Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells: Mathematical Modeling and Experimental Observations
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cham [u.a.]
Springer International Publishing
2015
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| Schriftenreihe: | Springer Theses
|
| Schlagworte: | |
| Online-Zugang: | FAW01 UBT01 Volltext Abstract Inhaltsverzeichnis |
| Beschreibung: | 1 Online-Ressource (XXI, 79 p. 47 illus., 46 illus. in color) |
| ISBN: | 9783319149622 |
| ISSN: | 2190-5053 |
| DOI: | 10.1007/978-3-319-14962-2 |
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Datensatz im Suchindex
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|---|---|
| adam_text | DYNAMICS OF CELL FATE DECISION MEDIATED BY THE INTERPLAY OF AUTOPHAGY
AND APOPTOSIS IN CANCER CELLS
/ TAVASSOLY, IMAN
: 2015
ABSTRACT / INHALTSTEXT
THIS INTERDISCIPLINARY THESIS INTRODUCES A SYSTEMS BIOLOGY APPROACH TO
STUDY THE CELL FATE DECISION MEDIATED BY AUTOPHAGY. A MATHEMATICAL MODEL
OF INTERACTION BETWEEN AUTOPHAGY AND APOPTOSIS IN MAMMALIAN CELLS IS
PROPOSED. IN THIS DYNAMIC MODEL AUTOPHAGY ACTS AS A GRADUAL RESPONSE TO
STRESS (RHEOSTAT) THAT DELAYS THE INITIATION OF BISTABLE SWITCH OF
APOPTOSIS TO GIVE THE CELLS AN OPPORTUNITY TO SURVIVE. THE AUTHOR SHOWS
THAT HIS DYNAMICAL MODEL IS CONSISTENT WITH EXISTING QUANTITATIVE
MEASUREMENTS OF TIME COURSES OF AUTOPHAGIC RESPONSES TO CISPLATIN
TREATMENT. TO UNDERSTAND THE FUNCTION OF THIS RESPONSE IN CANCER CELLS,
HE HAS PROVIDED A SYSTEMS BIOLOGY EXPERIMENTAL FRAMEWORK TO STUDY
QUANTITATIVE AND DYNAMICAL ASPECTS OF AUTOPHAGY IN SINGLE CANCER CELLS
USING LIVE-CELL IMAGING AND QUANTITATIVEFLUORESCENCE MICROSCOPY. THIS
FRAMEWORK CAN PROVIDE NEW INSIGHTS ON FUNCTION OF AUTOPHAGIC RESPONSE IN
CANCER CELLS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
DYNAMICS OF CELL FATE DECISION MEDIATED BY THE INTERPLAY OF AUTOPHAGY
AND APOPTOSIS IN CANCER CELLS
/ TAVASSOLY, IMAN
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
INTRODUCTION
MATHEMATICAL MODELING OF THE INTERPLAY OF AUTOPHAGY AND APOPTOSIS
AN EXPERIMENTAL FRAMEWORK TO STUDY THE DYNAMICS OF AUTOPHAGIC RESPONSE
CONCLUSIONS
SOURCE CODE
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| issn | 2190-5053 |
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| spelling | Tavassoly, Iman Verfasser aut Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells Mathematical Modeling and Experimental Observations Iman Tavassoly Cham [u.a.] Springer International Publishing 2015 1 Online-Ressource (XXI, 79 p. 47 illus., 46 illus. in color) txt rdacontent c rdamedia cr rdacarrier Springer Theses 2190-5053 Zugl.: Blacksburg, Va., Virginia Polytechnic Institute and State University, Diss. Oncology Bioinformatics Cytology Biomaterials Materials Science Computational Biology/Bioinformatics Cancer Research Cell Biology Biophysics and Biological Physics (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Druckausgabe 978-3-319-14961-5 https://doi.org/10.1007/978-3-319-14962-2 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027823144&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Abstract Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027823144&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Tavassoly, Iman Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells Mathematical Modeling and Experimental Observations Oncology Bioinformatics Cytology Biomaterials Materials Science Computational Biology/Bioinformatics Cancer Research Cell Biology Biophysics and Biological Physics |
| subject_GND | (DE-588)4113937-9 |
| title | Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells Mathematical Modeling and Experimental Observations |
| title_auth | Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells Mathematical Modeling and Experimental Observations |
| title_exact_search | Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells Mathematical Modeling and Experimental Observations |
| title_full | Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells Mathematical Modeling and Experimental Observations Iman Tavassoly |
| title_fullStr | Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells Mathematical Modeling and Experimental Observations Iman Tavassoly |
| title_full_unstemmed | Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells Mathematical Modeling and Experimental Observations Iman Tavassoly |
| title_short | Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells |
| title_sort | dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cells mathematical modeling and experimental observations |
| title_sub | Mathematical Modeling and Experimental Observations |
| topic | Oncology Bioinformatics Cytology Biomaterials Materials Science Computational Biology/Bioinformatics Cancer Research Cell Biology Biophysics and Biological Physics |
| topic_facet | Oncology Bioinformatics Cytology Biomaterials Materials Science Computational Biology/Bioinformatics Cancer Research Cell Biology Biophysics and Biological Physics Hochschulschrift |
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