Serotonin receptors and their ligands:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam
Elsevier
1997
|
| Schriftenreihe: | Pharmacochemistry library
v. 27 |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Beschreibung: | An international group of authors have produced an overview of the progress made in the medicinal chemistry of compounds (selectively) acting at serotonin receptors or serotonin transporters either as agonists, partial agonists or antagonists. Structure - affinity relationships and structure - activity relationships of agonists, partial agonists, and antagonists of 5-HT receptors and uptake sites, are discussed. Structure, sequence homology and the effect of site-directed mutations of 5-HT receptors and the reuptake site on the binding of ligands show the tremendous impact of molecular biology on medicinal chemistry research. Also discussed is the pharmacology and (potential) clinical applications of ligands for the 5-HT receptors and the reuptake site. By developing elegant techniques of cloning and expression of serotonin receptor subtypes, their mutants and chimeras, a unique opportunity was offered to study the binding mode of serotoninergic ligands to their receptors and transporters. The distribution, structure and homologies of serotonin receptor subtypes and the structure of the serotonin transporter are also taken into account. The (potential) therapeutic applications of ligands of the different subtypes are described. Altogether an excellent addition to the <IT>Pharmacochemical Library</IT> series Includes bibliographical references and index |
| Beschreibung: | 1 Online-Ressource (x, 367 p.) |
| ISBN: | 9780444820419 0444820418 9780080541112 0080541119 |
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| 300 | |a 1 Online-Ressource (x, 367 p.) | ||
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| 500 | |a An international group of authors have produced an overview of the progress made in the medicinal chemistry of compounds (selectively) acting at serotonin receptors or serotonin transporters either as agonists, partial agonists or antagonists. Structure - affinity relationships and structure - activity relationships of agonists, partial agonists, and antagonists of 5-HT receptors and uptake sites, are discussed. Structure, sequence homology and the effect of site-directed mutations of 5-HT receptors and the reuptake site on the binding of ligands show the tremendous impact of molecular biology on medicinal chemistry research. Also discussed is the pharmacology and (potential) clinical applications of ligands for the 5-HT receptors and the reuptake site. By developing elegant techniques of cloning and expression of serotonin receptor subtypes, their mutants and chimeras, a unique opportunity was offered to study the binding mode of serotoninergic ligands to their receptors and transporters. The distribution, structure and homologies of serotonin receptor subtypes and the structure of the serotonin transporter are also taken into account. The (potential) therapeutic applications of ligands of the different subtypes are described. Altogether an excellent addition to the <IT>Pharmacochemical Library</IT> series | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Serotonin / physiology | |
| 650 | 4 | |a Serotonin Agonists | |
| 650 | 4 | |a Serotonin Antagonists | |
| 650 | 7 | |a MEDICAL / Neuroscience |2 bisacsh | |
| 650 | 7 | |a PSYCHOLOGY / Neuropsychology |2 bisacsh | |
| 650 | 7 | |a Serotonine |2 gtt | |
| 650 | 7 | |a Receptoren |2 gtt | |
| 650 | 7 | |a Liganden |2 gtt | |
| 650 | 7 | |a Serotonin / Agonists |2 fast | |
| 650 | 7 | |a Serotonin / Antagonists |2 fast | |
| 650 | 7 | |a Serotonin / Receptors |2 fast | |
| 650 | 4 | |a Medizin | |
| 650 | 4 | |a Serotonin |x Receptors | |
| 650 | 4 | |a Serotonin |x Agonists | |
| 650 | 4 | |a Serotonin |x Antagonists | |
| 700 | 1 | |a Olivier, Berend |e Sonstige |4 oth | |
| 700 | 1 | |a Wijngaarden, I. van |e Sonstige |4 oth | |
| 700 | 1 | |a Soudijn, W. |e Sonstige |4 oth | |
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Datensatz im Suchindex
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| dewey-full | 612.8 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612.8 |
| dewey-search | 612.8 |
| dewey-sort | 3612.8 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
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| id | DE-604.BV042308314 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T01:17:58Z |
| institution | BVB |
| isbn | 9780444820419 0444820418 9780080541112 0080541119 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027745306 |
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| physical | 1 Online-Ressource (x, 367 p.) |
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| publishDate | 1997 |
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| publisher | Elsevier |
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| series2 | Pharmacochemistry library |
| spelling | Serotonin receptors and their ligands edited by B. Olivier, I. van Wijngaarden, W. Soudijn Amsterdam Elsevier 1997 1 Online-Ressource (x, 367 p.) txt rdacontent c rdamedia cr rdacarrier Pharmacochemistry library v. 27 An international group of authors have produced an overview of the progress made in the medicinal chemistry of compounds (selectively) acting at serotonin receptors or serotonin transporters either as agonists, partial agonists or antagonists. Structure - affinity relationships and structure - activity relationships of agonists, partial agonists, and antagonists of 5-HT receptors and uptake sites, are discussed. Structure, sequence homology and the effect of site-directed mutations of 5-HT receptors and the reuptake site on the binding of ligands show the tremendous impact of molecular biology on medicinal chemistry research. Also discussed is the pharmacology and (potential) clinical applications of ligands for the 5-HT receptors and the reuptake site. By developing elegant techniques of cloning and expression of serotonin receptor subtypes, their mutants and chimeras, a unique opportunity was offered to study the binding mode of serotoninergic ligands to their receptors and transporters. The distribution, structure and homologies of serotonin receptor subtypes and the structure of the serotonin transporter are also taken into account. The (potential) therapeutic applications of ligands of the different subtypes are described. Altogether an excellent addition to the <IT>Pharmacochemical Library</IT> series Includes bibliographical references and index Serotonin / physiology Serotonin Agonists Serotonin Antagonists MEDICAL / Neuroscience bisacsh PSYCHOLOGY / Neuropsychology bisacsh Serotonine gtt Receptoren gtt Liganden gtt Serotonin / Agonists fast Serotonin / Antagonists fast Serotonin / Receptors fast Medizin Serotonin Receptors Olivier, Berend Sonstige oth Wijngaarden, I. van Sonstige oth Soudijn, W. Sonstige oth http://www.sciencedirect.com/science/book/9780444820419 Verlag Volltext |
| spellingShingle | Serotonin receptors and their ligands Serotonin / physiology Serotonin Agonists Serotonin Antagonists MEDICAL / Neuroscience bisacsh PSYCHOLOGY / Neuropsychology bisacsh Serotonine gtt Receptoren gtt Liganden gtt Serotonin / Agonists fast Serotonin / Antagonists fast Serotonin / Receptors fast Medizin Serotonin Receptors |
| title | Serotonin receptors and their ligands |
| title_auth | Serotonin receptors and their ligands |
| title_exact_search | Serotonin receptors and their ligands |
| title_full | Serotonin receptors and their ligands edited by B. Olivier, I. van Wijngaarden, W. Soudijn |
| title_fullStr | Serotonin receptors and their ligands edited by B. Olivier, I. van Wijngaarden, W. Soudijn |
| title_full_unstemmed | Serotonin receptors and their ligands edited by B. Olivier, I. van Wijngaarden, W. Soudijn |
| title_short | Serotonin receptors and their ligands |
| title_sort | serotonin receptors and their ligands |
| topic | Serotonin / physiology Serotonin Agonists Serotonin Antagonists MEDICAL / Neuroscience bisacsh PSYCHOLOGY / Neuropsychology bisacsh Serotonine gtt Receptoren gtt Liganden gtt Serotonin / Agonists fast Serotonin / Antagonists fast Serotonin / Receptors fast Medizin Serotonin Receptors |
| topic_facet | Serotonin / physiology Serotonin Agonists Serotonin Antagonists MEDICAL / Neuroscience PSYCHOLOGY / Neuropsychology Serotonine Receptoren Liganden Serotonin / Agonists Serotonin / Antagonists Serotonin / Receptors Medizin Serotonin Receptors |
| url | http://www.sciencedirect.com/science/book/9780444820419 |
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