Cell Kinetic Modelling and the Chemotherapy of Cancer:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1988
|
| Schriftenreihe: | Lecture Notes in Biomathematics
75 |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Beschreibung: | During the last 30 years, many chemical compounds that are active against tumors have been discovered or developed. At the same time, new methods of testing drugs for cancer therapy have evolved. nefore 1964, drug testing on animal tumors was directed to observation of the incfease in life span of the host after a single dose. A new approach, in which the effects of multiple doses on the proliferation kinetics of the tumor in vivo as well as of cell lines in vitro are investigated, has been outlined by Skipper and his co-workers in a series of papers beginning in 1964 (Skipper, Schabel and Wilcox, 1964 and 1965). They also investigated the influence of the time schedule in the treatment of experimental tumors. Since the publication of those studies, cell population kinetics cannot be left out of any discussion of the rational basis of chemotherapy. When clinical oncologists began to apply cell kinetic concepts in practice about 15 years ago, the theoretical basis was still very poor, in spite of Skipper's progress, and the lack of re levant cytokinetic and pharmacologic data was apparent. Subsequently, much theoretical work has been done and many cell kinetic models have been elaborated (for a review see Eisen, 1977) |
| Beschreibung: | 1 Online-Ressource (VIII, 157p) |
| ISBN: | 9783642456510 9783540501534 |
| ISSN: | 0341-633X |
| DOI: | 10.1007/978-3-642-45651-0 |
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| discipline | Mathematik Medizin |
| doi_str_mv | 10.1007/978-3-642-45651-0 |
| format | Electronic eBook |
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| issn | 0341-633X |
| language | English |
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| spelling | Knolle, Helmut Verfasser aut Cell Kinetic Modelling and the Chemotherapy of Cancer by Helmut Knolle Berlin, Heidelberg Springer Berlin Heidelberg 1988 1 Online-Ressource (VIII, 157p) txt rdacontent c rdamedia cr rdacarrier Lecture Notes in Biomathematics 75 0341-633X During the last 30 years, many chemical compounds that are active against tumors have been discovered or developed. At the same time, new methods of testing drugs for cancer therapy have evolved. nefore 1964, drug testing on animal tumors was directed to observation of the incfease in life span of the host after a single dose. A new approach, in which the effects of multiple doses on the proliferation kinetics of the tumor in vivo as well as of cell lines in vitro are investigated, has been outlined by Skipper and his co-workers in a series of papers beginning in 1964 (Skipper, Schabel and Wilcox, 1964 and 1965). They also investigated the influence of the time schedule in the treatment of experimental tumors. Since the publication of those studies, cell population kinetics cannot be left out of any discussion of the rational basis of chemotherapy. When clinical oncologists began to apply cell kinetic concepts in practice about 15 years ago, the theoretical basis was still very poor, in spite of Skipper's progress, and the lack of re levant cytokinetic and pharmacologic data was apparent. Subsequently, much theoretical work has been done and many cell kinetic models have been elaborated (for a review see Eisen, 1977) Medicine Oncology Cytology Statistics Medicine & Public Health Mathematical and Computational Biology Cell Biology Statistics for Life Sciences, Medicine, Health Sciences Medizin Statistik Cytostatikum (DE-588)4068347-3 gnd rswk-swf Wirkung (DE-588)4190021-2 gnd rswk-swf Wachstum (DE-588)4064115-6 gnd rswk-swf Krebszelle (DE-588)4128704-6 gnd rswk-swf Mathematisches Modell (DE-588)4114528-8 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Proliferation (DE-588)4047461-6 gnd rswk-swf Statistisches Modell (DE-588)4121722-6 gnd rswk-swf Chemotherapie (DE-588)4127083-6 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Chemotherapie (DE-588)4127083-6 s Statistisches Modell (DE-588)4121722-6 s 1\p DE-604 Krebszelle (DE-588)4128704-6 s Wachstum (DE-588)4064115-6 s 2\p DE-604 Cytostatikum (DE-588)4068347-3 s Wirkung (DE-588)4190021-2 s Mathematisches Modell (DE-588)4114528-8 s 3\p DE-604 Proliferation (DE-588)4047461-6 s 4\p DE-604 https://doi.org/10.1007/978-3-642-45651-0 Verlag Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 4\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Knolle, Helmut Cell Kinetic Modelling and the Chemotherapy of Cancer Medicine Oncology Cytology Statistics Medicine & Public Health Mathematical and Computational Biology Cell Biology Statistics for Life Sciences, Medicine, Health Sciences Medizin Statistik Cytostatikum (DE-588)4068347-3 gnd Wirkung (DE-588)4190021-2 gnd Wachstum (DE-588)4064115-6 gnd Krebszelle (DE-588)4128704-6 gnd Mathematisches Modell (DE-588)4114528-8 gnd Krebs Medizin (DE-588)4073781-0 gnd Proliferation (DE-588)4047461-6 gnd Statistisches Modell (DE-588)4121722-6 gnd Chemotherapie (DE-588)4127083-6 gnd |
| subject_GND | (DE-588)4068347-3 (DE-588)4190021-2 (DE-588)4064115-6 (DE-588)4128704-6 (DE-588)4114528-8 (DE-588)4073781-0 (DE-588)4047461-6 (DE-588)4121722-6 (DE-588)4127083-6 |
| title | Cell Kinetic Modelling and the Chemotherapy of Cancer |
| title_auth | Cell Kinetic Modelling and the Chemotherapy of Cancer |
| title_exact_search | Cell Kinetic Modelling and the Chemotherapy of Cancer |
| title_full | Cell Kinetic Modelling and the Chemotherapy of Cancer by Helmut Knolle |
| title_fullStr | Cell Kinetic Modelling and the Chemotherapy of Cancer by Helmut Knolle |
| title_full_unstemmed | Cell Kinetic Modelling and the Chemotherapy of Cancer by Helmut Knolle |
| title_short | Cell Kinetic Modelling and the Chemotherapy of Cancer |
| title_sort | cell kinetic modelling and the chemotherapy of cancer |
| topic | Medicine Oncology Cytology Statistics Medicine & Public Health Mathematical and Computational Biology Cell Biology Statistics for Life Sciences, Medicine, Health Sciences Medizin Statistik Cytostatikum (DE-588)4068347-3 gnd Wirkung (DE-588)4190021-2 gnd Wachstum (DE-588)4064115-6 gnd Krebszelle (DE-588)4128704-6 gnd Mathematisches Modell (DE-588)4114528-8 gnd Krebs Medizin (DE-588)4073781-0 gnd Proliferation (DE-588)4047461-6 gnd Statistisches Modell (DE-588)4121722-6 gnd Chemotherapie (DE-588)4127083-6 gnd |
| topic_facet | Medicine Oncology Cytology Statistics Medicine & Public Health Mathematical and Computational Biology Cell Biology Statistics for Life Sciences, Medicine, Health Sciences Medizin Statistik Cytostatikum Wirkung Wachstum Krebszelle Mathematisches Modell Krebs Medizin Proliferation Statistisches Modell Chemotherapie |
| url | https://doi.org/10.1007/978-3-642-45651-0 |
| work_keys_str_mv | AT knollehelmut cellkineticmodellingandthechemotherapyofcancer |