiation A Multitype Branching Process Model Mathematics Immunology Zoology Statistics Mathematical and Computational Biology Statistics for Life Sciences, Medicine, Health Sciences Mathematik Statistik Blutstammzelle (DE-588)4146093-5 gnd Zelldifferenzierung (DE-588)4067536-1 gnd Mathematisches Modell (DE-588)4114528-8 gnd Proliferation (DE-588)4047461-6 gnd |
| subject_GND | (DE-588)4146093-5 (DE-588)4067536-1 (DE-588)4114528-8 (DE-588)4047461-6 |
| title | Stem Cell Proliferation and Differentiation A Multitype Branching Process Model |
| title_auth | Stem Cell Proliferation and Differentiation A Multitype Branching Process Model |
| title_exact_search | Stem Cell Proliferation and Differentiation A Multitype Branching Process Model |
| title_full | Stem Cell Proliferation and Differentiation A Multitype Branching Process Model by Catherine A. Macken, Alan S. Perelson |
| title_fullStr | Stem Cell Proliferation and Differentiation A Multitype Branching Process Model by Catherine A. Macken, Alan S. Perelson |
| title_full_unstemmed | Stem Cell Proliferation and Differentiation A Multitype Branching Process Model by Catherine A. Macken, Alan S. Perelson |
| title_short | Stem Cell Proliferation and Differentiation |
| title_sort | stem cell proliferation and differentiation a multitype branching process model |
| title_sub | A Multitype Branching Process Model |
| topic | Mathematics Immunology Zoology Statistics Mathematical and Computational Biology Statistics for Life Sciences, Medicine, Health Sciences Mathematik Statistik Blutstammzelle (DE-588)4146093-5 gnd Zelldifferenzierung (DE-588)4067536-1 gnd Mathematisches Modell (DE-588)4114528-8 gnd Proliferation (DE-588)4047461-6 gnd |
| topic_facet | Mathematics Immunology Zoology Statistics Mathematical and Computational Biology Statistics for Life Sciences, Medicine, Health Sciences Mathematik Statistik Blutstammzelle Zelldifferenzierung Mathematisches Modell Proliferation |
| url | https://doi.org/10.1007/978-3-642-93396-7 |
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