Glutamate:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam
Elsevier
2000
|
| Ausgabe: | 1st ed |
| Schriftenreihe: | Handbook of chemical neuroanatomy
v. 18 |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Beschreibung: | Includes bibliographical references and index The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment. Particular emphasis is on the localizations of the molecular constituents of the synaptic machinery. Immunogold and other high-resolution methods are used extensively. Each chapter presents new data that have not previously been reviewed. The material presented forms the basis for work directed to understanding the functional properties of excitatory synapses in greater depth, to discover mechanisms of neurological and psychiatric disorders and novel methods for treatment. Chapter 1 deals with the transmitter molecule itself, mechanisms of release and pathways for glutamate synthesis. The anatomy of glutamatergic nerve projection pathways in different brain regions is dealt with. In Chapter 2, focus is on aspartate, the enigmatic congener of glutamate, and its possible role in excitatory neurotransmission. Chapters 3 through 6 deal with glutamate receptors. Metabotropic glutamate receptors are presented in Chapter 3. Chapter 4 presents an in situ hybridization atlas of the different classes of ionotropic glutamate receptors. The localizations of these receptors at the regional and synaptic level are presented in Chapter 5. The ways in which the receptors are brought to the synapse and held in position are the subject of Chapter 6. Chapter 7 deals with the enzymes responsible for formation and catabolism of glutamate. In Chapter 8, the regulation of extracellular glutamate levels by glutamate transporters is discussed. The final two chapters of the volume focus on two "model synapses" that, due to special features, lend themselves particularly well to demonstrating properties of glutamatergic synapses. The hair cell-to-afferent nerve terminal synapses in the inner ear (Chapter 9), with their supporting cells, share essential properties with glutamatergic synapses in the central nervous system. The salient features of the latter are illustrated by the synapses of the giant reticulo-spinal axons of the lamprey, used to unravel molecular mechanisms of the cycling of synaptic vesicles (Chapter 10) |
| Beschreibung: | 1 Online-Ressource (xvii, 291 p.) |
| ISBN: | 9780444502865 0444502866 9781435605282 1435605284 0080532578 9780080532578 |
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| 500 | |a Metabotropic glutamate receptors are presented in Chapter 3. Chapter 4 presents an in situ hybridization atlas of the different classes of ionotropic glutamate receptors. The localizations of these receptors at the regional and synaptic level are presented in Chapter 5. The ways in which the receptors are brought to the synapse and held in position are the subject of Chapter 6. Chapter 7 deals with the enzymes responsible for formation and catabolism of glutamate. In Chapter 8, the regulation of extracellular glutamate levels by glutamate transporters is discussed. The final two chapters of the volume focus on two "model synapses" that, due to special features, lend themselves particularly well to demonstrating properties of glutamatergic synapses. The hair cell-to-afferent nerve terminal synapses in the inner ear (Chapter 9), with their supporting cells, share essential properties with glutamatergic synapses in the central nervous system. | ||
| 500 | |a The salient features of the latter are illustrated by the synapses of the giant reticulo-spinal axons of the lamprey, used to unravel molecular mechanisms of the cycling of synaptic vesicles (Chapter 10) | ||
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Datensatz im Suchindex
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| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 573 - Specific physiological systems in animals |
| dewey-raw | 573.8/4 |
| dewey-search | 573.8/4 |
| dewey-sort | 3573.8 14 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| edition | 1st ed |
| format | Electronic eBook |
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| indexdate | 2024-07-10T01:17:55Z |
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| language | English |
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| spelling | Glutamate editors, O.P. Ottersen and J. Storm-Mathisen 1st ed Amsterdam Elsevier 2000 1 Online-Ressource (xvii, 291 p.) txt rdacontent c rdamedia cr rdacarrier Handbook of chemical neuroanatomy v. 18 Includes bibliographical references and index The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment. Particular emphasis is on the localizations of the molecular constituents of the synaptic machinery. Immunogold and other high-resolution methods are used extensively. Each chapter presents new data that have not previously been reviewed. The material presented forms the basis for work directed to understanding the functional properties of excitatory synapses in greater depth, to discover mechanisms of neurological and psychiatric disorders and novel methods for treatment. Chapter 1 deals with the transmitter molecule itself, mechanisms of release and pathways for glutamate synthesis. The anatomy of glutamatergic nerve projection pathways in different brain regions is dealt with. In Chapter 2, focus is on aspartate, the enigmatic congener of glutamate, and its possible role in excitatory neurotransmission. Chapters 3 through 6 deal with glutamate receptors. Metabotropic glutamate receptors are presented in Chapter 3. Chapter 4 presents an in situ hybridization atlas of the different classes of ionotropic glutamate receptors. The localizations of these receptors at the regional and synaptic level are presented in Chapter 5. The ways in which the receptors are brought to the synapse and held in position are the subject of Chapter 6. Chapter 7 deals with the enzymes responsible for formation and catabolism of glutamate. In Chapter 8, the regulation of extracellular glutamate levels by glutamate transporters is discussed. The final two chapters of the volume focus on two "model synapses" that, due to special features, lend themselves particularly well to demonstrating properties of glutamatergic synapses. The hair cell-to-afferent nerve terminal synapses in the inner ear (Chapter 9), with their supporting cells, share essential properties with glutamatergic synapses in the central nervous system. The salient features of the latter are illustrated by the synapses of the giant reticulo-spinal axons of the lamprey, used to unravel molecular mechanisms of the cycling of synaptic vesicles (Chapter 10) Glutamates / chemistry Brain Chemistry Receptors, Glutamate / physiology SOCIAL SCIENCE / Anthropology / Physical bisacsh MEDICAL / Neuroscience bisacsh PSYCHOLOGY / Neuropsychology bisacsh Glutamaat gtt Neurotransmitters gtt Brain / Histochemistry fast Glutamic acid fast Glutamic acid / Receptors fast Neurochemistry fast Medizin Glutamic acid Glutamic acid Receptors Neurochemistry Brain Histochemistry Glutamatrezeptor (DE-588)4325632-6 gnd rswk-swf Neurotransmitter (DE-588)4041905-8 gnd rswk-swf Glutamate (DE-588)4157708-5 gnd rswk-swf Neurotransmitter (DE-588)4041905-8 s Glutamate (DE-588)4157708-5 s 1\p DE-604 Glutamatrezeptor (DE-588)4325632-6 s 2\p DE-604 Ottersen, O. P. Sonstige (DE-588)1169611575 oth Storm, Theodor 1817-1888 Sonstige (DE-588)118618725 oth http://www.sciencedirect.com/science/book/9780444502865 Verlag Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Glutamate Glutamates / chemistry Brain Chemistry Receptors, Glutamate / physiology SOCIAL SCIENCE / Anthropology / Physical bisacsh MEDICAL / Neuroscience bisacsh PSYCHOLOGY / Neuropsychology bisacsh Glutamaat gtt Neurotransmitters gtt Brain / Histochemistry fast Glutamic acid fast Glutamic acid / Receptors fast Neurochemistry fast Medizin Glutamic acid Glutamic acid Receptors Neurochemistry Brain Histochemistry Glutamatrezeptor (DE-588)4325632-6 gnd Neurotransmitter (DE-588)4041905-8 gnd Glutamate (DE-588)4157708-5 gnd |
| subject_GND | (DE-588)4325632-6 (DE-588)4041905-8 (DE-588)4157708-5 |
| title | Glutamate |
| title_auth | Glutamate |
| title_exact_search | Glutamate |
| title_full | Glutamate editors, O.P. Ottersen and J. Storm-Mathisen |
| title_fullStr | Glutamate editors, O.P. Ottersen and J. Storm-Mathisen |
| title_full_unstemmed | Glutamate editors, O.P. Ottersen and J. Storm-Mathisen |
| title_short | Glutamate |
| title_sort | glutamate |
| topic | Glutamates / chemistry Brain Chemistry Receptors, Glutamate / physiology SOCIAL SCIENCE / Anthropology / Physical bisacsh MEDICAL / Neuroscience bisacsh PSYCHOLOGY / Neuropsychology bisacsh Glutamaat gtt Neurotransmitters gtt Brain / Histochemistry fast Glutamic acid fast Glutamic acid / Receptors fast Neurochemistry fast Medizin Glutamic acid Glutamic acid Receptors Neurochemistry Brain Histochemistry Glutamatrezeptor (DE-588)4325632-6 gnd Neurotransmitter (DE-588)4041905-8 gnd Glutamate (DE-588)4157708-5 gnd |
| topic_facet | Glutamates / chemistry Brain Chemistry Receptors, Glutamate / physiology SOCIAL SCIENCE / Anthropology / Physical MEDICAL / Neuroscience PSYCHOLOGY / Neuropsychology Glutamaat Neurotransmitters Brain / Histochemistry Glutamic acid Glutamic acid / Receptors Neurochemistry Medizin Glutamic acid Receptors Brain Histochemistry Glutamatrezeptor Neurotransmitter Glutamate |
| url | http://www.sciencedirect.com/science/book/9780444502865 |
| work_keys_str_mv | AT ottersenop glutamate AT stormtheodor glutamate |