Vascular Endothelium: Receptors and Transduction Mechanisms
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Springer US
1989
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| Schlagworte: | |
| Online-Zugang: | Volltext |
| Beschreibung: | Beyond their obvious role of a barrier between blood and tissue, vascular endothelial cells are now firmly established as active and essential participants in a host of crucial physiological and pathophysiological functions. Probably the two most important factors responsible for promoting the current knowledge of endothelial functions are 1) observations in the late sixties-early seventies that many non-ventilatory properties of the lung could be attributed to the pulmonary endothelium and 2) the establishment, in the early and mid-seventies of procedures for routine culture of vascular endothelial cells. Many of these endothelial functions require the presence of receptors on the surface of the plasma membrane. There is now evidence for the existence among others of muscarinic, a-and /3-adrenergic, purine, insulin, histamine, bradykinin, lipoprotein, thrombin, paf, fibronectin, vitronectin, interleukin and albumin receptors. For some of these ligands, there is evidence only for the existence of endothelial binding sites. Traditionally, agonist binding must elicit a response for the binding site to be considered a receptor and, in some cases, the nature of the response resulting from the interaction of a substance with the endothelium remains unclear. It is beyond the scope of this introduction to even enumerate the various endothelial homeostatic processes. This monograph contains the proceedings of the Advanced Studies Institute on "Vascular Endothelium: Receptors and Transduction Mechanisms" held in Porto Carras, Greece from June 18-29, 1988 |
| Beschreibung: | 1 Online-Ressource (XII, 308 p) |
| ISBN: | 9781468485325 9781468485349 |
| DOI: | 10.1007/978-1-4684-8532-5 |
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| 500 | |a Beyond their obvious role of a barrier between blood and tissue, vascular endothelial cells are now firmly established as active and essential participants in a host of crucial physiological and pathophysiological functions. Probably the two most important factors responsible for promoting the current knowledge of endothelial functions are 1) observations in the late sixties-early seventies that many non-ventilatory properties of the lung could be attributed to the pulmonary endothelium and 2) the establishment, in the early and mid-seventies of procedures for routine culture of vascular endothelial cells. Many of these endothelial functions require the presence of receptors on the surface of the plasma membrane. There is now evidence for the existence among others of muscarinic, a-and /3-adrenergic, purine, insulin, histamine, bradykinin, lipoprotein, thrombin, paf, fibronectin, vitronectin, interleukin and albumin receptors. For some of these ligands, there is evidence only for the existence of endothelial binding sites. Traditionally, agonist binding must elicit a response for the binding site to be considered a receptor and, in some cases, the nature of the response resulting from the interaction of a substance with the endothelium remains unclear. It is beyond the scope of this introduction to even enumerate the various endothelial homeostatic processes. This monograph contains the proceedings of the Advanced Studies Institute on "Vascular Endothelium: Receptors and Transduction Mechanisms" held in Porto Carras, Greece from June 18-29, 1988 | ||
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Datensatz im Suchindex
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| author | Catravas, John D. |
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| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572 |
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| dewey-tens | 570 - Biology |
| discipline | Physik Biologie |
| doi_str_mv | 10.1007/978-1-4684-8532-5 |
| format | Electronic eBook |
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| spelling | Catravas, John D. Verfasser aut Vascular Endothelium Receptors and Transduction Mechanisms edited by John D. Catravas, C. Norman Gillis, Una S. Ryan Boston, MA Springer US 1989 1 Online-Ressource (XII, 308 p) txt rdacontent c rdamedia cr rdacarrier Beyond their obvious role of a barrier between blood and tissue, vascular endothelial cells are now firmly established as active and essential participants in a host of crucial physiological and pathophysiological functions. Probably the two most important factors responsible for promoting the current knowledge of endothelial functions are 1) observations in the late sixties-early seventies that many non-ventilatory properties of the lung could be attributed to the pulmonary endothelium and 2) the establishment, in the early and mid-seventies of procedures for routine culture of vascular endothelial cells. Many of these endothelial functions require the presence of receptors on the surface of the plasma membrane. There is now evidence for the existence among others of muscarinic, a-and /3-adrenergic, purine, insulin, histamine, bradykinin, lipoprotein, thrombin, paf, fibronectin, vitronectin, interleukin and albumin receptors. For some of these ligands, there is evidence only for the existence of endothelial binding sites. Traditionally, agonist binding must elicit a response for the binding site to be considered a receptor and, in some cases, the nature of the response resulting from the interaction of a substance with the endothelium remains unclear. It is beyond the scope of this introduction to even enumerate the various endothelial homeostatic processes. This monograph contains the proceedings of the Advanced Studies Institute on "Vascular Endothelium: Receptors and Transduction Mechanisms" held in Porto Carras, Greece from June 18-29, 1988 Life sciences Biochemistry Life Sciences Biochemistry, general Biowissenschaften Endothel (DE-588)4014675-3 gnd rswk-swf Rezeptor (DE-588)4049722-7 gnd rswk-swf Blutgefäß (DE-588)4069549-9 gnd rswk-swf 1\p (DE-588)1071861417 Konferenzschrift 1988 Porto Karras gnd-content Blutgefäß (DE-588)4069549-9 s Endothel (DE-588)4014675-3 s Rezeptor (DE-588)4049722-7 s 2\p DE-604 Gillis, C. Norman Sonstige oth Ryan, Una S. Sonstige oth https://doi.org/10.1007/978-1-4684-8532-5 Verlag Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Catravas, John D. Vascular Endothelium Receptors and Transduction Mechanisms Life sciences Biochemistry Life Sciences Biochemistry, general Biowissenschaften Endothel (DE-588)4014675-3 gnd Rezeptor (DE-588)4049722-7 gnd Blutgefäß (DE-588)4069549-9 gnd |
| subject_GND | (DE-588)4014675-3 (DE-588)4049722-7 (DE-588)4069549-9 (DE-588)1071861417 |
| title | Vascular Endothelium Receptors and Transduction Mechanisms |
| title_auth | Vascular Endothelium Receptors and Transduction Mechanisms |
| title_exact_search | Vascular Endothelium Receptors and Transduction Mechanisms |
| title_full | Vascular Endothelium Receptors and Transduction Mechanisms edited by John D. Catravas, C. Norman Gillis, Una S. Ryan |
| title_fullStr | Vascular Endothelium Receptors and Transduction Mechanisms edited by John D. Catravas, C. Norman Gillis, Una S. Ryan |
| title_full_unstemmed | Vascular Endothelium Receptors and Transduction Mechanisms edited by John D. Catravas, C. Norman Gillis, Una S. Ryan |
| title_short | Vascular Endothelium |
| title_sort | vascular endothelium receptors and transduction mechanisms |
| title_sub | Receptors and Transduction Mechanisms |
| topic | Life sciences Biochemistry Life Sciences Biochemistry, general Biowissenschaften Endothel (DE-588)4014675-3 gnd Rezeptor (DE-588)4049722-7 gnd Blutgefäß (DE-588)4069549-9 gnd |
| topic_facet | Life sciences Biochemistry Life Sciences Biochemistry, general Biowissenschaften Endothel Rezeptor Blutgefäß Konferenzschrift 1988 Porto Karras |
| url | https://doi.org/10.1007/978-1-4684-8532-5 |
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