Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Tokyo [u.a.]
Springer
2015
|
| Schriftenreihe: | Springer Theses
|
| Schlagworte: | |
| Online-Zugang: | FAW01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource (XIII, 109 p. 84 illus., 14 illus. in color) |
| ISBN: | 9784431554479 |
| ISSN: | 2190-5053 |
| DOI: | 10.1007/978-4-431-55447-9 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV042326362 | ||
| 003 | DE-604 | ||
| 005 | 20150302 | ||
| 006 | a m||| 00||| | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 150204s2015 |||| o||u| ||||||eng d | ||
| 020 | |a 9784431554479 |c Online |9 978-4-431-55447-9 | ||
| 024 | 7 | |a 10.1007/978-4-431-55447-9 |2 doi | |
| 035 | |a (OCoLC)902845643 | ||
| 035 | |a (DE-599)BVBBV042326362 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-1046 |a DE-703 | ||
| 082 | 0 | |a 547 |2 23 | |
| 100 | 1 | |a Ohsawa, Kosuke |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer |c Kosuke Ohsawa |
| 264 | 1 | |a Tokyo [u.a.] |b Springer |c 2015 | |
| 300 | |a 1 Online-Ressource (XIII, 109 p. 84 illus., 14 illus. in color) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a Springer Theses |x 2190-5053 | |
| 502 | |a Zugl.: Sendai, Tohoku University, Diss. | ||
| 650 | 4 | |a Chemistry | |
| 650 | 4 | |a Chemistry, Organic | |
| 650 | 4 | |a Biochemistry | |
| 650 | 4 | |a Pharmacy | |
| 650 | 4 | |a Organic Chemistry | |
| 650 | 4 | |a Medicinal Chemistry | |
| 650 | 4 | |a Chemie | |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druckausgabe |z 978-4-431-55446-2 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-4-431-55447-9 |x Verlag |3 Volltext |
| 856 | 4 | 2 | |m Springer Fremddatenuebernahme |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027763199&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 856 | 4 | 2 | |m Springer Fremddatenuebernahme |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027763199&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |3 Abstract |
| 912 | |a ZDB-2-CMS | ||
| 940 | 1 | |q ZDB-2-CMS_2015 | |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-027763199 | ||
| 966 | e | |u https://doi.org/10.1007/978-4-431-55447-9 |l FAW01 |p ZDB-2-CMS |x Verlag |3 Volltext | |
| 966 | e | |u https://doi.org/10.1007/978-4-431-55447-9 |l UBT01 |p ZDB-2-CMS |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804152928538198016 |
|---|---|
| adam_text | TOTAL SYNTHESIS OF THIELOCIN B1 AS A PROTEIN-PROTEIN INTERACTION
INHIBITOR OF PAC3 HOMODIMER
/ OHSAWA, KOSUKE
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
INTRODUCTION
TOTAL SYNTHESIS OF THIELOCIN B1 AND NMR CHEMICAL SHIFT PERTURBATION
EXPERIMENTS WITH PAC3 HOMODIMER
SYNTHESIS OF SPIN-LABELED THIELOCIN B1 AND OBSERVATION OF PARAMAGNETIC
RELAXATION ENHANCEMENT EFFECTS
AN IMPROVED METHOD FOR THE DIRECT FORMYLATION OB SUBSTITUTED BENZENES
USING DICHLOROMETHYL METHYL ETHER-SILVER TRIFLUOROMETHANESULFONATE
CONCLUSIONS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
TOTAL SYNTHESIS OF THIELOCIN B1 AS A PROTEIN-PROTEIN INTERACTION
INHIBITOR OF PAC3 HOMODIMER
/ OHSAWA, KOSUKE
: 2015
ABSTRACT / INHALTSTEXT
THIS BOOK FOCUSES ON THIELOCIN B1 (TB1), WHICH WAS FOUND TO BE AN
INHIBITOR OF PROTEIN–PROTEIN INTERACTIONS (PPIS) OF PROTEASOME
ASSEMBLING CHAPERONE (PAC) 3 HOMODIMER, AND ELUCIDATES THE MECHANISM BY
NUCLEAR MAGNETIC RESONANCE (NMR) STUDIES. INTERFACES OF PPIS RECENTLY
HAVE BEEN EXPECTED TO BE NOVEL THERAPEUTIC TARGETS, WHILE IT IS
DIFFICULT TO APPLY CONVENTIONAL METHODOLOGY BASED ON LOCK AND KEY
THEORY. THE AUTHOR ACHIEVED THE FIRST TOTAL SYNTHESIS OF TB1 AND ITS
SPIN-LABELED DERIVATIVE TO CARRY OUT NMR EXPERIMENTS BECAUSE THE SUPPLY
OF TB1 FROM NATURAL SOURCES WAS LIMITED. UNIQUE
2,2’,6,6’-TETRASUBSTITUTED DIPHENYL ETHER MOIETY OF TB1 WAS
SYNTHESIZED FROM A DEPSIDONE SKELETON BY CHEMOSELECTIVE REDUCTION OF
LACTONE. IN THE PROCESS OF ELONGATING SIDE WINGS, EFFICIENT FORMYLATION
UTILIZING DICHLOROMETHYL METHYL ETHER–SILVER TRIFLUOROMETHANESULFONATE
WAS DEVELOPED FOR THE STERICALLY HINDERED AROMATIC COMPOUND. NMR
TITRATION EXPERIMENTS AND PARAMAGNETIC RELAXATION ENHANCEMENT
OBSERVATION OF PAC3 HOMODIMER WERE PERFORMED WITH SYNTHESIZED TB1 AND
ITS MOLECULAR PROBE, RESPECTIVELY. THE RESULTS OF THE ABOVE NMR STUDIES
AND ADDITIONAL IN SILICO DOCKING STUDIES SUGGESTED THAT TB1 PROMOTES THE
DISSOCIATION TO MONOMERIC PAC3 AFTER INTERACTION WITH PAC3 HOMODIMER.
THE RARE MECHANISM SHOWN IN THIS BOOK INDICATES A POTENTIAL NOVEL DRUG
TARGET IN THE INTERFACES OF PPIS WITH NO CAVITY OR GROOVE
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
| any_adam_object | 1 |
| author | Ohsawa, Kosuke |
| author_facet | Ohsawa, Kosuke |
| author_role | aut |
| author_sort | Ohsawa, Kosuke |
| author_variant | k o ko |
| building | Verbundindex |
| bvnumber | BV042326362 |
| collection | ZDB-2-CMS |
| ctrlnum | (OCoLC)902845643 (DE-599)BVBBV042326362 |
| dewey-full | 547 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 547 - Organic chemistry |
| dewey-raw | 547 |
| dewey-search | 547 |
| dewey-sort | 3547 |
| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie |
| doi_str_mv | 10.1007/978-4-431-55447-9 |
| format | Thesis Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02198nmm a2200505zc 4500</leader><controlfield tag="001">BV042326362</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20150302 </controlfield><controlfield tag="006">a m||| 00||| </controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">150204s2015 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9784431554479</subfield><subfield code="c">Online</subfield><subfield code="9">978-4-431-55447-9</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/978-4-431-55447-9</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)902845643</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV042326362</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-1046</subfield><subfield code="a">DE-703</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">547</subfield><subfield code="2">23</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ohsawa, Kosuke</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer</subfield><subfield code="c">Kosuke Ohsawa</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Tokyo [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">2015</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (XIII, 109 p. 84 illus., 14 illus. in color)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Springer Theses</subfield><subfield code="x">2190-5053</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="a">Zugl.: Sendai, Tohoku University, Diss.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chemistry, Organic</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biochemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pharmacy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Organic Chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medicinal Chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chemie</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druckausgabe</subfield><subfield code="z">978-4-431-55446-2</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1007/978-4-431-55447-9</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Springer Fremddatenuebernahme</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027763199&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Springer Fremddatenuebernahme</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027763199&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Abstract</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-2-CMS</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">ZDB-2-CMS_2015</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-027763199</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-4-431-55447-9</subfield><subfield code="l">FAW01</subfield><subfield code="p">ZDB-2-CMS</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-4-431-55447-9</subfield><subfield code="l">UBT01</subfield><subfield code="p">ZDB-2-CMS</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV042326362 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T01:18:30Z |
| institution | BVB |
| isbn | 9784431554479 |
| issn | 2190-5053 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027763199 |
| oclc_num | 902845643 |
| open_access_boolean | |
| owner | DE-1046 DE-703 |
| owner_facet | DE-1046 DE-703 |
| physical | 1 Online-Ressource (XIII, 109 p. 84 illus., 14 illus. in color) |
| psigel | ZDB-2-CMS ZDB-2-CMS_2015 |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Springer |
| record_format | marc |
| series2 | Springer Theses |
| spelling | Ohsawa, Kosuke Verfasser aut Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer Kosuke Ohsawa Tokyo [u.a.] Springer 2015 1 Online-Ressource (XIII, 109 p. 84 illus., 14 illus. in color) txt rdacontent c rdamedia cr rdacarrier Springer Theses 2190-5053 Zugl.: Sendai, Tohoku University, Diss. Chemistry Chemistry, Organic Biochemistry Pharmacy Organic Chemistry Medicinal Chemistry Chemie (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Druckausgabe 978-4-431-55446-2 https://doi.org/10.1007/978-4-431-55447-9 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027763199&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027763199&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Ohsawa, Kosuke Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer Chemistry Chemistry, Organic Biochemistry Pharmacy Organic Chemistry Medicinal Chemistry Chemie |
| subject_GND | (DE-588)4113937-9 |
| title | Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer |
| title_auth | Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer |
| title_exact_search | Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer |
| title_full | Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer Kosuke Ohsawa |
| title_fullStr | Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer Kosuke Ohsawa |
| title_full_unstemmed | Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer Kosuke Ohsawa |
| title_short | Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer |
| title_sort | total synthesis of thielocin b1 as a protein protein interaction inhibitor of pac3 homodimer |
| topic | Chemistry Chemistry, Organic Biochemistry Pharmacy Organic Chemistry Medicinal Chemistry Chemie |
| topic_facet | Chemistry Chemistry, Organic Biochemistry Pharmacy Organic Chemistry Medicinal Chemistry Chemie Hochschulschrift |
| url | https://doi.org/10.1007/978-4-431-55447-9 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027763199&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027763199&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT ohsawakosuke totalsynthesisofthielocinb1asaproteinproteininteractioninhibitorofpac3homodimer |