Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Springer US
1980
|
| Schriftenreihe: | Environmental Science Research
22 |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Beschreibung: | More than one hundred short-term bioassays are now available for detecting the toxicity, mutagenicity, and potential carcinogenicity of chemicals. These bioassays were developed and validated with individual compounds, and their principal application was perceived to be in evaluating the health hazard of such materials. However, man is rarely exposed to single chemicals; his exposure to hazardous chemicals is more commonly a multifactorial phenomenon. Although chemical analysis can be used to detect known hazardous compounds, it would be a staggering and expensive task to analyze large numbers of samples for all known or suspected hazardous constituents. Furthermore, the biological activity of a complex mixture cannot be reliably predicted from knowledge of its components. On the other hand, bioassays alone cannot tell us which components of complex mixtures are responsible for the biological activity detected. Thus, cost effectiveness and technical feasibility dictate stepwise and perhaps iterative application -of both chemical and biological methods in evaluating the health effects of complex environmental mixtures. Through the coupling of reliable biological detection systems with methods of chemical fractionation and analysis, it is frequently possible to isolate the individual chemical species that show biological activity. Initially, complex mixtures may be separated and bioassayed in carefully defined chemical fractions. The results of such short-term screening bioassays then may be used td guide the course of further fractionation and to determine the need for more stringent and comprehensive biological testing |
| Beschreibung: | 1 Online-Ressource (524p) |
| ISBN: | 9781468441215 9781468441239 |
| DOI: | 10.1007/978-1-4684-4121-5 |
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| 500 | |a More than one hundred short-term bioassays are now available for detecting the toxicity, mutagenicity, and potential carcinogenicity of chemicals. These bioassays were developed and validated with individual compounds, and their principal application was perceived to be in evaluating the health hazard of such materials. However, man is rarely exposed to single chemicals; his exposure to hazardous chemicals is more commonly a multifactorial phenomenon. Although chemical analysis can be used to detect known hazardous compounds, it would be a staggering and expensive task to analyze large numbers of samples for all known or suspected hazardous constituents. Furthermore, the biological activity of a complex mixture cannot be reliably predicted from knowledge of its components. On the other hand, bioassays alone cannot tell us which components of complex mixtures are responsible for the biological activity detected. Thus, cost effectiveness and technical feasibility dictate stepwise and perhaps iterative application -of both chemical and biological methods in evaluating the health effects of complex environmental mixtures. Through the coupling of reliable biological detection systems with methods of chemical fractionation and analysis, it is frequently possible to isolate the individual chemical species that show biological activity. Initially, complex mixtures may be separated and bioassayed in carefully defined chemical fractions. The results of such short-term screening bioassays then may be used td guide the course of further fractionation and to determine the need for more stringent and comprehensive biological testing | ||
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Datensatz im Suchindex
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| discipline | Physik |
| doi_str_mv | 10.1007/978-1-4684-4121-5 |
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| id | DE-604.BV042412020 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T01:20:49Z |
| institution | BVB |
| isbn | 9781468441215 9781468441239 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027847513 |
| oclc_num | 863959251 |
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| publishDate | 1980 |
| publishDateSearch | 1980 |
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| publisher | Springer US |
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| series2 | Environmental Science Research |
| spelling | Waters, Michael D. Verfasser aut Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II edited by Michael D. Waters, Shahbeg S. Sandhu, Joellen Lewtas Huisingh, Larry Claxton, Stephen Nesnow Boston, MA Springer US 1980 1 Online-Ressource (524p) txt rdacontent c rdamedia cr rdacarrier Environmental Science Research 22 More than one hundred short-term bioassays are now available for detecting the toxicity, mutagenicity, and potential carcinogenicity of chemicals. These bioassays were developed and validated with individual compounds, and their principal application was perceived to be in evaluating the health hazard of such materials. However, man is rarely exposed to single chemicals; his exposure to hazardous chemicals is more commonly a multifactorial phenomenon. Although chemical analysis can be used to detect known hazardous compounds, it would be a staggering and expensive task to analyze large numbers of samples for all known or suspected hazardous constituents. Furthermore, the biological activity of a complex mixture cannot be reliably predicted from knowledge of its components. On the other hand, bioassays alone cannot tell us which components of complex mixtures are responsible for the biological activity detected. Thus, cost effectiveness and technical feasibility dictate stepwise and perhaps iterative application -of both chemical and biological methods in evaluating the health effects of complex environmental mixtures. Through the coupling of reliable biological detection systems with methods of chemical fractionation and analysis, it is frequently possible to isolate the individual chemical species that show biological activity. Initially, complex mixtures may be separated and bioassayed in carefully defined chemical fractions. The results of such short-term screening bioassays then may be used td guide the course of further fractionation and to determine the need for more stringent and comprehensive biological testing Physics Physics, general Sandhu, Shahbeg S. Sonstige oth Huisingh, Joellen Lewtas Sonstige oth Claxton, Larry Sonstige oth Nesnow, Stephen Sonstige oth https://doi.org/10.1007/978-1-4684-4121-5 Verlag Volltext |
| spellingShingle | Waters, Michael D. Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II Physics Physics, general |
| title | Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II |
| title_auth | Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II |
| title_exact_search | Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II |
| title_full | Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II edited by Michael D. Waters, Shahbeg S. Sandhu, Joellen Lewtas Huisingh, Larry Claxton, Stephen Nesnow |
| title_fullStr | Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II edited by Michael D. Waters, Shahbeg S. Sandhu, Joellen Lewtas Huisingh, Larry Claxton, Stephen Nesnow |
| title_full_unstemmed | Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II edited by Michael D. Waters, Shahbeg S. Sandhu, Joellen Lewtas Huisingh, Larry Claxton, Stephen Nesnow |
| title_short | Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II |
| title_sort | short term bioassays in the analysis of complex environmental mixtures ii |
| topic | Physics Physics, general |
| topic_facet | Physics Physics, general |
| url | https://doi.org/10.1007/978-1-4684-4121-5 |
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