Humanized Mice for HIV Research:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Springer
2014
|
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Abstract Inhaltsverzeichnis |
| Beschreibung: | 1 Online-Ressource (XXI, 538 p. 54 illus., 45 illus. in color) |
| ISBN: | 9781493916559 |
| DOI: | 10.1007/978-1-4939-1655-9 |
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| 245 | 1 | 0 | |a Humanized Mice for HIV Research |c Larisa Y. Poluektova, J. Victor Garcia, Yoshio Koyanagi, Markus G. Manz, Andrew M. Tager, ed. |
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Datensatz im Suchindex
| _version_ | 1804153033326592000 |
|---|---|
| adam_text | HUMANIZED MICE FOR HIV RESEARCH
/ POLUEKTOVA, LARISA Y.
: 2014
ABSTRACT / INHALTSTEXT
OVER THE LAST SEVERAL YEARS THE FIELD OF HUMANIZED MICE HAS MATURED AND
DEVELOPED INTO AN ESSENTIAL COMPONENT OF TRANSLATIONALRESEARCH FOR
HIV/AIDS. HUMANIZED MICE SERVE BOTH AS VEHICLES FOR DISCOVERY AND AS
HIGHLY SOPHISTICATED PLATFORMS FOR BIOMEDICAL RESEARCH. IN ADDITION,
HUMANIZED MICE HAVE DEMONSTRATED OUTSTANDING POTENTIAL FOR THE
INVESTIGATION OF CRITICAL ASPECTS OF THE INFECTION AND PATHOGENESIS OF
THE HEPATITIS AND HERPES VIRUSES, AS WELL AS HIGHLY RELEVANT MICROBIAL
INFECTIONS SUCH AS TUBERCULOSIS AND MALARIA.HUMANIZED MICE FOR HIV
RESEARCH PROVIDES A COMPREHENSIVE PRESENTATION OF THE HISTORY,
EVOLUTION, APPLICATIONS, AND CURRENT STATE OF THE ART OF THIS UNIQUE
ANIMAL MODEL. AS AN EXPANSION OF TWELVE REVIEW ARTICLES THAT WERE
PUBLISHED IN HUMANIZED MICE BY SPRINGER IN 2008 (EDS: NOMURA T, WATANABE
T, HABU S), THIS BOOK EXPERTLY CAPTURES THE OUTSTANDING PROGRESS THAT
HAS BEEN MADE IN THE DEVELOPMENT, IMPROVEMENT, IMPLEMENTATION, AND
VALIDATION OF HUMANIZED MOUSE MODELS. THE FIRST TWOPARTS OF THIS BOOK
COVER THE BASICS OF HUMAN-TO-MOUSE XENOTRANSPLANTATION BIOLOGY, AND
PROVIDE CRITICAL INFORMATION ABOUT HUMAN IMMUNE CELL DEVELOPMENT AND
FUNCTION BASED ON INDIVIDUAL MODELS CREATED FROM DIFFERENT
IMMUNODEFICIENT STRAINS OF MICE. THE THIRD AND FOURTHPARTS INVESTIGATE
HIV-1 BIOLOGY, INCLUDING DIFFERENT ROUTES OF TRANSMISSION, PREVENTION,
TREATMENT, PATHOGENESIS, AND THE DEVELOPMENT OF ADAPTIVE IMMUNITY IN
HUMANIZED MICE.THE FIFTHPART SHOWS THE BROAD APPLICABILITY OF
HUMANIZED MICE FOR THERAPEUTIC DEVELOPMENT, FROM LONG-ACTING
ANTIRETROVIRAL COMBINATIONS TO GENETIC MANIPULATIONS WITH HUMAN CELLS
AND CELL-BASED APPROACHES. THE SIXTHPART INCLUDES LIVER TISSUE
ENGINEERING AND THE EXPANSION OF HUMANIZED MICE FOR MANY OTHER HUMAN
CELL-TROPIC PATHOGENS. ABOUT THE EDITORS THE EDITORS HAVE
WELL-DOCUMENTED TRACK RECORDS IN EACH OF THE SUBJECT AREAS COVERED,
INCLUDING HIV NEUROPATHOGENESIS AND THERAPEUTICS (LARISA Y. POLUEKTOVA,
UNIVERSITY OF NEBRASKA MEDICAL CENTER, OMAHA, USA), DEVELOPING NOVEL
HUMANIZED MOUSE MODELS AND PIONEERING APPLICATIONS FOR HIV TRANSMISSION,
PREVENTION, PERSISTENCY AND ERADICATION(J. VICTOR GARCIA, UNIVERSITY
OF NORTH CAROLINA AT CHAPEL HILL, USA), RETROVIROLOGY AND HOST
RESTRICTION FACTORS (YOSHIO KOYANAGI, CENTER FOR HUMAN RETROVIRUS
RESEARCH, INSTITUTE FOR VIRUS RESEARCH, KYOTO UNIVERSITY, JAPAN),
HEMATOPOIESIS AND CYTOKINE TRANSGENIC EXPRESSION (MARKUS G.MANZ,
DIVISION OF HEMATOLOGY, UNIVERSITY HOSPITAL ZUERICH, SWITZERLAND), AND
DEVELOPING ADAPTIVE IMMUNITY TO HIV IN HUMANIZED MICE (ANDREW M. TAGER,
CENTER FOR IMMUNOLOGY AND INFLAMMATORY DISEASES, MASSACHUSETTS GENERAL
HOSPITAL AND RAGON INSTITUTE OF MGH, MIT AND HARVARD, USA).
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
HUMANIZED MICE FOR HIV RESEARCH
/ POLUEKTOVA, LARISA Y.
: 2014
TABLE OF CONTENTS / INHALTSVERZEICHNIS
MAMORU ITO S VISION FOR THE FUTURE OF HUMANIZED MOUSE MODELS
PART I. MOUSE GENETIC BACKGROUND AND HUMAN HEMATOPOIETIC STEM CELLS
BIOLOGY
HUMANIZED MICE AS MODELS FOR HUMAN DISEASE
ROLE OF MOUSE INNATE IMMUNITY IN IMMUNODEFICIENT MICE FOR
XENOTRANSPLANTATION
MOUSE GENETIC BACKGROUND AND HUMAN HEMATOPOIETIC STEM CELLS BIOLOGY;
TIPS FOR HUMANIZATION
BIOLOGY OF HUMAN HEMATOPOIETIC STEM CELL XENOTRANSPLANTATION IN MICE
IMPACT OF THE MOUSE IL-2RG CHAIN ON LYMPHOID TISSUE DEVELOPMENT AND
HUMAN RECONSTITUTION IN IMMUNODEFICIENT MICE
BM HEMATOPOIETIC NICHE OCCUPANCY DEFECT OF HSC IN SCID MICE
IMPROVEMENT OF HUMAN MULTILINEAGE HEMATOPOIETIC ENGRAFTMENT BY CYTOKINE
KNOCKIN REPLACEMENT IN HUMAN-HEMATO-LYMPHOID SYSTEM MICE
PART II. SECTION 2: UNDERSTANDING OF HUMAN IMMUNE CELLS DEVELOPMENT AND
FUNCTION IN MOUSE ENVIRONMENT
CYTOKINE SPECIES-SPECIFICITY AND HUMANIZED MICE
HUMAN T CELL BIOLOGY IN A MOUSE ENVIRONMENT
THYMIC EDUCATION OF HUMAN T CELLS AND REGULATORY T CELL DEVELOPMENT IN
HUMANIZED MICE
HUMAN B CELL DEVELOPMENT IN A MOUSE ENVIRONMENT
THE ANALYSIS OF THE FUNCTIONS OF HUMAN B AND T CELLS IN HUMANIZED NOG
MICE
NK CELL DEVELOPMENT IN HUMAN IMMUNE SYSTEM (HIS) MICE AND THEIR ROLE IN
HIV PATHOGENESIS
MAINTENANCE AND FUNCTION OF HUMAN CD8+ T CELLS AND NK CELLS IN HUMANIZED
MICE
PHENOTYPICAL AND FUNCTIONAL PROPERTIES OF ANTIGEN-PRESENTING CELLS
DERIVED FROM HUMANIZED MICE
PART III: HUMANIZED MICE FOR HIV-1 VIRUS BIOLOGY AND PATHOGENESIS. IS IT
POSSIBLE TO ADDRESS?
HUMANIZED MOUSE VERSUS NON-HUMAN PRIMATE MODELS OF HIV-1 INFECTION
HOST FACTOR-MEDIATED RESISTANCE TO HIV-1 INFECTION
VAGINAL AND RECTAL HIV TRANSMISSION IN HUMANIZED MICE
ORAL HIV-1 TRANSMISSION IN BLT HUMANIZED MICE
SELECTIVE INFECTION OF CD4+ MEMORY T CELLS
DEVELOPMENT AND FUNCTION OF HUMAN CD4+CD25+FOXP3+ REGULATORY T CELLS IN
HUMANIZED MOUSE AND HIV-1 INFECTION
ROLE OF TLR SIGNALING IN HIV-1-INDUCED ADAPTIVE IMMUNE ACTIVATION
LATENT HIV-1 INFECTION OF RESTING CD4+ T CELLS: TESTING APPROACHES TO
OVERCOME HIV LATENCY
BRAIN HIV-1 INFECTION MODELING IN HUMANIZED MICE
PART IV. HUMANIZED MICE FOR HIV-1-SPECIFIC ADAPTIVE CELLULAR AND HUMORAL
IMMUNE RESPONSES
ANTIBODY-BASED PROTECTION AGAINST HIV INFECTION
B-CELL RESPONSES IN HUMANIZED MICE: THE GLASS IS HALF FULL
PART V. THERAPEUTICS DEVELOPMENTS FOR HIV-1
SPECIES SIMILARITIES AND DIFFERENCES IN PHARMACOKINETICS AND
DISTRIBUTION OF ANTIRETROVIRAL DRUGS
ANTI-RETROVIRAL TREATMENT TESTING IN HIV-INFECTED HUMANIZED MICE
HUMANIZED MICE AS A PLATFORM FOR THE DEVELOPMENT OF LONG-ACTING
NANOFORMULATED ANTIRETROVIRAL THERAPY
TARGETED DELIVERY OF APTAMERS AND SIRNAS FOR HIV PREVENTION AND
THERAPIES IN HUMANIZED MICE
ZINC FINGER NUCLEASE EDITING OF HEMATOPOIETIC STEM CELLS AS AN ANTI-HIV
THERAPY
HEMATOPOIETIC PROGENITOR CELL TRANSDUCTION BY A UNIQUE SHORT HAIRPIN RNA
TO CHEMOKINE RECEPTOR 5
CELL-BASED APPROACHES FOR TREATING HIV INFECTION
A CONDITIONALLY REPLICATING HUMAN IMMUNODEFICIENCY VIRUS IN BRG-HIS MICE
PART VI.NEW MODELS FOR OTHER HUMAN-SPECIFIC OR HUMAN SELECTIVE
PATHOGENS
DUAL RECONSTITUTED MICE FOR HEPATOTROPIC PATHOGENS
DENGUE VIRAL PATHOGENESIS AND IMMUNE RESPONSES IN HUMANIZED MICE
HIV-1 AND TB: HOW HUMANIZED MICE CAN HELP
EPSTEIN-BARR VIRUS INFECTION IN HUMANIZED MICE
HTLV-1 INFECTION OF HUMANIZED NOD/SCID IL2 GC-/- AND BALB/C-RAG2-/-GC-/-
MOUSE MODELS
PLASMODIUM FALCIPARUM PARASITE DEVELOPMENT IN HUMANIZED MICE: LIVER AND
BLOOD STAGES
PART VII. NEW HORIZONS IN MOUSE HUMANIZATION
THE FUTURE IS NOW FOR HUMANIZED MOUSE MODELS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| spelling | Humanized Mice for HIV Research Larisa Y. Poluektova, J. Victor Garcia, Yoshio Koyanagi, Markus G. Manz, Andrew M. Tager, ed. New York, NY [u.a.] Springer 2014 1 Online-Ressource (XXI, 538 p. 54 illus., 45 illus. in color) txt rdacontent c rdamedia cr rdacarrier Medicine Immunology Microbiology Medical virology Biomedicine Medical Microbiology Virology Medizin Poluektova, Larisa Y. Sonstige oth Garcia, J. Victor Sonstige oth Koyanagi, Yoshio Sonstige oth Manz, Markus G. Sonstige oth Tager, Andrew M. Sonstige oth Erscheint auch als Druckausgabe 978-1-4939-1654-2 https://doi.org/10.1007/978-1-4939-1655-9 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027823002&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Abstract Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027823002&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Humanized Mice for HIV Research Medicine Immunology Microbiology Medical virology Biomedicine Medical Microbiology Virology Medizin |
| title | Humanized Mice for HIV Research |
| title_auth | Humanized Mice for HIV Research |
| title_exact_search | Humanized Mice for HIV Research |
| title_full | Humanized Mice for HIV Research Larisa Y. Poluektova, J. Victor Garcia, Yoshio Koyanagi, Markus G. Manz, Andrew M. Tager, ed. |
| title_fullStr | Humanized Mice for HIV Research Larisa Y. Poluektova, J. Victor Garcia, Yoshio Koyanagi, Markus G. Manz, Andrew M. Tager, ed. |
| title_full_unstemmed | Humanized Mice for HIV Research Larisa Y. Poluektova, J. Victor Garcia, Yoshio Koyanagi, Markus G. Manz, Andrew M. Tager, ed. |
| title_short | Humanized Mice for HIV Research |
| title_sort | humanized mice for hiv research |
| topic | Medicine Immunology Microbiology Medical virology Biomedicine Medical Microbiology Virology Medizin |
| topic_facet | Medicine Immunology Microbiology Medical virology Biomedicine Medical Microbiology Virology Medizin |
| url | https://doi.org/10.1007/978-1-4939-1655-9 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027823002&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027823002&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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