Bioorganometallic chemistry: applications in drug discovery, biocatalysis, and imaging
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| Sprache: | English |
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Weinheim
Wiley-VCH
2015
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| Beschreibung: | XX, 398 S. 220 schw.-w. Ill., 10 farb. Ill. 244 mm x 170 mm |
| ISBN: | 3527335277 9783527335275 9783527673438 |
Internformat
MARC
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| 245 | 1 | 0 | |a Bioorganometallic chemistry |b applications in drug discovery, biocatalysis, and imaging |c ed. by Gérard Jaouen and Michèle Salmain |
| 264 | 1 | |a Weinheim |b Wiley-VCH |c 2015 | |
| 300 | |a XX, 398 S. |b 220 schw.-w. Ill., 10 farb. Ill. |c 244 mm x 170 mm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 650 | 0 | 7 | |a Bioanorganische Chemie |0 (DE-588)4126727-8 |2 gnd |9 rswk-swf |
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| 689 | 0 | 0 | |a Bioanorganische Chemie |0 (DE-588)4126727-8 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Jaouen, Gérard |0 (DE-588)130516546 |4 edt | |
| 700 | 1 | |a Salmain, Michèle |4 edt | |
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Datensatz im Suchindex
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CONTENTS
LIST OF CONTRIBUTORS XIII
PREFACE XVII
PART ONE MEDICINAL CHEMISTRY 1
1 ORGANOMETALLIC COMPLEXES AS ENZYME INHIBITORS: A CONCEPTUAL
OVERVIEW 3
PHILIPP ANSTAETT AND
GILLES GASSER
1.1 INTRODUCTION 3
1.2 ORGANOMETALLIC COMPOUNDS AS INERT STRUCTURAL SCAFFOLDS FOR ENZYME
INHIBITION 3
1.3 ORGANOMETALLIC COMPOUNDS TARGETING SPECIFIC PROTEIN RESIDUES
11
1.4 THE BIOISOSTERIC SUBSTITUTION 14
1.5 NOVEL MECHANISMS OF ENZYME INHIBITION WITH ORGANOMETALLIC
COMPOUNDS 19
1.6 ORGANOMETALLIC COMPOUNDS AS CARGO DELIVERS OF ENZYME
INHIBITORS 25
1.7 ORGANOMETALLIC ENZYME INHIBITORS FOR THERANOSTIC PURPOSES 30
1.8 CONCLUSION 34
ACKNOWLEDGMENTS 35
ABBREVIATIONS 35
REFERENCES 36
2 THE BIOLOGICAL TARGET POTENTIAL OF ORGANOMETALLIC STEROIDS 43
GERARD JAOUEN, SIDEN TOP, AND MICHAEL
J. MCGLINCHEY
2.1 INTRODUCTORY NOTE ON NUCLEAR RECEPTORS 43
2.1.1 EARLY HISTORY 43
2.1.2 PRIMARY STRUCTURE OF NUCLEAR RECEPTORS 44
2.1.3 ESTROGEN RECEPTORS 45
2.1.4 ANDROGENS 45
2.1.5 GLUCOCORTICOIDS 46
2.1.6 PROGESTERONE AND PROGESTOGENS 46
HTTP://D-NB.INFO/1052323677
VI | CONTENTS
2.1.7 MINERALOCORTICOIDS AND ALDOSTERONE 46
2.1.8 SELECTIVE MODULATORS OF NUCLEAR RECEPTORS 47
2.1.8.1 SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERMS) 47
2.1.8.2 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) 48
2.1.8.3 SELECTIVE PROGESTERONE RECEPTOR MODULATORS (SPRMS) 48
2.1.9 MECHANISM OF ACTION OF NUCLEAR RECEPTORS 48
2.1.10 ENDOCRINE DISRUPTORS 50
2.2 STEROIDS AND ORGANOMETALLICS: AN OVERVIEW OF THE TRANSITIONAL
PERIOD FROM THE USE OF ORGANOMETALLICS IN SYNTHESIS TO THE
EMERGENCE OF BIOORGANOMETALLICS S3
2.2.1 EARLY EXAMPLES OF ORGANOMETALLIC ESTRADIOL DERIVATIVES WITH
BIOLOGICAL POTENTIAL: MODIFIED HORMONE SHOWN TO BIND TO ESTROGEN
RECEPTOR A 56
2.2.2 EXAMPLES OF ESTROGENS MODIFIED BY ORGANOMETALLICS AT THE
LIP-POSITION 62
2.2.3 TARGETING PROSTATE CANCER WITH ORGANOMETALLIC ANDROGENS AND
ANTIANDROGENS 64
2.2.4 APPROACH TOWARD ORGANOMETALLIC RADIOPHARMACEUTICALS
66
2.2.4.1 STEROIDAL DERIVATIVES 66
2.2.4.2 NONSTEROIDAL COMPLEXES 73
2.3 EPILOG 75
ACKNOWLEDGMENTS 76
REFERENCES 76
3 CHIRALITY IN ORGANOMETALLIC ANTICANCER COMPLEXES 85
MARIA J. ROMERO AND
PETER J. SADLER
3.1 INTRODUCTION 85
3.2 CHIRALITY IN ARENE COMPLEXES 87
3.3 CIP SYSTEM FOR THE NOMENCLATURE OF CHIRAL-AT-METAL ARENE
COMPLEXES 89
3.4 CHIRAL ORGANOMETALLIC COMPLEXES AS ANTICANCER AGENTS 90
3.4.1 CHIRAL CARBENE COMPLEXES 90
3.4.2 CHIRAL METALLOCENE COMPLEXES 91
3.4.3 CHIRAL HALF-SANDWICH ARENE COMPLEXES 93
3.4.4 CHIRALITY AT METAL IN SUPRAMOLECULAR COMPLEXES 97
3.5 HALF-SANDWICH COMPLEXES WITH CHIRAL METAL CENTERS 99
3.5.1 FACTORS INFLUENCING THE CHIRALITY AT THE METAL CENTER 100
3.5.1.1 USE OF CHIRAL LIGANDS FOR CHIRAL RESOLUTION AT THE METAL CENTER:
DIASTEREOISOMERISM 100
3.5.1.2 CH-JT INTERACTIONS: P-PHENYL EFFECT AND HYDROGEN BOND
INTERACTIONS 101
3.5.1.3 EFFECT OF THE TEMPERATURE, SOLVENT AND LIGANDS ON THE METAL
CONFIGURATION 103
CONTENTS | VII
3.6 CONCLUSIONS 110
ACKNOWLEDGMENTS 111
REFERENCES 111
4 GOLD ORGANOMETALLICS WITH BIOLOGICAL PROPERTIES 117
MARIA AGOSTINA CINELLU,
INGO OTT,
AND ANGELA CASINI
4.1 INTRODUCTION: THE USE OF GOLD IN MEDICINE 117
4.2 ANTICANCER GOLD ORGANOMETALLICS AND PROPOSED BIOLOGICAL
TARGETS 117
4.2.1 CYCLOMETALATED GOLD(III) COMPLEXES WITH C,N-DONOR LIGANDS 121
4.2.1.1 TYPES OF CYCLOAURATED COMPLEXES, SYNTHETIC METHODS, AND
REACTIVITY 122
4.2.1.2 CYCLOAURATED COMPLEXES WITH BIOLOGICAL ACTIVITIES 125
4.2.2 GOLD N-HETEROCYCLIC CARBENE (NHC) COMPLEXES 129
4.2.3 GOLD ALKYNYL COMPLEXES 132
4.3 CONCLUSIONS AND PERSPECTIVES 134
LIST OF ABBREVIATIONS 135
REFERENCES 135
5 ON THE MOLECULAR MECHANISMS OF THE ANTIMALARIAL ACTION
OF FERROQUINE 141
FAUSTINE DUBAR AND CHRISTOPHE
BIOT
5.1 HISTORY AND DEVELOPMENT 141
5.2 MECHANISM(S) OF ACTION OF 4-AMINOQUINOLINE ANTIMALARIALS 141
5.3 MECHANISM(S) OF ACTION OF FERROQUINE AS AN ANTIMALARIAL 144
5.3.1 ANTIMALARIAL ACTIVITY 144
5.3.2 METABOLIC PATHWAY OF FERROQUINE 144
5.3.3 REDOX PROPERTIES OF FQ 144
5.3.4 BASIC PROPERTIES AND ACCUMULATION 147
5.3.5 IMPORTANCE OF REDOX PROPERTIES OF FERROCENE ON ANTIMALARIAL
ACTIVITY OF FQ 155
5.3.6 INHIBITION OF HEMOZOIN FORMATION 157
5.4 CONCLUSION 160
ACKNOWLEDGMENTS 161
LIST OF ABBREVIATIONS 161
REFERENCES 161
6 METAL CARBONYL PRODRUGS: CO DELIVERY AND BEYOND 165
CARLOS C. ROMAO AND HELENA LA. VIEIRA
6.1 INTRODUCING CO IN BIOLOGY 165
6.1.1 ORIGIN 165
6.1.2 BIOLOGICAL ACTION AND TARGETS OF CO 166
6.1.3 THERAPEUTIC OUTLOOK 266
6.1.4 MEASURING CO IN BIOLOGY 167
6.2 THERAPEUTIC DELIVERY OF CO 167
VIIII CONTENTS
6.2.1 CO GAS AND INHALATION 167
6.2.2 PRODRUGS FOR CO DELIVERY: CO-RELEASING MOLECULES (CORM) 168
6.2.2.1 DEFINITIONS AND CONCEPT 168
6.2.3 EARLY CORMS 169
6.2.3.1 NONMETAL-BASED CORMS 169
6.2.3.2 METAL CARBONYL-BASED CORMS 169
6.2.4 THE CHEMICAL BIOLOGY OF EARLY CORMS 171
6.2.4.1 [RU(CO)
3
]
2+
-BASED CORMS 171
6.2.4.2 [MO(CO)
N
]-BASED CORMS 176
6.2.4.3 MISCELLANEOUS BIOLOGICALLY SIGNIFICANT OBSERVATIONS ON
EARLY-STAGE
CORMS 177
6.3 BIOLOGICAL AND THERAPEUTIC RESULTS OBTAINED WITH THE EARLY-STAGE
CORMS 178
6.3.1 CORM AND INFLAMMATORY RESPONSE 178
6.3.2 ' CARDIOPROTECTIVE EFFECTS OF CORM 180
6.3.3 CENTRAL NERVOUS SYSTEM AND CORMS 180
6.3.4 TRANSPLANTATION 181
6.3.5 BACTERICIDE EFFECTS OF CORMS 181
6.3.6 CORMS: TISSUE REGENERATION AND MODULATION OF CELL PROLIFERATION/
DIFFERENTIATION 182
6.3.7 CORMS AND CANCER THERAPY? 182
6.4 BEYOND THE EARLY-STAGE CORMS: STRATEGIES FOR FINDING NEW
CANDIDATES 183
6.4.1 EVALUATION OF CO RELEASE FROM CORMS 184
6.4.2 LIGHT ACTIVATED OR PHOTOCORMS 185
6.4.3 CHEMICALLY ACTIVATED CORMS 187
6.4.4 BIOACTIVATED OR ENZYME-TRIGGERED CORMS (ET-CORMS) 191
6.5 INTRACELLULAR DETECTION OF CORMS, MECHANISTIC STUDIES, AND
OTHER UNANSWERED QUESTIONS 192
6.6 DESIGNING PHARMACOLOGICALLY USEFUL, DRUG-LIKE CORMS 193
6.6.1 THE FIRST DRUG-LIKE CORM 195
6.7 FINAL REMARKS AND PERSPECTIVES 196
LIST OF ABBREVIATIONS 196
REFERENCES 198
7 DINITROSYL IRON COMPLEXES WITH NATURAL THIOL-CONTAINING LIGANDS:
PHYSICOCHEMISTRY, BIOLOGY, AND MEDICINE 203
ANATOLY F. VANIN
7.1 INTRODUCTION 203
7.2 THE HISTORY OF DETECTION AND IDENTIFICATION OF DNIC WITH
THIOL-CONTAINING LIGANDS IN MICROORGANISMS AND ANIMAL
TISSUES 204
7.3 PHYSICOCHEMISTRY OF DNIC WITH NATURAL THIOL-CONTAINING
LIGANDS 208
CONTENTS | IX
7.3.1 MONO- AND BINUCLEAR FORMS OF DNIC WITH NATURAL THIOL-CONTAINING
LIGANDS 208
7.3.2 TWO APPROACHES TO THE SYNTHESIS OF DNIC WITH NATURAL
THIOL-CONTAINING LIGANDS 209
7.3.3 MECHANISMS OF FORMATION OF DNIC WITH NATURAL THIOL-CONTAINING
LIGANDS 210
7.3.4 THE ELECTRONIC AND SPATIAL STRUCTURES OF DNIC WITH
THIOL-CONTAINING
LIGANDS 212
7.3.5 DNIC WITH THIOL-CONTAINING LIGANDS AS NO AND NO
+
DONORS 213
7.4 BIOLOGICAL EFFECTS OF DNIC WITH THIOL-CONTAINING LIGANDS 219
7.4.1 S-NITROSATING EFFECT OF DNIC WITH THIOL-CONTAINING LIGANDS 219
7.4.2 VASODILATOR AND HYPOTENSIVE EFFECTS OF DNIC WITH THIOL-CONTAINING
LIGANDS 220
7.4.3 INHIBITING EFFECT OF DNIC WITH THIOL-CONTAINING LIGANDS
ON PLATELET AGGREGATION 224
7.4.4 DNIC WITH THIOL-CONTAINING LIGANDS INCREASE ERYTHROCYTE
ELASTICITY 225
7.4.5 DNIC WITH THIOL-CONTAINING LIGANDS ACCELERATE SKIN WOUND
HEALING IN ANIMALS 225
7.4.6 ERECTIVE ACTIVITY OF DNIC 226
7A.7 DNIC AND APOPTOSIS 227
7.4.8 DNIC WITH GLUTATHIONE INHIBITS THE DEVELOPMENT OF EXPERIMENTAL
ENDOMETRIOSIS IN RATS 230
7.4.9 OTHER EXAMPLES OF BIOLOGICAL EFFECTS OF DNIC WITH THIOL-CONTAINING
LIGANDS 232
7.5 DNIC WITH THIOL-CONTAINING LIGANDS AS A BASIS IN THE DESIGN
OF DRUGS WITH A BROAD RANGE OF THERAPEUTIC ACTIVITIES 233
LIST OF ABBREVIATIONS 234
ACKNOWLEDGMENTS 235
REFERENCES 235
PART TWO METALLOPROTEINS, CATALYSIS, AND ENERGY PRODUCTION 239
8 THE BIOORGANOMETALLIC CHEMISTRY OF HYDROGENASE 241
RYAN D. BETHEL AND MARCETTA Y. DARENSBOURG
8.1 INTRODUCTION 241
8.1.1 HYDROGENASE 241
8.1.2 THE CHEMISTRY OF HYDROGEN 243
8.1.3 DIHYDROGEN METAL COMPLEXES 244
8.1.4 FIRST COORDINATION SPHERE LIGANDS 247
8.2 STRUCTURE AND FUNCTION 247
8.2.1 THE ACTIVE SITES OF THE HYDROGENASES 247
8.2.1.1 [NIFE]- AND [FEFE]-HYDROGENASE 247
8.2.1.2 [FE]-HYDROGENASE 250
X| CONTENTS
8.2.2 THE MECHANISMS OF THE HYDROGENASES 251
8.3 NATURAL BIOSYNTHESIS AND SYNTHETIC ANALOGS OF THE ACTIVE SITES 253
8.3.1 NATURAL BIOSYNTHESIS OF HYDROGENASE ACTIVE SITES 253
8.3.1.1 BIOSYNTHESIS OF [NIFE]-HYDROGENASE 254
8.3.1.2 BIOSYNTHESIS OF [FEFE]-HYDROGENASE 255
8.3.2 SYNTHETIC ANALOGS 256
8.3.2.1 MODELS OF THE [NIFE]-HYDROGENASE ACTIVE SITE 256
8.3.2.2 MODELS OF THE [FEFE]-HYDROGENASE ACTIVE SITE 259
8.3.2.3 MODELS OF THE [FE]-HYDROGENASE ACTIVE SITE 263
8.4 COMMENTS AND CONCLUSION 265
REFERENCES 268
9 BIO-ORGANOMETALLIC SYSTEMS FOR THE HYDROGEN ECONOMY: ENGINEERING
OF ELECTRODE MATERIALS AND LIGHT-DRIVEN DEVICES 273
MURIELLE CHAVAROT-KERLIDOU, PASCALE CHENEVIER, AND VINCENT ARTERO
9.1 INTRODUCTION 273
9.2 ELECTRODE MATERIALS FOR HYDROGEN EVOLUTION AND UPTAKE 274
9.2.1 ELECTRODE MATERIALS-BASED ON HYDROGENASES 274
9.2.2 HYDROGEN FUEL CELL ELECTRODES BASED ON HYDROGENASES 277
9.2.3 ELECTRODE MATERIALS BASED ON BIO-INSPIRED MOLECULAR CATALYSTS 279
9.2.3.1 COVALENT ATTACHMENT OF CATALYST TO ELECTRODE MATERIAL 279
9.2.3.2 NONCOVALENT ATTACHMENT OF CATALYST TO ELECTRODE MATERIAL VIA
JC
-
JI
STACKING INTERACTION 283
9.3 LIGHT-DRIVEN SYSTEMS FOR HYDROGEN EVOLUTION 284
9.3.1 BIOLOGICAL AND BIOHYBRID SYSTEMS 286
9.3.2 BIO-INSPIRED CATALYSIS APPROACHES 288
9.3.2.1 IRON-BASED CATALYSTS 289
9.3.2.2 NICKEL-BASED CATALYSTS 294
9.3.2.3 FIRST APPROACHES TOWARD MOLECULAR-BASED PHOTOELECTRODES 295
9.4 ARTIFICIAL PHOTOSYNTHETIC SYSTEMS 297
9.5 SUMMARY AND CONCLUSIONS 298
LIST OF ABBREVIATIONS 298
REFERENCES 299
10 ARTIFICIAL METALLOENZYMES CONTAINING AN ORGANOMETALLIC
ACTIVE SITE 305
AKIRA ONODA, TAKASHI HAYASHI, AND MICH&E SALMAIN
10.1 INTRODUCTION 305
10.2 DATIVE ANCHORING 306
10.2.1 METALLOPROTEINS AS PROTEIN HOSTS 306
10.2.2 OTHER PROTEIN HOSTS 313
10.3 SUPRAMOLECULAR ANCHORING 316
10.3.1 (STREPT)AVIDIN AS PROTEIN HOSTS 316
10.3.2 ANTIBODIES AS PROTEIN HOSTS 319
10.3.3 OTHER PROTEIN HOSTS 320
CONTENTS
10.4 COVALENT ANCHORING 321
10.5 MIXED ANCHORING MODES 326
10.5.1 SUPRAMOLECULAR + COVALENT ANCHORING 326
10.5.2 SUPRAMOLECULAR + DATIVE ANCHORING 327
10.5.3 DATIVE + COVALENT ANCHORING 327
10.6 PEPTIDE SCAFFOLDS 328
10.7 SUMMARY AND OUTLOOK 332
LIST OF ABBREVIATIONS 332
REFERENCES 333
PART THREE BIOANALYSIS 339
11 ORGANOMETALLIC BIOPROBES FOR CELLULAR IMAGING 341
EMANUELA LICANDRO, MONICA
PANIGATI, MICHILE SALMAIN, AND ANNE VESSIERES
11.1 INTRODUCTION 341
11.1.1 DEFINITION OF ORGANOMETALLIC BIOPROBES 342
11.1.2 COMPARISON OF DIFFERENT IMAGING TECHNIQUES 343
11.2 LUMINESCENCE 346
11.2.1 PHOTOPHYSICAL PROPERTIES OF AN IDEAL FLUOROPHORE FOR CELL
IMAGING 347
11.2.2 EMISSION PROPERTIES OF THE MAIN CLASSES OF ORGANOMETALLIC
COMPLEXES 348
11.2.3 OTHER ADVANTAGES IN THE USE OF ORGANOMETALLIC COMPLEXES FOR
LUMINESCENCE IMAGING 351
11.2.4 TIME-RESOLVED TECHNIQUES 352
11.2.5 RHENIUM 352
11.2.5.1 MONONUCLEAR RHENIUM COMPLEXES 352
11.2.5.2 DINUCLEAR RHENIUM COMPLEXES 360
11.2.5.3 BIMODAL RHENIUM AGENTS 362
11.2.6 IRIDIUM 362
11.2.6.1 SIMPLE ORGANOMETALLIC IRIDIUM COMPLEXES 362
11.2.6.2 IRIDIUM BIOCONJUGATES 365
11.2.7 RHODIUM 367
11.2.7.1 SIMPLE ORGANOMETALLIC RHODIUM COMPLEXES 367
11.2.7.2 RHODIUM BIOCONJUGATES 367
11.2.8 PLATINUM 368
11.2.8.1 CONFOCAL FLUORESCENCE MICROSCOPY IMAGING WITH PLATINUM
COMPLEXES
WITH ONE OR TWO PHOTON EXCITATION 368
11.2.8.2 TIME-RESOLVED IMAGING WITH PLATINUM COMPLEXES 370
11.2.9 GOLD 371
11.2.9.1 SIMPLE ORGANOMETALLIC GOLD COMPLEXES 371
11.2.9.2 GOLD BIOCONJUGATES 372
11.3 VIBRATIONAL SPECTROSCOPY 372
11.3.1 INFRARED MICROSCOPY 374
XII
| CONTENTS
11.3.2 BIMODAL DETECTION (BY INFRARED AND LUMINESCENCE) 377
11.3.3 AFM-IR SPECTROSCOPY 378
11.3.4 RAMAN SPECTROMICROSCOPY 379
11.4 MISCELLANEOUS 381
11.4.1 NANOIMAGING BASED ON X-RAY FLUORESCENCE 381
11.4.2 FERROCENE-BASED FLUORESCENT PROBE 382
11.5 CONCLUSIONS 383
ACKNOWLEDGMENTS 384
ABBREVIATIONS 384
REFERENCES 386
INDEX 393 |
| any_adam_object | 1 |
| author2 | Jaouen, Gérard Salmain, Michèle |
| author2_role | edt edt |
| author2_variant | g j gj m s ms |
| author_GND | (DE-588)130516546 |
| author_facet | Jaouen, Gérard Salmain, Michèle |
| building | Verbundindex |
| bvnumber | BV042334684 |
| classification_rvk | VH 9700 VH 9750 VS 9400 |
| ctrlnum | (OCoLC)882484212 (DE-599)DNB1052323677 |
| dewey-full | 572.51 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572.51 |
| dewey-search | 572.51 |
| dewey-sort | 3572.51 |
| dewey-tens | 570 - Biology |
| discipline | Chemie / Pharmazie Biologie |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV042334684 |
| illustrated | Illustrated |
| indexdate | 2024-09-10T01:36:26Z |
| institution | BVB |
| isbn | 3527335277 9783527335275 9783527673438 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027771339 |
| oclc_num | 882484212 |
| open_access_boolean | |
| owner | DE-11 DE-703 DE-91G DE-BY-TUM DE-19 DE-BY-UBM |
| owner_facet | DE-11 DE-703 DE-91G DE-BY-TUM DE-19 DE-BY-UBM |
| physical | XX, 398 S. 220 schw.-w. Ill., 10 farb. Ill. 244 mm x 170 mm |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Bioorganometallic chemistry applications in drug discovery, biocatalysis, and imaging ed. by Gérard Jaouen and Michèle Salmain Weinheim Wiley-VCH 2015 XX, 398 S. 220 schw.-w. Ill., 10 farb. Ill. 244 mm x 170 mm txt rdacontent n rdamedia nc rdacarrier Bioanorganische Chemie (DE-588)4126727-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Bioanorganische Chemie (DE-588)4126727-8 s DE-604 Jaouen, Gérard (DE-588)130516546 edt Salmain, Michèle edt Erscheint auch als Online-Ausgabe, EPUB 978-3-527-67345-2 Erscheint auch als Online-Ausgabe, MOBI 978-3-527-67344-5 Erscheint auch als Online-Ausgabe, PDF 978-3-527-67346-9 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=4691249&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027771339&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bioorganometallic chemistry applications in drug discovery, biocatalysis, and imaging Bioanorganische Chemie (DE-588)4126727-8 gnd |
| subject_GND | (DE-588)4126727-8 (DE-588)4143413-4 |
| title | Bioorganometallic chemistry applications in drug discovery, biocatalysis, and imaging |
| title_auth | Bioorganometallic chemistry applications in drug discovery, biocatalysis, and imaging |
| title_exact_search | Bioorganometallic chemistry applications in drug discovery, biocatalysis, and imaging |
| title_full | Bioorganometallic chemistry applications in drug discovery, biocatalysis, and imaging ed. by Gérard Jaouen and Michèle Salmain |
| title_fullStr | Bioorganometallic chemistry applications in drug discovery, biocatalysis, and imaging ed. by Gérard Jaouen and Michèle Salmain |
| title_full_unstemmed | Bioorganometallic chemistry applications in drug discovery, biocatalysis, and imaging ed. by Gérard Jaouen and Michèle Salmain |
| title_short | Bioorganometallic chemistry |
| title_sort | bioorganometallic chemistry applications in drug discovery biocatalysis and imaging |
| title_sub | applications in drug discovery, biocatalysis, and imaging |
| topic | Bioanorganische Chemie (DE-588)4126727-8 gnd |
| topic_facet | Bioanorganische Chemie Aufsatzsammlung |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=4691249&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027771339&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT jaouengerard bioorganometallicchemistryapplicationsindrugdiscoverybiocatalysisandimaging AT salmainmichele bioorganometallicchemistryapplicationsindrugdiscoverybiocatalysisandimaging |