The Variation and Adaptive Expression of Antibodies:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cambridge, Mass.
Harvard University Press
[1973]
|
| Schlagworte: | |
| Online-Zugang: | FAB01 FAW01 FCO01 FHA01 FKE01 FLA01 UPA01 Volltext |
| Beschreibung: | 43 schw.-w. Abb., 33 schw.-w. Tab George P. Smith presents a critical study of these theories in this detailed treatment of immunological problems from the point of view of molecular genetics. This is a timely book offering a succinct and coherent summary of the various lines of evidence in a confused and controversial field During the past ten years, several theories have been proposed on the origin of the diversity of antibodies. George P. Smith presents a critical study of these theories in this detailed treatment of immunological problems from the point of view of molecular genetics. Mr. Smith uses a new and simplifying approach to this long-standing controversy. By a comprehensive computerized analysis of antibody amino acid sequences (particularly the myeloma proteins), the author traces their evolution and matches his results against the expectations of the various theories of diversity. He discusses at length the other types of evidence as well. Mr. Smith also deals with the clonal specialization of cells to produce a single antibody, and the relationship of this specialization to the somatic joining of antibody half-genes, which is one of the immune system's most important peculiarities. Introductory material is provided to make this work understandable to molecular geneticists not versed in immunology and to immunologists not versed in molecular genetics. This is a timely book offering a succinct and coherent summary of the various lines of evidence in a confused and controversial field |
| Beschreibung: | 1 Online-Ressource (xii,219p.) |
| ISBN: | 9780674365148 |
| DOI: | 10.4159/harvard.9780674365148 |
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Datensatz im Suchindex
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| any_adam_object | |
| author | Smith, George P. |
| author_facet | Smith, George P. |
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| author_sort | Smith, George P. |
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| building | Verbundindex |
| bvnumber | BV042344095 |
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| ctrlnum | (OCoLC)1013938185 (DE-599)BVBBV042344095 |
| dewey-full | 574.2/93 |
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| dewey-ones | 574 - [Unassigned] |
| dewey-raw | 574.2/93 |
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| discipline | Biologie |
| doi_str_mv | 10.4159/harvard.9780674365148 |
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| id | DE-604.BV042344095 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T01:18:58Z |
| institution | BVB |
| isbn | 9780674365148 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027780576 |
| oclc_num | 1013938185 |
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| physical | 1 Online-Ressource (xii,219p.) |
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| publishDate | 1973 |
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| publisher | Harvard University Press |
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| spelling | Smith, George P. Verfasser aut The Variation and Adaptive Expression of Antibodies George P. Smith Cambridge, Mass. Harvard University Press [1973] 1 Online-Ressource (xii,219p.) txt rdacontent c rdamedia cr rdacarrier 43 schw.-w. Abb., 33 schw.-w. Tab George P. Smith presents a critical study of these theories in this detailed treatment of immunological problems from the point of view of molecular genetics. This is a timely book offering a succinct and coherent summary of the various lines of evidence in a confused and controversial field During the past ten years, several theories have been proposed on the origin of the diversity of antibodies. George P. Smith presents a critical study of these theories in this detailed treatment of immunological problems from the point of view of molecular genetics. Mr. Smith uses a new and simplifying approach to this long-standing controversy. By a comprehensive computerized analysis of antibody amino acid sequences (particularly the myeloma proteins), the author traces their evolution and matches his results against the expectations of the various theories of diversity. He discusses at length the other types of evidence as well. Mr. Smith also deals with the clonal specialization of cells to produce a single antibody, and the relationship of this specialization to the somatic joining of antibody half-genes, which is one of the immune system's most important peculiarities. Introductory material is provided to make this work understandable to molecular geneticists not versed in immunology and to immunologists not versed in molecular genetics. This is a timely book offering a succinct and coherent summary of the various lines of evidence in a confused and controversial field In English Biowissenschaften, Biologie Immunoglobulins Immunogenetics Antikörper (DE-588)4002290-0 gnd rswk-swf Antikörper (DE-588)4002290-0 s 1\p DE-604 Erscheint auch als Druckausgabe 978-0-674-36513-1 https://doi.org/10.4159/harvard.9780674365148 Verlag Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Smith, George P. The Variation and Adaptive Expression of Antibodies Biowissenschaften, Biologie Immunoglobulins Immunogenetics Antikörper (DE-588)4002290-0 gnd |
| subject_GND | (DE-588)4002290-0 |
| title | The Variation and Adaptive Expression of Antibodies |
| title_auth | The Variation and Adaptive Expression of Antibodies |
| title_exact_search | The Variation and Adaptive Expression of Antibodies |
| title_full | The Variation and Adaptive Expression of Antibodies George P. Smith |
| title_fullStr | The Variation and Adaptive Expression of Antibodies George P. Smith |
| title_full_unstemmed | The Variation and Adaptive Expression of Antibodies George P. Smith |
| title_short | The Variation and Adaptive Expression of Antibodies |
| title_sort | the variation and adaptive expression of antibodies |
| topic | Biowissenschaften, Biologie Immunoglobulins Immunogenetics Antikörper (DE-588)4002290-0 gnd |
| topic_facet | Biowissenschaften, Biologie Immunoglobulins Immunogenetics Antikörper |
| url | https://doi.org/10.4159/harvard.9780674365148 |
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