The chemistry and pharmacology of Taxol and its derivatives:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam
Elsevier
1995
|
| Schriftenreihe: | Pharmacochemistry library
v. 22 |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Beschreibung: | Taxol, a naturally occurring diterpenoid is one of the most exciting antitumor drugs available today. Its current indications (refractory ovarian and metastatic breast cancer) may soon be expanded since the drug is showing activity against lung and head-and-neck cancers. The book opens with a review of the naturally occurring taxoids, a chapter which is not a comprehensive list of all taxoids isolated to date, but attempts a systematic approact to describing the different classes of taxoids, with particular reference to all skeletal types and the various functionality patterns. Biosynthetic studies are also discussed, as well as some of the basic chemistry and common functionalities of taxoidic skeleton. Structural identification of taxoids, mostly by spectroscopic means; the formulation of taxanes; the metabolism and pharmacokinetics of Taxol are also discussed, as are the chemistry of taxanes in relation to SAR studies; SAR aspects of the phenylisoserine side chain; and the mode of action of the taxanes and the mechanisms of resistance. The book is therefore written for medical chemists, in order to stimulate further research in this area and to provide the reader with the necessary background information to start a research program in the area Includes bibliographical references and index |
| Beschreibung: | 1 Online-Ressource (ix, 339 p.) |
| ISBN: | 9780444817716 0444817719 9780080544991 0080544991 |
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| 500 | |a Taxol, a naturally occurring diterpenoid is one of the most exciting antitumor drugs available today. Its current indications (refractory ovarian and metastatic breast cancer) may soon be expanded since the drug is showing activity against lung and head-and-neck cancers. The book opens with a review of the naturally occurring taxoids, a chapter which is not a comprehensive list of all taxoids isolated to date, but attempts a systematic approact to describing the different classes of taxoids, with particular reference to all skeletal types and the various functionality patterns. Biosynthetic studies are also discussed, as well as some of the basic chemistry and common functionalities of taxoidic skeleton. Structural identification of taxoids, mostly by spectroscopic means; the formulation of taxanes; the metabolism and pharmacokinetics of Taxol are also discussed, as are the chemistry of taxanes in relation to SAR studies; SAR aspects of the phenylisoserine side chain; and the mode of action of the taxanes and the mechanisms of resistance. The book is therefore written for medical chemists, in order to stimulate further research in this area and to provide the reader with the necessary background information to start a research program in the area | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Drugs | |
| 650 | 4 | |a Paclitaxel / chemistry | |
| 650 | 4 | |a Paclitaxel / pharmacology | |
| 650 | 4 | |a Paclitaxel / analogs & derivatives | |
| 650 | 7 | |a MEDICAL / Pharmacology |2 bisacsh | |
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| 650 | 4 | |a Medizin | |
| 650 | 4 | |a Paclitaxel | |
| 650 | 4 | |a Paclitaxel |x Derivatives | |
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| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.3252 |
| dewey-search | 615/.3252 |
| dewey-sort | 3615 43252 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| id | DE-604.BV042308333 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T01:17:58Z |
| institution | BVB |
| isbn | 9780444817716 0444817719 9780080544991 0080544991 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027745325 |
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| physical | 1 Online-Ressource (ix, 339 p.) |
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| publishDate | 1995 |
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| series2 | Pharmacochemistry library |
| spelling | The chemistry and pharmacology of Taxol and its derivatives edited by Vittorio Farina Amsterdam Elsevier 1995 1 Online-Ressource (ix, 339 p.) txt rdacontent c rdamedia cr rdacarrier Pharmacochemistry library v. 22 Taxol, a naturally occurring diterpenoid is one of the most exciting antitumor drugs available today. Its current indications (refractory ovarian and metastatic breast cancer) may soon be expanded since the drug is showing activity against lung and head-and-neck cancers. The book opens with a review of the naturally occurring taxoids, a chapter which is not a comprehensive list of all taxoids isolated to date, but attempts a systematic approact to describing the different classes of taxoids, with particular reference to all skeletal types and the various functionality patterns. Biosynthetic studies are also discussed, as well as some of the basic chemistry and common functionalities of taxoidic skeleton. Structural identification of taxoids, mostly by spectroscopic means; the formulation of taxanes; the metabolism and pharmacokinetics of Taxol are also discussed, as are the chemistry of taxanes in relation to SAR studies; SAR aspects of the phenylisoserine side chain; and the mode of action of the taxanes and the mechanisms of resistance. The book is therefore written for medical chemists, in order to stimulate further research in this area and to provide the reader with the necessary background information to start a research program in the area Includes bibliographical references and index Drugs Paclitaxel / chemistry Paclitaxel / pharmacology Paclitaxel / analogs & derivatives MEDICAL / Pharmacology bisacsh Paclitaxel gtt Taxoïden gtt Farmacologia larpcal Quimica farmaceutica larpcal Drogas larpcal Paclitaxel fast Paclitaxel / Derivatives fast Medizin Paclitaxel Paclitaxel Derivatives Farina, Vittorio Sonstige oth http://www.sciencedirect.com/science/book/9780444817716 Verlag Volltext |
| spellingShingle | The chemistry and pharmacology of Taxol and its derivatives Drugs Paclitaxel / chemistry Paclitaxel / pharmacology Paclitaxel / analogs & derivatives MEDICAL / Pharmacology bisacsh Paclitaxel gtt Taxoïden gtt Farmacologia larpcal Quimica farmaceutica larpcal Drogas larpcal Paclitaxel fast Paclitaxel / Derivatives fast Medizin Paclitaxel Paclitaxel Derivatives |
| title | The chemistry and pharmacology of Taxol and its derivatives |
| title_auth | The chemistry and pharmacology of Taxol and its derivatives |
| title_exact_search | The chemistry and pharmacology of Taxol and its derivatives |
| title_full | The chemistry and pharmacology of Taxol and its derivatives edited by Vittorio Farina |
| title_fullStr | The chemistry and pharmacology of Taxol and its derivatives edited by Vittorio Farina |
| title_full_unstemmed | The chemistry and pharmacology of Taxol and its derivatives edited by Vittorio Farina |
| title_short | The chemistry and pharmacology of Taxol and its derivatives |
| title_sort | the chemistry and pharmacology of taxol and its derivatives |
| topic | Drugs Paclitaxel / chemistry Paclitaxel / pharmacology Paclitaxel / analogs & derivatives MEDICAL / Pharmacology bisacsh Paclitaxel gtt Taxoïden gtt Farmacologia larpcal Quimica farmaceutica larpcal Drogas larpcal Paclitaxel fast Paclitaxel / Derivatives fast Medizin Paclitaxel Paclitaxel Derivatives |
| topic_facet | Drugs Paclitaxel / chemistry Paclitaxel / pharmacology Paclitaxel / analogs & derivatives MEDICAL / Pharmacology Paclitaxel Taxoïden Farmacologia Quimica farmaceutica Drogas Paclitaxel / Derivatives Medizin Paclitaxel Derivatives |
| url | http://www.sciencedirect.com/science/book/9780444817716 |
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