Advances in medicinal chemistry, Volume 4:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
[Place of publication not identified]
Elsevier Science
1999
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Beschreibung: | Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers |
| Beschreibung: | 1 Online-Ressource (1 online resource) |
| ISBN: | 9780762300648 0762300647 9780080526379 0080526373 1281308684 9781281308689 |
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| 500 | |a Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers | ||
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Datensatz im Suchindex
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| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
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| dewey-sort | 3615 219 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
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| indexdate | 2024-07-10T01:17:58Z |
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| isbn | 9780762300648 0762300647 9780080526379 0080526373 1281308684 9781281308689 |
| language | English |
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| publishDate | 1999 |
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| spelling | Advances in medicinal chemistry, Volume 4 [Place of publication not identified] Elsevier Science 1999 1 Online-Ressource (1 online resource) txt rdacontent c rdamedia cr rdacarrier Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers Chemistry / general Pharmacology Medicine Pharmaceutical chemistry fast Chemie Medizin Pharmaceutical chemistry Maryanoff, B. E. Sonstige oth Reitz, A. B. Sonstige oth http://www.sciencedirect.com/science/book/9780762300648 Verlag Volltext |
| spellingShingle | Advances in medicinal chemistry, Volume 4 Chemistry / general Pharmacology Medicine Pharmaceutical chemistry fast Chemie Medizin Pharmaceutical chemistry |
| title | Advances in medicinal chemistry, Volume 4 |
| title_auth | Advances in medicinal chemistry, Volume 4 |
| title_exact_search | Advances in medicinal chemistry, Volume 4 |
| title_full | Advances in medicinal chemistry, Volume 4 |
| title_fullStr | Advances in medicinal chemistry, Volume 4 |
| title_full_unstemmed | Advances in medicinal chemistry, Volume 4 |
| title_short | Advances in medicinal chemistry, Volume 4 |
| title_sort | advances in medicinal chemistry volume 4 |
| topic | Chemistry / general Pharmacology Medicine Pharmaceutical chemistry fast Chemie Medizin Pharmaceutical chemistry |
| topic_facet | Chemistry / general Pharmacology Medicine Pharmaceutical chemistry Chemie Medizin |
| url | http://www.sciencedirect.com/science/book/9780762300648 |
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