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Animal models for the study of human disease:

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Weitere Verfasser:	Conn, Patrick Michael 1949-2016 (HerausgeberIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Amsterdam [u.a.] Acad. Press 2013
Ausgabe:	1. ed.
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XVIII, 1089 S. Ill., graph. Darst.
ISBN:	9780124158948

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Datensatz im Suchindex

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adam_text	Titel: Animal models for the study of human disease Autor: Conn, Patrick Michael Jahr: 2013 Contents Preface xiii List of Contributors xv _I_ ETHICS, RESOURCES AND APPROACHES 1 - Ethics in Biomedical Animal Research JERROLD TANNENBAUM Nature and Scope of the Chapter 4 The Subject Matter of Animal Research Ethics 5 Aspects of Animal Use and Care Relevant to Animal Research Ethics 6 Why Investigators are Uniquely Qualified to Engage in Ethical Assessment of Animal Research 6 Why Investigators Should Commit Themselves to Ethical Conduct of Animal Research 7 Why Investigators Play the Key Role in Assuring the Ethical Conduct of Animal Research Projects 8 Sources of Support and Guidance in Conducting Ethical Research 11 Developing Useful Ethical Guidelines 13 Fundamental Principles of Animal Research Ethics 14 Practical Ethical Guidelines for Investigators 26 Some Current Difficult Issues in Animal Research Ethics 28 General Suggestions for Investigators 32 References 33 2. Access to Resources JUDITH AXLER TURNER The Problem 37 The LAMHDI Solution 38 The Ideal Solution 45 Acknowledgments 46 References 47 3. The Advent of the Golden Era of Animal Alternatives DANIEL BUTZKE, BARBARA GRUNE, JOSEPHINE KUGLER, MICHAEL OELGESCHLÄGER, ANDREA SEILER, DANA SITTNER, MANFRED LIEBSCH, ANDREAS LUCH Introduction 49 Analytical Tools for the Detection of Food-Borne Disease 50 An in Vitro System to Assess Adverse Effects During Development 53 Diseases-in-A-Dish 57 Non-invasive Imaging and Recording 62 Conclusions 65 References 66 4. Environmental Enrichment for Animals Used in Research KRISTINE COLEMAN, JAMES L. WEED, STEVEN J. SCHAPIRO Introduction 75 Applied Science: Enrichment as a Welfare Tool 76 Basic Science: Enrichment and Animal Models 82 Enrichment and Experimental Variability 84 Environmental Enrichment Regulations 85 Implementing an Enrichment Plan 86 Conclusions 88 Acknowledgments 88 References 88 _II_ VISION 5. Animal Models of Age-Related Macular Degeneration CAROLINE J. ZEISS Introduction 97 Comparative Retinal Anatomy and the Pathology of AMD 98 The Genetics of AMD 103 Inflammation in AMD 103 HTRAl and LOC387715/ARMS2 in AMD 108 Oxidative Damage and AMD 108 Lipid Metabolism and AMD 109 Spontaneously Occurring Primate Models of AMD 109 Modeling Choroidal Neovascularization in Advanced AMD 110 Conclusion 112 References 112 6. N-Methyl-N-Nitrosourea Animal Models for Retinitis Pigmentosa AIRO TSUBURA, KATSUHIKO YOSHIZAWA, MAKI KURO Introduction 117 Time-Course Progression of MNU-Induced Retinal Degeneration 118 Retinal Degeneration Caused by MNU in Various Animal Species 120 Age-Related Photoreceptor Cell Damage and Sensitivity to MNU 121 V vi CONTENTS Photoreceptor Cell Death, Cell Debris Removal, and Rpe Cell Migration 122 Molecular Mechanisms in Photoreceptor Cell Death Caused by MNU 126 Therapeutic Trials Against MNU-Induced Photoreceptor Apoptosis 129 Concluding Remarks 138 Acknowledgments 138 References 138 _m_ CARDIAC AND CARDIOVASCULAR 7. Animal Models of Myocardial Disease ROSS A. BRECKENRIDGE Introduction 145 The Spectrum of Cardiovascular Disease 146 Choice of Animal System 146 Experimental Design 147 Ischemic Heart Disease 150 Systolic Heart Failure 154 Diastolic Heart Failure 157 Infective Myocarditis 157 Cardiomyopathies 158 Diabetes and Obesity-Related Heart Disease 162 The Future of Animal Models for Cardiovascular Disease 164 References 164 8. Animal Models for Cardiovascular Research LI CHEN, RICHARD P. SHANNON, YOU-TANG SHEN Introduction 173 Myocardial Ischemic Models 174 Hypertension and Left Ventricular Hypertrophy Models 183 Heart Failure Models 186 Cardiovascular Denervation Models 187 Future Directions 191 References 192 9. Cardiovascular Models: Heart Secondarily Affected by Disease JITKA SVIGLEROVA, JITKA KUNCOVA, MILAN STENGL Introduction 195 The Heart and Diabetes Mellitus 196 The Heart and Renal Failure 201 The Heart and Dysfunctional Sympathetic Innervation 208 Acknowledgment 217 References 217 10. Models for the Study of Atherosclerosis and Thrombosis LINA BADIMON, LAURA CASANI, GEMMA VILAHUR Small Versus Large: Size Matters? 221 Atherosclerosis 222 Thrombosis 227 Animal Models of Von Willebrand Disease 232 Animal Models of Venous Thrombosis 232 Animal Models of Plaque Rupture 232 Conclusions and Future Perspectives 233 Acknowledgments 234 References 234 _IV_ OBESITY, METABOLIC AND LIVER 11. Animal Models of Metabolic Syndrome HEATHER A. LAWSON Introduction and Overview 243 Choosing an Animal Model of MetS 244 Animal Models of MetS Etiology 246 Genetic Factors 246 Environmental Factors 253 Animal Models of MetS Pathophysiology 255 Conclusions 258 References 258 12. Invertebrates in Obesity Research: A Worm s Perspective SOUDABEH IMANIKIA, STEPHEN R. STÜRZENBAUM Obesity Worldwide 265 Model Organisms 266 Introducing the Nematode C. Elegans 266 Lipids in C. Elegans 268 C. Elegans as a Model for Obesity Research 269 Fat Pathways in Mammals and Worms 269 Obesity in Humans and Model Organisms: A Genomic Approach 271 The Link Between Fat Metabolism and Other Diseases 272 Other Invertebrate Models in Obesity Research 272 Conclusion 273 References 273 13. Animal Models of Dietary-Induced Obesity LOUISE THIBAULT Usefulness of Animal Models of Human Obesity 277 Fat-Rich Diets 279 Physiological Mechanisms of Fat-Rich-Diet-Induced Obesity 291 Behavioral Mechanisms of Dietary Obesity 294 Reversal of Dietary Obesity 296 Conclusions 297 Acknowledgments 297 References 298 CONTENTS vii 14. Animal Models for Manipulation of Thermogenesis BELINDA A. HENRY, IAIN J. CLARKE Introduction 305 Brown Fat 306 Bat and Thermogenesis in White Adipose Tissue 310 Browning of White Adipose Tissue 310 Skeletal Muscle 311 Models of Obesity 315 Diet-Induced Obesity and Thermogenesis 315 Photoperiod and Seasonality as Models of Metabolic Function 316 Fetal Growth Retardation and Effect on Metabolic Balance 320 Transgenerational Effects of Obesity 323 Polygenic Models of Obesity 323 Concluding Remarks 324 References 324 15. Animal Models of Cholestasis PETER FICKERT, MARION J. POLLHEIMER, CHRISTOPH H. ÖSTERREICHER, MICHAEL TRAUNER Introduction 331 General Concepts of Normal Bile Formation 333 Liver Fibrosis in Cholestatic Liver Diseases 334 Models for (Primary) Sclerosing Cholangitis 334 Models for Primary Biliary Cirrhosis 340 Obstructive Cholestasis 342 Drug-Induced Cholestasis 343 Inflammation-Induced Cholestasis 343 Biliary Atresia 344 Inherited Cholestatic Syndromes 344 Summary and Conclusions 345 References 345 ____V_ BONE AND SKIN 16. Animal Models of Bone Diseases-A LIXIN KAN Introduction 353 Animal Models of Age-Dependent Degenerative Bone Disorders 354 Animal Models of Congenital Bone Disorders 379 Conclusions 382 Acknowledgments 382 References 382 17. Animal Models of Bone Disease-B MEGHAN E. MCGEE-LAWRENCE, FRANK J. SECRETO, FARHAN A. SYED Introduction 392 Criteria for Choosing Animal Models for Bone Loss and Regeneration 392 Common Animal Models for Skeletal Research 395 Genetic Mouse Models for Elucidating Mechanistic Changes 403 Methods Used in Evaluating Bone Structure and Strength in Animal Models 404 In Vitro Models of Skeletal Biology 407 Conclusion and Closing Remarks 410 Acknowledgment 410 References 410 I S. Animal Models for Implant-Associated Osteomyelitis JOSHUA G. HUNTER, JOHN L. DAISS, STEPHEN L. KATES, EDWARD M. SCHWARZ Introduction 419 General Features of Osteomyelitis Animal Models 421 Rabbit Osteomyelitis Models 422 Rat Osteomyelitis Models 424 Mouse Models of Osteomyelitis 425 Large-Animal Models of Osteomyelitis 425 Areas for Improvement of Animal Models of Osteomyelitis 427 Biomarkers of Infection 427 Conclusion 430 Acknowledgments 430 References 430 19. Animal Models of Fibrosis in Human Disease GIDEON P. SMITH Introduction 435 Animal Models of Fibrosis in Scleroderma 435 Conclusions 442 Liver Fibrosis 442 Conclusions 452 References 452 _VI_ URINARY TRACT, KIDNEY AND BOWEL 20. Animal Models of Lower Urinary Tract Dysfunction RITA I. JABR, CHRISTOPHER H. FRY The Requirement for Animal Models 461 The Normal Urinary Tract 462 Aging Animal Models 464 Bladder Outflow Tract Obstruction 465 Stress Urinary Incontinence 466 Bladder Pain Syndrome 467 Lower Urinary Tract Disorders of Neurological Origin 469 Animal Models of Central Nervous System Control Over Bladder Function 470 Diabetes and Lower Urinary Tract Dysfunction 471 Urinary Tract Infections 473 Congenital Anomalies 473 Tissue Engineering and the Urinary Tract 475 References 476 viii CONTENTS 21. Animal Models of Calcium Oxalate Kidney Stone Formation SAEED R. KHAN Introduction 483 Calcium Oxalate Crystal Deposition in Rats 484 Calcium Oxalate Crystal Deposition in Mice 491 Calcium Oxalate Crystal Deposition in Pigs 492 Calcium Phosphate Crystal Deposition in Rats 492 Calcium Phosphate Crystal Deposition in Mice 492 Calcium Oxalate/Calcium Phosphate Association in Animal Models 494 Foreign-Body Stones 494 Comparison Between Rat and Human Nephrolithiasis 494 Concluding Remarks 495 References 496 22. Animal Models of Inflammatory Bowel Disease for Drug Discovery ATSUSHI MIZOGUCHI, AKIRA ANDOH Introduction 499 Classification of Mouse IBD Models 501 Etiology and Mouse IBD Models 501 Classical Therapy and IBD Models 503 Biological Therapy and IBD Models 505 Conclusion 518 Acknowledgments 518 References 518 _VII_ THE BRAIN, STROKE, AND NEUROMUSCULAR 23. Animal Models of Stroke Versus Clinical Stroke: Comparison of Infarct Size, Cause, Location, Study Design, and Efficacy of Experimental Therapies VICTORIA E. O COLLINS, GEOFFREY A. DONNAN, MALCOLM R. MACLEOD, DAVID W. HOWELLS Introduction 532 Systematic Review and Meta-Analysis Method 532 Results 536 Discussion 557 Conclusion 563 Acknowledgments 563 References 563 24- Animal Models and Methods to Study the Relationships Between Brain and Tissues in Metabolic Regulation LUC PENICAUD, ALEXANDRE BENANI, FRÉDÉRIQUE DATICHE, XAVIER FIORAMONTI, CORINNE LELOUP, FABIENNE LIEN ARD Introduction 570 General Considerations 571 Technical Means to Investigate the Role of the Central Nervous System 571 Modulating Central Nervous System Activity 576 Study of Cerebral Responses 580 Behavioral and Metabolic Responses 585 Conclusion 589 References 589 25. Models of Alzheimer s Disease MENGQI CHEN, DORIS KRETZSCHMAR, GIUSEPPE VERDILE, MICHAEL LARDELLI Introduction 595 Invertebrate Models 597 Nonmammalian Vertebrates 603 Mammalian Models 611 Conclusions 622 References 622 26. Neurotoxin l-Methyl-4-phenyl-l,2,3, 6-tetrahydropyridine-Induced Animal Models for Parkinson s Disease JIRO KASAHARA, MOHAMMED EMAMUSSALEHIN CHOUDHURY, HIRONORI YOKOYAMA, NAOTO KADOGUCHI, MASAHIRO NOMOTO Abbreviations 634 Introduction 634 Clinical Characteristics of PD and Their Relevant Symptoms in Animal Models 636 Molecular Pathophysiology of PD 637 Neurotoxins for Making PD Models 638 MPTP-Induced Mouse Model for PD 641 MPTP-lnduced Common Marmoset Model for PD 645 Concluding Remarks 647 Acknowledgment 647 References 647 27. The Importance of Olfactory and Motor Endpoints for Zebrafish Models of Neurodegenerative Disease ANGELA L. SHAMCHUK, KEITH B. TIERNEY Introduction 651 Building Relevant Models 654 Olfactory-Neuromuscular Diseases 656 ; Conclusions 667 References 668 _vm_ BEHAVIOR 28. Animal Models of Drug Abuse: Place and Taste Conditioning CATHERINE M. DAVIS What is Drug Addiction and why Should We Study it? 681 Reward and Reinforcement 682 CONTENTS ix Aversive Drug Effects 683 The Place-Conditioning Procedure 684 The Flavor-Conditioning Procedure 693 Conclusion 703 Acknowledgments 703 References 703 29. Animal Models of Reward Behavior CHARLES W. SCHINDLER, STEVEN R. GOLDBERG Reward Behavior 711 Examples of Reward Learning 713 What can be a Reward? 715 Factors Affecting Conditioning with Rewards 717 Role of Pavlovian Conditioning in Reward Learning 723 Conclusion 725 Acknowledgment 725 References 725 30. Modeling Schizophrenia in Animals DAVID FEIFEL, PAUL D. SHILLING Overview of Schizophrenia 727 Approaches to Creating Animal Models with Relevance to Schizophrenia 730 Features of Schizophrenia That can be Modeled in Animals 731 Specific Animal Models 739 References 748 _IX_ GENETICS 31. Mouse Models for the Exploration of Klinefelter s Syndrome JOACHIM WISTUBA, STEFFI WERLER, LARS LEWEJOHANN Introductory Remarks 759 KS—An Underestimated Disease 760 The X Chromosome in the Male 761 Clinical Features of KS 763 Sex Chromosomal Aberrations in Male Mammals 765 Mouse Models for KS 766 Lessons from Animal Experiments 769 Perspectives—What can be Expected from Future Animal Experiments and How to Retranslate Experimental Findings into Clinical Routine—Conclusive Remarks 779 Acknowledgments 780 References 780 32. Genetically Tailored Pig Models for Translational Biomedical Research BERNHARD AIGNER, BARBARA KESSLER, NIKOLAI KLYMIUK, MAYUKO KUROME, SIMONE RENNER, ANNEGRET WÜNSCH, ECKHARD WOLF Introduction 785 Techniques for the Production of Genetically Engineered Pigs 786 Genetically Engineered Pigs as Models for Human Diseases 792 Conclusions 805 Acknowledgments 805 References 805 33. Genetically Modified Animal Models LUCAS M. CHAIBLE, DENISE KINOSHITA, MARCUS A. FINZI CORAT, MARIA L. ZAIDAN DAGLI Introduction 811 Some Historical Aspects 812 Techniques for the Managed Creation of Genetically Modified Animal Models 812 Types of Genetically Modified Animals and How They Are Produced 813 Genetically Modified Mice as Models of Human Diseases 816 References 826 34. Mouse Models for Human Diseases by Forward and Reverse Genetics YOICHI GONDO Genetics and Diseases 834 Genetic or Environmental Factors 834 Power of Mouse Models for Human Diseases 835 The Human Genome Project and Human Diseases 835 Basic Genetics for Developing and Using Model Mice 836 Mutant Mice as Disease Models 843 Unique Positional Cloning: High Reversion Rates of dv and pun Mutations 846 Mutagenesis for Forward Genetics 847 Mutagenesis for Reverse Genetics 852 Concluding Remarks 855 Acknowledgments 855 References 855 _X_ EARLY LIFE 35. Animal Models for the Study of Infection-Associated Preterm Birth MATTHEW W. KEMP, GABRIELLE C. MUSK, MASATOSHI SAITO Introduction 863 Infection, Inflammation, and Parturition 864 Practical Study: Surgical Studies in the Pregnant Sheep 872 Acknowledgment 885 References 885 36. Animal Models of Febrile Seizures RYUTA KOYAMA Introduction 889 Febrile Seizure in Humans and Its Relationship to Epilepsy 890 Animal Models of Febrile Seizures 891 Other Animal Models of Early-Life Seizures 893 X CONTENTS Mechanisms Underlying Hyperthermia-Induced Experimental Febrile Seizures 893 Neuroanatomical Changes after Experimental Febrile Seizures 894 Neurophysiological Changes after Experimental Febrile Seizures 896 Neuronal Hyperactivity after Experimental Febrile Seizures 897 Behavioral Changes after Experimental Febrile Seizures 897 Conclusions 898 Acknowledgments 898 References 898 _XI_ VIRAL DISEASE 37. Human Herpesviruses and Animal Models ALISTAIR MCGREGOR, K. YEON CHOI, SCOTT SCHACHTELE, JAMES LOKENSGARD Introduction 906 CMV (HHV-5) and Other Betaherpesviruses (HHV-6 and -7) 906 Gammaherpesviruses (Epstein-Barr Virus and Kaposi s Sarcoma-Associated Herpesvirus) 908 Herpes Simplex (HSV-1 and -2) 909 Varicella Zoster (HHV-4) 910 Recombinant Viruses and Reporter Genes 910 Protocols 911 Protocol 1. Generation of Mutants via Conventional Homologous Strategy 911 Protocol 2. Generation of Recombinant Virus via Manipulation of an Infectious BAC Clone 913 Protocol 3. Virus Titration 914 Protocol 4. Detection and Tracking of Cells in Response to Virus Infection 915 Bioluminescent Tracking of Immune Cells during Viral Brain Infection 917 Protocol 5. Detection of Viral Load in Target Organs of Virus-Infected Animals (CMV, HSV, and VZV) 918 Protocol 6. BLI of Virus Infection in an Animal Model 922 Acknowledgments 923 References 923 38. Animal Models of Human Viral Diseases SARA I. RUIZ, ELIZABETH E. ZUMBRUN, AYSEGUL NALCA Introduction 928 Picornaviridae 928 Caliciviridae 930 Togaviridae 930 Flaviviridae 933 Coronoviridae 936 Rhabdoviridae 937 Filoviridae 938 Paramyxoviridae 940 Orthomyxoviridae 942 Bunyaviridae 944 Arenaviridae 947 Reoviridae 948 Retroviridae 949 Papillomaviridae 951 Poxviridae 951 Hepadnaviridae 954 Conclusions 955 References 955 _XII_ CANCER 39. Xenograft, Transgenic, and Knockout Models of Prostate Cancer ANN-CHRISTIN GAUPEL, WEI-LIN WINNIE WANG, SARAH MORDAN-MCCOMBS, EDMUND CHUN YU LEE, MARTIN TENNISWOOD Introduction 973 Xenograft Models of Prostate Cancer 975 The LOBUND-Wistar Rat Model of Prostate Cancer 983 Transgenic Models of Prostate Cancer 983 Knockout Models of Prostate Cancer 987 Transgenic Models of the Tumor Microenvironment 988 References 990 40. Animal Models for Studying Prevention and Treatment of Breast Cancer JOELLEN WELSH Introduction to Animal Models of Breast Cancer 998 Concepts of Breast Cancer Biology 998 Modeling Breast Cancer in Rodents 999 Spontaneous and Induced Mammary Tumorigenesis in Rodents 1000 Grafting and Transplantation Approaches 1004 Genetically Engineered Mice Models of Breast Cancer 1012 References 1016 _xra_ SCLEROSIS 41. Animal Models of Systemic Sclerosis TOSHIYUKI YAMAMOTO Introduction 1021 Bleomycin-Induced Murine Scleroderma 1021 HOCl-Induced Murine Scleroderma 1026 Tsk Mouse 1026 Scl-GvHD Model 1028 Skin Fibrosis by Exogenous Injection of Growth Factors 1028 UCD-200 Chicken 1028 CONTENTS Transgenic Mouse Models 1029 Knockout Mouse Models 1029 Conclusions 1029 References 1030 42. Animal Models for the Study of Multiple Sclerosis ROBERT H. MILLER, SHARYL FYFFE-MARICICH, ANDREW V. CAPRARIELLO The Complex Biology of Multiple Sclerosis 1005 Immunological Models for CNS Demyelination 1039 Local Induction of Demyelination following Injection of Myelin Peptides 1040 Development of MS Therapies Based on Models of Immune-Mediated Demyelinating Diseases 1041 Viral-Mediated Models of Demyelination 1041 Oligodendrocyte-lnduced Cell Death Models of Demyelination 1042 Toxin Models of Demyelination 1046 Conclusions and Comments 1050 References 1050 Index 1059
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