Excitatory amino acids: clinical results with antagonists
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Bibliographische Detailangaben
Format: Elektronisch E-Book
Sprache:English
Veröffentlicht: San Diego Academic Press c1997
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Beschreibung:Glutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chronic pain, and schizophrenia. Excitatory amino acid receptor agonists and antagonists are therefore of major interest as potential drugs for central nervous system disorders. Excitatory Amino Acids is the first book entirely dedicated to the results of human testing of modulators of excitatory amino acid neurotransmitters. Features include: * Coverage of the field of excitatory amino acids from synaptic function to preclinical and clinical pharmacology * Description of the development of NMDA (Nmethyl-d-aspartate) and non-NMDA antagonists * Reports of potential drugs in early and late clinical stages of development
Includes bibliographical references (p. [129]-152) and index
Beschreibung:1 Online-Ressource (xii, 156 p.)
ISBN:9780125468206
0125468202
9780080531342
0080531342

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