Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk:
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Springer US
1983
|
| Schriftenreihe: | Environmental Science Research
28 |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Beschreibung: | The magnitude of the threat to the human genetic material posed by environmental agents has not as yet been fully determined. Nevertheless, the potential hazards of many chemicals have been identified by studies on lower organisms. However, too little is known regarding the comparability or lack of it between the metabolic pathways available in such organisms and those in man. Although at present there is great public concern for what is considered by some as the excessive use of laboratory animals in toxicological testing, it seems clear that the usage of mammalian systems may be deemed necessary. It has been proposed that cell culture systems might suffice to meet this need, however, such approaches cannot match the complexity of physiological occurances that are present in the intact animal. For studies of genetic effects, some non-invasive human test systems are presently available. These do not, however, meet the requirements for extensive laboratory studies. In order to assess the risks to humans of environmental factors such laboratory investigations are essential. Therefore, for the forseeable future reliance on experiments using laboratory animals will be necessary. This Volume, which contains the proceedings of a workshop which was held at the National Institute of Environmental Health Sciences, March 29-31, 1982, explores the existing methodologies and their utility for risk estimations. It covers the most well developed human systems, as well as the most widely used animal tests |
| Beschreibung: | 1 Online-Ressource (341p) |
| ISBN: | 9781461337393 9781461337416 |
| DOI: | 10.1007/978-1-4613-3739-3 |
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| 500 | |a The magnitude of the threat to the human genetic material posed by environmental agents has not as yet been fully determined. Nevertheless, the potential hazards of many chemicals have been identified by studies on lower organisms. However, too little is known regarding the comparability or lack of it between the metabolic pathways available in such organisms and those in man. Although at present there is great public concern for what is considered by some as the excessive use of laboratory animals in toxicological testing, it seems clear that the usage of mammalian systems may be deemed necessary. It has been proposed that cell culture systems might suffice to meet this need, however, such approaches cannot match the complexity of physiological occurances that are present in the intact animal. For studies of genetic effects, some non-invasive human test systems are presently available. These do not, however, meet the requirements for extensive laboratory studies. In order to assess the risks to humans of environmental factors such laboratory investigations are essential. Therefore, for the forseeable future reliance on experiments using laboratory animals will be necessary. This Volume, which contains the proceedings of a workshop which was held at the National Institute of Environmental Health Sciences, March 29-31, 1982, explores the existing methodologies and their utility for risk estimations. It covers the most well developed human systems, as well as the most widely used animal tests | ||
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| spelling | Serres, Frederick J. edt Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk edited by Frederick J. Serres, William Sheridan Boston, MA Springer US 1983 1 Online-Ressource (341p) txt rdacontent c rdamedia cr rdacarrier Environmental Science Research 28 The magnitude of the threat to the human genetic material posed by environmental agents has not as yet been fully determined. Nevertheless, the potential hazards of many chemicals have been identified by studies on lower organisms. However, too little is known regarding the comparability or lack of it between the metabolic pathways available in such organisms and those in man. Although at present there is great public concern for what is considered by some as the excessive use of laboratory animals in toxicological testing, it seems clear that the usage of mammalian systems may be deemed necessary. It has been proposed that cell culture systems might suffice to meet this need, however, such approaches cannot match the complexity of physiological occurances that are present in the intact animal. For studies of genetic effects, some non-invasive human test systems are presently available. These do not, however, meet the requirements for extensive laboratory studies. In order to assess the risks to humans of environmental factors such laboratory investigations are essential. Therefore, for the forseeable future reliance on experiments using laboratory animals will be necessary. This Volume, which contains the proceedings of a workshop which was held at the National Institute of Environmental Health Sciences, March 29-31, 1982, explores the existing methodologies and their utility for risk estimations. It covers the most well developed human systems, as well as the most widely used animal tests Physics Physics, general Mutagenitätstest (DE-588)4261911-7 gnd rswk-swf Genetik (DE-588)4071711-2 gnd rswk-swf Mutation (DE-588)4170883-0 gnd rswk-swf Umweltverschmutzung (DE-588)4186812-2 gnd rswk-swf Mensch (DE-588)4038639-9 gnd rswk-swf Säugetiere (DE-588)4051253-8 gnd rswk-swf 1\p (DE-588)1071861417 Konferenzschrift 1982 Research Triangle Park NC gnd-content Mutation (DE-588)4170883-0 s Umweltverschmutzung (DE-588)4186812-2 s Säugetiere (DE-588)4051253-8 s 2\p DE-604 Mensch (DE-588)4038639-9 s 3\p DE-604 Genetik (DE-588)4071711-2 s 4\p DE-604 Mutagenitätstest (DE-588)4261911-7 s 5\p DE-604 Sheridan, William edt Environmental Science Research 28 (DE-604)BV000001503 28 https://doi.org/10.1007/978-1-4613-3739-3 Verlag Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 4\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 5\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk Environmental Science Research Physics Physics, general Mutagenitätstest (DE-588)4261911-7 gnd Genetik (DE-588)4071711-2 gnd Mutation (DE-588)4170883-0 gnd Umweltverschmutzung (DE-588)4186812-2 gnd Mensch (DE-588)4038639-9 gnd Säugetiere (DE-588)4051253-8 gnd |
| subject_GND | (DE-588)4261911-7 (DE-588)4071711-2 (DE-588)4170883-0 (DE-588)4186812-2 (DE-588)4038639-9 (DE-588)4051253-8 (DE-588)1071861417 |
| title | Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk |
| title_auth | Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk |
| title_exact_search | Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk |
| title_full | Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk edited by Frederick J. Serres, William Sheridan |
| title_fullStr | Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk edited by Frederick J. Serres, William Sheridan |
| title_full_unstemmed | Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk edited by Frederick J. Serres, William Sheridan |
| title_short | Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk |
| title_sort | utilization of mammalian specific locus studies in hazard evaluation and estimation of genetic risk |
| topic | Physics Physics, general Mutagenitätstest (DE-588)4261911-7 gnd Genetik (DE-588)4071711-2 gnd Mutation (DE-588)4170883-0 gnd Umweltverschmutzung (DE-588)4186812-2 gnd Mensch (DE-588)4038639-9 gnd Säugetiere (DE-588)4051253-8 gnd |
| topic_facet | Physics Physics, general Mutagenitätstest Genetik Mutation Umweltverschmutzung Mensch Säugetiere Konferenzschrift 1982 Research Triangle Park NC |
| url | https://doi.org/10.1007/978-1-4613-3739-3 |
| volume_link | (DE-604)BV000001503 |
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